Insulin therapy cause weight gain and may increase its own requirement. Type 2 diabetes mellitus is associated with insulin resistance and affect both endogenous and exogenous insulin effect. Metformin and Pioglitazon...Insulin therapy cause weight gain and may increase its own requirement. Type 2 diabetes mellitus is associated with insulin resistance and affect both endogenous and exogenous insulin effect. Metformin and Pioglitazone, commonly used insulin sensitizers, have the potentiality of reducing the insulin dose, in Type-2 diabetes mellitus (T2DM) patients. This study was held to assess and compare such potentiality. 40 T2DM patients not controlled by diet, exercise and oral antidiabetic agents were selected for this study. Study had observed that Pioglitazone and metformin both significantly had reduced the dose of insulin. But metformin reduce the dose of insulin significantly more than that of Pioglitazone. Metformin had reduced the triglyceride, LDL-c, waist hip ratio significantly but modestly increased serum lactic acid and HDL-c. It can be concluded that co-administration of metformin with insulin is more beneficial in relation to the dose of insulin, waist hip ratio, and lipid modification when compare to Pioglitazone.展开更多
Introduction: There is minimal literature to support the appropriate dosing for the initiation of IV regular insulin therapy in DKA patients. A 0.1 unit/kg bolus followed by 0.1 units/kg/hour or 0.14 units/kg/hour is ...Introduction: There is minimal literature to support the appropriate dosing for the initiation of IV regular insulin therapy in DKA patients. A 0.1 unit/kg bolus followed by 0.1 units/kg/hour or 0.14 units/kg/hour is commonly utilized and recommended in guidelines. Objective: We sought to assess clinical and safety outcomes associated with various insulin infusion starting doses in patients diagnosed with DKA in the emergency department in an effort to help guide prescribing. Methods: A retrospective cohort study was conducted within an academic emergency department and included patients who received continuous infusion regular insulin with an ICD-10 code for DKA between January 2016 and January 2019. A predictive regression model was applied to test if predefined lab values influenced the starting insulin infusion rates. Clinical and safety outcomes were evaluated by starting insulin infusion rate. Data was analyzed based on starting insulin infusion rates. Results: 347 patients met inclusion criteria with 92 (26.5%) patients receiving Conclusion: Glucose levels significantly influenced the insulin starting infusion rate, with no identified differences in adverse effects or clinical outcomes.展开更多
Objective: To observe the value of HbA1c level evaluating the total daily basal insulin dose by continuous subcuta- neous insulin infusion (CSII) in 268 patients with type 2 diabetes mellitus. Methods: 5-point capilla...Objective: To observe the value of HbA1c level evaluating the total daily basal insulin dose by continuous subcuta- neous insulin infusion (CSII) in 268 patients with type 2 diabetes mellitus. Methods: 5-point capillary blood glucose was moni- tored in pre- and post-CSII and the insulin dose which could stabilize blood glucose was defined as the total daily dose of insulin, including basal and bolus total dose. Correlation between HbA1c level and total daily dose of insulin in patients with type 2 dia- betes mellitus was analyzed. Correlation between HbA1c level and 5-point capillary blood glucose was also analyzed. Results: Obvious correlation was observed between HbA1c level and the basal total daily dose of insulin if HbA1c was more than 9.3% (r=0.635, P<0.05). The average of 5-point capillary blood glucose was best correlated with HbA1c and fasting blood glucose next best. Conclusion: HbA1c level can forecast basal total daily dose of insulin in CSII.展开更多
