It is assumed from the energy level that ultraviolet (UV) photons may have intensifying effect on BaFBr∶Eu 2+. In this paper, effect of UV photons (220～290 nm) on the PSL intensity of X-ray irradiated BaFBr∶Eu 2+...It is assumed from the energy level that ultraviolet (UV) photons may have intensifying effect on BaFBr∶Eu 2+. In this paper, effect of UV photons (220～290 nm) on the PSL intensity of X-ray irradiated BaFBr∶Eu 2+ was measured and compared to that on the PSL intensity of 220 nm photons irradiated BaFBr∶Eu 2+. It was found that after the excitation of UV photons the PSL intensity of X-ray irradiated samples decreases least at 250 nm and that of 220 nm photons irradiated samples increases most at 250 nm. When the irradiation sources are X-rays and 220 nm photons the excited electrons are photoelectron and thermal-electrons, respectively, and they have different possibility of being captured by electron traps or combined with luminescent centers. And the peak at 250 nm can be explained with the model of electrons tunneling. It is assumed that the electrons excited by 250 nm have the most possibility of tunneling.展开更多
As a non-destructive testing technology,neutron imaging plays an important role in various fields,including material science,nuclear engineering,and fundamental science.An imaging detector with a neutron-sensitive ima...As a non-destructive testing technology,neutron imaging plays an important role in various fields,including material science,nuclear engineering,and fundamental science.An imaging detector with a neutron-sensitive image intensifier has been developed and demonstrated to achieve good spatial resolution and timing resolution.However,the influence of the working voltage on the performance of the neutron-sensitive imaging intensifier has not been studied.To optimize the performance of the neutron-sensitive image intensifier at different voltages,experiments have been performed at the China Spallation Neutron Source(CSNS)neutron beamline.The change in the light yield and imaging quality with different voltages has been acquired.It is shown that the image quality benefits from the high gain of the microchannel plate(MCP)and the high accelerating electric field between the MCP and the screen.Increasing the accelerating electric field is more effective than increasing the gain of MCPs for the improvement of the imaging quality.Increasing the total gain of the MCP stack can be realized more effectively by improving the gain of the standard MCP than that of the n MCP.These results offer a development direction for image intensifiers in the future.展开更多
The Chinese government attaches great importance to the legal protection of innovation and intellectual property rights.At the parallel forum named"Rule of Law and Innovation"with the theme of"Intellect...The Chinese government attaches great importance to the legal protection of innovation and intellectual property rights.At the parallel forum named"Rule of Law and Innovation"with the theme of"Intellectual Property and the Development of New Productive Forces"held during the Global Business and Law Conference2024,experts had a heated discussion.Zhang Shaogang,Vice Chairman of the CCPIT,said at the forum,"At present,the momentum of world economic growth is insufficient,and the competition in the frontier areas of the new round of scientific and technological revolution and industrial transformation has intensified.展开更多
This year marks the 50th anniversary of the establishment of diplomatic ties between China and Malaysia.Over the past half century,China and Malaysia have maintained close economic and trade ties and intensified peopl...This year marks the 50th anniversary of the establishment of diplomatic ties between China and Malaysia.Over the past half century,China and Malaysia have maintained close economic and trade ties and intensified people-to-people exchanges.China and Malaysia are important trade partners and enjoy complementary economic advantages.展开更多
CNPC achieved a high-quality“Good Start”in Q12024 On April 29,PetroChina Company Limited announced its Q12024 achievements,highlighting coordinated efforts in production and operations,safety and environmental prote...CNPC achieved a high-quality“Good Start”in Q12024 On April 29,PetroChina Company Limited announced its Q12024 achievements,highlighting coordinated efforts in production and operations,safety and environmental protection,quality improvement and efficiency enhancement,reform and innovation,and green transformation.The Company optimized operations and product mixes,intensified market outreach,and rigorously managed costs.Its oil and gas chains ran safely and efficiently,while new energy and materials sectors witnessed rapid growth.展开更多
As part of the important trends of the current development of the world economy,the reshaping of global industry and supply chains interacts with the intensified changes unprecedented in the past century in an increas...As part of the important trends of the current development of the world economy,the reshaping of global industry and supply chains interacts with the intensified changes unprecedented in the past century in an increasingly close manner.“Benefit-sharing and risk-sharing”,the characteristics of global industry and supply chains,have a profound influence on the distribution of benefits among countries and the effectiveness of global economic governance.展开更多
