The stromal interaction molecule(STIM)-calcium release-activated calcium channel protein(ORAI) and inositol1,4,5-trisphosphate receptors(IP_3Rs) play pivotal roles in the modulation of Ca^(2+)-regulated pathways from ...The stromal interaction molecule(STIM)-calcium release-activated calcium channel protein(ORAI) and inositol1,4,5-trisphosphate receptors(IP_3Rs) play pivotal roles in the modulation of Ca^(2+)-regulated pathways from gene transcription to cell apoptosis by driving calcium-dependent signaling processes.Increasing evidence has implicated the dysregulation of STIM-ORAI and IP_3Rs in tumorigenesis and tumor progression.By controlling the activities,structure,and/or expression levels of these Ca^(2+)-transporting proteins,malignant cancer cells can hijack them to drive essential biological functions for tumor development.However,the molecular mechanisms underlying the participation of STIM-ORAI and IP_3Rs in the biological behavior of cancer remain elusive.In this review,we summarize recent advances regarding STIM-ORAI and IP_3Rs and discuss how they promote cell proliferation,apoptosis evasion,and cell migration through temporal and spatial rearrangements in certain types of malignant cells.An understanding of the essential roles of STIM-ORAI and IP_3Rs may provide new pharmacologic targets that achieve a better therapeutic effect by inhibiting their actions in key intracellular signaling pathways.展开更多
With the inclusion of satellite Internet as the information infrastructure in China's "new infrastructure" category,relevant domestic industries and scientific research institutes have successively carri...With the inclusion of satellite Internet as the information infrastructure in China's "new infrastructure" category,relevant domestic industries and scientific research institutes have successively carried out the design of broadband low earth orbit(LEO) constellation systems and key technical research.As the core technology for the satellite-to-ground network communications of a broadband LEO constellation system,routing technology is extremely important for the efficient and reliable transmission of various service data.Focusing on the two important broadband LEO constellation systems in China,in-depth analysis and simulation of the high dynamics of the satellite-to-ground satellites are conducted in this paper to obtain more accurate network topology changes and characteristics;then the adaptability of the ground standard IP routing protocol to the broadband LEO constellation system is analyzed,and an LEO constellation simulation scenario is built with the Opnet software.The simulation results of the convergence performance of the standard IP routing protocol are produced.The results show that the IP protocol does not perform well for LEO satellite constellation networks.Based on the studies,some solutions are proposed to take full advantages of the characteristics of LEO satellite systems.These can also provide a reference for the choice of intersatellite routing architecture and protocol technology for broadband LEO constellation in the future development.展开更多
Various extensions of UML have been developed to meet the challenges of designing modern software systems, such as agent based electronic commerce applications. Recent advances in model checking technology have led i...Various extensions of UML have been developed to meet the challenges of designing modern software systems, such as agent based electronic commerce applications. Recent advances in model checking technology have led it to be introduced into the development of approaches and tools to check the correctness of electronic commerce protocols. This paper focuses on the research of a method that connects an extension of AUML to model checker SPIN/Promela for the specification and verification of agent interaction protocols (AIP) in electronic commerce. The method presented here allows us to combine the benefits of visual specification with the power of some static analysis and model checking. Some algorithms and rules are developed to permit all visual modeling constructs translated mechanically into some Promela models of AIP, as supported by the model checker SPIN. Moreover, a process is illustrated to guide the specification and verification of AIP. The method is demonstrated thoroughly using the e commerce protocol NetBill as an example.展开更多
