Several possible definitions of local injectivity for a homomorphism of an oriented graph G to an oriented graph H are considered. In each case, we determine the complexity of deciding whether there exists such a homo...Several possible definitions of local injectivity for a homomorphism of an oriented graph G to an oriented graph H are considered. In each case, we determine the complexity of deciding whether there exists such a homomorphism when G is given and H is a fixed tournament on three or fewer vertices. Each possible definition leads to a locally-injective oriented colouring problem. A dichotomy theorem is proved in each case.展开更多
With the increasing awareness of privacy protection and the improvement of relevant laws,federal learning has gradually become a new choice for cross-agency and cross-device machine learning.In order to solve the prob...With the increasing awareness of privacy protection and the improvement of relevant laws,federal learning has gradually become a new choice for cross-agency and cross-device machine learning.In order to solve the problems of privacy leakage,high computational overhead and high traffic in some federated learning schemes,this paper proposes amultiplicative double privacymask algorithm which is convenient for homomorphic addition aggregation.The combination of homomorphic encryption and secret sharing ensures that the server cannot compromise user privacy from the private gradient uploaded by the participants.At the same time,the proposed TQRR(Top-Q-Random-R)gradient selection algorithm is used to filter the gradient of encryption and upload efficiently,which reduces the computing overhead of 51.78%and the traffic of 64.87%on the premise of ensuring the accuracy of themodel,whichmakes the framework of privacy protection federated learning lighter to adapt to more miniaturized federated learning terminals.展开更多
BACKGROUND: To date, many 6-hydroxydopamine (6-OHDA)-lesioned rat models have been established by injecting 6-OHDA into two or more sites in the substantia nigra pars compacta, striatum or median forebrain bundle. ...BACKGROUND: To date, many 6-hydroxydopamine (6-OHDA)-lesioned rat models have been established by injecting 6-OHDA into two or more sites in the substantia nigra pars compacta, striatum or median forebrain bundle. The success rate of models established by this method is satisfactory, but it can raise the death rate, and is elaborate and tedious to perform. OBJECTIVE: To observe the difference between injections of 6-OHDA into the striatum from one site and two sites, and to explore the feasibility of establishing Parkinson's disease rat models via striatal one-site double injection. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment based on a modeling comparison was performed at the Pharmacology Laboratory of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine between August 2005 and April 2006. MATERIALS: A total of 46 male Wistar rats were purchased from Beijing Weitong Lihua Experimental Animal Technical Co., Ltd., China. 6-OHDA hydrogen bromide was sourced from Sigma Co., Ltd., USA. METHODS: All 46 rats were randomized to three groups: one-site injection (n = 18), two-site injection (n = 18), and control (n = 10). Lesions in rat brains were established by infusing 5 μg 6-OHDA into the striatum at the following coordinates: anteroposterior (AP) 1.0 mm, mediolateral (ML) 2.7 mm, dorsoventral (DV)-5.2 or-6.0 mm for the one-site injection group, and AP 1.0 mm, ML 2.5 mm, DV -4.5 mm/AP-0.4 mm, ML 3.5 mm, DV-4.5 mm for the two-site injection group, respectively. Rats in the control group were injected with the same volume of 0.01% ascorbic acid as above. MAIN OUTCOME MEASURES: Tyrosine hydroxylase-positive neurons were detected by immunohistochemistry. Success rates of PD models established by one-site and two-site injection techniques were examined. RESULTS: One rat died in the one-site injection group and four in the two-site injection group. Thus behavioral testing was performed on 31 rats. There was no significant difference in the success rate of PD model establishment between one-site injection and two-site injection groups [82% (14/17) vs. 86% (12/14), P 〉 0.05]. The numbers of tyrosine hydroxylase -positive neurons in one-site injection and two-site injection groups were not significantly different ( P 〉 0.05), but they were significantly lower than in the control group(P 〈 0.01 ). CONCLUSION: A Parkinson's disease model can be established in rats via striatal one-site double injection.展开更多
