Multiple sclerosis：integration of modeling with biology,clinical and imaging measures to provide better monitoring of disease progression and prediction of outcome

Multiple Sclerosis（MS） is a major cause of neurological disability in adults and has an annual cost of approximately $28 billion in the United States. MS is a very complex disorder as demyelination can happen in a variety of locations throughout the brain; therefore, this disease is never the same in two patients making it very hard to predict disease progression. A modeling approach which combines clinical, biological and imaging measures to help treat and fight this disorder is needed. In this paper, I will outline MS as a very heterogeneous disorder, review some potential solutions from the literature, demonstrate the need for a biomarker and will discuss how computational modeling combined with biological, clinical and imaging data can help link disparate observations and decipher complex mechanisms whose solutions are not amenable to simple reductionism.

Analysis of Social Integration Models of Tourism Labor Migrants——A Case Study of Jiuhua Mountain of Anhui Province, China

The grounded theory of qualitative methods was applied to researching the social integration of tourism la-bor migrants in the Jiuhua Mountain of Anhui Province, China. The research was conducted based on the in-depth in-terviewing of 15 samples, open-consultation and the analysis of secondhand data. The integration models of tourism labor migrants in the Jiuhua Mountain were formed through four processes including theoretic sampling, cod-ing-analysis, cross-tabulation and contextualization. The result shows that modes of production and life styles decide self-integration orientation of tourism labor migrants in the Jiuhua Mountain. Cultural differences are fundamental dis-similarity between tourism labor migrants and natives. There are three kinds of integration models including rapid, free and gradually advancing integration. The differences among different types of migrants’ integration models are re-markable. Taking the working integration as the abscissa and taking the life integration as the coordinate, an "S" model of integration matrix appears in the gradually advancing integration of intermediate and high administers from the working to the life which should be paid special attention to.

Integrated modeling of spacecraft relative motion dynamics using dual quaternion

To realize high accurate control of relative position and attitude between two spacecrafts, the coupling between position and attitude must be fully considered and a more precise model should be established. This paper breaks the traditional divide and conquer idea, and uses a mathematical tool, namely dual quaternion to establish the integrated 6 degree-of-freedom(6-DOF) model of relative position and attitude, which describes the coupled relative motion in a compact and efficient form and needs less information of the target. Considering the complex operation rules and the unclarity of the current relative motion model in dual quaternion, necessary mathematical foundations are given at first, followed by clear and detailed modeling process and analysis. Finally a generalized proportion-derivative(PD) controller law is designed. The simulation results show that based on the integrated model established by dual quaternion, this control law can achieve a high control accuracy of relative motion.

Integration of axiomatic design and theory of inventive problem solving for conceptual design

Axiomatic design (AD) and theory of inventive problem solving (TRIZ) are widely used in conceptual design. Both of them have limitations, however. We presented an integrated model of these two methods to increase the efficiency and quality of the problem solving process for conceptual design. AD is used for systematically defining and structuring a problem into a hierarchy. Sometimes, the design matrix is coupled in AD which indicates the functional requirements are coupled. TRIZ separation principles can be used to separate non-independent design parameters, which provide innovative solutions at each hierarchical level. We applied the integrated model to the heating and drying equipment of bitumen reproduction device. The result verifies that the integrated model can work very well in conceptual design.

Concise Modeling of Amorphous Dual-Gate In-Ga-Zn-O Thin-Film Transistors for Integrated Circuit Designs

An analytical model for current-voltage behavior of amorphous In-Ga-Zn-O thin-film transistors（a-IGZO TFTs）with dual-gate structures is developed.The unified expressions for synchronous and asynchronous operating modes are derived on the basis of channel charges,which are controlled by gate voltage.It is proven that the threshold voltage of asynchronous dual-gate IGZO TFTs is adjusted in proportion to the ratio of top insulating capacitance to the bottom insulating capacitance（C_（TI）/C_（BI））.Incorporating the proposed model with Verilog-A,a touch-sensing circuit using dual-gate structure is investigated by SPICE simulations.Comparison shows that the touch sensitivity is increased by the dual-gate IGZO TFT structure.

