Amorphous Iridium Oxide-Integrated Anode Electrodes with Ultrahigh Material Utilization for Hydrogen Production at Industrial Current Densities

Herein,ionomer-free amorphous iridium oxide(IrO_(x))thin electrodes are first developed as highly active anodes for proton exchange membrane electrolyzer cells(PEMECs)via low-cost,environmentally friendly,and easily scalable electrodeposition at room temperature.Combined with a Nafion 117 membrane,the IrO_(x)-integrated electrode with an ultralow loading of 0.075 mg cm^(-2)delivers a high cell efficiency of about 90%,achieving more than 96%catalyst savings and 42-fold higher catalyst utilization compared to commercial catalyst-coated membrane(2 mg cm^(-2)).Additionally,the IrO_(x)electrode demonstrates superior performance,higher catalyst utilization and significantly simplified fabrication with easy scalability compared with the most previously reported anodes.Notably,the remarkable performance could be mainly due to the amorphous phase property,sufficient Ir^(3+)content,and rich surface hydroxide groups in catalysts.Overall,due to the high activity,high cell efficiency,an economical,greatly simplified and easily scalable fabrication process,and ultrahigh material utilization,the IrO_(x)electrode shows great potential to be applied in industry and accelerates the commercialization of PEMECs and renewable energy evolution.

Integrated numerical simulation of hydraulic fracturing and production in shale gas well considering gas-water two-phase flow

Based on the displacement discontinuity method and the discrete fracture unified pipe network model,a sequential iterative numerical method was used to build a fracturing-production integrated numerical model of shale gas well considering the two-phase flow of gas and water.The model accounts for the influence of natural fractures and matrix properties on the fracturing process and directly applies post-fracturing formation pressure and water saturation distribution to subsequent well shut-in and production simulation,allowing for a more accurate fracturing-production integrated simulation.The results show that the reservoir physical properties have great impacts on fracture propagation,and the reasonable prediction of formation pressure and reservoir fluid distribution after the fracturing is critical to accurately predict the gas and fluid production of the shale gas wells.Compared with the conventional method,the proposed model can more accurately simulate the water and gas production by considering the impact of fracturing on both matrix pressure and water saturation.The established model is applied to the integrated fracturing-production simulation of practical horizontal shale gas wells.The simulation results are in good agreement with the practical production data,thus verifying the accuracy of the model.

Crosstalk between degradation and bioenergetics: how autophagy and endolysosomal processes regulate energy production

Cells undergo metabolic reprogramming to adapt to changes in nutrient availability, cellular activity, and transitions in cell states. The balance between glycolysis and mitochondrial respiration is crucial for energy production, and metabolic reprogramming stipulates a shift in such balance to optimize both bioenergetic efficiency and anabolic requirements. Failure in switching bioenergetic dependence can lead to maladaptation and pathogenesis. While cellular degradation is known to recycle precursor molecules for anabolism, its potential role in regulating energy production remains less explored. The bioenergetic switch between glycolysis and mitochondrial respiration involves transcription factors and organelle homeostasis, which are both regulated by the cellular degradation pathways. A growing body of studies has demonstrated that both stem cells and differentiated cells exhibit bioenergetic switch upon perturbations of autophagic activity or endolysosomal processes. Here, we highlighted the current understanding of the interplay between degradation processes, specifically autophagy and endolysosomes, transcription factors, endolysosomal signaling, and mitochondrial homeostasis in shaping cellular bioenergetics. This review aims to summarize the relationship between degradation processes and bioenergetics, providing a foundation for future research to unveil deeper mechanistic insights into bioenergetic regulation.

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor prognosis.In the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal cancer.Therefore,we further explored the survival benefits in the population with BRAF V600E mutant mCRC.AIM To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal cancer.METHODS A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December 2022.The patients were divided into two cohorts.RESULTS A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,respectively.Subgroup analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

Theory and practice of integrated coal production and gas extraction

The integrated extraction of coal and gas combines coal mining with gas capture. Taking into account the gas deposition and flow conditions in the Chinese coal basins, this paper describes the status of the theory and key technologies of this integrated extraction system, and presents its application and practice in the Shaqu, Zhongxing, Fenghuangshan and Pingmei mines. Areas for further improvements in future studies are discussed, focusing in particular on the fundamentals of the extraction system to make it greener, more scientific, and more advanced in both the exploitation and utilization of coal and the gas in coal.

