In this paper,we prove that there exists a unique local solution for the Cauchy problem of a system of the incompressible Navier-Stokes-Landau-Lifshitz equations with the Dzyaloshinskii-Moriya interaction and V-flow t...In this paper,we prove that there exists a unique local solution for the Cauchy problem of a system of the incompressible Navier-Stokes-Landau-Lifshitz equations with the Dzyaloshinskii-Moriya interaction and V-flow term inR^(2) and R^(3).Our methods rely upon approximating the system with a perturbed parabolic system and parallel transport.展开更多
Based on the fundamental equations of piezoelasticity of quasicrystal material,we investigated the interaction between a screw dislocation and a wedge-shaped crack in the piezoelectricity of one-dimensional hexagonal ...Based on the fundamental equations of piezoelasticity of quasicrystal material,we investigated the interaction between a screw dislocation and a wedge-shaped crack in the piezoelectricity of one-dimensional hexagonal quasicrystals.Explicit analytical solutions are obtained for stress and electric displacement intensity factors of the crack,as well as the force on dislocation.The derivation is based on the conformal mapping method and the perturbation technique.The influences of the wedge angle and dislocation location on the image force are also discussed.The results obtained in this paper can be fully reduced to some special cases already available or deriving new ones.展开更多
We analyze the electromagnetic interaction between local surface plasmon polaritons (SPPs) and an atmospheric surface wave plasma jet (ASWPJ) in combination with our designed discharge device. Before discharge, th...We analyze the electromagnetic interaction between local surface plasmon polaritons (SPPs) and an atmospheric surface wave plasma jet (ASWPJ) in combination with our designed discharge device. Before discharge, the excitation of the SPPs and the spatial distribution of the enhanced electric field are analyzed. During discharge, the critical breakdown electric field of the gases at atmospheric gas pressure and the surface wave of the SPPs converted into electron plasma waves at resonant points are studied. After discharge, the ionization development process of the ASWPJ is simulated using a two- dimensional fluid model. Our results suggest that the local enhanced electric field of SPPs is merely the precondition of gas breakdown, and the key mechanism in maintaining the discharge development of a low-power ASWPJ is the wave-mode conversion of the local enhanced electric field at the resonant point.展开更多
A method for decomposition of cellulose to produce 5-hydroxymethyl-furaldehyde (5- HMF) in subcritical water-carbon dioxide binary system was proposed. A series of experiments were performed in a batch reaction vess...A method for decomposition of cellulose to produce 5-hydroxymethyl-furaldehyde (5- HMF) in subcritical water-carbon dioxide binary system was proposed. A series of experiments were performed in a batch reaction vessel. Main products of the decomposition of cellulose are 5-HMF, furfural, levulinic acid and 1, 2, 4-benzenetrioI.The optimum condition for the preparation of 5-HMF was found as 523.15 K, 5.0% carbon dioxide mole fraction, and 30 min reaction time. The addition of carbon dioxide to water conduced to the decomposition of cellulose to 5-HMF. As can be seen from the distribution of the prod-ucts, the decomposition mechanism of cellulose is similar to the hydrothermal reaction of D-glucose and D-fructose.展开更多
Wrinkling analysis of a rectangular membrane with a single crease under shearing is performed to understand the wrinkle-crease interaction behaviors. The crease is considered by introducing the residual stresses from ...Wrinkling analysis of a rectangular membrane with a single crease under shearing is performed to understand the wrinkle-crease interaction behaviors. The crease is considered by introducing the residual stresses from creasing and the effective modulus into the baseline configuration with assumed circular cross-sectional crease geometry. The wrinkling analysis of the creased membrane is then performed by using the direct perturb-force (DP) simulation technique which is based on our modified displacement components (MDC) method. Results reveal that the crease may influence the stress transfer path in the membrane and further change the wrinkling direction. The crease appears to improve the bending stiffness of the membrane which has an effective resistance on the wrinkling evolution. The effects of the crease orientation on wrinkle-crease interaction are studied toward the end of this paper. The results show that the wrinkling amplitude, wavelength, and direction increase as the crease orientation increases, and the wrinkling number decreases with the increasing crease orientation. These results will be of great benefit to the analysis and the control of the wrinkles in the membrane structures.展开更多
Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological beh...Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis;infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD);thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form展开更多
