P-glycoprotein mediated interactions between Chinese materia medica and pharmaceutical drugs

P-glycoprotein(P-gp)is an important transmembrane ATP-binding cassette(ABC)drug efflux transporter expressed in various human tissues such as the intestines,liver,kidneys,and bloodbrain barrier.It limits the intracellular concentration of xenobiotics by pumping them out of the cells,affecting drug pharmacokinetics and therapeutic effects.With its broad substrate specificity,it has the potential to remove a wide range of drugs from Chinese materia medica(CMM),including conventional medicines and active compounds.Increasing evidence has confirmed the superior therapeutic effectiveness of CMM in treating a wide range of diseases worldwide,as well as in conjunction with western drugs.As a result,herbal medicine-drug compounds have prompted widespread concern,with the majority of these interactions involving transporters such as P-gp.This review systematically summarizes the inhibition or induction of P-gp expression/function by active CMM compounds and the underlying regulatory mechanisms.It will aid in improving understanding of the synergistic or inhibiting effects associated with transporter P-gp as well as rational safety concerns for using CMM,particularly in combination with drugs.

A Contrastive Study of Honorific and Depreciatory Address Forms in Chinese,English and Japanese

Honorific and depreciatory address forms, as an indispensable part of speech communication, occur in all languages. But due to the cultural diversity, different languages require different laws and regularities in the choice of them. This paper is firstly to make a contrastive analysis of honorific and depreciatory address forms in Chinese, English and Japanese, then explore the different basic values in Chinese, American and Japanese culture and discuss their influences on honorific and depreciatory address forms in the hope of a better understanding of their pragmatic and cultural differences and an avoidance of miscommunication in intercultural interactions.

Association between PPARG genetic polymorphisms and ischemic stroke risk in a northern Chinese Han population: a case-control study

Two common polymorphisms of the peroxisome proliferator-activated receptor gamma(PPARG) gene, rs1801282 and rs3856806, may be important candidate gene loci affecting the susceptibility to ischemic stroke. This case-control study sought to identify the relationship between these two single-nucleotide polymorphisms and ischemic stroke risk in a northern Chinese Han population. A total of 910 ischemic stroke participants were recruited from the First Hospital of China Medical University, Shenyang, China as a case group, of whom 895 completed the study. The 883 healthy controls were recruited from the Health Check Center of the First Hospital of China Medical University, Shenyang, China. All participants or family members provided informed consent. The study protocol was approved by the Ethics Committee of the First Hospital of China Medical University, China on February 20, 2012(approval No. 2012-38-1). The protocol was registered with the Chinese Clinical Trial Registry(registration number: ChiCTR-COC-17013559). Plasma genomic DNA was extracted from all participants and analyzed for rs1801282 and rs3856806 single nucleotide polymorphisms using a SNaPshot Multiplex sequencing assay. Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated using unconditional logistic regression to estimate the association between ischemic stroke and a particular genotype. Results demonstrated that the G allele frequency of the PPARG gene rs1801282 locus was significantly higher in the case group than in the control group(P < 0.001). Individuals carrying the G allele had a 1.844 fold increased risk of ischemic stroke(OR = 1.844, 95% CI: 1.286–2.645, P < 0.001). Individuals carrying the rs3856806 T allele had a 1.366 fold increased risk of ischemic stroke(OR = 1.366, 95% CI: 1.077–1.733, P = 0.010). The distribution frequencies of the PPARG gene haplotypes rs1801282-rs3856806 in the control and case groups were determined. The frequency of distribution in the G-T haplotype case group was significantly higher than that in the control group. The risk of ischemic stroke increased to 2.953 times in individuals carrying the G-T haplotype(OR = 2.953, 95% CI: 2.082–4.190, P < 0.001). The rs1801282 G allele and rs3856806 T allele had a multiplicative interaction(OR = 3.404, 95% CI: 1.631–7.102, P < 0.001) and additive interaction(RERI = 41.705, 95% CI: 14.586–68.824, AP = 0.860;95% CI: 0.779–0.940;S = 8.170, 95% CI: 3.772–17.697) on ischemic stroke risk, showing a synergistic effect. Of all ischemic stroke cases, 86% were attributed to the interaction of the G allele of rs1801282 and the T allele of rs3856806. The effect of the PPARG rs1801282 G allele on ischemic stroke risk was enhanced in the presence of the rs3856806 T allele(OR = 8.001 vs. 1.844). The effect of the rs3856806 T allele on ischemic stroke risk was also enhanced in the presence of the rs1801282 G allele(OR = 2.546 vs. 1.366). Our results confirmed that the G allele of the PPARG gene rs1801282 locus and the T allele of the rs3856806 locus may be independent risk factors for ischemic stroke in the Han population of northern China, with a synergistic effect between the two alleles.