Security protocols are the basis of many mobile communication systems,thus it is important to ensure protocol property correct. Using Protocol Composition Logic (PCL),this paper proves a Mobile IP (MIP) registration p...Security protocols are the basis of many mobile communication systems,thus it is important to ensure protocol property correct. Using Protocol Composition Logic (PCL),this paper proves a Mobile IP (MIP) registration protocol that is based on certificateless public key signature without pairing between home agent and foreign agent,which minimizes the registration time and cost as well as improves the security compared with the identity-based and certificate-based registration protocol. Analysis and proof shows that the proposed protocol provides users security and authentications,moreover,the anonymity property is proved correct.展开更多
With the rapid development of the embedded technology, research and implement of the Internet of things will be a new technology revolution, yet the implement of the Internet of things is on the base of the communicat...With the rapid development of the embedded technology, research and implement of the Internet of things will be a new technology revolution, yet the implement of the Internet of things is on the base of the communication between the things. For this reason, realizing the function of communication between singlechip is particularly important. Based on the characteristics of the embedded microcontroller, we analyzed the traditional PC TCP/IP protocol, and appropriately tailored TCP/IP protocol cluster on the basis of the characteristics of embedded singlechip. At last, we realized the reduced TCP/IP protocol cluster suitable for embedded singlechip, on AVR singlechip platform.展开更多
常规的新闻演播室系统主要依赖自动化控制,但大量的自动化应用增加了系统的运行负担,进而影响新闻制作的实时性与稳定性。鉴于此,设计基于网际互连协议(Internet Protocol,IP)电影和电视工程师协会(The Society of Motion Picture and T...常规的新闻演播室系统主要依赖自动化控制,但大量的自动化应用增加了系统的运行负担,进而影响新闻制作的实时性与稳定性。鉴于此,设计基于网际互连协议(Internet Protocol,IP)电影和电视工程师协会(The Society of Motion Picture and Television Engineers,SMPTE)2110流的新闻演播室系统。在硬件层面,该系统配备HDVF-L750//CCN彩色寻像器和IP画面分割器;在软件层面,建立演播室IP SMPTE2110流标准协议,以此作为演播室内媒体传输的基础,确保演播室内视频、音频和辅助数据的高质量传输。此外,开发新闻演播视频格式文件读取程序,该程序能够分析新闻演播视频文件的格式和编码标准,确定需要支持的文件类型,从而满足新闻演播视频文件的读取与播放需求。经过测试,系统的运行性能较好,具备实际应用价值。展开更多
An accurate estimation of wind loads on telecommunication towers is crucial for design,as well as for perform-ing reliability,resilience,and risk assessments.In particular,drag coefficient and interference factor are ...An accurate estimation of wind loads on telecommunication towers is crucial for design,as well as for perform-ing reliability,resilience,and risk assessments.In particular,drag coefficient and interference factor are the most significant factors for wind load computations.Wind tunnel tests and computational fluid dynamics(CFD)are the most appropriate methods to estimate these parameters.While wind tunnel tests are generally preferred in practice,they require dedicated facilities and personnel,and can be expensive if multiple configurations of tower panels and antennas need to be tested under various wind directions(e.g.,fragility curve development for system resilience analysis).This paper provides a simple,robust,and easily accessible CFD protocol with widespread applicability,offering a practical solution in situations where wind tunnel testing is not feasible,such as complex tower configurations or cases where the cost of running experiments for all the tower-antennas configurations is prohibitively high.Different turbulence models,structural and fluid boundary conditions and mesh types are tested to provide a streamlined CFD modeling strategy that shows good convergence and balances accuracy,computational time,and robustness.The protocol is calibrated and validated with experimental studies available in the literature.To demonstrate the capabilities of the protocol,three lattice tower panels and