China Increases Payment Convenience for Foreigners China has recently intensified efforts to enhance the convenience of payment services for foreigners,who primarily rely on bank cards and cash,while mobile payment is...China Increases Payment Convenience for Foreigners China has recently intensified efforts to enhance the convenience of payment services for foreigners,who primarily rely on bank cards and cash,while mobile payment is emerging as the predominant method of payment in China.展开更多
Rare Appearance.An aurora is seen above the Jinshanlin section of the Great Wall in Chengde,north China’s Hebei Province,on 11 October.Recently,intensified solar activity has made auroras occasionally visible in part...Rare Appearance.An aurora is seen above the Jinshanlin section of the Great Wall in Chengde,north China’s Hebei Province,on 11 October.Recently,intensified solar activity has made auroras occasionally visible in parts of China.SOURCE:VCG.展开更多
NEW QUALITY PRODUCTIVE FORCES Outlook Weekly 11 March Faced with increasingly fierce international competition,China’s intensified push to foster new quality productive forces is of great significance in propelling t...NEW QUALITY PRODUCTIVE FORCES Outlook Weekly 11 March Faced with increasingly fierce international competition,China’s intensified push to foster new quality productive forces is of great significance in propelling the intelligent,green and highend development of industries,improving the resilience and security of industrial and supply chains,and consolidating the economic recovery momentum.展开更多
Joaquim Chissano,former President of Mozambique,has said that Africa has gained much from China’s economic development,particularly due to its reform and opening up policy.China inspires African nations in their ques...Joaquim Chissano,former President of Mozambique,has said that Africa has gained much from China’s economic development,particularly due to its reform and opening up policy.China inspires African nations in their quest for national renewal and creates new development prospects through mutually beneficial cooperation.Since the establishment of the Forum on China-Africa Cooperation in 2000 and the launch of the Belt and Road Initiative in 2013,exchanges between the two sides have intensified.Platforms such as the China-Africa Economic and Trade Expo and the China International Import Expo have further strengthened this momentum.展开更多
Surface morphology and inner structure of the dust were observed by ICP-AES, SEM-EDS and XRD to examine the strengthening measures of leaching potassium salt from the sintering dust by water. The results showed that t...Surface morphology and inner structure of the dust were observed by ICP-AES, SEM-EDS and XRD to examine the strengthening measures of leaching potassium salt from the sintering dust by water. The results showed that the main component of the sintering dust was iron-oxygen compound, with KCl adsorbed on its surface. Leaching experiments showed that the KCl in the ESP dust could be separated and recovered by water leaching and fractional crystallization. The yield of K-Na vaporized crystalline salt was 18.56%, in which the mass fractions of KCl, NaCl, CaSO4 and K2SO4 were about 61.21%, 13.40%, 14.62%and 10.86%, respectively. The leaching kinetics of potassium salt from the sintering dust fits the external diffusion model well. The leaching speed and the leaching rate of the potassium salt can be increased by increasing the leaching temperature, strengthening the stirring speed and increasing the liquid-solid ratio.展开更多
Liquid storage tanks are essential structures that are often located in residential and industrial areas; thus an assessment of their seismic performance is an important engineering issue. In this paper, the seismic r...Liquid storage tanks are essential structures that are often located in residential and industrial areas; thus an assessment of their seismic performance is an important engineering issue. In this paper, the seismic response ofunanchored steel liquid storage tanks is investigated using the endurance time （ET） dynamic analysis procedure and compared to responses obtained for anchored tanks under actual ground motions and intensifying ET records. In most cases, the results from ground motions are properly obtained with negligible differences using ET records. It is observed that uplifting of the tank base, which is closely related to the tank aspect ratio, has the greatest significance in the responses of the tank and can be predicted with reasonable accuracy by using currently available ET records.展开更多