Mock Impoliteness and Co-Construction of Hudui Rituals in Chinese Online Interaction

This paper examines an under-researched phenomenon of mock impoliteness in Chinese online interaction,namely,the practice of hudui(lit.reciprocal jocular abuse)as a solidarity enhancing device among acquaintances.Drawing on data from Qzone interaction among Chinese university students,this study focuses on ritual features,sequential patterns and interpersonal functions of hudui through the lens of Kádár’s(2013,2017)interpersonal ritual theory.The results show that hudui is co-constructed by the online participants with the symmetric pattern of mutual abuse,which distinguishes it from previous studies of jocular abuse(i.e.,the asymmetric pattern of abuser–recipient).They also reveal that hudui accomplishes various kinds of relational work,including fostering intimacy,enhancing mutual affection-based face and creating amusement.

Regard History as a Mirror and Create a New World of Peace,Development and Cooperation—In Commemoration of the 60^(th) Anniversary of the Victory of the Chinese People's War of Resistance Against Japanese Aggression and the World's Anti-Fascist War

The year 2005 marks the 60th anniversary of the victory of the Chinese People’s War of Resistance Against Japanese Aggression and the world’s anti-fascist war. China and many other countries have held all kinds of activities to commemorate this event that has most deeply impacted human history. The Second World War, the crudest war

Buddhist Nuns in Early Medieval Japanese Sources （In Comparison With Tibetan Yoginis and Chinese Nuns）

A history of the formation of the first Buddhist Sangha in Japan in VI c. A.D. could serve as an example of the unique history of interaction between Buddhism and Japanese autochthonous religion Shinto. The first Buddhist Sangha in Japan, at the same time was also a female Buddhist community of nuns in this country. It could be assumed that the choice of the women, designed to embody the Dharma in Japan, was not accidental and was driven by the perception of the Buddha image at the time of its introduction in Japan in VI century, especially to compare with the hagiographies of Tibetan yoginis （Machig LabdrSn, Yeshe Tsogyal） and Chinese nuns （＂Bikuni Zhuan＂） of V-VII cc. With a number of similarities （persecutions of the anti-Buddhists, desire to receive a full knowledge of Dharma）, the information of the first Japanese nuns still differ considerably from the hagiographies of yoginis and Chinese Buddhist nuns. The activity of first Japanese nuns, consisted in the worship of the statue of the Buddha, rather remind the shamanistic responsibilities of the Shinto priestesses, who were the intermediates between people and gods. This is reflected in the early Japanese description of Buddhist monks and nuns in Nihon ShOki, Gangoji Garan Engi and Nihon ryOiM as the Shamanistic priests and guardians of the Buddha-imase with a special magical status, rather than the preachers of Dharma, in comparison with the Tibetan and Chinese sources.

The Changes and Characteristics of the Exchange of Chinese and Japanese Food Culture—From the Perspective of the Acceptance of Japanese Food Culture

This paper investigates the characteristics and evolution process of Sino-Japanese diet culture exchange in each historical period,analyzes the possible impact of globalization on Sino-Japanese diet culture exchange,and discusses the development direction of innovative mode of Sino-Japanese diet culture exchange under the background of globalization.

Comparative Study on Physical Fitness Test Models of Chinese, Japanese and American Students

The physical health of adolescents is related to the future of the nation and the competitiveness of the country.Through a comparative analysis of the backgrounds,organizations,testing programs and evolution processes of physical health tests in China,Japan and the United States,the three countries are explored.The development trends and problems of student physical fitness tests,find the differences,learn about the research results and experiences of physical fitness tests in Japan and the United States,draw on Japanese and American management models and successful cases,and propose some methods to optimize and improve China's physical fitness test models.It is recommended to make full use of the existing resources to promote the improvement of students'physical fitness.

A Contrastive Analysis of Chinese and Japanese Homographs and a Study on the Causes of Differences

Since ancient times,China and Japan have had a close relationship in cultural exchanges,and there are words borrowed and influenced by each other in terms of words.Therefore,there are a large number of words in the languages of China and Japan that are identical or similar in appearance,but differ in meaning or usage.As Learners of Japanese,it is necessary for us to make a comparative study of homomorphic words.This paper tries to analyze and discuss the characteristics and causes of homomorphic words based on the classification of homomorphic words from the perspective of lexicology.

