Müller cells：The neglected neighbor：Müller cells constitute the majority of retinal glial cells and offer more alternating functions than any other cell of the retina.Uniquely,Müller cells cover the c...Müller cells：The neglected neighbor：Müller cells constitute the majority of retinal glial cells and offer more alternating functions than any other cell of the retina.Uniquely,Müller cells cover the complete thickness of the retina,and their roles therefore differ correspondingly to the retinal segment in which they are located.In the inner retina,Müller cells are crucial in taking up toxic molecules,such as excessive.展开更多
AIM: To evaluate baseline foveal disorganisation of retinal inner layers(DRIL) as a prognostic factor in eyes with central retinal artery occlusion(CRAO). METHODS: Twenty-eight CRAO patients who were followed-up betwe...AIM: To evaluate baseline foveal disorganisation of retinal inner layers(DRIL) as a prognostic factor in eyes with central retinal artery occlusion(CRAO). METHODS: Twenty-eight CRAO patients who were followed-up between 2010 and 2016 were retrospectively investigated. Demographic characteristics and detailed ophthalmological examination findings of all patients were recorded. Macular thicknesses(MTs) from 5 separate spots and DRIL were measured with spectral-domain optic coherence tomography(SD-OCT). Correlations between DRIL score and logMAR converted visual acuity(VA), change in VA, patient reference time(RT), number of hyperbaric oxygen therapy(HBOT) sessions, MT and MT change were investigated.RESULTS: There was a positive correlation between the DRIL score and the final VA(r=0.787) and a negative correlation with the change in VA(r=-0.763). The RT and MT were closely related to the DRIL score. A negative correlation was found between the number of HBOT sessions and the DRIL score(r=-0.341).CONCLUSION: The DRIL score is a parameter assessed by SD-OCT, which can provide us reliable information regarding the prognosis of visual functions and response to the treatment for CRAO patients at acute phase.展开更多
目的观察早期糖尿病患者视网膜功能。方法对视力正常、眼底正常或为轻度非增殖性糖尿病性视网膜病变的糖尿病患者共60眼行多焦视网膜电图二阶 kernel 反应(second order kernel,SOK)检查,将检查结果与36眼正常同龄对照组比较。结果与正...目的观察早期糖尿病患者视网膜功能。方法对视力正常、眼底正常或为轻度非增殖性糖尿病性视网膜病变的糖尿病患者共60眼行多焦视网膜电图二阶 kernel 反应(second order kernel,SOK)检查,将检查结果与36眼正常同龄对照组比较。结果与正常对照组相比,糖尿病组后极部视网膜 SOK 总合反应的 P_1波振幅密度值降低、峰时延迟,差异均有统计学意义(t=2.6000.P=0.0109和 t=2.3657,P=0.0201);与无糖尿病性视网膜病组相比,轻度糖尿病性视网膜病组后极部视网膜 SOK 总合反应的 P_1波峰时延迟,差异有统计学意义(t=2.5080,P=0.0150)。结论糖尿病患者中心视力尚正常时,由 SOK 检测到的内层视网膜功能已有异常;轻度糖尿病性视网膜病眼峰时异常更明显;SOK 可作为早期糖尿病性视网膜病变检测的指标。(中国眼耳鼻喉科杂志,2005,5:358～360)展开更多
Intracellular recordings were made from amacrine cells in the isolated, superfused carp retina, and the effects of γ-aminobutyric acid (GABA) on sustained and transient ON signals of these cells were studied. Exogeno...Intracellular recordings were made from amacrine cells in the isolated, superfused carp retina, and the effects of γ-aminobutyric acid (GABA) on sustained and transient ON signals of these cells were studied. Exogenous GABA application partially suppressed the sustained response of ON amacrine cells, which could be completely reversed by picrotoxin (PTX), a chloride channel blocker, and by bicuculline (BCC), a specific GABA_A receptor antagonist. On the other hand, suppression by GABA of the ON response which was predominantly driven by rod signals in a certain portion of transient ON-OFF amacrine cells was completely blocked by PTX, but not by BCC, indicating that GABA_C receptors may be involved in the effect. These results suggest that GABA_A and GABA_C receptors may be respectively involved in mediating the transmission of sustained and transient signals in the carp inner retina.展开更多
文摘Müller cells：The neglected neighbor：Müller cells constitute the majority of retinal glial cells and offer more alternating functions than any other cell of the retina.Uniquely,Müller cells cover the complete thickness of the retina,and their roles therefore differ correspondingly to the retinal segment in which they are located.In the inner retina,Müller cells are crucial in taking up toxic molecules,such as excessive.