Actuality and Influencing Factors of Integrated Production Capacity of Foodstuff in Heilongjiang Province

Heilongjiang Province is an important marketable grain depot in China. Since the reform and opening up, Heilongjiang Province production capacity of foodstuff is increasingly growing into a new level. This paper started with the actuality of Heilongjiang Province integrated production capacity of foodstuff, and analyzed its major factors empirically through the mathematical model, then proposed some measures to enhance Heilongjiang Province production capacity of foodstuff which ensured China foodstuff security

Evaluation of Integrated Production Capacity of Well- facilitated Farmland in Jiangsu Province

The fundamental task of well-facilitated farmland construction is to continuously lift the integrated production capacity. External project construction for well-facilitated farmland can not completely solve existing problems in improvement of intrinsic quality of farmland.Based on research findings of integrated production capacity of farmland,starting from basic elements such as water,soil,seed,fertilizer,and pesticide,this paper introduced factors influencing the integrated production capacity of well-facilitated farmland,including natural quality of farmland,supporting infrastructure,agricultural technology level and management level,and labor quality. Besides,it establish an evaluation system for integrated production capacity of well-facilitated farmland in Jiangsu Province by Analytic Hierarchy Process( AHP),and made an empirical study using indicator data of 2010- 2014. Results indicated that the general index of integrated production capacity of farmland in Jiangsu Province in 2010- 2014 was ascending,reflecting improvement of integrated production capacity of farmland. With the aid of radar map,it further found that the coupling between water,soil,seed,fertilizer,and pesticide and other elements play a crucial role in lifting the integrated production capacity of farmland. Finally,based on existing problems in construction of well-facilitated farmland in Jiangsu Province,it came up with some pertinent recommendations from the perspective of coordinated development of all elements.

Multiproduct and multistage integrated production planning model and algorithm based on an available production capacity network

This research attempts to devise a multistage and multiproduct short-term integrative production plan that can dynamically change based on the order priority and virtual occupancy for application in steel plants. Considering factors such as the delivery time, varietal compatibility between different products, production capacity of variety per hour, minimum or maximum batch size, and transfer time, we propose an available production capacity network with varietal compatibility and virtual occupancy for enhancing production plan implementation and quick adjustment in the case of dynamic production changes. Here available means the remaining production capacity after virtual occupancy.To quickly build an available production capacity network and increase the speed of algorithm solving, constraint selection and cutting methods with order priority were used for model solving. Finally, the genetic algorithm improved with local search was used to optimize the proposed production plan and significantly reduce the order delay rate. The validity of the proposed model and algorithm was numerically verified by simulating actual production practices. The simulation results demonstrate that the model and improved algorithm result in an effective production plan.

Energy Efficiency Evaluation Based on Data Envelopment Analysis Integrated Analytic Hierarchy Process in Ethylene Production

Energy efficiency data from ethylene production equipment are of high dimension, dynamic and time sequential, so their evaluation is affected by many factors. Abnormal data from ethylene production are eliminated through consistency test, making the data consumption uniform to improve the comparability of data. Due to the limit of input and output data of decision making unit in data envelopment analysis(DEA), the energy efficiency data from the same technology in a certain year are disposed monthly using DEA. The DEA data of energy efficiency from the same technology are weighted and fused using analytic hierarchy process. The energy efficiency data from different technologies are evaluated by their relative effectiveness to find the direction of energy saving and consumption reduction.

Application of vertically integrated sampling approach to study of new production via ^(234)Th -^(238)U disequilibria

The spatial and temporal distributions of new production vary largely in different sea areas. To understand the level of new production in the sea area studied better, an estimate of new production must be obtained in large spatial and temporal scales. The ~234Th/ ~238U disequilibrium is an effective method for the study of new production. Two sampling strategies, vertically integrated sampling ap proach based on trapezoidal integration principle and discrete layer sampling approach, were compared in the studies of the xiamen Bay and the northern South China Sea. The scavenging fluxes and removal fluxes of ~234Th and the residence times for dissolved and particulate ~234Th were calculated. The coinci dent results from two Sampling approach suggest that vertically integrated sampling approach is not only effective and reliable, but also significantly reduces the number and volume of samples. It allows us to study new production by ba ^(234)Th - ^(238)U disequilibria in large spatial scale.

Integrated Manufacturing Cell Formation Technology Orienting Multi-product Type and Variant Volume Production

What is pursued by multi-product type and variant volume（MPTVV） production is rapid response and quick switching,so that structure of transferring line in manufacturing system is no longer unalterable.Cell formation（CF） algorithm is the key technology of cellular manufacturing system（CMS）.Currently,CF methods are mainly extended on the idea of group technology（GT） that covers a lot on analysis of resource capability matching and its algorithm.Various constraints are considered,but seldom utilized comprehensively.Aimed to the problem of manufacturing cell（MC） formation under MPTVV production mode,integrated formation technologies for typical MC as group type of cell（GC）,flow type of cell（FC） and inherited cell（IC） are presented based on technical analysis of CF.Oriented to practical production constraints like delivery time,product batch,equipment ability,key machine,key part and machine sharing,etc,an integrated formation model is constructed and internal interrelations of these constraints are analyzed synthetically.Ulteriorly,formation goals of types of MCs and their formation procedures under joint effect of formation constraints and rules are spread.In case study,three highly balanced GC are formed first;then FC formation are implemented based on the same data which indicate good balancing effect of cell load and flow-style production for key tasks;When task is adjusted,a new scheme is constructed on the result of FC configuration by using IC formation method,and more optimal performance of flow-style production is manifested.The proposed comparative study of different type of cells strongly explains the validation of integrated MC formation in support of rapid manufacturing resource transformation under MPTVV production mode.