To achieve the electric field strength and the induced currents in equivalence in susceptibility tests with the high-level field radiation above 400 MHz,a double differential-mode(DM) current injection method based on...To achieve the electric field strength and the induced currents in equivalence in susceptibility tests with the high-level field radiation above 400 MHz,a double differential-mode(DM) current injection method based on directional couplers is proposed.Two cascaded symmetrical directional couplers compose a coupling device to inject the DM currents.When the coupling device is used,two devices are necessary to achieve the equivalence between radiation and injection,i.e.the equivalence between the injected voltages and the field strength,which is linear,regardless of the characteristics of the equipment under test(EUT).The results are verified by experiments using typical coaxial cables and nonlinear devices,where the equivalence between the nonlinear EUT responses induced by radiation and injection at both ends is achieved by using two coupling devices.At a frequency up to 1.75 GHz,the maximal experimental error is only 3.39%.The experimental results confirm the accuracy of the proposed method even both the EUTs work in the nonlinear region.The proposed method is applicable for radiated susceptibility(RS) testing of interconnected systems in the microwave frequency band.展开更多
To overcome hole-injection limitation of p^+-n emitter junction in 4H-SiC light triggered thyristor, a novel high- voltage 4H-SiC light triggered thyristor with double-deck thin n-base structure is proposed and demon...To overcome hole-injection limitation of p^+-n emitter junction in 4H-SiC light triggered thyristor, a novel high- voltage 4H-SiC light triggered thyristor with double-deck thin n-base structure is proposed and demonstrated by two- dimensional numerical simulations. In this new structure, the conventional thin n-base is split to double-deck. The hole- injection of p^+-n emitter junction is modulated by modulating the doping concentration and thickness of upper-deck thin n- base. With double-deck thin n-base, the current gain coefficient of the top pnp transistor in 4H-SiC light triggered thyristor is enhanced. As a result, the triggering light intensity and the turn-on delay time of 4H-SiC light triggered thyristor are both reduced. The simulation results show that the proposed 10-kV 4H-SiC light triggered thyristor is able to be triggered on by 500-mW/cm^2 ultraviolet light pulse. Meanwhile, the turn-on delay time of the proposed thyristor is reduced to 337 ns.展开更多
A highly sensitive double artificial neural network (DANN) analysis with flow-injection chemiluminescence (FI-CL) has been developed to simultaneously determine the trace amounts of the gold and platinum in simula...A highly sensitive double artificial neural network (DANN) analysis with flow-injection chemiluminescence (FI-CL) has been developed to simultaneously determine the trace amounts of the gold and platinum in simulated mixed samples, without the boring process.展开更多
Based on the double-injection effect,the dual-mode interference principle and the free-carrier plasma dispersion effect,a double-injection bifurcation optical active switch integrated on silicon-on-insulator has been ...Based on the double-injection effect,the dual-mode interference principle and the free-carrier plasma dispersion effect,a double-injection bifurcation optical active switch integrated on silicon-on-insulator has been proposed and fabricated.Its insertion loss and crosstalk are measured to be less than 5.32 and -14.4dB,respectively,at wavelength 1.3μm and the total switching current 90mA.Response time is about 180ns.展开更多
There are the application scope limits for single differential-mode current injection test method, so in order to carry out injection susceptibility test for two-pieces equipment interconnected with both ends of a cab...There are the application scope limits for single differential-mode current injection test method, so in order to carry out injection susceptibility test for two-pieces equipment interconnected with both ends of a cable simultaneously, a double differential-mode current in- jection test method (DDMCI) is proposed. The method adopted the equivalence source wave theorem and Baum-Liu-Tesche(BLT) equation as its theory foundation. The equivalent corresponding relation between injection voltage and radiation electric field intensity is derived, and the phase relation between the two injection voltage sources is confirmed. The results indicate that the amplitude and phase of the equivalent injection voltage source is closely related to the S parameter of directional coupling device, the transmission line length, and the source vector in BLT equation, but has nothing to do with the reflection coefficient between the two equipment pieces. Therefore, by choosing the right amplitude and phase of the double injection voltage sources, the DDMCI test is equivalent to the radiation test for two interconnected equipment of a system.展开更多