文摘AIM: To evaluate baseline foveal disorganisation of retinal inner layers(DRIL) as a prognostic factor in eyes with central retinal artery occlusion(CRAO). METHODS: Twenty-eight CRAO patients who were followed-up between 2010 and 2016 were retrospectively investigated. Demographic characteristics and detailed ophthalmological examination findings of all patients were recorded. Macular thicknesses(MTs) from 5 separate spots and DRIL were measured with spectral-domain optic coherence tomography(SD-OCT). Correlations between DRIL score and logMAR converted visual acuity(VA), change in VA, patient reference time(RT), number of hyperbaric oxygen therapy(HBOT) sessions, MT and MT change were investigated.RESULTS: There was a positive correlation between the DRIL score and the final VA(r=0.787) and a negative correlation with the change in VA(r=-0.763). The RT and MT were closely related to the DRIL score. A negative correlation was found between the number of HBOT sessions and the DRIL score(r=-0.341).CONCLUSION: The DRIL score is a parameter assessed by SD-OCT, which can provide us reliable information regarding the prognosis of visual functions and response to the treatment for CRAO patients at acute phase.
文摘目的观察早期糖尿病患者视网膜功能。方法对视力正常、眼底正常或为轻度非增殖性糖尿病性视网膜病变的糖尿病患者共60眼行多焦视网膜电图二阶 kernel 反应(second order kernel,SOK)检查,将检查结果与36眼正常同龄对照组比较。结果与正常对照组相比,糖尿病组后极部视网膜 SOK 总合反应的 P_1波振幅密度值降低、峰时延迟,差异均有统计学意义(t=2.6000.P=0.0109和 t=2.3657,P=0.0201);与无糖尿病性视网膜病组相比,轻度糖尿病性视网膜病组后极部视网膜 SOK 总合反应的 P_1波峰时延迟,差异有统计学意义(t=2.5080,P=0.0150)。结论糖尿病患者中心视力尚正常时,由 SOK 检测到的内层视网膜功能已有异常;轻度糖尿病性视网膜病眼峰时异常更明显;SOK 可作为早期糖尿病性视网膜病变检测的指标。(中国眼耳鼻喉科杂志,2005,5:358～360)
基金Project supported by the State Commission of Science and Technology of China (Climbing Project)the National Natural Science Foundation of China (Grant Nos. 39670253 and 39770256)the National Research Center of Life Science of China (Shanghai)
文摘Intracellular recordings were made from amacrine cells in the isolated, superfused carp retina, and the effects of γ-aminobutyric acid (GABA) on sustained and transient ON signals of these cells were studied. Exogenous GABA application partially suppressed the sustained response of ON amacrine cells, which could be completely reversed by picrotoxin (PTX), a chloride channel blocker, and by bicuculline (BCC), a specific GABA_A receptor antagonist. On the other hand, suppression by GABA of the ON response which was predominantly driven by rod signals in a certain portion of transient ON-OFF amacrine cells was completely blocked by PTX, but not by BCC, indicating that GABA_C receptors may be involved in the effect. These results suggest that GABA_A and GABA_C receptors may be respectively involved in mediating the transmission of sustained and transient signals in the carp inner retina.