目的探讨大剂量维生素D联合门冬胰岛素治疗妊娠期糖尿病(GDM)的效果及对血糖变异性的影响。方法选取2020年2月至2022年3月我院收治的70例GDM患者为研究对象,按照随机数字表法将其分为对照组与观察组,各35例。对照组给予常规治疗+门冬胰...目的探讨大剂量维生素D联合门冬胰岛素治疗妊娠期糖尿病(GDM)的效果及对血糖变异性的影响。方法选取2020年2月至2022年3月我院收治的70例GDM患者为研究对象,按照随机数字表法将其分为对照组与观察组,各35例。对照组给予常规治疗+门冬胰岛素治疗,观察组在对照组基础上加用大剂量维生素D治疗。比较两组的治疗效果。结果治疗后,观察组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及糖化血红蛋白(HbA1c)低于对照组,25羟基维生素D_(3)[25(OH)D_(3)]水平高于对照组(P<0.05)。治疗后,观察组的血糖标准差(SDBG)、平均血糖波动幅度(MAGE)、最大血糖波动幅度(LAGE)水平及血糖变异系数(CV)均低于对照组(P<0.05)。治疗后,观察组的胰岛β细胞功能指数(HOMA-β)、胰岛素敏感指数(ISI)高于对照组,胰岛素抵抗指数(HOMA-IR)低于对照组(P<0.05)。观察组的不良妊娠结局总发生率低于对照组(P<0.05)。结论大剂量维生素D联合门冬胰岛素治疗GDM能够提高血糖控制效果,调节血糖变异性指标,减轻胰岛素抵抗,降低不良妊娠结局发生风险,值得推广。展开更多
目的 分析持续大剂量胰岛素泵注射对小儿糖尿病的临床效果及对不良反应的影响。方法 选取2021年6月至2022年6月山东省邹平市人民医院收治的小儿糖尿病患者62例,按照随机数字表法分为对照组、研究组,各31例。给予对照组患儿常规计量胰岛...目的 分析持续大剂量胰岛素泵注射对小儿糖尿病的临床效果及对不良反应的影响。方法 选取2021年6月至2022年6月山东省邹平市人民医院收治的小儿糖尿病患者62例,按照随机数字表法分为对照组、研究组,各31例。给予对照组患儿常规计量胰岛素泵治疗,给予研究组患儿大剂量胰岛素泵注射治疗,分析两组患儿临床指标、血脂指标[低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)]、血糖指标[糖化血红蛋白(GHb)、餐后2 h血糖(2 h PBG)、空腹血糖(FPG)],分析两组患儿治疗有效率及不良反应发生情况。结果 与对照组相比,研究组血糖下降速度、血糖达标时间均较低,具有统计学差异(P>0.05);治疗后两组患儿LDL-C、TG水平有所下降,HDL-C水平有所上升,且与对照组相比,研究组患儿LDL-C、TG水平较低,HDL-C水平较高(P<0.05);治疗后两组患儿GHb、2 h PBG、FPG水平有所下降,且与对照组相比,研究组GHb、2 h PBG、FPG水平较低(P<0.05);与对照组相比,研究组治疗总有效率较高,两组相比具有统计学意义(P<0.05);相较于对照组,研究组小儿治疗后不良反应发生情况略高,但两组相比无统计学差异(P>0.05)。结论 给予糖尿病患儿大剂量胰岛素泵治疗,患儿血糖指标以及血脂指标得到较好的改善,有着较好的治疗效果,并且治疗中不良反应发生情况较低。展开更多
文摘Insulin therapy cause weight gain and may increase its own requirement. Type 2 diabetes mellitus is associated with insulin resistance and affect both endogenous and exogenous insulin effect. Metformin and Pioglitazone, commonly used insulin sensitizers, have the potentiality of reducing the insulin dose, in Type-2 diabetes mellitus (T2DM) patients. This study was held to assess and compare such potentiality. 40 T2DM patients not controlled by diet, exercise and oral antidiabetic agents were selected for this study. Study had observed that Pioglitazone and metformin both significantly had reduced the dose of insulin. But metformin reduce the dose of insulin significantly more than that of Pioglitazone. Metformin had reduced the triglyceride, LDL-c, waist hip ratio significantly but modestly increased serum lactic acid and HDL-c. It can be concluded that co-administration of metformin with insulin is more beneficial in relation to the dose of insulin, waist hip ratio, and lipid modification when compare to Pioglitazone.
文摘Introduction: There is minimal literature to support the appropriate dosing for the initiation of IV regular insulin therapy in DKA patients. A 0.1 unit/kg bolus followed by 0.1 units/kg/hour or 0.14 units/kg/hour is commonly utilized and recommended in guidelines. Objective: We sought to assess clinical and safety outcomes associated with various insulin infusion starting doses in patients diagnosed with DKA in the emergency department in an effort to help guide prescribing. Methods: A retrospective cohort study was conducted within an academic emergency department and included patients who received continuous infusion regular insulin with an ICD-10 code for DKA between January 2016 and January 2019. A predictive regression model was applied to test if predefined lab values influenced the starting insulin infusion rates. Clinical and safety outcomes were evaluated by starting insulin infusion rate. Data was analyzed based on starting insulin infusion rates. Results: 347 patients met inclusion criteria with 92 (26.5%) patients receiving Conclusion: Glucose levels significantly influenced the insulin starting infusion rate, with no identified differences in adverse effects or clinical outcomes.