Effects of Si^3+ and H+ irradiation on tungsten were investigated by internal friction (IF) technique. Scanning electron microscope (SEM) analysis revealed that sequential dual Si+H irradiation resulted in more...Effects of Si^3+ and H+ irradiation on tungsten were investigated by internal friction (IF) technique. Scanning electron microscope (SEM) analysis revealed that sequential dual Si+H irradiation resulted in more serious damage than single Si irradiation. After irradiation, the IF background was significantly enhanced. Besides, two obvious IF peaks were initially found in tem- perature range of 70~330 K in the sequential Si+H irradiated tungsten sample. The mechanism of increased IF background for the irradiated samples was suggested to originate from the high density dislocations induced by ion irradiation. On the other hand, the relaxation peak PL and non-relaxation peak PH in the Si+H irradiated sample were ascribed to the interaction process of hydrogen atoms with mobile dislocations and transient processes of hydrogen redistribution, respectively. The obtained experimental results verified the high sensitivity of IF method on the irradiation damage behaviors in nuclear materials.展开更多
Surface functionalization of sensor chip for probe immobilization is crucial for the biosensing applications of surface plasmon resonance(SPR)sensors.In this paper,we report a method circulating the dopamine aqueous s...Surface functionalization of sensor chip for probe immobilization is crucial for the biosensing applications of surface plasmon resonance(SPR)sensors.In this paper,we report a method circulating the dopamine aqueous solution to coat polydopamine film on sensing surface for surface functionalization of SPR chip.The polydopamine film with available thickness can be easily prepared by controlling the circulation time and the biorecognition elements can be immobilized on the polydopamine film for specific molecular interaction analysis.These opera-tions are all performed under flow condition in the fuidic system,and have the advantages of easy implementation,less time consuming,and low cost,because the reagents and devices used in the operations are routinely applied in most laboratories.In this study,the specific absorption between the protein A probe immobilized on the sensing surface and human immunoglobulin G in the buffer is monitored based on this surface functionalization strategy to demonstrated its feasibility for SPR biosensing applications.展开更多
According to the question of how to transfer data between Pro/E and ADAMS correctly, the paper gives an improved importing solution, which combines the interface and the Standard Data Format(SDF) files. It settles t...According to the question of how to transfer data between Pro/E and ADAMS correctly, the paper gives an improved importing solution, which combines the interface and the Standard Data Format(SDF) files. It settles the problems caused by improper geometry during the import conducted by the interface software. With the solution ,fea- ture points can be conveniently picked to build kinematic constraints are the preparation of the model will be simpli- fied. An example is given for the method, and corresponding simulations are conducted. The results of the simula- tions verify the validity of the solution.展开更多
In this paper, the instability boundaries of an axially moving viscoelastic beam due to parametric resonance are revisited for the internal resonance case. The relation between the time-dependent tension and the time-...In this paper, the instability boundaries of an axially moving viscoelastic beam due to parametric resonance are revisited for the internal resonance case. The relation between the time-dependent tension and the time-dependent axial speed is constructed, which provides a new model in the study of axially moving material with pulsation parameters. The instability boundaries caused by the combination of parametric and internal resonances are studied using the method of multiple time scales. Some strange instability boundaries are detected when the internal resonance is considered. The phenomenon of local zigzag boundary contour is explained from the viewpoint of modal interactions.展开更多
Advanced micro/nanofabrication of functional materials and structures with various dimensions represents a key research topic in modem nanoscience and technology and becomes critically important for numerous emerging ...Advanced micro/nanofabrication of functional materials and structures with various dimensions represents a key research topic in modem nanoscience and technology and becomes critically important for numerous emerging technologies such as nanoelectronics, nanopho- tonics and micro/nanoelectromechanical systems. This review systematically explores the non-conventional material processing approaches in fabricating nanomaterials and micro/nanostructures of various dimensions which are challenging to be fabricated via conventional approaches. Research efforts are focused on laser-based techniques for the growth and fabrication of one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) nanomaterials and micro/nanostructures. The following research topics are covered, including: 1) laser-assisted chemical vapor deposition (CVD) for highly efficient growth and integration of 1D nanomaterial of carbon nanotubes (CNTs), 2) laser direct writing (LDW) of graphene ribbons under ambient conditions, and 3) LDW of 3D micro/nanostructures via additive and subtractive processes. Comparing with the conventional fabrication methods, the laser-based methods exhibit several unique advantages in the micro/nanofabrication of advanced functional materials and structures. For the 1D CNT growth, the laser-assisted CVD process can realize both rapid material synthesis and tight control of growth location and orientation of CNTs due to the highly intense energy delivery and laser-induced optical near-field effects. For the 2D graphene synthesis and patterning, roomtemperature and open-air fabrication of large-scale graphene patterns on dielectric surface has been successfully realized by a LDW process. For the 3D micro/nanofabrica- tion, the combination of additive two-photon polymeriza- tion (TPP) and subtractive multi-photon ablation (MPA) processes enables the fabrication of arbitrary complex 3D micro/nanostructures which tional fabrication methods are challenging for conven- Considering the numerous unique advantages of laser-based techniques, the laser- based micro/nanofabrication is expected to play a more and more important role in the fabrication of advanced functional micro/nano-devices.展开更多
Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, whi...Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (Ln) and their analogues 1, 2-diacyI-sn-glycerol-3-phosphoric add bro-moethyl ester (Pn), have been investigated in MeOH-H2O binary systems of different volume fractions (designated as Φ) of the organic component, by employing a-nephthylethyl lauryl ether (Np-12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i.e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deag-gregation are also discussed.展开更多
The F-BAR domain containing proteins PACSINs are cytoplasmic phosphoproteins involved in various mem-brane deformations,such as actin reorganization,vesicle transport and microtubule movement.Our previous study shows ...The F-BAR domain containing proteins PACSINs are cytoplasmic phosphoproteins involved in various mem-brane deformations,such as actin reorganization,vesicle transport and microtubule movement.Our previous study shows that all PACSINs are composed of crescent shaped dimers with two wedge loops,and the wedge loop-mediated lateral interaction between neighboring dimers is important for protein packing and tubulation activity.Here,from the crystal packing of PACSIN 2,we observed a tight tip-to-tip interaction,in addition to the wedge loop-mediated lateral interaction.With this tip-to-tip interaction,the whole packing of PACSIN 2 shows a spiral-like assem-bly with a central hole from the top view.Elimination of this tip-to-tip connection inhibited the tubulation function of PACSIN 2,indicating that tip-to-tip interaction plays an important role in membrane deformation activity.Together with our previous study,we proposed a packing model for the assembly of PACSIN 2 on membrane,where the pro-teins are connected by tip-to-tip and wedge loop-mediated lateral interactions on the surface of membrane to gener-ate various diameter tubules.展开更多
An increasing number of social computational systems consist of a great amount of autonomous entities and operate in highly dynamic and unpredictable environments. To construct such systems needs to seek high-level ab...An increasing number of social computational systems consist of a great amount of autonomous entities and operate in highly dynamic and unpredictable environments. To construct such systems needs to seek high-level abstrac- tion to manage the complexity of the systems and novel mechanism to support their characteristics, i.e., dynamism and flexibility. Agent-oriented programming (AOP) is con- sidered as a potential paradigm for developing such systems by exhibiting a number of characteristics, such as autonomy, flexibility, social ability, etc. However, current researches on AOP mainly focus on the construction of multi-agent system (MAS) with theory and language facilities inspired from arti- ficial intelligence (AI) and distributed AI, seldom considering and integrating the proven principles and practices of pro- gramming and software engineering. Moreover, abstractions and mechanism based on AI are inadequate for developing dynamic and flexible MAS in open environment. This paper proposes a novel AOP approach, namely Oragent, for con- structing and implementing dynamic and flexible systems. From a software engineering perspective, Oragent integrates organizational concepts and mechanism into AOP language, and support the dynamism and flexibility with explicit prim- itives. The proposed approach consists of a programming model and a corresponding programming language. This paper presents the syntax and formal operational semanticsof Oragent language, and studies a case to demonstrate our approach.展开更多
文摘In this paper,we prove that there exists a unique local solution for the Cauchy problem of a system of the incompressible Navier-Stokes-Landau-Lifshitz equations with the Dzyaloshinskii-Moriya interaction and V-flow term inR^(2) and R^(3).Our methods rely upon approximating the system with a perturbed parabolic system and parallel transport.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11262017,11262012,and 11462020)the Natural Science Foundation of Inner Mongolia Autonomous Region,China(Grant No.2015MS0129)+1 种基金the Programme of Higher-level Talents of Inner Mongolia Normal University(Grant No.RCPY-2-2012-K-035)the Key Project of Inner Mongolia Normal University(Grant No.2014ZD03)
文摘Based on the fundamental equations of piezoelasticity of quasicrystal material,we investigated the interaction between a screw dislocation and a wedge-shaped crack in the piezoelectricity of one-dimensional hexagonal quasicrystals.Explicit analytical solutions are obtained for stress and electric displacement intensity factors of the crack,as well as the force on dislocation.The derivation is based on the conformal mapping method and the perturbation technique.The influences of the wedge angle and dislocation location on the image force are also discussed.The results obtained in this paper can be fully reduced to some special cases already available or deriving new ones.
