AIM: To evaluate combination transjugular intrahepatic portosystemic shunt(TIPS) and other interventions for hepatocellular carcinoma(HCC) and portal hypertension.METHODS: Two hundred and sixty-one patients with HCC a...AIM: To evaluate combination transjugular intrahepatic portosystemic shunt(TIPS) and other interventions for hepatocellular carcinoma(HCC) and portal hypertension.METHODS: Two hundred and sixty-one patients with HCC and portal hypertension underwent TIPS combined with other interventional treatments(transarterial chemoembolization/transarterial embolization,radiofrequency ablation,hepatic arterio-portal fistulas embolization,and splenic artery embolization) from January 1997 to January 2010 at Beijing Shijitan Hospital. Two hundred and nine patients(121 male and 88 female,aged 25-69 years,mean 48.3 ± 12.5 years) with complete clinical data were recruited. We evaluated the safety of the procedure(procedurerelated death and serious complications),change of portal vein pressure before and after TIPS,symptom relief [e.g.,ascites,hydrothorax,esophageal gastricfundus variceal bleeding(EGVB)],cumulative rates of survival,and distributary channel restenosis. The characteristics of the patients surviving ≥ 5 and < 5 years were also analyzed.RESULTS: The portosystemic pressure was decreased from 29.0 ± 4.1 mm Hg before TIPS to 18.1 ± 2.9 mm Hg after TIPS(t = 69.32,P < 0.05). Portosystemic pressure was decreased and portal hypertension symptoms were ameliorated. During the 5 year followup,the total recurrence rate of resistant ascites or hydrothorax was 7.2%(15/209); 36.8%(77/209) for EGVB; and 39.2%(82/209) for hepatic encephalopathy. The cumulative rates of distributary channel restenosis at 1,2,3,4,and 5 years were 17.2%(36/209),29.7%(62/209),36.8%(77/209),45.5%(95/209) and 58.4%(122/209),respectively. No procedure-related deaths and serious complications(e.g.,abdominal bleeding,hepatic failure,and distant metastasis) occurred. Moreover,Child-Pugh score,portal vein tumor thrombosis,lesion diameter,hepatic arterio-portal fistulas,HCC diagnosed before or after TIPS,stent type,hepatic encephalopathy,and type of other interventional treatments were related to 5 year survival after comparing patient characteristics.CONCLUSION: TIPS combined with other interventional treatments seems to be safe and efficacious in patients with HCC and portal hypertension.展开更多
The intestinal epithelium constitutes a physical and functional barrier between the external environment and the host organism. It is formed by a continuous monolayer of intestinal epithelial cells maintained together...The intestinal epithelium constitutes a physical and functional barrier between the external environment and the host organism. It is formed by a continuous monolayer of intestinal epithelial cells maintained together by intercellular junctional complex, limiting access of pathogens, toxins and xenobiotics to host tissues. Once this barrier integrity is disrupted, inflammatory disorders and tissue injury are initiated and perpetuated. Beneath the intestinal epithelial cells lies a population of astrocyte-like cells that are known as enteric glia. The morphological characteristics and expression markers of these enteric glia cells were identical to the astrocytes of the central nervous system. In the past few years, enteric glia have been demonstrated to have a trophic and supporting relationship with intestinal epithelial cells. Enteric glia lesions and/or functional defects can be involved in the barrier dysfunction. Besides, factors secreted by enteric glia are important for the regulation of gut barrier function. Moreover, enteric glia have an important impact on epithelial cell transcriptome and induce a shift in epithelial cell phenotype towards increased cell adhesion and cell differentiation.Enteric glia can also preserve epithelial barrier against intestinal bacteria insult. In this review, we will describe the current body of evidence supporting functional roles of enteric glia on intestinal barrier.展开更多
interleukin(iL)28B genetic polymorphism is significantly associated with the sustained virological response rate in patients with chronic hepatitis C treated with pegylated interferon-α(PEG-iFN)plus ribavirin and wit...interleukin(iL)28B genetic polymorphism is significantly associated with the sustained virological response rate in patients with chronic hepatitis C treated with pegylated interferon-α(PEG-iFN)plus ribavirin and with spontaneous hepatitis C virus clearance.However,a consensus on the relationship between iL28B genetic polymorphism and the favorable outcome of chronic hepatitis B virus infection defined by hepatitis B e antigen seroconversion,and/or hepatitis B surface antigen seroclearance in patients treated with interferon or PEG-iFN has not been reached.Several reports failed to show a positive association,while some studies demonstrated a positive association in certain subject settings.More prospective studies including large cohorts are needed to determine the possible association between iL28B genetic polymorphism and the outcome of interferon or PEG-iFN treatment for chronic hepatitis B.展开更多