Applying Nearpod to the Teaching Chinese as a Second Language Class to Enhance Interactions and Collaborations in the Secondary Schools

The quick spread of the epidemic since 2019 together with fast advancing of technology has exposed teachers to online education,including Teaching Chinese as a Second Language(TCSL)classrooms.Some Chinese as a Second Language(CSL)teachers were reluctant to utilize technology tools in their teaching due to the lack of technological knowledge.Thus,this study designed a CSL curriculum with the lens of the TPACK framework(Technological Pedagogical Content Knowledge).Nearpod was specifically adopted as a web-based technology tool to support the teaching Chinese language due to its powerful functions provided.Nearpod allows teachers to design interactive activities in multiple ways to facilitate interactions and collaboration in the CSL learning process.This paper aimed to help Chinese teachers improve their understanding of how to effectively integrate technology into CSL teaching.Chinese teachers will develop a deeper comprehension of distance teaching from the perspectives of technology,pedagogy,and content knowledge,enhance students’deeper learning,and promote interaction and collaboration in L2 class.The effective use of the technology can develop language skills in a meaningful context knowledge with the guidance of pedagogical content knowledge.

An Exploratory Data Analysis of Mazu Culture Research Based on Diaolong-Full-Text Database of Ancient Chinese and Japanese Books

Mazu is the most famous goddess of canal transport in China,and one of the three folk beliefs in China.Japan is our neighbor across the sea.As early as 1000 years ago,Japan was influenced by the Mazu ceremonial culture.Through big data analysis,this study conducted database counting,screening,and analysis on the Mazu culture in Diaolong,the full-text database of Chinese and Japanese ancient books.Besides,it explored the hot topics of concern and emotional attitudes,and then analyzed the important role of Mazu culture in the cultural exchange and mutual learning between China and Japan in the new era,with a view to completing the contemporary task of“people-to-people bond”and achieving common development.

Chinese Wushu and Japanese Judo

Wushu routine techniques were greatly developed during the Song Dynasty (960-1279), mainly to meet the demand for civilian entertainment as well as in military training. More attention began to be paid to bodywork, physical strength, and rhythm and movement design. Each routine consisted of a starting position and a finishing position.

Japanese Cartoons, "Eye Candy" for Chinese Kids

Is this sort of thing inevitable,as China opens her doors to the outside?Are these cartoons therefore to be simply filed away under the harmless excuse of"cultural exchange?"To be fair,Japan has its own fears about Western cultural imperialism,but a few people in China,more threatened by Astroboy than Sony,feel that measures must be taken to man Chi-na's cultural barricades and resist the invasion.Look at what happened to Peking opera,they warmn.Because children are inheritors of the great cultural tradition and the hope of any country,they must not be sacrificed to the Transformers or the Flower Fairy Lady.

Chinese and Japanese Hànzìand Kanji Etymologies:Explanations on Liùshū 六書 and Rikusho 六書

This paper outlines Liùshū六書interpretations of Chinese character etymology to help cocreate a better approach for educators in supporting character literacy development in students of the East Asian languages that utilize Chinese writing.The Liùshū六書Rikusho六書approach to character instruction can be interpreted as a strategy to spark interest in western learners providing more detailed explanations that deal with the pictographic and compound nature of Chinese character formation.All non-English words are italicized or bolded,Chinese based terms are in Mandarin Pīnyīn拼音,and Japanese terms are written in Romajiローマ字representing their differences phonetically to integrate foreign terminology.

Battle of Human Rights and Anti-Human Rights in Chinese People's War of Resistance against Japanese Aggression

The Chinese Anti-Japanese War was a battle between human rights protections and abuses, between civilization and brutality, and between justice and evil. During the war, the human rights of Chinese people were completely violated by the Japanese aggressors, causing an unprecedented human rights catastrophe. At the same time, Chinese people vigorously resisted the aggression in order to defend the national survival right and safeguard the human peace against war. The history of human rights’ victory over human rights abuses tells us: aggressive wars are the most serious violations of human rights. We must protect people’s right to peace for every country in the world. In order to avoid violations of human rights by war once again, we must safeguard the international postwar order and prevent the revival of fascism, whose essences are contempt for and trample on human rights. Therefore we have to respect and protect human rights and defend both the collective rights of every nation and the individual rights of every person in the world.

The Role of Japanese Candlestick in DVAR Model

The decomposition-based vector autoregressive model （DVAR） provides a new framework for scrutinizing the efficiency of technical analysis in forecasting stock returns. However, its relation- ships with other technical indicators still remain unknown. This paper investigates the relationships of DVAR model with the Japanese Candlestick indicators using simulations, theoretical explanations and empirical studies. The main finding of this paper is that both lower and upper shadows in Japanese Candlestick Granger contribute to the DVAR model explanation power, and thus, providing useful information for improving the DVAR forecasts. This finding makes sense as it means that the infor- mation contained in the lower and upper shadows should be used when modeling the stock returns with DVAR. Empirical studies performed on China SSEC stock index demonstrate that DVAR model with upper and lower shadows as exogenous variables does have informative and valuable out-of-sample forecasts.