Calculation of moderator analogues for 14 MeV neutrons as source were made at a IBM/PC AT computer using TAMAKER-ANISN program and 46 groups (25 neutron groups, 21 photon groups) UW cross section data. The intensifyin...Calculation of moderator analogues for 14 MeV neutrons as source were made at a IBM/PC AT computer using TAMAKER-ANISN program and 46 groups (25 neutron groups, 21 photon groups) UW cross section data. The intensifying effect of lead and natural uranium for moderating 14 MeV neutrons is confirmed. Adopting proper structure of the moderator, the intensifying factor M (times) may be larger than 3. Using lead and natural uranium in sub-critical assemblies (or call boosters),with 14 MeV neutrons as source, with the same dimension as that of above, the intensifying effect is also condrmed. With a proper structure of sub-critical assembly,the intensifying factor M may be close to or eved larger than (1 - k)-1 where k isthe effective multiplication factor.展开更多
Based on the holographic theory, a pair of reflective holographic lenses have been utilized with an aim to improve the optical properties of night vision goggles. The aberration distribution of the holographic lens ha...Based on the holographic theory, a pair of reflective holographic lenses have been utilized with an aim to improve the optical properties of night vision goggles. The aberration distribution of the holographic lens has been confirmed by experiments and compensated by a conventional symmetrical spherical system. Resulting data of the whole optical system are given.展开更多
AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patient...AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control.展开更多
Experiments were conducted to investigate the behavior of the sequential system of intensified zero-valent iron process(IZVI) and anaerobic filter and biological aerated filter(AF/BAF) reactors for advanced treatment ...Experiments were conducted to investigate the behavior of the sequential system of intensified zero-valent iron process(IZVI) and anaerobic filter and biological aerated filter(AF/BAF) reactors for advanced treatment of biologically pretreated coking wastewater. Particular attention was paid to the performance of the integrated system for the removal of chemical oxygen demand(COD), ammonia nitrogen(NH3-N) and total nitrogen(TN). The average removal efficiencies of COD, NH3-N and TN were 76.28%, 96.76% and 59.97%, with the average effluent mass concentrations of 56, 0.53 and 18.83 mg/L, respectively, reaching the first grade of the national discharge standard. Moreover, the results of gas chromatography/mass spectrum(GC/MS) and gel permeation chromatography(GPC) analysis demonstrated that the refractory organic compounds with high relative molecular mass were partly removed in IZVI process by the function of oxidation-reduction, flocculation and adsorption which could also enhance the biodegradability of the system effluent. The removal efficiencies of NH3-N and TN were achieved mainly in the subsequent AF/BAF reactors by nitrification and denitrification. Overall, the results obtained show that the application of IZVI in combination with AF/BAF is a promising technology for advanced treatment of biologically pretreated coking wastewater.展开更多
Dividing-wall columns(DWCs)are widely used in the separation of ternary mixtures,but rarely seen in the separation of petroleum fractions.This work develops two novel and energy-efficient designs of lubricant-type vac...Dividing-wall columns(DWCs)are widely used in the separation of ternary mixtures,but rarely seen in the separation of petroleum fractions.This work develops two novel and energy-efficient designs of lubricant-type vacuum distillation process(LVDP)for the separation of hydroisomerization fractions(HIF)of a hydrocracking tail oil(HTO).First,the HTO hydroisomerization reaction is investigated in an experimental fixed-bed reactor to achieve the optimum liquid HIF by analyzing the impact of the operating conditions.A LVDP used for HIF separation is proposed and optimized.Subsequently,two thermal coupling intensified technologies,including side-stream(SC)and dividing-wall column(DWC),are combined with the LVDP to develop side-stream vacuum distillation process(SC-LVDP)and dividing-wall column vacuum distillation process(DWC-LVDP).The performance of LVDP,SC-LVDP,and DWC-LVDP are evaluated in terms of energy consumption,capital cost,total annual cost,product yields,and stripping steam consumption.The results demonstrates that the intensified processes,SC-LVDP and DWC-LVDP significantly decreases the energy consumption and capital cost compared with LVDP.DWC-LVDP further decreases in capital cost due to the removal of the side stripper and narrows the overlap between the third lube oils and fourth lube oils.This study attempts to combine DWC structure into the separation of petroleum fractions,and the proposed approach and the results presented provide an incentive for the industrial implementation of high-quality utilization of HTO through intensified LVDP.展开更多