文摘Objective: To observe the value of HbA1c level evaluating the total daily basal insulin dose by continuous subcuta- neous insulin infusion (CSII) in 268 patients with type 2 diabetes mellitus. Methods: 5-point capillary blood glucose was moni- tored in pre- and post-CSII and the insulin dose which could stabilize blood glucose was defined as the total daily dose of insulin, including basal and bolus total dose. Correlation between HbA1c level and total daily dose of insulin in patients with type 2 dia- betes mellitus was analyzed. Correlation between HbA1c level and 5-point capillary blood glucose was also analyzed. Results: Obvious correlation was observed between HbA1c level and the basal total daily dose of insulin if HbA1c was more than 9.3% (r=0.635, P<0.05). The average of 5-point capillary blood glucose was best correlated with HbA1c and fasting blood glucose next best. Conclusion: HbA1c level can forecast basal total daily dose of insulin in CSII.
文摘目的探讨大剂量维生素D联合门冬胰岛素治疗妊娠期糖尿病(GDM)的效果及对血糖变异性的影响。方法选取2020年2月至2022年3月我院收治的70例GDM患者为研究对象,按照随机数字表法将其分为对照组与观察组,各35例。对照组给予常规治疗+门冬胰岛素治疗,观察组在对照组基础上加用大剂量维生素D治疗。比较两组的治疗效果。结果治疗后,观察组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)水平及糖化血红蛋白(HbA1c)低于对照组,25羟基维生素D_(3)[25(OH)D_(3)]水平高于对照组(P<0.05)。治疗后,观察组的血糖标准差(SDBG)、平均血糖波动幅度(MAGE)、最大血糖波动幅度(LAGE)水平及血糖变异系数(CV)均低于对照组(P<0.05)。治疗后,观察组的胰岛β细胞功能指数(HOMA-β)、胰岛素敏感指数(ISI)高于对照组,胰岛素抵抗指数(HOMA-IR)低于对照组(P<0.05)。观察组的不良妊娠结局总发生率低于对照组(P<0.05)。结论大剂量维生素D联合门冬胰岛素治疗GDM能够提高血糖控制效果,调节血糖变异性指标,减轻胰岛素抵抗,降低不良妊娠结局发生风险,值得推广。
文摘目的 分析持续大剂量胰岛素泵注射对小儿糖尿病的临床效果及对不良反应的影响。方法 选取2021年6月至2022年6月山东省邹平市人民医院收治的小儿糖尿病患者62例,按照随机数字表法分为对照组、研究组,各31例。给予对照组患儿常规计量胰岛素泵治疗,给予研究组患儿大剂量胰岛素泵注射治疗,分析两组患儿临床指标、血脂指标[低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)]、血糖指标[糖化血红蛋白(GHb)、餐后2 h血糖(2 h PBG)、空腹血糖(FPG)],分析两组患儿治疗有效率及不良反应发生情况。结果 与对照组相比,研究组血糖下降速度、血糖达标时间均较低,具有统计学差异(P>0.05);治疗后两组患儿LDL-C、TG水平有所下降,HDL-C水平有所上升,且与对照组相比,研究组患儿LDL-C、TG水平较低,HDL-C水平较高(P<0.05);治疗后两组患儿GHb、2 h PBG、FPG水平有所下降,且与对照组相比,研究组GHb、2 h PBG、FPG水平较低(P<0.05);与对照组相比,研究组治疗总有效率较高,两组相比具有统计学意义(P<0.05);相较于对照组,研究组小儿治疗后不良反应发生情况略高,但两组相比无统计学差异(P>0.05)。结论 给予糖尿病患儿大剂量胰岛素泵治疗,患儿血糖指标以及血脂指标得到较好的改善,有着较好的治疗效果,并且治疗中不良反应发生情况较低。