BACKGROUND : Experimental animal models of intracerebral hemorrhag (ICH) are greatly needed, so the process of establishment should be ideal in hematoma formation and easy to operate. OBJECTIVE : To construct mode...BACKGROUND : Experimental animal models of intracerebral hemorrhag (ICH) are greatly needed, so the process of establishment should be ideal in hematoma formation and easy to operate. OBJECTIVE : To construct model of ICH in rats with double injection of autologous blood taken from the cut tail cut and double withdrawal of the needle (shortened as two-step injection model), and compare with those induced by single and double injections. DESIGN : A randomized controlled tria SETTING: Department of Neurology, General Hospital of Military Area Command of Chinese PLA. MATERIALS: Thirty male Wistar rats of 10 to 12 months, weighing (400±25) g, provided by the Experimental Center of Medical Animals, General Hospital of Shenyang Military Area Command of Chinese PLA, were divided randomly into 3 groups with 10 rats in each group: two-step injection group, single injection group, double injection group. METHODS : The experiment was carried out in the Department of Neurology, General Hospital of Military Area Command of Chinese PLA from March to June in 2004. Autologous blood ICH model in rats were established as follows: In the two-step injection group, 50 μL unclotted autologous blood was taken from the rat tail cut, then injected with microsyringe into the caudate nucleus, 10 μL injected at first, paused for 2 minutes, and then the rest 40 μL injected slowly and continuously within 2 minutes. After the injection, the needle was kept immovable for about 4 minutes, withdrawn 2.0 mm, again kept immovable for about 4 minute, and then removed wholly at a slow speed. In the single injection group, 50 μL unclotted tail blood was injected slowly and continuously all within 2 minutes and the needle was slowly removed;(4) In the double injection group, 10 mL blood was injected at first, paused for 2 minutes, the rest 40 μL injected evenly within 2 minutes, and then the needle was withdrawn slowly and uninterruptedly. Neurologic findings were scored in accordance with Longa's five-point scale (0-4 scores, the higher the score, the severer the neurological dysfunction). The rats were killed to remove and sections were prepared, the morphological features of hematomas were grossly observed, the maximal diameter and size of hematomas in each slice were measured with the imaging analytical system, and the volume was calculated. Meanwhile, the conveniences of the techniques were compared. MAIN OUTCOME MEASURES: The morphological features and volume of hematomas, neurologic deficit score (NDS), and the convenience of the techniques were compared. RESULTS: All the 30 rats were involved in the analysis of results without deletion. (1) Results of the morphological observation of volume of hematoma: In the two-step injection group, hematomas located in the right caudate nucleus area regularly in circular or analogously circular shape in each slice. The formation rate of hematomas in the single injection group and double injection group were lower than those in the two-step injection group [60% (6/10), 80% (8/10), 100% (10/10), P〈 0.01, 0.05]. The volume of hematomas in the single injection group and double injection group were smaller than those in the two-step injection group [(28.5±14.8), (33.4±7.4), (41.6±3.9) mm3, P〈 0.01, 0.05]. (2) NDS results: The NDS scores in the single injection group and double injection group were smaller than that in the two-step injection group (0.90±0.83, 1.30±0.78, 1.90±0.57, P〈 0.05). (3)Comparison of the convenience of the techniques: The double injection method allowed generating reproducible hematomas in rats with shortcomings that it needed autologous arterial blood from femoral artery, and precision instruments such as microinfusion pump. The two-step injection injected fresh unclotting blood taken directly from the tail cut with microsyringe into the rat brain, and it has the advantages of easy operation, no influence on the activity of thrombase, shorter duration for model establishment, and higher rate of hematoma formation, which could generate ideal and economical models of ICH. The two-step injection induced hemotoma regularly in circular or analogously circular shape in each slice, but those induced by single and double injections were mostly in strip or fusiform shapes and extending along the needle tracks or into the ventricle or subarachnoid space. CONCLUSION : The autologous blood ICH model induced by the two-step injection method is a reproducible and reliable one in regular shape, which is better than those induced by double and single injections.展开更多