Energy efficiency evaluation based on DEA integrated factor analysis in ethylene production

Energy efficiency evaluation plays an important role in energy efficiency improvement of the ethylene production. It is observed from the actual production data that the ethylene production energy efficiency often varies with the complex production working conditions. In the favored methods for energy efficiency evaluation,DEA models may show poor resolution when directly used to evaluate the efficiency values. Therefore, a new energy efficiency evaluation method for ethylene production is proposed based on DEA integrated factor analysis with respect to operation classification. Three key factors, including raw material composition, cracking depth and load rate, are taken into account in determining the production working conditions by means of k-means algorithm. Based on the multi-working conditions mode the energy efficiency evaluation of the ethylene production is made by using DEA model, where the most related energy data are screened by factor analysis.Furthermore, the supporting decision of energy efficiency improvement is provided to the operators. The accuracy and effectiveness of the proposed method are illustrated by applying in a practical ethylene production,which gives more effective energy efficiency evaluation in the complicated working conditions of ethylene production with declined dimension of input indicators.

A new method to evaluate integrated production system capacity in oil fields

To improve the design and management of an integrated production system(IPS),a set of mathematical models and workflows are developed for evaluating the capacity of an IPS at steady-state conditions.Combining the conservation laws with applicable multiphase fluid and choke models,these mathematical models are solved to characterize the hydraulics of an integrated system of reservoir,wells,chokes,flowlines,and separator at steady state.The controllable variables such as well count,choke size and separator pressure are adjusted to optimize the performance of the IPs at a specific time.It is found that increasing the well count can increase the bulk flow rate of the production network,but too many wells may increase the manifold pressure,leading to decline of single-well production.Increasing the choke size can improve the capacity of the IPs.The production of the IPs is negatively correlated with the separator pressure.With increasing separator pressure and decreasing choke size,the increment of total fluid production(the capacity of IPS)induced by increasing well count decreases.Validation tests with field examples show a maximum absolute deviation is 1.5%,demonstrating the robustness and validity of the proposed mathematical models and workflows.

Effect of Interaction Intensity on Alignment and EFL Learners’ Oral Production in the ReadingSpeaking Integrated Continuation Task

This study aims to uncover the relationship between interaction and alignment in a readingspeaking integrated continuation task, especially focusing on whether an increase in interaction intensity can lead to stronger alignment and further generate positive effects on L2 learning. To this end, 31 participants were asked to perform reading-speaking integrated continuation tasks under three different conditions featuring low, medium and high interaction intensity respectively. The results showed that 1) alignment existed in the reading-speaking integrated continuation task;2)increasing interaction intensity generated stronger alignment at both linguistic and situational levels;3) growing interaction intensity contributed to more coherent and accurate L2 oral production. These findings not only proved the workings of mind-body-world alignment, but also testified that increasing interaction intensity could bring about a stronger alignment effect(Wang,2010), which then contributed to better L2 oral performance. These findings confirm again the role of interaction in L2 learning and suggest that alignment could possibly be a mediating factor that links interaction and L2 development. Pedagogical implications for teaching and learning L2 speaking are discussed.

Integrated Production and Transportation Scheduling Method in Hybrid Flow Shop

The connection between production scheduling and transportation scheduling is getting closer in smart manufacturing system, and both of those problems are summarized as NP-hard problems. However, only a few studies have considered them simultaneously. This paper solves the integrated production and transportation scheduling problem(IPTSP) in hybrid flow shops, which is an extension of the hybrid flow shop scheduling problem(HFSP). In addition to the production scheduling on machines, the transportation scheduling process on automated guided vehicles(AGVs)is considered as another optimization process. In this problem, the transfer tasks of jobs are performed by a certain number of AGVs. To solve it, we make some preparation(including the establishment of task pool, the new solution representation and the new solution evaluation), which can ensure that satisfactory solutions can be found efficiently while appropriately reducing the scale of search space. Then, an effective genetic tabu search algorithm is used to minimize the makespan. Finally, two groups of instances are designed and three types of experiments are conducted to evaluate the performance of the proposed method. The results show that the proposed method is effective to solve the integrated production and transportation scheduling problem.