antennas with different configurations are analyzed as examples.The protocol successfully estimates the drag and lateral wind loads and their coefficients under different wind directions.Noticeable differences are observed between the esti-mated wind loads with this protocol and those computed by a simple linear superposition used in most practical applications,indicating the importance of tower-antenna interaction.Also,as expected,the wind loads recom-mended by design codes overestimate the simulated results.More importantly,the telecommunication design codes inadequately identify the most favorable wind directions that are associated with the lowest wind loads,while the results of the proposed protocol align with observations from experimental studies.This information may be used to select the tower orientation before construction.The findings of this study are of importance for the telecommunication industry,which seeks reliable results with minimal computational efforts.In addition,it enhances the fragility analysis of telecommunication towers under strong winds,and the portfolio risk and resilience assessment of telecommunication systems.展开更多
基于电影和电视工程师协会(The Society of Motion Picture and Television Engineers,SMPTE)ST 2110标准,详细阐述总控建设、超高清同播技术、高动态范围(High Dynamic Range,HDR)技术、视音频系统、控制网络技术以及时钟同步技术等多...基于电影和电视工程师协会(The Society of Motion Picture and Television Engineers,SMPTE)ST 2110标准,详细阐述总控建设、超高清同播技术、高动态范围(High Dynamic Range,HDR)技术、视音频系统、控制网络技术以及时钟同步技术等多个方面的关键内容,为电视制播系统的网际互连协议(Internet Protocol,IP)化转型提供理论支持和实践指导。展开更多
江苏省广电有线信息网络股份有限公司无锡分公司设计了一套基于数字视频广播(Digital Video Broadcast,DVB)+网际互连协议(Internet Protocol,IP)的数字电视全业务融合播出平台模型。在此基础上,根据项目部署地的实际需求,设计并完成项...江苏省广电有线信息网络股份有限公司无锡分公司设计了一套基于数字视频广播(Digital Video Broadcast,DVB)+网际互连协议(Internet Protocol,IP)的数字电视全业务融合播出平台模型。在此基础上,根据项目部署地的实际需求,设计并完成项目一期工程的数字电视前端系统。详细介绍全系统包含卫星电视节目的信号接收、无锡地区电视节目的 IP传输、自办节目播出、电子节目单(Electrical Program Guide,EPG)开机广告、信号复用、信号调制以及信号分配等功能。展开更多
在广播电视行业,4K、8K超高清技术的快速发展,对于信号传输产生了更高的要求,需要更高的带宽和更低的延迟。在这种情况下,传统的串行数字接口(Serial Digital Interface,SDI)技术已经不能满足,需要向网际互连协议(Internet Protocol,IP...在广播电视行业,4K、8K超高清技术的快速发展,对于信号传输产生了更高的要求,需要更高的带宽和更低的延迟。在这种情况下,传统的串行数字接口(Serial Digital Interface,SDI)技术已经不能满足,需要向网际互连协议(Internet Protocol,IP)化转化。针对SDI技术的局限性以及IP技术的优势进行阐述,发现IP化不仅可以提升传输效率、降低传输成本,还可以促进广播电视行业的创新和发展。展开更多
网际互连协议(Internet Protocol,IP)化网络作为一种新兴的传输技术,正在改变传统的电视制作和播出模式。基于此,概述了IP化技术的相关概念,分析了IP化技术的数字编码和分组传输机制,阐述了IP化技术在推动电视制播融合方面的作用,提出...网际互连协议(Internet Protocol,IP)化网络作为一种新兴的传输技术,正在改变传统的电视制作和播出模式。基于此,概述了IP化技术的相关概念,分析了IP化技术的数字编码和分组传输机制,阐述了IP化技术在推动电视制播融合方面的作用,提出了电视制播IP化网络的分层架构,解析了IP化核心网和接入网的组成,以及软件定义网络(Software Defined Network,SDN)在IP化网络中的控制作用。展开更多
数字电视信号对传输质量有着十分严苛的要求,传统网际互连协议(Internet Protocol,IP)网络在提供端到端服务质量(Quality of Service,QoS)保障方面仍面临诸多挑战。对此,分析数字电视信号的业务特点和传输需求,梳理IP网络QoS领域的发展...数字电视信号对传输质量有着十分严苛的要求,传统网际互连协议(Internet Protocol,IP)网络在提供端到端服务质量(Quality of Service,QoS)保障方面仍面临诸多挑战。对此,分析数字电视信号的业务特点和传输需求,梳理IP网络QoS领域的发展脉络,提出一种端到端QoS保障解决方案的总体架构,从接入网、骨干网、综合管理平台三个层面给出优化措施。展开更多
文摘The stromal interaction molecule(STIM)-calcium release-activated calcium channel protein(ORAI) and inositol1,4,5-trisphosphate receptors(IP_3Rs) play pivotal roles in the modulation of Ca^(2+)-regulated pathways from gene transcription to cell apoptosis by driving calcium-dependent signaling processes.Increasing evidence has implicated the dysregulation of STIM-ORAI and IP_3Rs in tumorigenesis and tumor progression.By controlling the activities,structure,and/or expression levels of these Ca^(2+)-transporting proteins,malignant cancer cells can hijack them to drive essential biological functions for tumor development.However,the molecular mechanisms underlying the participation of STIM-ORAI and IP_3Rs in the biological behavior of cancer remain elusive.In this review,we summarize recent advances regarding STIM-ORAI and IP_3Rs and discuss how they promote cell proliferation,apoptosis evasion,and cell migration through temporal and spatial rearrangements in certain types of malignant cells.An understanding of the essential roles of STIM-ORAI and IP_3Rs may provide new pharmacologic targets that achieve a better therapeutic effect by inhibiting their actions in key intracellular signaling pathways.