In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is de...In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is deeper than anticipated, needle penetration may cause damage to nerves, arteries and veins. Few clinical studies were done to evaluate the depth of needle length insertion reaching the intended gluteal muscle. The aim of this study was to evaluate the suitable depth of injecting RLAI. Twenty-six patients with schizophrenia were treated with RLAI, and randomly divided into two groups: 50 mm needle inserted group (Group-D, deep insertion, n = 13) and 20 mm needle insertion group (Group-S, shallow insertion, n = 13). For Group-S, the needle length was marked with a spacer at exactly 20 mm. Injections were performed by the psychiatrist or nurse, alternating between the two gluteal sites by double-cross method every two weeks. Clinical psychotic symptoms and injection site reactions were recorded throughout the study period. Experienced psychologists who were blinded from the needle-length experimental variable evaluated patients’ psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS) every two weeks. The plasma 9-hydroxyrisperidone (9-OH-RIS) concentrations were measured every two weeks;comparison data were determined on the 8th week and the 14th week. No significant difference was observed in 9-OH-RIS concentrations, psychotic symptoms, injection site skin reactions of subjects in both groups. However, in Group-D, injection site adverse reactions were confirmed in two subjects (15%). In Group-S, injection site reactions were confirmed in six subjects (46%). Although effective 9-OH-RIS concentrations were obtained with the insertion using both depth, it was concluded that the 50 mm insertion length was more suitable for dorsogluteal IM injections in adult patients with schizophrenia as demonstrated by the incidence of local adverse skin reactions.展开更多
In heavy oil production,the loss of energy to ambient surroundings decreases the temperature of the heavy oil flowing upwards in a vertical wellbore,which increases the oil viscosity and the oil may not flow normally ...In heavy oil production,the loss of energy to ambient surroundings decreases the temperature of the heavy oil flowing upwards in a vertical wellbore,which increases the oil viscosity and the oil may not flow normally in the wellbore.Therefore,it is necessary to lower the heavy oil viscosity by heating methods to allow it to be lifted easily.Heating of heavy oil in an oil well is achieved by circulating hot water in annuli in the well(tubing-casing annulus,casing-casing annulus).In this paper,based on heat transfer principles and fluid flow theory,a model is developed for produced fluids and hot water flowing in a vertical wellbore.The temperature and pressure of produced fluids and hot water in the wellbore are calculated and the effect of hot water on heavy oil temperature is analyzed.Calculated results show that the hot water circulating in the annuli may effectively heat the heavy oil in the tubing,so as to significantly reduce both oil viscosity and resistance to oil flow.展开更多
We prove that the R-matrix and Drinfeld presentations of the Yangian double in type A are isomorphic.The central elements of the completed Yangian double in type A at the critical level are constructed.The images of t...We prove that the R-matrix and Drinfeld presentations of the Yangian double in type A are isomorphic.The central elements of the completed Yangian double in type A at the critical level are constructed.The images of these elements under a Harish-Chandra-type homomorphism are calculated by applying a version of the Poincaré-Birkhoff-Witt theorem for the R-matrix presentation.These images coincide with the eigenvalues of the central elements in the Wakimoto modules.展开更多
文摘Several possible definitions of local injectivity for a homomorphism of an oriented graph G to an oriented graph H are considered. In each case, we determine the complexity of deciding whether there exists such a homomorphism when G is given and H is a fixed tournament on three or fewer vertices. Each possible definition leads to a locally-injective oriented colouring problem. A dichotomy theorem is proved in each case.
基金supported by the National Natural Science Foundation of China(Grant Nos.62172436,62102452)the National Key Research and Development Program of China(2023YFB3106100,2021YFB3100100)the Natural Science Foundation of Shaanxi Province(2023-JC-YB-584).
文摘With the increasing awareness of privacy protection and the improvement of relevant laws,federal learning has gradually become a new choice for cross-agency and cross-device machine learning.In order to solve the problems of privacy leakage,high computational overhead and high traffic in some federated learning schemes,this paper proposes amultiplicative double privacymask algorithm which is convenient for homomorphic addition aggregation.The combination of homomorphic encryption and secret sharing ensures that the server cannot compromise user privacy from the private gradient uploaded by the participants.At the same time,the proposed TQRR(Top-Q-Random-R)gradient selection algorithm is used to filter the gradient of encryption and upload efficiently,which reduces the computing overhead of 51.78%and the traffic of 64.87%on the premise of ensuring the accuracy of themodel,whichmakes the framework of privacy protection federated learning lighter to adapt to more miniaturized federated learning terminals.