Dioecious species evolved from species with monomorphic sex systems in order to achieve overall fitness gains by separating male and female functions.As reproductive organs,unisexual flowers have different reproductiv...Dioecious species evolved from species with monomorphic sex systems in order to achieve overall fitness gains by separating male and female functions.As reproductive organs,unisexual flowers have different reproductive roles and exhibit conspicuous sexual dimorphism.To date,little is known about the temporal variations in and molecular mechanisms underlying the morphology and reproductive costs of dioecious flowers.We investigated male and female flowers of Salix paraplesia in three flowering stages before pollination(the early,blooming and late stages)via transcriptional sequencing as well as metabolite content and phenotypic analysis.We found that a large number of sex-biased genes,rather than sex-limited genes,were responsible for sexual dimorphism in S.paraplesia flowers and that the variation in gene expression in male flowers intensified this situation throughout flower development.The temporal dynamics of sex-biased genes derived from changes in reproductive function during the different flowering stages.Sexually differentiated metabolites related to respiration and flavonoid biosynthesis exhibited the same bias directions as the sex-biased genes.These sex-biased genes were involved mainly in signal transduction,photosynthesis,respiration,cell proliferation,phytochrome biosynthesis,and phenol metabolism;therefore,they resulted in more biomass accumulation and higher energy consumption in male catkins.Our results indicated that sex-biased gene expression in S.paraplesia flowers is associated with different reproductive investments in unisexual flowers;male flowers require a greater reproductive investment to meet their higher biomass accumulation and energy consumption needs.展开更多
文摘It is assumed from the energy level that ultraviolet (UV) photons may have intensifying effect on BaFBr∶Eu 2+. In this paper, effect of UV photons (220～290 nm) on the PSL intensity of X-ray irradiated BaFBr∶Eu 2+ was measured and compared to that on the PSL intensity of 220 nm photons irradiated BaFBr∶Eu 2+. It was found that after the excitation of UV photons the PSL intensity of X-ray irradiated samples decreases least at 250 nm and that of 220 nm photons irradiated samples increases most at 250 nm. When the irradiation sources are X-rays and 220 nm photons the excited electrons are photoelectron and thermal-electrons, respectively, and they have different possibility of being captured by electron traps or combined with luminescent centers. And the peak at 250 nm can be explained with the model of electrons tunneling. It is assumed that the electrons excited by 250 nm have the most possibility of tunneling.
基金Project supported by the National Key R&D Program of China (Grant Nos.2023YFC2206502 and 2021YFA1600703)the National Natural Science Foundation of China (Grant Nos.12175254 and 12227810)the Guangdong–Hong Kong–Macao Joint Laboratory for Neutron Scattering Science and Technology。
文摘As a non-destructive testing technology,neutron imaging plays an important role in various fields,including material science,nuclear engineering,and fundamental science.An imaging detector with a neutron-sensitive image intensifier has been developed and demonstrated to achieve good spatial resolution and timing resolution.However,the influence of the working voltage on the performance of the neutron-sensitive imaging intensifier has not been studied.To optimize the performance of the neutron-sensitive image intensifier at different voltages,experiments have been performed at the China Spallation Neutron Source(CSNS)neutron beamline.The change in the light yield and imaging quality with different voltages has been acquired.It is shown that the image quality benefits from the high gain of the microchannel plate(MCP)and the high accelerating electric field between the MCP and the screen.Increasing the accelerating electric field is more effective than increasing the gain of MCPs for the improvement of the imaging quality.Increasing the total gain of the MCP stack can be realized more effectively by improving the gain of the standard MCP than that of the n MCP.These results offer a development direction for image intensifiers in the future.
文摘The Chinese government attaches great importance to the legal protection of innovation and intellectual property rights.At the parallel forum named"Rule of Law and Innovation"with the theme of"Intellectual Property and the Development of New Productive Forces"held during the Global Business and Law Conference2024,experts had a heated discussion.Zhang Shaogang,Vice Chairman of the CCPIT,said at the forum,"At present,the momentum of world economic growth is insufficient,and the competition in the frontier areas of the new round of scientific and technological revolution and industrial transformation has intensified.
文摘This year marks the 50th anniversary of the establishment of diplomatic ties between China and Malaysia.Over the past half century,China and Malaysia have maintained close economic and trade ties and intensified people-to-people exchanges.China and Malaysia are important trade partners and enjoy complementary economic advantages.
文摘CNPC achieved a high-quality“Good Start”in Q12024 On April 29,PetroChina Company Limited announced its Q12024 achievements,highlighting coordinated efforts in production and operations,safety and environmental protection,quality improvement and efficiency enhancement,reform and innovation,and green transformation.The Company optimized operations and product mixes,intensified market outreach,and rigorously managed costs.Its oil and gas chains ran safely and efficiently,while new energy and materials sectors witnessed rapid growth.
