We describe the last glaciation climatic history Marine Isotope Stage(MIS, 2-4) from 66.7 ka to 14.5 ka in Hexigten, northeast Inner Mongolia, North China. The climate of the region experienced frequent and significan...We describe the last glaciation climatic history Marine Isotope Stage(MIS, 2-4) from 66.7 ka to 14.5 ka in Hexigten, northeast Inner Mongolia, North China. The climate of the region experienced frequent and significant fluctuations between dry-cold and less dry-cold during the late MIS4. The climate was generally warm and humid during early MIS3(MIS3 c) and late MIS3(MIS3 a), whereas it was cold and dry in middle MIS3(MIS3 b) and during MIS2. In this study, the cold and dry conditions were correlated with a stronger East Asian winter monsoon and strong dune activity; whereas, warm and humid conditions were related to a stronger East Asian summer monsoon(EASM) and weak dune activity. This study establishes six distinct dry and cold intervals during the last glacial period(66.7-14.5 ka) based on optically stimulated luminescence data, multi-proxies record(magnetic susceptibility, grain size analysis, Rb/Sr, SiO2/TiO2) and chemical index of alteration(CIA). The last glacial period may be correlated with Heinrich events 1 to 6 which were further confirmed by comparison with the Hulu cave stalagmites and Greenland ice core records. It is concluded that the study area was substantially affected by the EASM, as compared with the loess-desert transition zone of the Chinese Loess Plateau, especially in MIS3 c and suggested that the East Asian monsoon played a pivotal role in the last glacial period climate and dune activity.展开更多
AIM： To address the possibility that insulin-like growth factor （IGF）-Ⅱ is a growth factor and its signaling pathway so as to develop a molecular therapy for hepatoblastoma. METHODS： Huh-6 and HepG2, human hepato...AIM： To address the possibility that insulin-like growth factor （IGF）-Ⅱ is a growth factor and its signaling pathway so as to develop a molecular therapy for hepatoblastoma. METHODS： Huh-6 and HepG2, human hepatoblastoma cell lines, were used. IGF-Ⅱ was added to the medium deprived of serum. Western blot analysis was performed to clarify the expression of IGF-Ⅰ receptor （IGF-IR）. Inhibitors of IGF-IR （piclopodophyllin, PPP）, phosphatidyl-inositol （PI） 3-kinase （LY294002 and Wortmannin）, or mitogen-activated protein （MAP） kinase （PD98059） were added to unveil the signaling pathway of IGF-Ⅱ. Cells were analyzed morphologically with hematoxylin-eosin staining to reveal the mechanism of suppression of cell proliferation. RESULTS： IGF-Ⅱ stimulated cells proliferated to 2.7 （269% ± 76%） （mean ± SD） （Huh-6） and 2.1 （211% ± 85%） times （HepG2）. IGF-IR was expressed in Huh-6 and HepG2. PPP suppressed the cell number to 44% ± 11% （Huh-6） and 39% ± 5% （HepG2）. LY294002 and Wortmannin suppressed the cell number to 30% ± 5% （Huh-6）, 44% ± 0.4% （HepG2）, 49% ± 1.0% （Huh-6） and 46% ± 1.1% （HepG2）, respectively. PD98059 suppressed the cell number to 33% ± 11% for HepG2 but not for Huh-6. When cell proliferation was prohibited, many Huh-6 and HepG2 cells were dead with pyknotic or fragmented nuclei, suggesting apoptosis. CONCLUSION： IGF- Ⅱ was shown to be a growth factor of hepatoblastoma via IGF-Ⅰ receptor and PI3 kinase which were good candidates for target of molecular therapy.展开更多
Thermal manikin plays important roles in simulating thethermal state of human bodies to facilitate the evaluationof thermal comfort properties of various clothing assem-blies.Based on the heat balance principle and an...Thermal manikin plays important roles in simulating thethermal state of human bodies to facilitate the evaluationof thermal comfort properties of various clothing assem-blies.Based on the heat balance principle and analysis ofrelated factors,the heat production rate of manikin isrecommended as an efficient evaluation index.Whereas,its inside heat production which occurs as a result of theexistence of temperature difference between its insidepart and outside surface,should not be ignored.Through a series of theoretical analysis and calculations,a compensative equation is deduced in this paper.展开更多