Data-driven source-load robust optimal scheduling of integrated energy production unit including hydrogen energy coupling

A robust low-carbon economic optimal scheduling method that considers source-load uncertainty and hydrogen energy utilization is developed.The proposed method overcomes the challenge of source-load random fluctuations in integrated energy systems(IESs)in the operation scheduling problem of integrated energy production units(IEPUs).First,to solve the problem of inaccurate prediction of renewable energy output,an improved robust kernel density estimation method is proposed to construct a data-driven uncertainty output set of renewable energy sources statistically and build a typical scenario of load uncertainty using stochastic scenario reduction.Subsequently,to resolve the problem of insufficient utilization of hydrogen energy in existing IEPUs,a robust low-carbon economic optimal scheduling model of the source-load interaction of an IES with a hydrogen energy system is established.The system considers the further utilization of energy using hydrogen energy coupling equipment(such as hydrogen storage devices and fuel cells)and the comprehensive demand response of load-side schedulable resources.The simulation results show that the proposed robust stochastic optimization model driven by data can effectively reduce carbon dioxide emissions,improve the source-load interaction of the IES,realize the efficient use of hydrogen energy,and improve system robustness.

Water-recycled Cassava Bioethanol Production Integrated with Two-stage UASB Treatment

Considering limited success in target-hitting discharge from alcohol industry, our attention was directed toward a recycling use of distillery spentwash (DS) in cassava bioethanol production by using a two-stage up-flow anaerobic sludge blanket bioremediation (TS-UASBB). With the TS-UASBB, 2 4 SO , COD, N and P in the effluent from the DS degraded significantly and their concentrations were kept at 0.2 g·L -1 , 2.0 g·L -1 , 1.0 g·L -1 and 15 mg·L -1 , respectively, in 13 batch processes for water-recycled ethanol fermentation. With the effluent used directly as dilution water, no heat-resistant bacteria were found alive. The thirteen-batch ethanol production individually achieved 10% after 48 h fermentation. The starch utilization ratio and total sugar consumption were 90% and 99.5%, respectively. The novel water-recycled bioethanol production process with ethanol fermentation and TS-UASBB has a considerable potential in other starchy and cellulosic ethanol production.

A production prediction method of single well in water flooding oilfield based on integrated temporal convolutional network model

Since the oil production of single well in water flooding reservoir varies greatly and is hard to predict, an oil production prediction method of single well based on temporal convolutional network(TCN) is proposed and verified. This method is started from data processing, the correspondence between water injectors and oil producers is determined according to the influence radius of the water injectors, the influence degree of a water injector on an oil producer in the month concerned is added as a model feature, and a Random Forest(RF) model is built to fill the dynamic data of water flooding. The single well history is divided into 4 stages according to its water cut, that is, low water cut, middle water cut, high water cut and extra-high water cut stages. In each stage, a TCN based prediction model is established, hyperparameters of the model are optimized by the Sparrow Search Algorithm(SSA). Finally, the models of the 4 stages are integrated into one whole-life model of the well for production prediction. The application of this method in Daqing Oilfield, NE China shows that:(1) Compared with conventional data processing methods, the data obtained by this processing method are more close to the actual production, and the data set obtained is more authentic and complete.(2) The TCN model has higher prediction accuracy than other 11 models such as Long Short Term Memory(LSTM).(3) Compared with the conventional full-life-cycle models, the model of integrated stages can significantly reduce the error of production prediction.

Integrated Knitwear Production for Hong Kong and the Interior of China

Hong Kong knitwear manufacturers were among the pioneers to invest in the Pearl River Delta region of Guang-dong,China.Owing to limitations on technological levelat the time of the initial investments,the content of pro-duction-sharing for the Inland in China were basically of simple technology and labour intensive in nature.Through venturing hardships,the investment has been able to boost the economy of Guangdong and foster close trade relationship,especially in outward processing trade,By now,the co-operative production

Simulation and design of a heat-integrated double-effect reactive distillation process for propylene glycol methyl ether production

A double-effect reactive distillation(DERD)process was proposed for the production of propylene glycol methyl ether from propylene oxide and methanol to overcome the shortcoming of low selectivity and high-energy consumption in the tubular plug-flow reactor.A single-column reactive distillation(RD)process was conducted under optimized operating conditions based on sensitivity analysis as a reference.The results demonstrated that the proposed DERD process is able to achieve more than 95%selectivity of the desired product.After that,a design approach of the DERD process with an objective of the minimum operating cost was proposed to achieve further energy savings in the RD process.The proposed DERD configuration can provide a large energy-savings by totally utilization of the overhead vapor steam in the high-pressure RD column.A comparison of the single-column RD process revealed that the proposed DERD process can reduce the operating cost and the total annual cost of 25.3%and 30.7%,respectively,even though the total capital cost of DERD process is larger than that of the RD process.