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Ryanodine receptor-protein regulator interaction revealed a general molecular mechanism of channel inhibition
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作者 Chang-Cheng Yin Department of Biophysics, Health Science Center, Peking University, 38 Xueyuan Road, Beijing 100191, 《生物物理学报》 CAS CSCD 北大核心 2009年第S1期79-79,共1页
Ryanodine receptors (RyR) are the major Ca2+ release channels in both cardiac and skeletal muscle, they play a crucial role in the Ca2+ signaling pathway that govern the
关键词 RyR Ryanodine receptor-protein regulator interaction revealed a general molecular mechanism of channel inhibition
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Distributed Differences Structures Underlie Gating between the Kin Channel KAT1 and the Kout Channel SKOR 被引量:2
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作者 Janin Riedelsberger Tripti Sharma +7 位作者 Wendy Gonzalez Pawel Gajdanowicz Samuel Elias Morales-Navarro Carlos Garcia-Mata Bernd Mueller-Roeber Fernando Danilo Gonzalez-Nilo Michael R. Blatt Ingo Dreyer 《Molecular Plant》 SCIE CAS CSCD 2010年第1期236-245,共10页
The family of voltage-gated (Shaker-like) potassium channels in plants includes both inward-rectifying (Kin) channels that allow plant cells to accumulate K+ and outward-rectifying (Kout) channels that mediate ... The family of voltage-gated (Shaker-like) potassium channels in plants includes both inward-rectifying (Kin) channels that allow plant cells to accumulate K+ and outward-rectifying (Kout) channels that mediate K+ efflux. Despite their dose structural similarities, Kin and Kout channels differ in their gating sensitivity towards voltage and the extracellular K+ concentration. We have carried out a systematic program of domain swapping between the Kout channel SKOR and the Kin channel KAT1 to examine the impacts on gating of the pore regions, the S4, S5, and the S6 helices. We found that, in particular, the N-terminal part of the S5 played a critical role in KAT1 and SKOR gating. Our findings were supported by molecular dynamics of KAT1 and SKOR homology models. In silico analysis revealed that during channel opening and closing, displacement of certain residues, especially in the S5 and S6 segments, is more pronounced in KAT1 than in SKOR. From our analysis of the S4-S6 region, we conclude that gating (and K+-sensing in SKOR) depend on a number of structural elements that are dispersed over this -145-residue sequence and that these place additional constraints on configurational rearrangement of the channels during gating. 展开更多
关键词 ARABIDOPSIS K+ channel outward rectifier inward rectifier channel protein structure channel protein-cation interaction gating K+-dependent.
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