The traditional foundry industry has developed rapidly in recently years due to advancements in computer technology. Modifying and designing the feeding system has become more convenient with the help of the casting s...The traditional foundry industry has developed rapidly in recently years due to advancements in computer technology. Modifying and designing the feeding system has become more convenient with the help of the casting software, Inte CAST. A common method of designing a feeding system is to first design the initial systems, run simulations with casting software, analyze the feedback, and then redesign. In this work, genetic, fruit fly, and interior point optimizer(IPOPT) algorithms were introduced to guide the optimal riser design for the feeding system. The results calculated by the three optimal algorithms indicate that the riser volume has a weak relationship with the modulus constraint; while it has a close relationship with the volume constraint. Based on the convergence rate, the fruit fly algorithm was obviously faster than the genetic algorithm. The optimized riser was also applied during casting, and was simulated using Inte CAST. The numerical simulation results reveal that with the same riser volume, the riser optimized by the genetic and fruit fly algorithms has a similar improvement on casting shrinkage. The IPOPT algorithm has the advantage of causing the smallest shrinkage porosities, compared to those of the genetic and fruit fly algorithms, which were almost the same.展开更多
Hepatobiliary & Pancreatic Diseases International (HBPD INT) is a journal published bimonthly in English language by the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. We welco...Hepatobiliary & Pancreatic Diseases International (HBPD INT) is a journal published bimonthly in English language by the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. We welcome original展开更多
《International Journal of Mass Spectrometry》（缩写为 INT J MASS SPECTROM（ ISSN：1387-3806）是目前国际公认的质谱学高水平学术期刊之一，Elsevier Science 公司出版。该刊创刊于1968年，早期刊名《International Journal of M...《International Journal of Mass Spectrometry》（缩写为 INT J MASS SPECTROM（ ISSN：1387-3806）是目前国际公认的质谱学高水平学术期刊之一，Elsevier Science 公司出版。该刊创刊于1968年，早期刊名《International Journal of Mass Spectrometry and Ion Physics》，1983年10月更名为《International Journal of Mass Spectrometry and Ion Processes》，1998年6月更名为《International Journal of Mass Spectrometry》，现为半月刊。展开更多
Hepatobiliary & Pancreatic Diseases International(HBPD Int)is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine,Hang-zhou,China.We welcome ori...Hepatobiliary & Pancreatic Diseases International(HBPD Int)is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine,Hang-zhou,China.We welcome original articles fromany part of the world;no charge is made for re-view.The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers,then either accepted for publi-cation or rejected by the Editor.Please send allsubmissions to:The EditorHepatobiliary & Pancreatic Diseases International(HBPD Int),First Affiliated Hospital,ZhejiangUniversity School of Medicine,79 Qingchun Road,展开更多
Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome...Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome original articles fromany part of the world; no charge is made for re-view. The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers, then either accepted for publi-cation or rejected by the Editor. Please send allsubmissions to:展开更多
Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome...Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome original articles fromany part of the world; no charge is made for re-view. The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers, then either accepted for publi-cation or rejected by the Editor. Please send allsubmissions to:The EditorHopatobiliary & Pancreatic Diseases International(HBPD Int), First Affiliated Hospital, Zhejiang展开更多
Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome...Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome original articles fromany part of the world; no charge is made for re-view. The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers, then either accepted for publi-cation or rejected by the Editor. Please send allsubmissions to:展开更多
Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surg...Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surgical, radiological, pathological, biochemical,physiological and historical aspects of the subjectareas under the headings Liver, Biliary, Pancreas,Transplantation, Research, Special Reports, Edi-torials, Reviews, Brief Communications and CaseReports. The journal also deals with the basic sci-ences and experimental work. All submitted papersare reviewed by at least two referees expert in the展开更多
Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surg...Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surgical, radiological, pathological, biochemical,physiological and historical aspects of the subjectareas under the headings Liver, Biliary, Pancreas,Transplantation, Research, Special Reports, Edi-torials, Reviews, Brief Communications and CaseReports. The journal also deals with the basic sci-ences and experimental work. All submitted papersare reviewed by at least two referees expert in thefield of the submitted paper. For detailed instruc-tions concerning the submission of manuscripts,展开更多
Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surg...Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surgical, radiological, pathological, biochemical,physiological and historical aspects of the subjectareas under the headings Liver, Biliary, Pancreas,Transplantation, Research, Special Reports, Edi-torias, Reviews , Brief Communications and CaseReports. The journal also deals with the basic sci-ences and experimental work. All submitted papersare reviewed by at least two referees expert in the展开更多
Copyright 2010,Hepatobiliary & Pancreatic Diseases International. All rights reserved.www.hbpdint.com General information Hepatobiliary & Pancreatic Diseases International (HBPD INT)
Copyright 2014,Hepatobiliary&Pancreatic Diseases International.All rights reserved.www.hbpdint.comGeneral information Hepatobiliary&Pancreatic Diseases International(HBPD INT)is a journal published bimonthly i...Copyright 2014,Hepatobiliary&Pancreatic Diseases International.All rights reserved.www.hbpdint.comGeneral information Hepatobiliary&Pancreatic Diseases International(HBPD INT)is a journal published bimonthly in English language by the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China.We welcome original research articles,review articles,editorials,and others from any part of the world.Manuscripts are reviewed by members of the international editorial board and our expert peer reviewers,then either accepted for publication展开更多
Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed original papers, reviews (meta-analysis,systematic review) and editorials concerned with clinical practice and research in t...Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed original papers, reviews (meta-analysis,systematic review) and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical,展开更多
Copyright 2013, Hepatobiliary & Pancreatic Diseases International. All rights reserved. www.hbpdint.com Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed original papers,...Copyright 2013, Hepatobiliary & Pancreatic Diseases International. All rights reserved. www.hbpdint.com Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed original papers, reviews (meta-analysis, systematic review) and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic展开更多
文摘AIM: To evaluate combination transjugular intrahepatic portosystemic shunt(TIPS) and other interventions for hepatocellular carcinoma(HCC) and portal hypertension.METHODS: Two hundred and sixty-one patients with HCC and portal hypertension underwent TIPS combined with other interventional treatments(transarterial chemoembolization/transarterial embolization,radiofrequency ablation,hepatic arterio-portal fistulas embolization,and splenic artery embolization) from January 1997 to January 2010 at Beijing Shijitan Hospital. Two hundred and nine patients(121 male and 88 female,aged 25-69 years,mean 48.3 ± 12.5 years) with complete clinical data were recruited. We evaluated the safety of the procedure(procedurerelated death and serious complications),change of portal vein pressure before and after TIPS,symptom relief [e.g.,ascites,hydrothorax,esophageal gastricfundus variceal bleeding(EGVB)],cumulative rates of survival,and distributary channel restenosis. The characteristics of the patients surviving ≥ 5 and < 5 years were also analyzed.RESULTS: The portosystemic pressure was decreased from 29.0 ± 4.1 mm Hg before TIPS to 18.1 ± 2.9 mm Hg after TIPS(t = 69.32,P < 0.05). Portosystemic pressure was decreased and portal hypertension symptoms were ameliorated. During the 5 year followup,the total recurrence rate of resistant ascites or hydrothorax was 7.2%(15/209); 36.8%(77/209) for EGVB; and 39.2%(82/209) for hepatic encephalopathy. The cumulative rates of distributary channel restenosis at 1,2,3,4,and 5 years were 17.2%(36/209),29.7%(62/209),36.8%(77/209),45.5%(95/209) and 58.4%(122/209),respectively. No procedure-related deaths and serious complications(e.g.,abdominal bleeding,hepatic failure,and distant metastasis) occurred. Moreover,Child-Pugh score,portal vein tumor thrombosis,lesion diameter,hepatic arterio-portal fistulas,HCC diagnosed before or after TIPS,stent type,hepatic encephalopathy,and type of other interventional treatments were related to 5 year survival after comparing patient characteristics.CONCLUSION: TIPS combined with other interventional treatments seems to be safe and efficacious in patients with HCC and portal hypertension.