文摘As part of the important trends of the current development of the world economy,the reshaping of global industry and supply chains interacts with the intensified changes unprecedented in the past century in an increasingly close manner.“Benefit-sharing and risk-sharing”,the characteristics of global industry and supply chains,have a profound influence on the distribution of benefits among countries and the effectiveness of global economic governance.
文摘China Increases Payment Convenience for Foreigners China has recently intensified efforts to enhance the convenience of payment services for foreigners,who primarily rely on bank cards and cash,while mobile payment is emerging as the predominant method of payment in China.
文摘Rare Appearance.An aurora is seen above the Jinshanlin section of the Great Wall in Chengde,north China’s Hebei Province,on 11 October.Recently,intensified solar activity has made auroras occasionally visible in parts of China.SOURCE:VCG.
文摘NEW QUALITY PRODUCTIVE FORCES Outlook Weekly 11 March Faced with increasingly fierce international competition,China’s intensified push to foster new quality productive forces is of great significance in propelling the intelligent,green and highend development of industries,improving the resilience and security of industrial and supply chains,and consolidating the economic recovery momentum.
文摘Joaquim Chissano,former President of Mozambique,has said that Africa has gained much from China’s economic development,particularly due to its reform and opening up policy.China inspires African nations in their quest for national renewal and creates new development prospects through mutually beneficial cooperation.Since the establishment of the Forum on China-Africa Cooperation in 2000 and the launch of the Belt and Road Initiative in 2013,exchanges between the two sides have intensified.Platforms such as the China-Africa Economic and Trade Expo and the China International Import Expo have further strengthened this momentum.
基金Projects (2012AA062502,2012AA06A118) supported by the High-tech Research and Development Program of China
文摘Surface morphology and inner structure of the dust were observed by ICP-AES, SEM-EDS and XRD to examine the strengthening measures of leaching potassium salt from the sintering dust by water. The results showed that the main component of the sintering dust was iron-oxygen compound, with KCl adsorbed on its surface. Leaching experiments showed that the KCl in the ESP dust could be separated and recovered by water leaching and fractional crystallization. The yield of K-Na vaporized crystalline salt was 18.56%, in which the mass fractions of KCl, NaCl, CaSO4 and K2SO4 were about 61.21%, 13.40%, 14.62%and 10.86%, respectively. The leaching kinetics of potassium salt from the sintering dust fits the external diffusion model well. The leaching speed and the leaching rate of the potassium salt can be increased by increasing the leaching temperature, strengthening the stirring speed and increasing the liquid-solid ratio.
文摘Liquid storage tanks are essential structures that are often located in residential and industrial areas; thus an assessment of their seismic performance is an important engineering issue. In this paper, the seismic response ofunanchored steel liquid storage tanks is investigated using the endurance time （ET） dynamic analysis procedure and compared to responses obtained for anchored tanks under actual ground motions and intensifying ET records. In most cases, the results from ground motions are properly obtained with negligible differences using ET records. It is observed that uplifting of the tank base, which is closely related to the tank aspect ratio, has the greatest significance in the responses of the tank and can be predicted with reasonable accuracy by using currently available ET records.
文摘Calculation of moderator analogues for 14 MeV neutrons as source were made at a IBM/PC AT computer using TAMAKER-ANISN program and 46 groups (25 neutron groups, 21 photon groups) UW cross section data. The intensifying effect of lead and natural uranium for moderating 14 MeV neutrons is confirmed. Adopting proper structure of the moderator, the intensifying factor M (times) may be larger than 3. Using lead and natural uranium in sub-critical assemblies (or call boosters),with 14 MeV neutrons as source, with the same dimension as that of above, the intensifying effect is also condrmed. With a proper structure of sub-critical assembly,the intensifying factor M may be close to or eved larger than (1 - k)-1 where k isthe effective multiplication factor.
文摘Based on the holographic theory, a pair of reflective holographic lenses have been utilized with an aim to improve the optical properties of night vision goggles. The aberration distribution of the holographic lens has been confirmed by experiments and compensated by a conventional symmetrical spherical system. Resulting data of the whole optical system are given.
文摘AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control.
