Coping with uncertainties through an automated workflow for 3D reservoir modelling of carbonate reservoirs

Reliable 3D modelling of underground hydrocarbon reservoirs is a challenging task due to the complexity of the underground geological formations and to the availability of different types of data that are typically affected by uncertainties. In the case of geologically complex depositional environments, such as fractured hydrocarbon reservoirs, the uncertainties involved in the modelling process demand accurate analysis and quantification in order to provide a reliable confidence range of volumetric estimations. In the present work, we used a 3D model of a fractured carbonate reservoir and populated it with different lithological and petrophysical properties. The available dataset also included a discrete fracture network(DFN) property that was used to model the fracture distribution. Uncertainties affecting lithological facies, their geometry and absolute positions(related to the fault system), fracture distribution and petrophysical properties were accounted for. We included all different types of uncertainties in an automated approach using tools available in today’s modelling software packages and combining all the uncertain input parameters in a series of statistically representative geological realizations. In particular, we defined a specific workflow for the definition of the absolute permeability according to an equivalent, single porosity approach, taking into account the contribution of both the matrix and the fracture system. The results of the analyses were transferred into a 3D numerical fluid-dynamic simulator to evaluate the propagation of the uncertainties associated to the input data down to the final results, and to assess the dynamic response of the reservoir following a selected development plan. The "integrated approach" presented in this paper can be useful for all technicians involved in the construction and validation of 3D numerical models of hydrocarbon-bearing reservoirs and can potentially become part of the educational training for young geoscientists and engineers, since an integrated and well-constructed workflow is the backbone of any reservoir study.

Study on Integration of Suburban Forest Park and Eco-city into “Mega-landscape”

On the basis of analyzing the development of suburban forest parks, the paper proposed the combination of eco-city construction and suburban forest parks, and the construction of "mega-landscape" mode, which offers a new concept for the development of suburban forest parks.

Design and Application of an Intelligent Agent for Web Information Discovery

With the propagation of applications on the internet, the internet has become a great information source which supplies users with valuable information. But it is hard for users to quickly acquire the right information on the web. This paper an intelligent agent for internet applications to retrieve and extract web information under user's guidance. The intelligent agent is made up of a retrieval script to identify web sources, an extraction script based on the document object model to express extraction process, a data translator to export the extracted information into knowledge bases with frame structures, and a data reasoning to reply users' questions. A GUI tool named Script Writer helps to generate the extraction script visually, and knowledge rule databases help to extract wanted information and to generate the answer to questions.

Can the management of depression in type 2 diabetes be democratized?

Both type 2 diabetes and depression are common and are projected to increase.There is increasing evidence for a bidirectional relationship between the two.Diabetes is a risk factor for depression;contrariwise,individuals with depression are at greater risk of developing diabetes.They are a burden for both the individual and the society.Co-existent depression worsens diabetic control because of obesity,insulin resistance and the adverse metabolic effects of anti-diabetes medicines.In addition,compliance to lifestyle measures required for diabetes is also compromised such as following a specific diet,taking proper medications on time,getting metabolic parameters assessed and maintaining a sleep cycle.Depression occurs in many grades;mild depression is more common in diabetes than frank or full-blown depression leading to suicide.Unfortunately,there are not enough trained and accessible mental health professionals such as psychologists or psychiatrists to deal with the increasing burden of depression in diabetes.Therefore,alternate models for management of mild to moderate depression are required.There is evidence that a team-approach by employing health care assistants can lower the risk of cardiac risk factors.INtegrating DEPrEssioN and Diabetes treatmENT study was carried out to determine whether the team-approach using non-health care professionals could be effective in managing mild to moderate depression and to study its effects on metabolic parameters among subjects with type 2 diabetes mellitus.The international study,carried out in four independent centers in India assessed the impact of a trained but not qualified non-psychiatrist in coordinating and forming a fulcrum between the patient,the family and the consultant endocrinologist/diabetologist.The interventions were fine-tuned to be culturally appropriate by qualitative interviews before they began.It was shown that the outcomes of both depression and diabetes could be improved by the employment of a clinical care coordinator.It is possible to scale up the studies to wider geographical areas and health-care organizations.

Study on Security Technologies for Wireles Network Integration

The network integration provides users with a new network with long connection time and a high data rate when needed, but it also brings the defects of all the networks that integrate together into the integrated network. This will cause all kinds of existing and some new security problems in the operation of the integrated network. A complete protection based on recovery is proposed in the paper. It uses the public-key algorithm to authorize and private-key algorithm to encrypt the communicating data. This solution can provide the system with reliable security, and avoid Denial of Service (DoS) of the user. This solution has been proposed lately, and we should further identify the correct action of all the layers and figure out how to react when a legal node is framed by multiple malicious nodes.