基金Supported by the National Natural Science Foundation of China,NSFC,No.81200270the Scientific Research Foundation for Outstanding Young Scientist of Shandong Province,No.BS2012SW012
文摘The intestinal epithelium constitutes a physical and functional barrier between the external environment and the host organism. It is formed by a continuous monolayer of intestinal epithelial cells maintained together by intercellular junctional complex, limiting access of pathogens, toxins and xenobiotics to host tissues. Once this barrier integrity is disrupted, inflammatory disorders and tissue injury are initiated and perpetuated. Beneath the intestinal epithelial cells lies a population of astrocyte-like cells that are known as enteric glia. The morphological characteristics and expression markers of these enteric glia cells were identical to the astrocytes of the central nervous system. In the past few years, enteric glia have been demonstrated to have a trophic and supporting relationship with intestinal epithelial cells. Enteric glia lesions and/or functional defects can be involved in the barrier dysfunction. Besides, factors secreted by enteric glia are important for the regulation of gut barrier function. Moreover, enteric glia have an important impact on epithelial cell transcriptome and induce a shift in epithelial cell phenotype towards increased cell adhesion and cell differentiation.Enteric glia can also preserve epithelial barrier against intestinal bacteria insult. In this review, we will describe the current body of evidence supporting functional roles of enteric glia on intestinal barrier.
文摘interleukin(iL)28B genetic polymorphism is significantly associated with the sustained virological response rate in patients with chronic hepatitis C treated with pegylated interferon-α(PEG-iFN)plus ribavirin and with spontaneous hepatitis C virus clearance.However,a consensus on the relationship between iL28B genetic polymorphism and the favorable outcome of chronic hepatitis B virus infection defined by hepatitis B e antigen seroconversion,and/or hepatitis B surface antigen seroclearance in patients treated with interferon or PEG-iFN has not been reached.Several reports failed to show a positive association,while some studies demonstrated a positive association in certain subject settings.More prospective studies including large cohorts are needed to determine the possible association between iL28B genetic polymorphism and the outcome of interferon or PEG-iFN treatment for chronic hepatitis B.
基金financially supported by the National Science and Technology Key Projects of Numerical Control(2012ZX04012-011)the State Key Laboratory of Materials Processing and Die&Mold Technology Research Project(2014,2015)
文摘The traditional foundry industry has developed rapidly in recently years due to advancements in computer technology. Modifying and designing the feeding system has become more convenient with the help of the casting software, Inte CAST. A common method of designing a feeding system is to first design the initial systems, run simulations with casting software, analyze the feedback, and then redesign. In this work, genetic, fruit fly, and interior point optimizer(IPOPT) algorithms were introduced to guide the optimal riser design for the feeding system. The results calculated by the three optimal algorithms indicate that the riser volume has a weak relationship with the modulus constraint; while it has a close relationship with the volume constraint. Based on the convergence rate, the fruit fly algorithm was obviously faster than the genetic algorithm. The optimized riser was also applied during casting, and was simulated using Inte CAST. The numerical simulation results reveal that with the same riser volume, the riser optimized by the genetic and fruit fly algorithms has a similar improvement on casting shrinkage. The IPOPT algorithm has the advantage of causing the smallest shrinkage porosities, compared to those of the genetic and fruit fly algorithms, which were almost the same.