基金Project supported by the National Natural Science Foundation of China(Grant No.11105002)the Open-end Fund of State Key Laboratory of Structural Analysis for Industrial Equipment,China(Grant No.GZ1215)+1 种基金the Natural Science Foundation for University in Anhui Province of China(Grant No.KJ2013A106)the Doctoral Scientific Research Funds of Anhui University of Science and Technology,China
文摘We analyze the electromagnetic interaction between local surface plasmon polaritons (SPPs) and an atmospheric surface wave plasma jet (ASWPJ) in combination with our designed discharge device. Before discharge, the excitation of the SPPs and the spatial distribution of the enhanced electric field are analyzed. During discharge, the critical breakdown electric field of the gases at atmospheric gas pressure and the surface wave of the SPPs converted into electron plasma waves at resonant points are studied. After discharge, the ionization development process of the ASWPJ is simulated using a two- dimensional fluid model. Our results suggest that the local enhanced electric field of SPPs is merely the precondition of gas breakdown, and the key mechanism in maintaining the discharge development of a low-power ASWPJ is the wave-mode conversion of the local enhanced electric field at the resonant point.
文摘A method for decomposition of cellulose to produce 5-hydroxymethyl-furaldehyde (5- HMF) in subcritical water-carbon dioxide binary system was proposed. A series of experiments were performed in a batch reaction vessel. Main products of the decomposition of cellulose are 5-HMF, furfural, levulinic acid and 1, 2, 4-benzenetrioI.The optimum condition for the preparation of 5-HMF was found as 523.15 K, 5.0% carbon dioxide mole fraction, and 30 min reaction time. The addition of carbon dioxide to water conduced to the decomposition of cellulose to 5-HMF. As can be seen from the distribution of the prod-ucts, the decomposition mechanism of cellulose is similar to the hydrothermal reaction of D-glucose and D-fructose.
基金supported by the National Natural Science Foundation of China (10902027)the Specialized Research Fund for the Doctoral Program of Higher Education of China (200802131046)+1 种基金Aeronautical Science Foundation of China (2010ZA77001)the Fundamental Research Funds for the Central Universities(HIT.NSRIF.201156)
文摘Wrinkling analysis of a rectangular membrane with a single crease under shearing is performed to understand the wrinkle-crease interaction behaviors. The crease is considered by introducing the residual stresses from creasing and the effective modulus into the baseline configuration with assumed circular cross-sectional crease geometry. The wrinkling analysis of the creased membrane is then performed by using the direct perturb-force (DP) simulation technique which is based on our modified displacement components (MDC) method. Results reveal that the crease may influence the stress transfer path in the membrane and further change the wrinkling direction. The crease appears to improve the bending stiffness of the membrane which has an effective resistance on the wrinkling evolution. The effects of the crease orientation on wrinkle-crease interaction are studied toward the end of this paper. The results show that the wrinkling amplitude, wavelength, and direction increase as the crease orientation increases, and the wrinkling number decreases with the increasing crease orientation. These results will be of great benefit to the analysis and the control of the wrinkles in the membrane structures.