基金supported by the Research Fund for Hexigten Global Geopark(Grant No.62932014004)Specialized Fund for Fundamental Research Program of China University of Geosciences,Beijing(Grant No.2011YYL016)+1 种基金the Specialized Fund for Public Welfare Industry,Ministry of Land and Resources of China(Grant No.201211077-3)the Specialized Research Fund for the Doctoral Program of Higher Education of China(for PhD supervisors,Grant No.20110022110005)
文摘We describe the last glaciation climatic history Marine Isotope Stage(MIS, 2-4) from 66.7 ka to 14.5 ka in Hexigten, northeast Inner Mongolia, North China. The climate of the region experienced frequent and significant fluctuations between dry-cold and less dry-cold during the late MIS4. The climate was generally warm and humid during early MIS3(MIS3 c) and late MIS3(MIS3 a), whereas it was cold and dry in middle MIS3(MIS3 b) and during MIS2. In this study, the cold and dry conditions were correlated with a stronger East Asian winter monsoon and strong dune activity; whereas, warm and humid conditions were related to a stronger East Asian summer monsoon(EASM) and weak dune activity. This study establishes six distinct dry and cold intervals during the last glacial period(66.7-14.5 ka) based on optically stimulated luminescence data, multi-proxies record(magnetic susceptibility, grain size analysis, Rb/Sr, SiO2/TiO2) and chemical index of alteration(CIA). The last glacial period may be correlated with Heinrich events 1 to 6 which were further confirmed by comparison with the Hulu cave stalagmites and Greenland ice core records. It is concluded that the study area was substantially affected by the EASM, as compared with the loess-desert transition zone of the Chinese Loess Plateau, especially in MIS3 c and suggested that the East Asian monsoon played a pivotal role in the last glacial period climate and dune activity.
基金Supported by the Japan Society for the Promotion of Science (JSPS) (16590577) and the Kawano Masanori Memorial Foundation for Promotion of Pediatrics (15-6)
文摘AIM： To address the possibility that insulin-like growth factor （IGF）-Ⅱ is a growth factor and its signaling pathway so as to develop a molecular therapy for hepatoblastoma. METHODS： Huh-6 and HepG2, human hepatoblastoma cell lines, were used. IGF-Ⅱ was added to the medium deprived of serum. Western blot analysis was performed to clarify the expression of IGF-Ⅰ receptor （IGF-IR）. Inhibitors of IGF-IR （piclopodophyllin, PPP）, phosphatidyl-inositol （PI） 3-kinase （LY294002 and Wortmannin）, or mitogen-activated protein （MAP） kinase （PD98059） were added to unveil the signaling pathway of IGF-Ⅱ. Cells were analyzed morphologically with hematoxylin-eosin staining to reveal the mechanism of suppression of cell proliferation. RESULTS： IGF-Ⅱ stimulated cells proliferated to 2.7 （269% ± 76%） （mean ± SD） （Huh-6） and 2.1 （211% ± 85%） times （HepG2）. IGF-IR was expressed in Huh-6 and HepG2. PPP suppressed the cell number to 44% ± 11% （Huh-6） and 39% ± 5% （HepG2）. LY294002 and Wortmannin suppressed the cell number to 30% ± 5% （Huh-6）, 44% ± 0.4% （HepG2）, 49% ± 1.0% （Huh-6） and 46% ± 1.1% （HepG2）, respectively. PD98059 suppressed the cell number to 33% ± 11% for HepG2 but not for Huh-6. When cell proliferation was prohibited, many Huh-6 and HepG2 cells were dead with pyknotic or fragmented nuclei, suggesting apoptosis. CONCLUSION： IGF- Ⅱ was shown to be a growth factor of hepatoblastoma via IGF-Ⅰ receptor and PI3 kinase which were good candidates for target of molecular therapy.
文摘Thermal manikin plays important roles in simulating thethermal state of human bodies to facilitate the evaluationof thermal comfort properties of various clothing assem-blies.Based on the heat balance principle and analysis ofrelated factors,the heat production rate of manikin isrecommended as an efficient evaluation index.Whereas,its inside heat production which occurs as a result of theexistence of temperature difference between its insidepart and outside surface,should not be ignored.Through a series of theoretical analysis and calculations,a compensative equation is deduced in this paper.