Structural modeling of proteins by integrating small-angle x-ray scattering data

Elucidating the structure of large biomolecules such as multi-domain proteins or protein complexes is challenging due to their high flexibility in solution. Recently, an ＂integrative structural biology＂ approach has been proposed, which aims to determine the protein structure and characterize protein flexibility by combining complementary high- and lowresolution experimental data using computer simulations. Small-angle x-ray scattering（SAXS） is an efficient technique that can yield low-resolution structural information, including protein size and shape. Here, we review computational methods that integrate SAXS with other experimental datasets for structural modeling. Finally, we provide a case study of determination of the structure of a protein complex formed between the tandem SH3 domains in c-Cb1-associated protein and the proline-rich loop in human vinculin.

Numerical Modeling of Shallow Water Table Behavior with Lisse Effect

Air entrapment is an important consideration in environments with shallow water tables and sandy soil, like the condition of highly conductive sandy soils and flat topography in Florida, USA. It causes water table rises in soils, which are significantly faster and higher than those in soils without air entrapment. Two numerical models, Integrated Hydrologic Model (IHM) and HYDRUS-1D (a single-phase, one-dimensional Richards′ equation model) were tested at an area of west central Florida to help further understanding the shallow water table behavior during a long term air entrapment. This investigation employed field data with two modeling approaches to quantify the variation of air pressurization values. It was found that the air pressurization effect was responsible at time up to 40 cm of water table rise being recorded by the observation well for these two models. The values of air pressurization calculated from IHM and HYDRUS-1D match the previously published values. Results also indicated that the two numerical models did not consider air entrapment effect (as the predictive parameters remain uncertain) and thus results of depth to water table from these models did not compare to the observations for these selected periods. Incorporating air entrapment in prediction models is critical to reproduce shallow water table observations.

Modeling of the Dyeing Uptake Rate for Direct Dyestuff on Cotton in Batch Dyeing Process Based on Grey System Theory

The grey system theory, with the characteristics of fewer modeling data and higher accuracy, was employed to model the batch dyeing process for the purpose of accurate online control. The GM（1, 1） and GM （0, N） models of the grey system theory were discussed for their feasibilities of modding for batch dyeing process. The combination of direct dyestuff Fast Red F3B on cotton was chosen as a representative of the common dyeing method for describing the modeling process. Firstly, the GM（ 1, 1 ） model and the GM（1, 1） combined with GM（0, N） model were employed to model the equilibrium percentage of dyeing uptake rate. Secondly, an integrated dyeing uptake rate model with three factors （ temperature, salt concentration, and pH） was established based on the adsorption rate equation. Experimental results show that this model has higher accuracy and beetler generalization ability, which can predict the results of batch dyeing process. Due to the application of grey system theory, the model has a lot of advantages, such as being easy to determine the parameter value and small amount of calculation. So it can also be suitable for the same type of combination of dyestuff-fahric by changing the parameters value only.

A STUDY ON FORMAL MODEL INTEGRATION

Model integration is an important section of the model management research area. The paper puts forward a formalization representation of model, and presents some concepts, such as the compound model re- lation, the composite model and so on. Additionally, the existence of model integration is also analyzed in de- tail and several sufficient conditions are proved.

Application of Capability Maturity Model Integration to Innovation Management for Software and Service Companies

To look through innovation management in small project-based firms, such as software engineering companies, which are service firms that conduct projects for their clients, capability maturity model integration （CMMI） is introduced. It is a process improvement approach that provides organizations with the essential elements of effective processes. Taking ABC Software Company as an example, the performances before and after the introduction of CMMI in the firm were compared. The results indicated that after two years of application, the productivity increased 92%, and the ability of detecting errors improved 26.45% ; while the rate of faults and the cost of software development dropped 12.45% and 77.55%, respectively. To conclude, small project-based firms benefit a lot if they take CMMI into their process of innovation management, particularly for those R＆D firms, since the implementation of CMMI leads them to a promising future with higher efficiency and better effects.