文摘With the inclusion of satellite Internet as the information infrastructure in China's "new infrastructure" category,relevant domestic industries and scientific research institutes have successively carried out the design of broadband low earth orbit(LEO) constellation systems and key technical research.As the core technology for the satellite-to-ground network communications of a broadband LEO constellation system,routing technology is extremely important for the efficient and reliable transmission of various service data.Focusing on the two important broadband LEO constellation systems in China,in-depth analysis and simulation of the high dynamics of the satellite-to-ground satellites are conducted in this paper to obtain more accurate network topology changes and characteristics;then the adaptability of the ground standard IP routing protocol to the broadband LEO constellation system is analyzed,and an LEO constellation simulation scenario is built with the Opnet software.The simulation results of the convergence performance of the standard IP routing protocol are produced.The results show that the IP protocol does not perform well for LEO satellite constellation networks.Based on the studies,some solutions are proposed to take full advantages of the characteristics of LEO satellite systems.These can also provide a reference for the choice of intersatellite routing architecture and protocol technology for broadband LEO constellation in the future development.
基金Supported by the Research Grants Council of Hong Kong(DAG99/0 0 .EG0 5 ) the Sino-French Advanced ResearchProgram 2 0 0 0 (PR
文摘Various extensions of UML have been developed to meet the challenges of designing modern software systems, such as agent based electronic commerce applications. Recent advances in model checking technology have led it to be introduced into the development of approaches and tools to check the correctness of electronic commerce protocols. This paper focuses on the research of a method that connects an extension of AUML to model checker SPIN/Promela for the specification and verification of agent interaction protocols (AIP) in electronic commerce. The method presented here allows us to combine the benefits of visual specification with the power of some static analysis and model checking. Some algorithms and rules are developed to permit all visual modeling constructs translated mechanically into some Promela models of AIP, as supported by the model checker SPIN. Moreover, a process is illustrated to guide the specification and verification of AIP. The method is demonstrated thoroughly using the e commerce protocol NetBill as an example.
基金Supported by the National Natural Science Foundation of China (No.60572147)State Key Laboratory Specific Foundation (ISN090307)the 111 Project (B08038)
文摘Security protocols are the basis of many mobile communication systems,thus it is important to ensure protocol property correct. Using Protocol Composition Logic (PCL),this paper proves a Mobile IP (MIP) registration protocol that is based on certificateless public key signature without pairing between home agent and foreign agent,which minimizes the registration time and cost as well as improves the security compared with the identity-based and certificate-based registration protocol. Analysis and proof shows that the proposed protocol provides users security and authentications,moreover,the anonymity property is proved correct.
文摘With the rapid development of the embedded technology, research and implement of the Internet of things will be a new technology revolution, yet the implement of the Internet of things is on the base of the communication between the things. For this reason, realizing the function of communication between singlechip is particularly important. Based on the characteristics of the embedded microcontroller, we analyzed the traditional PC TCP/IP protocol, and appropriately tailored TCP/IP protocol cluster on the basis of the characteristics of embedded singlechip. At last, we realized the reduced TCP/IP protocol cluster suitable for embedded singlechip, on AVR singlechip platform.
文摘常规的新闻演播室系统主要依赖自动化控制,但大量的自动化应用增加了系统的运行负担,进而影响新闻制作的实时性与稳定性。鉴于此,设计基于网际互连协议(Internet Protocol,IP)电影和电视工程师协会(The Society of Motion Picture and Television Engineers,SMPTE)2110流的新闻演播室系统。在硬件层面,该系统配备HDVF-L750//CCN彩色寻像器和IP画面分割器;在软件层面,建立演播室IP SMPTE2110流标准协议,以此作为演播室内媒体传输的基础,确保演播室内视频、音频和辅助数据的高质量传输。此外,开发新闻演播视频格式文件读取程序,该程序能够分析新闻演播视频文件的格式和编码标准,确定需要支持的文件类型,从而满足新闻演播视频文件的读取与播放需求。经过测试,系统的运行性能较好,具备实际应用价值。
基金support from the Pennsylvania Department of Community&Economic Development(DCED)through grant PIT-19-02 and of Lehigh University through the“Research Futures:Major Program Development”the“Research Fu-tures:Special Seed Funding Opportunity”grants are gratefully acknowl-edged.