文摘BACKGROUND: To date, many 6-hydroxydopamine (6-OHDA)-lesioned rat models have been established by injecting 6-OHDA into two or more sites in the substantia nigra pars compacta, striatum or median forebrain bundle. The success rate of models established by this method is satisfactory, but it can raise the death rate, and is elaborate and tedious to perform. OBJECTIVE: To observe the difference between injections of 6-OHDA into the striatum from one site and two sites, and to explore the feasibility of establishing Parkinson's disease rat models via striatal one-site double injection. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment based on a modeling comparison was performed at the Pharmacology Laboratory of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine between August 2005 and April 2006. MATERIALS: A total of 46 male Wistar rats were purchased from Beijing Weitong Lihua Experimental Animal Technical Co., Ltd., China. 6-OHDA hydrogen bromide was sourced from Sigma Co., Ltd., USA. METHODS: All 46 rats were randomized to three groups: one-site injection (n = 18), two-site injection (n = 18), and control (n = 10). Lesions in rat brains were established by infusing 5 μg 6-OHDA into the striatum at the following coordinates: anteroposterior (AP) 1.0 mm, mediolateral (ML) 2.7 mm, dorsoventral (DV)-5.2 or-6.0 mm for the one-site injection group, and AP 1.0 mm, ML 2.5 mm, DV -4.5 mm/AP-0.4 mm, ML 3.5 mm, DV-4.5 mm for the two-site injection group, respectively. Rats in the control group were injected with the same volume of 0.01% ascorbic acid as above. MAIN OUTCOME MEASURES: Tyrosine hydroxylase-positive neurons were detected by immunohistochemistry. Success rates of PD models established by one-site and two-site injection techniques were examined. RESULTS: One rat died in the one-site injection group and four in the two-site injection group. Thus behavioral testing was performed on 31 rats. There was no significant difference in the success rate of PD model establishment between one-site injection and two-site injection groups [82% (14/17) vs. 86% (12/14), P 〉 0.05]. The numbers of tyrosine hydroxylase -positive neurons in one-site injection and two-site injection groups were not significantly different ( P 〉 0.05), but they were significantly lower than in the control group(P 〈 0.01 ). CONCLUSION: A Parkinson's disease model can be established in rats via striatal one-site double injection.
基金supported by National Basic Research Program of China(973 Program)
文摘To achieve the electric field strength and the induced currents in equivalence in susceptibility tests with the high-level field radiation above 400 MHz,a double differential-mode(DM) current injection method based on directional couplers is proposed.Two cascaded symmetrical directional couplers compose a coupling device to inject the DM currents.When the coupling device is used,two devices are necessary to achieve the equivalence between radiation and injection,i.e.the equivalence between the injected voltages and the field strength,which is linear,regardless of the characteristics of the equipment under test(EUT).The results are verified by experiments using typical coaxial cables and nonlinear devices,where the equivalence between the nonlinear EUT responses induced by radiation and injection at both ends is achieved by using two coupling devices.At a frequency up to 1.75 GHz,the maximal experimental error is only 3.39%.The experimental results confirm the accuracy of the proposed method even both the EUTs work in the nonlinear region.The proposed method is applicable for radiated susceptibility(RS) testing of interconnected systems in the microwave frequency band.
基金supported by the National Natural Science Foundation of China(Grant No.51677149)
文摘To overcome hole-injection limitation of p^+-n emitter junction in 4H-SiC light triggered thyristor, a novel high- voltage 4H-SiC light triggered thyristor with double-deck thin n-base structure is proposed and demonstrated by two- dimensional numerical simulations. In this new structure, the conventional thin n-base is split to double-deck. The hole- injection of p^+-n emitter junction is modulated by modulating the doping concentration and thickness of upper-deck thin n- base. With double-deck thin n-base, the current gain coefficient of the top pnp transistor in 4H-SiC light triggered thyristor is enhanced. As a result, the triggering light intensity and the turn-on delay time of 4H-SiC light triggered thyristor are both reduced. The simulation results show that the proposed 10-kV 4H-SiC light triggered thyristor is able to be triggered on by 500-mW/cm^2 ultraviolet light pulse. Meanwhile, the turn-on delay time of the proposed thyristor is reduced to 337 ns.
文摘A highly sensitive double artificial neural network (DANN) analysis with flow-injection chemiluminescence (FI-CL) has been developed to simultaneously determine the trace amounts of the gold and platinum in simulated mixed samples, without the boring process.