文摘Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis;infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD);thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form
基金supported by National Natural Science Foundation of China (Nos. 11075177, 11175203, 91126002) and Strategic Priority Research Program of Chinese Academy of Sciences (Nos. KJCX2-YW-N35, XDA03010303) and the National Magnetic Confinement Pusion Program of China (No. 2011GB108004) and MOST of China (Nos. 2010CB832902, 2010CB832904)
文摘Effects of Si^3+ and H+ irradiation on tungsten were investigated by internal friction (IF) technique. Scanning electron microscope (SEM) analysis revealed that sequential dual Si+H irradiation resulted in more serious damage than single Si irradiation. After irradiation, the IF background was significantly enhanced. Besides, two obvious IF peaks were initially found in tem- perature range of 70~330 K in the sequential Si+H irradiated tungsten sample. The mechanism of increased IF background for the irradiated samples was suggested to originate from the high density dislocations induced by ion irradiation. On the other hand, the relaxation peak PL and non-relaxation peak PH in the Si+H irradiated sample were ascribed to the interaction process of hydrogen atoms with mobile dislocations and transient processes of hydrogen redistribution, respectively. The obtained experimental results verified the high sensitivity of IF method on the irradiation damage behaviors in nuclear materials.
基金This research was made possible with the financial support from NSFC China(61275188,61378089,81470029,61361160416)the 863 project,China,the Technology Development Program of Shenzhen City,the Committee of Science and Technology Innovation of Shenzhen(JCYJ20140902110354241)Science and Technology Project of Guangdong Province(2015A010106002).
文摘Surface functionalization of sensor chip for probe immobilization is crucial for the biosensing applications of surface plasmon resonance(SPR)sensors.In this paper,we report a method circulating the dopamine aqueous solution to coat polydopamine film on sensing surface for surface functionalization of SPR chip.The polydopamine film with available thickness can be easily prepared by controlling the circulation time and the biorecognition elements can be immobilized on the polydopamine film for specific molecular interaction analysis.These opera-tions are all performed under flow condition in the fuidic system,and have the advantages of easy implementation,less time consuming,and low cost,because the reagents and devices used in the operations are routinely applied in most laboratories.In this study,the specific absorption between the protein A probe immobilized on the sensing surface and human immunoglobulin G in the buffer is monitored based on this surface functionalization strategy to demonstrated its feasibility for SPR biosensing applications.
文摘According to the question of how to transfer data between Pro/E and ADAMS correctly, the paper gives an improved importing solution, which combines the interface and the Standard Data Format(SDF) files. It settles the problems caused by improper geometry during the import conducted by the interface software. With the solution ,fea- ture points can be conveniently picked to build kinematic constraints are the preparation of the model will be simpli- fied. An example is given for the method, and corresponding simulations are conducted. The results of the simula- tions verify the validity of the solution.
基金This work was supported by the National Natural Science Foundation of China (Project No. 11672186, 11672007, 11502147, 11602146), the Chen Guang Project supported by Shanghai Municipal Education Commission and Shanghai Education Development Foundation (No. 14CG57), the training scheme for the Youth Teachers of Higher Education of Shanghai (No. ZZyyy12035), and the Alliance Program (No.LM201663).
文摘In this paper, the instability boundaries of an axially moving viscoelastic beam due to parametric resonance are revisited for the internal resonance case. The relation between the time-dependent tension and the time-dependent axial speed is constructed, which provides a new model in the study of axially moving material with pulsation parameters. The instability boundaries caused by the combination of parametric and internal resonances are studied using the method of multiple time scales. Some strange instability boundaries are detected when the internal resonance is considered. The phenomenon of local zigzag boundary contour is explained from the viewpoint of modal interactions.