基金Project(2006BAJ04A)suppprted by the National Sci-Tech Support Plan,China
文摘Experiments were conducted to investigate the behavior of the sequential system of intensified zero-valent iron process(IZVI) and anaerobic filter and biological aerated filter(AF/BAF) reactors for advanced treatment of biologically pretreated coking wastewater. Particular attention was paid to the performance of the integrated system for the removal of chemical oxygen demand(COD), ammonia nitrogen(NH3-N) and total nitrogen(TN). The average removal efficiencies of COD, NH3-N and TN were 76.28%, 96.76% and 59.97%, with the average effluent mass concentrations of 56, 0.53 and 18.83 mg/L, respectively, reaching the first grade of the national discharge standard. Moreover, the results of gas chromatography/mass spectrum(GC/MS) and gel permeation chromatography(GPC) analysis demonstrated that the refractory organic compounds with high relative molecular mass were partly removed in IZVI process by the function of oxidation-reduction, flocculation and adsorption which could also enhance the biodegradability of the system effluent. The removal efficiencies of NH3-N and TN were achieved mainly in the subsequent AF/BAF reactors by nitrification and denitrification. Overall, the results obtained show that the application of IZVI in combination with AF/BAF is a promising technology for advanced treatment of biologically pretreated coking wastewater.
基金funded by Shanghai Sailing Program (No.19YF1410800)National Natural Science Foundation of China(No. 21908056)。
文摘Dividing-wall columns(DWCs)are widely used in the separation of ternary mixtures,but rarely seen in the separation of petroleum fractions.This work develops two novel and energy-efficient designs of lubricant-type vacuum distillation process(LVDP)for the separation of hydroisomerization fractions(HIF)of a hydrocracking tail oil(HTO).First,the HTO hydroisomerization reaction is investigated in an experimental fixed-bed reactor to achieve the optimum liquid HIF by analyzing the impact of the operating conditions.A LVDP used for HIF separation is proposed and optimized.Subsequently,two thermal coupling intensified technologies,including side-stream(SC)and dividing-wall column(DWC),are combined with the LVDP to develop side-stream vacuum distillation process(SC-LVDP)and dividing-wall column vacuum distillation process(DWC-LVDP).The performance of LVDP,SC-LVDP,and DWC-LVDP are evaluated in terms of energy consumption,capital cost,total annual cost,product yields,and stripping steam consumption.The results demonstrates that the intensified processes,SC-LVDP and DWC-LVDP significantly decreases the energy consumption and capital cost compared with LVDP.DWC-LVDP further decreases in capital cost due to the removal of the side stripper and narrows the overlap between the third lube oils and fourth lube oils.This study attempts to combine DWC structure into the separation of petroleum fractions,and the proposed approach and the results presented provide an incentive for the industrial implementation of high-quality utilization of HTO through intensified LVDP.
基金the Second Tibetan Plateau Scientific Expedition and Research Program(2019QZKK0404)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA20020401)+1 种基金the National Natural Science Foundation of China(31770650)the Fundamental Research Funds for the Central Universities.
文摘Dioecious species evolved from species with monomorphic sex systems in order to achieve overall fitness gains by separating male and female functions.As reproductive organs,unisexual flowers have different reproductive roles and exhibit conspicuous sexual dimorphism.To date,little is known about the temporal variations in and molecular mechanisms underlying the morphology and reproductive costs of dioecious flowers.We investigated male and female flowers of Salix paraplesia in three flowering stages before pollination(the early,blooming and late stages)via transcriptional sequencing as well as metabolite content and phenotypic analysis.We found that a large number of sex-biased genes,rather than sex-limited genes,were responsible for sexual dimorphism in S.paraplesia flowers and that the variation in gene expression in male flowers intensified this situation throughout flower development.The temporal dynamics of sex-biased genes derived from changes in reproductive function during the different flowering stages.Sexually differentiated metabolites related to respiration and flavonoid biosynthesis exhibited the same bias directions as the sex-biased genes.These sex-biased genes were involved mainly in signal transduction,photosynthesis,respiration,cell proliferation,phytochrome biosynthesis,and phenol metabolism;therefore,they resulted in more biomass accumulation and higher energy consumption in male catkins.Our results indicated that sex-biased gene expression in S.paraplesia flowers is associated with different reproductive investments in unisexual flowers;male flowers require a greater reproductive investment to meet their higher biomass accumulation and energy consumption needs.