基金Supported by the National Natural Science Foundation of China under Grant No.696007004.
文摘Based on the double-injection effect,the dual-mode interference principle and the free-carrier plasma dispersion effect,a double-injection bifurcation optical active switch integrated on silicon-on-insulator has been proposed and fabricated.Its insertion loss and crosstalk are measured to be less than 5.32 and -14.4dB,respectively,at wavelength 1.3μm and the total switching current 90mA.Response time is about 180ns.
基金Project supported by Arm Pre-research Program (51333040101), National Defense 973 Program (6131380301 ), National Natural Science Foundation of China (61040003).
文摘There are the application scope limits for single differential-mode current injection test method, so in order to carry out injection susceptibility test for two-pieces equipment interconnected with both ends of a cable simultaneously, a double differential-mode current in- jection test method (DDMCI) is proposed. The method adopted the equivalence source wave theorem and Baum-Liu-Tesche(BLT) equation as its theory foundation. The equivalent corresponding relation between injection voltage and radiation electric field intensity is derived, and the phase relation between the two injection voltage sources is confirmed. The results indicate that the amplitude and phase of the equivalent injection voltage source is closely related to the S parameter of directional coupling device, the transmission line length, and the source vector in BLT equation, but has nothing to do with the reflection coefficient between the two equipment pieces. Therefore, by choosing the right amplitude and phase of the double injection voltage sources, the DDMCI test is equivalent to the radiation test for two interconnected equipment of a system.
文摘BACKGROUND : Experimental animal models of intracerebral hemorrhag (ICH) are greatly needed, so the process of establishment should be ideal in hematoma formation and easy to operate. OBJECTIVE : To construct model of ICH in rats with double injection of autologous blood taken from the cut tail cut and double withdrawal of the needle (shortened as two-step injection model), and compare with those induced by single and double injections. DESIGN : A randomized controlled tria SETTING: Department of Neurology, General Hospital of Military Area Command of Chinese PLA. MATERIALS: Thirty male Wistar rats of 10 to 12 months, weighing (400±25) g, provided by the Experimental Center of Medical Animals, General Hospital of Shenyang Military Area Command of Chinese PLA, were divided randomly into 3 groups with 10 rats in each group: two-step injection group, single injection group, double injection group. METHODS : The experiment was carried out in the Department of Neurology, General Hospital of Military Area Command of Chinese PLA from March to June in 2004. Autologous blood ICH model in rats were established as follows: In the two-step injection group, 50 μL unclotted autologous blood was taken from the rat tail cut, then injected with microsyringe into the caudate nucleus, 10 μL injected at first, paused for 2 minutes, and then the rest 40 μL injected slowly and continuously within 2 minutes. After the injection, the needle was kept immovable for about 4 minutes, withdrawn 2.0 mm, again kept immovable for about 4 minute, and then removed wholly at a slow speed. In the single injection group, 50 μL unclotted tail blood was injected slowly and continuously all within 2 minutes and the needle was slowly removed;(4) In the double injection group, 10 mL blood was injected at first, paused for 2 minutes, the rest 40 μL injected evenly within 2 minutes, and then the needle was withdrawn slowly and uninterruptedly. Neurologic findings were scored in accordance with Longa's five-point scale (0-4 scores, the higher the score, the severer the neurological dysfunction). The rats were killed to remove and sections were prepared, the morphological features of hematomas were grossly observed, the maximal diameter and size of hematomas in each slice were measured with the imaging analytical system, and the volume was calculated. Meanwhile, the conveniences of the techniques were compared. MAIN OUTCOME MEASURES: The morphological features and volume of hematomas, neurologic deficit score (NDS), and the convenience of the techniques were compared. RESULTS: All the 30 rats were involved in the analysis of results without deletion. (1) Results of the morphological observation of volume of hematoma: In the two-step injection group, hematomas located in the right caudate nucleus area regularly in circular or analogously circular shape in each slice. The formation rate of hematomas in the single injection group and double injection group were lower than those in the two-step injection group [60% (6/10), 80% (8/10), 100% (10/10), P〈 0.01, 0.05]. The volume of hematomas in the single injection group and double injection group were smaller than those in the two-step injection group [(28.5±14.8), (33.4±7.4), (41.6±3.9) mm3, P〈 0.01, 0.05]. (2) NDS results: The NDS scores in the single injection group and double injection group were smaller than that in the two-step injection group (0.90±0.83, 1.30±0.78, 1.90±0.57, P〈 0.05). (3)Comparison of the convenience of the techniques: The double injection method allowed generating reproducible hematomas in rats with shortcomings that it needed autologous arterial blood from femoral artery, and precision instruments such as microinfusion pump. The two-step injection injected fresh unclotting blood taken directly from the tail cut with microsyringe into the rat brain, and it has the advantages of easy operation, no influence on the activity of thrombase, shorter duration for model establishment, and higher rate of hematoma formation, which could generate ideal and economical models of ICH. The two-step injection induced hemotoma regularly in circular or analogously circular shape in each slice, but those induced by single and double injections were mostly in strip or fusiform shapes and extending along the needle tracks or into the ventricle or subarachnoid space. CONCLUSION : The autologous blood ICH model induced by the two-step injection method is a reproducible and reliable one in regular shape, which is better than those induced by double and single injections.