Integrating Downstream Ecological, Social and Economic Effects of Hydropower to Hydraulic Modeling: A Review

Hydropower gains increasing importance as a steerable and controllable power source in a renewable energy mix and deregulated markets. Although hydropower produces fossil-free energy, it has a significant impact on the local environment. This review investigates the effects of flow alterations by hydropower on the downstream river system and the possibilities to integrate these effects into hydraulic modeling. The results show that various effects of flow regulation on the ecosystem, but also social and economic effects on related communities were observed in the last decades. The application of hydraulic models for investigations of ecological effects is common. Especially hydraulic effects and effects on fish were extensively modeled with the help of hydraulic 1D- and 2D-simulations. Current applications to investigate social and economic effects integrated into hydraulic modeling are meanwhile limited. Approaches to realizing this integration are presented. Further research on the economic valuation of ecosystems and integration of social and economic effects to hydraulic models is necessary to develop holistic tools to support decision-making on sustainable hydropower.

Mechatronic Modeling and Domain Transformation of Multi-physics Systems

The enhanced definition of Mechatronics involves the four underlying characteristics of integrated,unified,unique,and systematic approaches.In this realm,Mechatronics is not limited to electro-mechanical systems,in the multi-physics sense,but involves other physical domains such as fluid and thermal.This paper summarizes the mechatronic approach to modeling.Linear graphs facilitate the development of state-space models of mechatronic systems,through this approach.The use of linear graphs in mechatronic modeling is outlined and an illustrative example of sound system modeling is given.Both time-domain and frequency-domain approaches are presented for the use of linear graphs.A mechatronic model of a multi-physics system may be simplified by converting all the physical domains into an equivalent single-domain system that is entirely in the output domain of the system.This approach of converting(transforming)physical domains is presented.An illustrative example of a pressure-controlled hydraulic actuator system that operates a mechanical load is given.

Towards an Integration of the Behaviorist,the Cognitivist and the Interactionist Models in SLA in China

Introduction English Language teaching as a profession has enjoyed a long history.And ever since itsinitiation,people have investigated different models in language acquisition/learning andteaching,although only in recent years has attention been paid to the studies of SLA.In theChinese setting,research in foreign language teaching(TEFL)has been made in the fashionof the theories of first language acguisition or SLA,for it is believed that the contributions tostudies of the input provided by mothers(i.e motherese) in L1 acquisition and teachers inter-locuters in SLA are necessarily important for understanding the direction that TEEL researchhas followed,as they have provided both a methodololgy for investigating input and the re-search questions.The behaviorist,the cognitivist and the interactionist approaches have putforward different models in interpreting L1 acquisition and SLA,which obviously have theirown merits and demerits,depending on the level at which they are employed and the purposethey

Integrated analysis of plasma rotation effect on HL-3 hybrid scenario

The hybrid scenario,which has good confinement and moderate MHD instabilities,is a proposed operation scenario for international thermonuclear experimental reactor(ITER).In this work,the effect of plasma rotation on the HL-3 hybrid scenario is analyzed with the integrated modeling framework OMFIT.The results show that toroidal rotation has no obvious effect on confinement with a high line averaged density of n_(bar)~(7)×10^(19)m^(-3).In this case,the ion temperature only changes from 4.7 keV to 4.4 keV with the rotation decreasing from 10^(5) rad/s to 10^(3) rad/s,which means that the turbulent heat transport is not dominant.While in the scenarios characterized by lower densities,such as n_(bar)~4×10^(19)m^(-3),turbulent transport becomes dominant in determining heat transport.The ion temperature rises from 3.8 keV to 6.1 keV in the core as the rotation velocity increases from 10^(3) rad/s to 10^(5) rad/s.Despite the ion temperature rising,the rotation velocity does not obviously affect electron temperature or density.Additionally,it is noteworthy that the variation in rotation velocity does not significantly affect the global confinement of plasma in scenarios with low density or with high density.

Regional Climate Damage Quantification and Its Impacts on Future Emission Pathways Using the RICE Model