文摘Advanced micro/nanofabrication of functional materials and structures with various dimensions represents a key research topic in modem nanoscience and technology and becomes critically important for numerous emerging technologies such as nanoelectronics, nanopho- tonics and micro/nanoelectromechanical systems. This review systematically explores the non-conventional material processing approaches in fabricating nanomaterials and micro/nanostructures of various dimensions which are challenging to be fabricated via conventional approaches. Research efforts are focused on laser-based techniques for the growth and fabrication of one-dimensional (1D), two-dimensional (2D) and three-dimensional (3D) nanomaterials and micro/nanostructures. The following research topics are covered, including: 1) laser-assisted chemical vapor deposition (CVD) for highly efficient growth and integration of 1D nanomaterial of carbon nanotubes (CNTs), 2) laser direct writing (LDW) of graphene ribbons under ambient conditions, and 3) LDW of 3D micro/nanostructures via additive and subtractive processes. Comparing with the conventional fabrication methods, the laser-based methods exhibit several unique advantages in the micro/nanofabrication of advanced functional materials and structures. For the 1D CNT growth, the laser-assisted CVD process can realize both rapid material synthesis and tight control of growth location and orientation of CNTs due to the highly intense energy delivery and laser-induced optical near-field effects. For the 2D graphene synthesis and patterning, roomtemperature and open-air fabrication of large-scale graphene patterns on dielectric surface has been successfully realized by a LDW process. For the 3D micro/nanofabrica- tion, the combination of additive two-photon polymeriza- tion (TPP) and subtractive multi-photon ablation (MPA) processes enables the fabrication of arbitrary complex 3D micro/nanostructures which tional fabrication methods are challenging for conven- Considering the numerous unique advantages of laser-based techniques, the laser- based micro/nanofabrication is expected to play a more and more important role in the fabrication of advanced functional micro/nano-devices.
基金National Natural Science Foundation of China(No.29392201).
文摘Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (Ln) and their analogues 1, 2-diacyI-sn-glycerol-3-phosphoric add bro-moethyl ester (Pn), have been investigated in MeOH-H2O binary systems of different volume fractions (designated as Φ) of the organic component, by employing a-nephthylethyl lauryl ether (Np-12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i.e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deag-gregation are also discussed.
基金the National High Technology and Develop-ment Program of China(973 Programs)(No.2010CB911800)the National Natural Science Foundation of China(Grant No.30930020).
文摘The F-BAR domain containing proteins PACSINs are cytoplasmic phosphoproteins involved in various mem-brane deformations,such as actin reorganization,vesicle transport and microtubule movement.Our previous study shows that all PACSINs are composed of crescent shaped dimers with two wedge loops,and the wedge loop-mediated lateral interaction between neighboring dimers is important for protein packing and tubulation activity.Here,from the crystal packing of PACSIN 2,we observed a tight tip-to-tip interaction,in addition to the wedge loop-mediated lateral interaction.With this tip-to-tip interaction,the whole packing of PACSIN 2 shows a spiral-like assem-bly with a central hole from the top view.Elimination of this tip-to-tip connection inhibited the tubulation function of PACSIN 2,indicating that tip-to-tip interaction plays an important role in membrane deformation activity.Together with our previous study,we proposed a packing model for the assembly of PACSIN 2 on membrane,where the pro-teins are connected by tip-to-tip and wedge loop-mediated lateral interactions on the surface of membrane to gener-ate various diameter tubules.
文摘An increasing number of social computational systems consist of a great amount of autonomous entities and operate in highly dynamic and unpredictable environments. To construct such systems needs to seek high-level abstrac- tion to manage the complexity of the systems and novel mechanism to support their characteristics, i.e., dynamism and flexibility. Agent-oriented programming (AOP) is con- sidered as a potential paradigm for developing such systems by exhibiting a number of characteristics, such as autonomy, flexibility, social ability, etc. However, current researches on AOP mainly focus on the construction of multi-agent system (MAS) with theory and language facilities inspired from arti- ficial intelligence (AI) and distributed AI, seldom considering and integrating the proven principles and practices of pro- gramming and software engineering. Moreover, abstractions and mechanism based on AI are inadequate for developing dynamic and flexible MAS in open environment. This paper proposes a novel AOP approach, namely Oragent, for con- structing and implementing dynamic and flexible systems. From a software engineering perspective, Oragent integrates organizational concepts and mechanism into AOP language, and support the dynamism and flexibility with explicit prim- itives. The proposed approach consists of a programming model and a corresponding programming language. This paper presents the syntax and formal operational semanticsof Oragent language, and studies a case to demonstrate our approach.