文摘In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is deeper than anticipated, needle penetration may cause damage to nerves, arteries and veins. Few clinical studies were done to evaluate the depth of needle length insertion reaching the intended gluteal muscle. The aim of this study was to evaluate the suitable depth of injecting RLAI. Twenty-six patients with schizophrenia were treated with RLAI, and randomly divided into two groups: 50 mm needle inserted group (Group-D, deep insertion, n = 13) and 20 mm needle insertion group (Group-S, shallow insertion, n = 13). For Group-S, the needle length was marked with a spacer at exactly 20 mm. Injections were performed by the psychiatrist or nurse, alternating between the two gluteal sites by double-cross method every two weeks. Clinical psychotic symptoms and injection site reactions were recorded throughout the study period. Experienced psychologists who were blinded from the needle-length experimental variable evaluated patients’ psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS) every two weeks. The plasma 9-hydroxyrisperidone (9-OH-RIS) concentrations were measured every two weeks;comparison data were determined on the 8th week and the 14th week. No significant difference was observed in 9-OH-RIS concentrations, psychotic symptoms, injection site skin reactions of subjects in both groups. However, in Group-D, injection site adverse reactions were confirmed in two subjects (15%). In Group-S, injection site reactions were confirmed in six subjects (46%). Although effective 9-OH-RIS concentrations were obtained with the insertion using both depth, it was concluded that the 50 mm insertion length was more suitable for dorsogluteal IM injections in adult patients with schizophrenia as demonstrated by the incidence of local adverse skin reactions.
基金supported by the Fundamental Research Funds for the Central Universities (No. 27R1015025A)the Natural Science Foundation of Shandong Province,China(Grant No. 05J10150300)
文摘In heavy oil production,the loss of energy to ambient surroundings decreases the temperature of the heavy oil flowing upwards in a vertical wellbore,which increases the oil viscosity and the oil may not flow normally in the wellbore.Therefore,it is necessary to lower the heavy oil viscosity by heating methods to allow it to be lifted easily.Heating of heavy oil in an oil well is achieved by circulating hot water in annuli in the well(tubing-casing annulus,casing-casing annulus).In this paper,based on heat transfer principles and fluid flow theory,a model is developed for produced fluids and hot water flowing in a vertical wellbore.The temperature and pressure of produced fluids and hot water in the wellbore are calculated and the effect of hot water on heavy oil temperature is analyzed.Calculated results show that the hot water circulating in the annuli may effectively heat the heavy oil in the tubing,so as to significantly reduce both oil viscosity and resistance to oil flow.
基金supported by National Natural Science Foundation of China(Grant Nos.12101261 and 12171303)the Simons Foundation(Grant No.523868)。
文摘We prove that the R-matrix and Drinfeld presentations of the Yangian double in type A are isomorphic.The central elements of the completed Yangian double in type A at the critical level are constructed.The images of these elements under a Harish-Chandra-type homomorphism are calculated by applying a version of the Poincaré-Birkhoff-Witt theorem for the R-matrix presentation.These images coincide with the eigenvalues of the central elements in the Wakimoto modules.