This study quantified the regional damages resulting from temperature and sea level changes using the Regional Integrated of Climate and Economy(RICE)model,as well as the effects of enabling and disabling the climate impact module on future emission pathways.Results highlight varied damages depending on regional economic development and locations.Specifically,China and Africa could suffer the most serious comprehensive damages caused by temperature change and sea level rise,followed by India,other developing Asian countries(OthAsia),and other high-income countries(OHI).The comprehensive damage fractions for China and Africa are projected to be 15.1%and 12.5%of gross domestic product(GDP)in 2195,with corresponding cumulative damages of 124.0 trillion and 87.3 trillion United States dollars(USD)from 2005 to 2195,respectively.Meanwhile,the comprehensive damage fractions in Japan,Eurasia,and Russia are smaller and projected to be lower than 5.6%of GDP in 2195,with cumulative damages of 6.8 trillion,4.2 trillion,and 3.3 trillion USD,respectively.Additionally,coastal regions like Africa,the European Union(EU),and OHI show comparable damages for sea level rise and temperature change.In China,however,sea level-induced damages are projected to exceed those from temperature changes.Moreover,this study indicates that switching the damage modules on or off affects the regional and global emission trajectories,but the magnitude is relatively small.By 2195,global emissions under the experiments with all of the damage modules switched off,only the sea level damage module switched on,and only the temperature damage module switched on,were 3.5%,2.3%and 1.2%higher than those with all of the damage modules switched on,respectively.

Influencing Factors and Prediction of Risk of Returning to Ecological Poverty in Liupan Mountain Region,China

China has resolved its overall regional poverty in 2020 by attaining moderate societal prosperity.The country has entered a new development stage designed to achieve its second centenary goal.However,ecological fragility and risk susceptibility have increased the risk of returning to ecological poverty.In this paper,the Liupan Mountain Region of China was used as a case study,and the counties were used as the scale to reveal the spatiotempora differentiation and influcing factors of the risk of returning to poverty in study area.The indicator data for returning to ecological poverty from 2011-2020 were collected and summarized in three dimensions:ecological,economic and social.The autoregressive integrated moving average model(ARIMA)time series and exponential smoothing method(ES)were used to predict the multidimensional indicators of returning to ecological poverty for 61 counties(districts)in the Liupan Mountain Region for 2021-2030.The back propagation neural network(BPNN)and geographic information system(GIS)were used to generate the spatial distribution and time variation for the index of the risk of returning to ecological poverty(RREP index).The results show that 1)ecological factors were the main factors in the risk of returning to ecological poverty in Liupan Mountain Region.2)The RREP index for the 61 counties(districts)exhibited a downward trend from 2021-2030.The RREP index declined more in medium-and high-risk areas than in low-risk areas.From 2021 to 2025,the RREP index exhibited a slight downward trend.From 2026 to2030,the RREP index was expected to decline faster,especially from 2029-2030.3)Based on the RREP index,it can be roughly divided into three types,namely,the high-risk areas,the medium-risk areas,and the low-risk areas.The natural resource conditions in lowrisk areas of returning to ecological poverty,were better than those in medium-and high-risk areas.

Quantifying Contribution of Recycled Moisture to Precipitation in Temperate Glacier Region,Southeastern Tibetan Plateau,China

Recycled moisture is an important indicator of the renewal capacity of regional water resources.Due to the existence of Yulong Snow Mountain,Lijiang in Yunnan Province,southeast of the Qinghai-Tibet Plateau,China,is the closest ocean glacier area to the equator in Eurasia.Daily precipitation samples were collected from 2017 to 2018 in Lijiang to quantify the effect of sub-cloud evaporation and recycled moisture on precipitation combined with the d-excess model during monsoon and non-monsoon periods.The results indicated that the d-excess values of precipitation fluctuated between–35.6‰and 16.0‰,with an arithmetic mean of 3.5‰.The local meteoric water line(LMWL)wasδD=7.91δ^(18)O+2.50,with a slope slightly lower than the global meteoric water line(GMWL).Subcloud evaporation was higher during the non-monsoon season than during the monsoon season.It tended to peak in March and was primarily influenced by the relative humidity.The source of the water vapour affected the proportion of recycled moisture.According to the results of the Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)model,the main sources of water vapour in Lijiang area during the monsoon period were the southwest and southeast monsoons.During the non-monsoon period,water vapour was transported by a southwesterly flow.The recycled moisture in Lijiang area between March and October 2017 was 10.62%.Large variations were observed between the monsoon and non-monsoon seasons,with values of 5.48%and 25.65%,respectively.These differences were primarily attributed to variations in the advection of water vapour.The recycled moisture has played a supplementary role in the precipitation of Lijiang area.

Oxygen and hydrogen isotope characteristics of different water bodies in the Burqin River Basin of the Altay Mountains,China

Characterization of the spatial and temporal variability of stable isotopes in surface water is essential for interpreting hydrological processes.In this study,we collected the water samples of river water,groundwater,and reservoir water in the Burqin River Basin of the Altay Mountains,China in 2021,and characterized the oxygen and hydrogen isotope variations in different water bodies via instrumental analytics and modeling.Results showed significant seasonal variations in stable isotope ratios of oxygen and hydrogen(δ18O andδ2H,respectively)and significant differences inδ18O andδ2H among different water bodies.Higherδ18O andδ2H values were mainly found in river water,while groundwater and reservoir water had lower isotope ratios.River water and groundwater showed differentδ18O-δ2H relationships with the local meteoric water line,implying that river water and groundwater are controlled by evaporative enrichment and multi-source recharge processes.The evaporative enrichment experienced by reservoir water was less significant and largely influenced by topography,recharge sources,local moisture cycling,and anthropogenic factors.Higher deuterium excess(d-excess)value of 14.34‰for river water probably represented the isotopic signature of combined contributions from direct precipitation,snow and glacial meltwater,and groundwater recharge.The average annual d-excess values of groundwater(10.60‰)and reservoir water(11.49‰)were similar to the value of global precipitation(10.00‰).The findings contribute to understanding the hydroclimatic information reflected in the month-by-month variations in stable isotopes in different water bodies and provide a reference for the study of hydrological processes and climate change in the Altay Mountains,China.

The Construction of Integrated Nursing Model Prevention of Oxaliplatin Chemotherapy-Induced Peripheral Nerve Injury

Objective: To investigate the effect of the integrated nursing model in the prevention of chemotherapy-induced peripheral injury. Methods: A total of 60 tumor patients receiving oxaliplatin for 1 - 6 cycles of chemotherapy from January to September 2023 were selected. 30 patients were selected from January to March and divided into the control group, and 30 patients were selected from July to 9 as the experimental group. The control group received conventional chemotherapy nursing, while the experimental group received integrated nursing. Anxiety, peripheral nerve toxicity stage and quality of life score were compared between the two groups before and after intervention. Results: After intervention, the scores of the self-rating Anxiety Scale (SAS) and the total scores of the oxaliplatin Levi specific sensory neurotoxicity scale in the experimental group were significantly lower than those in the control group, and the differences were statistically significant (P< 0.05);The Quality of Life Scale (FACT-G) score of cancer patients was higher than that of control group, and the difference was statistically significant (P< 0.05). Conclusion: The integrated nursing model can effectively reduce the anxiety of patients, reduce the incidence of peripheral nerve injury and improve the quality of life of patients.

Influence of Human Activity Intensity on Habitat Quality in Hainan Tropical Rainforest National Park,China

Due to long-term human activity interference,the Hainan Tropical Rainforest National Park(HTRNP)of China has experienced ecological problems such as habitat fragmentation and biodiversity loss,and with the expanding scope and intensity of human activity impact,the regional ecological security is facing serious challenges.A scientific assessment of the interrelationship between human activity intensity and habitat quality in the HTRNP is a prerequisite for achieving effective management of ecological disturbances caused by human activities and can also provide scientific strategies for the sustainable development of the region.Based on the land use change data in 2000,2010,and 2020,the spatial and temporal variations and the relationship between habitat quality(HQ)and human activity intensity(HAI)in the HTRNP were explored using the integrated valuation of ecosystem services and trade-offs(InVEST)model.System dynamics and land use simulation models were also combined to conduct multi-scenario simulations of their relationships.The results showed that during 2000–2020,the habitat quality of the HTRNP improved,the intensity of human activities decreased each year,and there was a negative correlation between the two.Second,the system dynamic model could be well coupled with the land use simulation model by combining socio-economic and natural factors.The simulation scenarios of the coupling model showed that the harmonious development(HD)scenario is effective in curbing the increasing trend of human activity intensity and decreasing trend of habitat quality,with a weaker trade-off between the two compared with the baseline development(BD)and investment priority oriented(IPO)scenarios.To maintain the authenticity and integrity of the HTRNP,effective measures such as ecological corridor construction,ecological restoration,and the implementation of ecological compensation policies need to be strengthened.