THE CLIMATIC STUDY OF CHANGBAI MOUNTAIN BY INTEGRATION OF REMOTE SENSING INFORMATION AND GEO-CODED IMAGES

Ⅰ. INTRODUCTION Changbai Mountain is situated between E127°54′-128°08′, N40°58′-42°06′ about 2700 meters above sea level. It is the typical area of the mountainous climate in the monsoon area of the temperate zone on the globe. The well reserved primeval vertical distribution of natural landscape belts and the Natural Conservation of Changbai Mountains adopted by the UNESCO′s MAB Program cause the worldwide attention of geographers. Beside the complexity of the climatic structure itself, the mechanical effection of the high mountain body also effect the climate in the eastern part of China. In the mountain area where short of meteorological observation data, the climatic study by remote sensing is favorable for discovery and representation of climatic law in large area.

Study on Integrated Automation of Three Gorges Cascades

This paper briefly describes the basic situation and features of Three Gorges Cascade, discusses the principle,functions, structure of the integrated automation system, and explains advanced techniques and principle and associated experiments of its monitoring and control

Exploration of the molecular mechanism of Indigo Naturalis in the treatment of myelodysplastic syndromes through integrated pharmacological study

Background:Oral administration of indigo naturalis(IN)is used as a complementary and alternative medicine(CAM)regimen for the treatment of myelodysplastic syndromes(MDS).However,its mechanism of action has not been fully elucidated and needs to be further explored.Methods:By searching the traditional Chinese medicine system and analyzing platforms(TCMSP),bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine(BATMAN-TCM),and Swiss Target Prediction network database,the main active components and potential targets of IN were obtained.Based on this,a component-target network was established by Cytoscape 3.6.1 software.Differentially expressed genes(DGEs)in MDS were obtained from three GEO(Gene Expression Omnibus)gene chips.Then,the protein-protein interaction(PPI)network of DGEs was constructed and analyzed by STRING database and Cytoscape 3.6.1 software.In addition,Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)biological enrichment analysis were carried out using REVIGO and KEGG Orthology Based Annotation System(KOBAS)on DGEs,respectively.Identification of IN-MDS compound targets was performed by matching potential targets of active components with disease-related targets.The results of KEGG pathway enrichment analysis were combined with compound targets to screen key targets.In the end,molecular docking was performed by SYBYL-X2.1 to verify the key targets.Results:Nine active components of IN and 439 potential targets of IN were identified by analyzing TCMSP,BATMAN-TCM,and Swiss Target Prediction network databases.Three MDS disease-related gene microarray chips were obtained from the GEO databases:GSE4619,GSE19429,and GSE58831.Through this analysis,87 DEGs were finally obtained using the Venn diagram.A PPI network of DEGs was then constructed,in which 18 genes were upregulated and 69 genes were downregulated.After the GO enrichment results were de-redundant,the representative GO terms were obtained by using REVIGO semantic similarity measuremen.The KEGG biological pathway analysis using the KOBAS indicated that the Hippo signaling pathway is important in MDS.The Hippo signaling pathway involves four genes:AREG,LEF1,SMAD7,and TCF4.By matching and mapping DEGs with potential targets,six IN-MDS compound targets were obtained:PDE4B,PLAUR,ELANE,NR3C1,AREG,and LEF1.We found that AREG and LEF1 are consistent with the genes involved in the Hippo signaling pathway.Through molecular docking simulation,we found that the indican binds best to AREG and LEF1.Conclusion:Based on the integrated pharmacology model,the material basis of the efficacy and biological molecular mechanism of IN in the treatment of MDS was systematically studied,which provided a novel indication of the CAM regimen for the improvement of MDS management.

Integrated studies of physical geography in China:Review and prospects

Modern physical geography in China grew from Chinese traditional geography and has been profoundly influenced by the geographical disciplines of Euro-America and Russia. Since the 1950 s, integrated studies of physical geography in China have made remarkable progress in the fields of comprehensive physical geographical regionalization, land studies, landscape ecology, and land surface geographical processes. During the past few decades, under the background of global change and rapid socio-economic transformation, a series of environmental and resources problems have boomed in China. To solve these problems and promote the development of integrated studies of physical geography, the following issues were proposed as research priorities：（1） coupling of land surface patterns and processes;（2） integrated research on regional responses and adaptation to global change;（3） analysis of human dimensions of the earth system;（4） ecosystem service research from a geographical perspective;（5） integration of multi-source data and model development;（6） integrated studies on unique geographical units; and（7） important global issues and relevant international programs.

INTRODUCING A NEW INTERNATIONAL PROGRAM:MONSOON ASIA INTEGRATED REGIONAL STUDY (MAIRS)

The Monsoon Asia Integrated Regional Study （MAIRS） is a new Earth System Science Partnership （ESSP） program aimed at the integrated study of environmental changes over monsoon Asian region. This paper briefly introduces MAIRS, its background and concept, scientific themes and objectives, data requirements and its information system, intensive observation experiment, and its linkage with ongoing international projects.

