Dust Distribution Study at the Blast Furnace Top Based on k-Sε-u_(p)Model

The dust distribution law acting at the top of a blast fumace(BF)is of great significance for understanding gas flow distribution and mitigating the negative influence of dust particles on the accuracy and service life of detection equipment.The harsh environment inside a BF makes it difficult to describe the dust disthibution.This paper adresses this problem by proposing a dust distribution k-Sε-u_(p)model based on interphase(gas-powder)coupling.The proposed model is coupled with a k-Sεmodel(which describes gas flow movement)and a u_(p)model(which depicts dust movement).First,the kinetic energy equation and turbulent dissipation rate equation in the k-Sεmodel are established based on the modeling theory and single Green-function two scale direct interaction approximation(SGF-TSDIA)theory.Second,a dust particle mnovement u_(p)model is built based on a force analysis of the dust and Newton's laws of motion.Finally,a coupling factor that descibes the interphase interaction is proposed,and the k-Sε-u_(p)model,with clear physical meaning.ligorous mathematical logic,and adequate generality,is dleveloped.Siumulation results and o-site verification show that the k-Sε-u_(p)model not only has high precision,but also reveals the aggregate distribution features of the dust,which are helpful in optimizing the installation position of the detection equipment and imnproving its accuracy and service life.

Non-spherical polymersomes driven by directional aromatic interactions

Polymersomes,nanoscopic polymer vesicles self-assembled from synthetic block copolymers,are ideal candidates for drug delivery and synthetic biology,due to their characteristic of high stability,chemical

Systematic Review on Social Engineering: Hacking by Manipulating Humans

Despite the availability of advanced security software and hardware mechanisms available, still, there has been a breach in the defence system of an organization or individual. Social engineering mostly targets the weakest link in the security system i.e. “Humans” for gaining access to sensitive information by manipulating human psychology. Social engineering attacks are arduous to defend as such attacks are not easily detected by available security software or hardware. This article surveys recent studies on social engineering attacks with discussion on the social engineering phases and categorizing the various attacks into two groups. The main aim of this survey is to examine the various social engineering attacks on individuals and countermeasures against social engineering attacks are also discussed.

Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents

The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction(PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. However, most known Nrf2 activators/ARE inducers are indirect inhibitors of Keap1–Nrf2PPI and they are electrophilic species that act by modifying the sulfhydryl groups of Keap1's cysteine residues. The electrophilicity of these indirect inhibitors may cause "off-target" side effects by reacting with cysteine residues of other important cellular proteins. Efforts have recently been focused on the development of direct inhibitors of Keap1–Nrf2 PPI. This article reviews these recent research efforts including the development of high throughput screening assays, the discovery of peptide and small molecule direct inhibitors, and the biophysical characterization of the binding of these inhibitors to the target Keap1 Kelch domain protein. These non-covalent direct inhibitors of Keap1–Nrf2 PPI could potentially be developed into effective therapeutic or preventive agents for a variety of diseases and conditions.

Lithographically directed assembly of one-dimensional DNA nanostructures via bivalent binding interactions

In order to exploit the outstanding physical properties of one-dimensional （1D） nanostructures such as carbon nanotubes and semiconducting nanowires and nanorods in future technological applications, it will be necessary to organize them on surfaces with precise control over both position and orientation. Here, we use a 1D rigid DNA motif as a model for studying directed assembly at the molecular scale to lithographically patterned nanodot anchors. By matching the inter-nanodot spacing to the length of the DNA nanostructure, we are able to achieve nearly 100% placement yield. By varying the length of single-stranded DNA linkers bound covalently to the nanodots, we are able to study the binding selectivity as a function of the strength of the binding interactions. We analyze the binding in terms of a thermodynamic model which provides insight into the bivalent nature of the binding, a scheme that has general applicability for the controlled assembly of a broad range of functional nanostructures.

Ultrasonic generation via direct interaction between photons and phonons in anharmonic lattice of ionic crystals

A theory of ultrasonic generation via direct interaction of transverse optic (TO) phonons with photons in anharmonic lattice of ionic crystals is presented. There are two methods of supplying light energy for the excitation of TO lattice wave as a high frequency ultrasound: (A) incident light comes from the source outside the cavity? fulfilled with ionic crystal medium, (B) photon mode of the cavity possesses the gain of amplification by stimulated radiation of active atoms doping in the medium. More attention is drawn to the case (B). The working system of case (B), as a mixture of lasing action and ultrasonic generation, has the threshold phenomena like usual laser. And the linear stability analysis shows that the nonlineax phonon-photon coupling and the interaction among phonons themselves, both of which reflect the anharmonicity of lattice vibration, are necessary to the stable ultrasonic output. So this laser-ultrasonic generation mixture would be also a measure to investigate the lattice-dynamic nonlinearity and correlated electromagnetic properties of ionic crystals.

Fully distributed time-varying formation tracking control for multiple quadrotor vehicles via finite-time convergent extended state observer

This paper investigates a time-varying anti-disturbance formation problem for a group of quadrotor aircrafts with time-varying uncertainties and a directed interaction topology.A novel Finite-Time Convergent Extended State Observer(FTCESO)based fully-distributed formation control scheme is proposed to enhance the disturbance rejection and the formation tracking performances for networked quadrotors.By adopting the hierarchical control strategy,the multiquadrotor system is separated into two subsystems:the outer-loop cooperative subsystem and the inner-loop attitude subsystem.In the outer-loop subsystem,with the estimation of disturbing forces and uncertain dynamics from FTCESOs,an adaptive consensus theory based cooperative controller is exploited to ensure the multiple quadrotors form and maintain a time-varying pattern relying only on the positions of the neighboring aircrafts.In the inner-loop subsystem,the desired attitude generated by the cooperative control law is stably tracked under a FTCESO-based attitude controller in a finite time.Based on a detailed algorithm to specify the cooperative control protocol,the feasibility condition to achieve the time-varying anti-disturbance formation tracking is derived and the rigorous analysis of the whole closed-loop multi-quadrotor system is given.Some numerical examples are conducted to intuitively demonstrate the effectiveness and the improvements of the proposed control framework.

Web Resources for Stem Cell Research

In this short review, we have presented a brief overview on major web resources relevant to stem cell research. To facilitate more efficient use of these resources, we have provided a preliminary rating based on our own user experience of the overall quality for each resource. We plan to update the information on an annual basis.