文摘An accurate estimation of wind loads on telecommunication towers is crucial for design,as well as for perform-ing reliability,resilience,and risk assessments.In particular,drag coefficient and interference factor are the most significant factors for wind load computations.Wind tunnel tests and computational fluid dynamics(CFD)are the most appropriate methods to estimate these parameters.While wind tunnel tests are generally preferred in practice,they require dedicated facilities and personnel,and can be expensive if multiple configurations of tower panels and antennas need to be tested under various wind directions(e.g.,fragility curve development for system resilience analysis).This paper provides a simple,robust,and easily accessible CFD protocol with widespread applicability,offering a practical solution in situations where wind tunnel testing is not feasible,such as complex tower configurations or cases where the cost of running experiments for all the tower-antennas configurations is prohibitively high.Different turbulence models,structural and fluid boundary conditions and mesh types are tested to provide a streamlined CFD modeling strategy that shows good convergence and balances accuracy,computational time,and robustness.The protocol is calibrated and validated with experimental studies available in the literature.To demonstrate the capabilities of the protocol,three lattice tower panels and antennas with different configurations are analyzed as examples.The protocol successfully estimates the drag and lateral wind loads and their coefficients under different wind directions.Noticeable differences are observed between the esti-mated wind loads with this protocol and those computed by a simple linear superposition used in most practical applications,indicating the importance of tower-antenna interaction.Also,as expected,the wind loads recom-mended by design codes overestimate the simulated results.More importantly,the telecommunication design codes inadequately identify the most favorable wind directions that are associated with the lowest wind loads,while the results of the proposed protocol align with observations from experimental studies.This information may be used to select the tower orientation before construction.The findings of this study are of importance for the telecommunication industry,which seeks reliable results with minimal computational efforts.In addition,it enhances the fragility analysis of telecommunication towers under strong winds,and the portfolio risk and resilience assessment of telecommunication systems.
文摘基于电影和电视工程师协会(The Society of Motion Picture and Television Engineers,SMPTE)ST 2110标准,详细阐述总控建设、超高清同播技术、高动态范围(High Dynamic Range,HDR)技术、视音频系统、控制网络技术以及时钟同步技术等多个方面的关键内容,为电视制播系统的网际互连协议(Internet Protocol,IP)化转型提供理论支持和实践指导。
文摘江苏省广电有线信息网络股份有限公司无锡分公司设计了一套基于数字视频广播(Digital Video Broadcast,DVB)+网际互连协议(Internet Protocol,IP)的数字电视全业务融合播出平台模型。在此基础上,根据项目部署地的实际需求,设计并完成项目一期工程的数字电视前端系统。详细介绍全系统包含卫星电视节目的信号接收、无锡地区电视节目的 IP传输、自办节目播出、电子节目单(Electrical Program Guide,EPG)开机广告、信号复用、信号调制以及信号分配等功能。
文摘在广播电视行业,4K、8K超高清技术的快速发展,对于信号传输产生了更高的要求,需要更高的带宽和更低的延迟。在这种情况下,传统的串行数字接口(Serial Digital Interface,SDI)技术已经不能满足,需要向网际互连协议(Internet Protocol,IP)化转化。针对SDI技术的局限性以及IP技术的优势进行阐述,发现IP化不仅可以提升传输效率、降低传输成本,还可以促进广播电视行业的创新和发展。
文摘网际互连协议(Internet Protocol,IP)化网络作为一种新兴的传输技术,正在改变传统的电视制作和播出模式。基于此,概述了IP化技术的相关概念,分析了IP化技术的数字编码和分组传输机制,阐述了IP化技术在推动电视制播融合方面的作用,提出了电视制播IP化网络的分层架构,解析了IP化核心网和接入网的组成,以及软件定义网络(Software Defined Network,SDN)在IP化网络中的控制作用。
文摘数字电视信号对传输质量有着十分严苛的要求,传统网际互连协议(Internet Protocol,IP)网络在提供端到端服务质量(Quality of Service,QoS)保障方面仍面临诸多挑战。对此,分析数字电视信号的业务特点和传输需求,梳理IP网络QoS领域的发展脉络,提出一种端到端QoS保障解决方案的总体架构,从接入网、骨干网、综合管理平台三个层面给出优化措施。