Theoretical study of tunable chirality from graphene integrated achiral metasurfaces

Control of chirality using metamaterials plays a critical role in a diverse set of advanced photonics applications,such as polarization control, bio-sensing, and polarization-sensitive imaging devices. However, this poses a major challenge, as it primarily involves the geometrical reconfiguration of metamolecules that cannot be adjusted dynamically. Real-world applications require active tuning of the chirality, which can easily manipulate the magnitude, handedness, and spectral range of chiroptical response. Here, enabled by graphene, we theoretically reveal a tunable/switchable achiral metasurface in the near-infrared region. In the model, the achiral metasurface consists of an array of circular holes embedded through a metal/dielectric/metal trilayer incorporated with the graphene sheet, where holes occupy the sites of a rectangular lattice. Circular conversion dichroism(CCD) originates from the mutual orientation between the achiral metasurface and oblique incident wave.The achiral metasurface possesses dual-band sharp features in the CCD spectra, which are tuned over a broad bandwidth by electrically modulating the graphene's Fermi level. By selecting aluminium as the metal materials,we numerically achieved strong CCD and considerably reduced materials costs with our nanostructures compared with the typically used noble metals such as gold and silver.

A Pragmatic Observational Feasibility Study on Integrated Treatment for Musculoskeletal Disorders：Design and Protocol

Background：Musculoskeletal disorders（MSD） comprise a wide range of conditions,associated with an enormous pain and impaired mobility,and are affecting people＇s lives and work.Management of musculoskeletal disorders typically involves a multidisciplinary team approach.Positive findings have been found in previous studies evaluating the effectiveness of complementary therapies,though little attention has been paid to evaluating of the effectiveness of integrated packages of care combining conventional and complementary approaches for musculoskeletal conditions in a National Health Service（NHS） setting.Objective：To determine the feasibility of all aspects of a pragmatic observational study designed：（1） to evaluate the effectiveness and cost effectiveness of integrated treatments for MSDs in an integrated NHS hospital in the UK;（2） to determine the acceptability of the study design and research process to patients;（3） to explore patients＇ expectation and experience of receiving integrated treatments.Methods：This is an observational feasibility study,with 1-year recruitment and 1-year follow-up,conducted in Royal London Hospital for Integrated Medicine,University College London Hospital Trust,UK.All eligible patients with MSDs newly referred to the hospital were included in the study.Interventions are integrated packages of care（conventional and complementary） as currently provided in the hospital.SF-36 Health Survey,short form Brief Pain Inventory,Visual Analogue Scale,and modified Client Service Receipt Inventory will be assessed at 4/5 time points.Semi-structured interview/focus group will be carried out before treatment,and 1 year after commence of treatment.Discussion：We intend to conduct a pragmatic observational study of integrated medical treatment of MSDs at a public sector hospital.It will inform the design of a future trial including recruitment,retention,suitability of the outcome measures and patients experiences.

LEI Yan(雷燕)——An Expert in Studying Cardiovascular Diseases with Integrated Medicine

Professor LEI Yan, Ph. D., female, was born in October 1960. After being graduated from Henan College of Traditional Chinese Medicine （ TOM ） in 1983, she worked as a resident physician in the TOM Hospital of Xinyang city, Henan province. She was enrolled in the master＇ s program of internal medicine of integrative traditional Chinese and Western medicine in Fujian College of TOM in 1988, and after finished her study in 1991, she was employed as a chief physician in Fujian Provincial Institute of Cardiovascular Diseases for two years. In 1993 she studied under the indoctrination of Prof. CHEN Ke-ji, majoring in cardiovascular diseases in the China Academy of Chinese Medical Sciences （CACMS） and got the doctoral degree in July 1996. In 1998, she finished the post-doctorate research on the prevention and treatment of senile dementia in Beijing University of Chinese Medicine. Since then, she took charge in managerial work as the assistant director of department of cardiovascular diseases of Xiyuan Hospital of CACMS and the director of department of scientific research supervisal in CACMS, meanwhile, as a Prof. of Medi- cine, the tutor of doctoral students on integrated traditional Chinese and Western medicine （TCM-WM） of CACMS.

People's Park,People's Square in Shanghai——Transit and Urban Integration Planning Study

Ⅰ.Introduction1) The People’s Park Square isShanghai’s best known land-mark and is the traditionalcenter of its cultural andrecreational facilities as wellas an extension of Shanghai’sprime commercial area.Thearea contains of Shanghai’sprime commercial area.Thearea contains a number ofbuildings of significant archi-tectural and heritage merit.