文摘Hepatobiliary & Pancreatic Diseases International (HBPD INT) is a journal published bimonthly in English language by the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. We welcome original
文摘《International Journal of Mass Spectrometry》（缩写为 INT J MASS SPECTROM（ ISSN：1387-3806）是目前国际公认的质谱学高水平学术期刊之一，Elsevier Science 公司出版。该刊创刊于1968年，早期刊名《International Journal of Mass Spectrometry and Ion Physics》，1983年10月更名为《International Journal of Mass Spectrometry and Ion Processes》，1998年6月更名为《International Journal of Mass Spectrometry》，现为半月刊。
文摘Hepatobiliary & Pancreatic Diseases International(HBPD Int)is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine,Hang-zhou,China.We welcome original articles fromany part of the world;no charge is made for re-view.The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers,then either accepted for publi-cation or rejected by the Editor.Please send allsubmissions to:The EditorHepatobiliary & Pancreatic Diseases International(HBPD Int),First Affiliated Hospital,ZhejiangUniversity School of Medicine,79 Qingchun Road,
文摘Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome original articles fromany part of the world; no charge is made for re-view. The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers, then either accepted for publi-cation or rejected by the Editor. Please send allsubmissions to:
文摘Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome original articles fromany part of the world; no charge is made for re-view. The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers, then either accepted for publi-cation or rejected by the Editor. Please send allsubmissions to:The EditorHopatobiliary & Pancreatic Diseases International(HBPD Int), First Affiliated Hospital, Zhejiang
文摘Hepatobiliary & Pancreatic Diseases International(HBPD Int) is a journal published quarterly inEnglish language by the First Affiliated Hospital,Zhejiang University School of Medicine, Hang-zhou, China. We welcome original articles fromany part of the world; no charge is made for re-view. The papers are reviewed by members of theEditorial Board and our international panel of ex-pert peer reviewers, then either accepted for publi-cation or rejected by the Editor. Please send allsubmissions to:
文摘Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surgical, radiological, pathological, biochemical,physiological and historical aspects of the subjectareas under the headings Liver, Biliary, Pancreas,Transplantation, Research, Special Reports, Edi-torials, Reviews, Brief Communications and CaseReports. The journal also deals with the basic sci-ences and experimental work. All submitted papersare reviewed by at least two referees expert in the
文摘Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surgical, radiological, pathological, biochemical,physiological and historical aspects of the subjectareas under the headings Liver, Biliary, Pancreas,Transplantation, Research, Special Reports, Edi-torials, Reviews, Brief Communications and CaseReports. The journal also deals with the basic sci-ences and experimental work. All submitted papersare reviewed by at least two referees expert in thefield of the submitted paper. For detailed instruc-tions concerning the submission of manuscripts,
文摘Aims and ScopeHBPD Int publishes peer-reviewed original papers,reviews and editorials concerned with clinical prac-tice and research in the fields of hepatobiliary andpancreatic diseases. Papers cover the medical,surgical, radiological, pathological, biochemical,physiological and historical aspects of the subjectareas under the headings Liver, Biliary, Pancreas,Transplantation, Research, Special Reports, Edi-torias, Reviews , Brief Communications and CaseReports. The journal also deals with the basic sci-ences and experimental work. All submitted papersare reviewed by at least two referees expert in the
文摘Copyright 2010,Hepatobiliary & Pancreatic Diseases International. All rights reserved.www.hbpdint.com General information Hepatobiliary & Pancreatic Diseases International (HBPD INT)
文摘Copyright 2014,Hepatobiliary&Pancreatic Diseases International.All rights reserved.www.hbpdint.comGeneral information Hepatobiliary&Pancreatic Diseases International(HBPD INT)is a journal published bimonthly in English language by the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China.We welcome original research articles,review articles,editorials,and others from any part of the world.Manuscripts are reviewed by members of the international editorial board and our expert peer reviewers,then either accepted for publication
文摘Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed original papers, reviews (meta-analysis,systematic review) and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases. Papers cover the medical, surgical,
文摘Copyright 2013, Hepatobiliary & Pancreatic Diseases International. All rights reserved. www.hbpdint.com Aims and Scope Hepatobiliary & Pancreatic Diseases International publishes peer-reviewed original papers, reviews (meta-analysis, systematic review) and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic
