Based on the traditional Human-Computer Interaction method which is mainly touch input system, the way of capturing the movement of people by using cameras is proposed. This is a convenient technique which can provide...Based on the traditional Human-Computer Interaction method which is mainly touch input system, the way of capturing the movement of people by using cameras is proposed. This is a convenient technique which can provide users more experience. In the article, a new way of detecting moving things is given on the basis of development of the image processing technique. The system architecture decides that the communication should be used between two different applications. After considered, named pipe is selected from many ways of communication to make sure that video is keeping in step with the movement from the analysis of the people moving. According to a large amount of data and principal knowledge, thinking of the need of actual project, a detailed system design and realization is finished. The system consists of three important modules: detecting of the people's movement, information transition between applications and video showing in step with people's movement. The article introduces the idea of each module and technique.展开更多
Seismic oscillations of the “building-building” system which is interconnected buildings built close to each other, and “building-stack-like structure” system which is adjacent and connected in different ways to e...Seismic oscillations of the “building-building” system which is interconnected buildings built close to each other, and “building-stack-like structure” system which is adjacent and connected in different ways to existing building are considered in the paper. Different types of connections, such as dampers, including the ones suggested by the authors, are studied. Seismic impact is given as a harmonic function and various existing accelerograms, including synthesized ones. Distinctive feature of this paper from previously published ones [1] [2] is the fact that the emphasis falls on the influence of soil-foundation interaction properties, which are described using various models of load-displacement connections. Calculation results are compared in the case of representation of the building as concentrated masses and spatial systems. Ways to reduce seismic response of buildings during the earthquakes are pointed out. Results of experimental studies are given in the paper and are compared with calculations.展开更多
The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKS...The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully understood.Research has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic spines.However,the function of CNKSR2 in the cytoplasm remains to be elucidated.In this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of CNKSR2.Through a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the centrosome.We also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker CEP290.Subsequent colocalization analysis confirmed the centrosomal localization of CNKSR2.When we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal genes.This manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and motility.Furthermore,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum disorder.Our findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.展开更多
Our paper presents a project that involves two research questions: does the choice of a related problem by the tutorial system allow the problem solving process which is blocked for the student to be restarted? What i...Our paper presents a project that involves two research questions: does the choice of a related problem by the tutorial system allow the problem solving process which is blocked for the student to be restarted? What information about learning do related problems returned by the system provide us? We answer the first question according to the didactic engineering, whose mode of validation is internal and based on the confrontation between an a priori analysis and an a posteriori analysis that relies on data from experiments in schools. We consider the student as a subject whose adaptation processes are conditioned by the problem and the possible interactions with the computer environment, and also by his knowledge, usually implicit, of the institutional norms that condition his relationship with geometry. Choosing a set of good problems within the system is therefore an essential element of the learning model. Since the source of a problem depends on the student’s actions with the computer tool, it is necessary to wait and see what are the related to problems that are returned to him before being able to identify patterns and assess the learning. With the simultaneity of collecting and analysing interactions in each class, we answer the second question according to a grounded theory analysis. By approaching the problems posed by the system and the designs in play at learning blockages, our analysis links the characteristics of problems to the design components in order to theorize on the decisional, epistemological, representational, didactic and instrumental aspects of the subject-milieu system in interaction.展开更多
Biography videos based on life performances of prominent figures in history aim to describe great mens' life.In this paper,a novel interactive video summarization for biography video based on multimodal fusion is ...Biography videos based on life performances of prominent figures in history aim to describe great mens' life.In this paper,a novel interactive video summarization for biography video based on multimodal fusion is proposed,which is a novel approach of visualizing the specific features for biography video and interacting with video content by taking advantage of the ability of multimodality.In general,a story of movie progresses by dialogues of characters and the subtitles are produced with the basis on the dialogues which contains all the information related to the movie.In this paper,JGibbsLDA is applied to extract key words from subtitles because the biography video consists of different aspects to depict the characters' whole life.In terms of fusing keywords and key-frames,affinity propagation is adopted to calculate the similarity between each key-frame cluster and keywords.Through the method mentioned above,a video summarization is presented based on multimodal fusion which describes video content more completely.In order to reduce the time spent on searching the interest video content and get the relationship between main characters,a kind of map is adopted to visualize video content and interact with video summarization.An experiment is conducted to evaluate video summarization and the results demonstrate that this system can formally facilitate the exploration of video content while improving interaction and finding events of interest efficiently.展开更多
To improve the human-physical-virtual coordination and integration of the digital twin workshop,3D visual monitoring and human-computer interaction of the digital twin workshop was studied.First,a novel 6D model of th...To improve the human-physical-virtual coordination and integration of the digital twin workshop,3D visual monitoring and human-computer interaction of the digital twin workshop was studied.First,a novel 6D model of the 3D visualization interactive system for digital twin workshops is proposed.As the traditional 5D digital twin model ignores the importance of human-computer interaction,a new dimension of the user terminal was added.A hierarchical real-time data-driven mapping model for the workshop production process is then proposed.Moreover,a real-time data acquisition method for the industrial Internet of things is proposed based on OPC UA(object linking and embedding for process control unified architecture).Based on the 6D model of the system,the process of creating a 3D visualization virtual environment based on virtual reality is introduced,in addition to a data-driven process based on the data management cloud platform.Finally,the 6D model of the system was confirmed using the blade rotor test workshop as the object,and a 3D visualization interactive system is developed.The results show that the system is more transparent,real-time,data-driven and more efficient,as well as promotes the coordination and integration of human-physical-virtual,which has practical significance for developing digital twin workshops.展开更多
In this paper, we conduct research on the new modern English teaching mode in higher vocational colleges based on multimediaand interactive system. Multimedia can make the local conditions and customs of English-speak...In this paper, we conduct research on the new modern English teaching mode in higher vocational colleges based on multimediaand interactive system. Multimedia can make the local conditions and customs of English-speaking countries, culture, art and life phenomenon,along with beautiful music and authentic English explanation, in order to real natural life scenes, abstract, boring of the learning content, becomevivid language communication environment, easy to stimulate students’ learning motivation, arouse their strong desire for knowledge, andthe thirst for knowledge into sustainable self-need, internalized learning motivation. Learning motivation is directly promote the inner power ofstudents in learning activities as point and level directly affect students’ learning behavior and academic achievement. Establishment situation,stimulate students’ curiosity and it is an effective way of training students’ learning motivations. This paper combines the related theories topropose the new perspective of the issues that will be meaningful.展开更多
In recent years,a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell(hUMSC)transplants for the treatment of ischemic cerebral infarction.These genes are i...In recent years,a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell(hUMSC)transplants for the treatment of ischemic cerebral infarction.These genes are involved in various biochemical processes,but the role of microRNAs(miRNAs)in this process is still unclear.From the Gene Expression Omnibus(GEO)database,we downloaded two microarray datasets for GSE78731(messenger RNA(mRNA)profile)and GSE97532(miRNA profile).The differentially expressed genes screened were compared between the hUMSC group and the middle cerebral artery occlusion group.Gene ontology enrichment and pathway enrichment analyses were subsequently conducted using the online Database for Annotation,Visualization,and Integrated Discovery.Identified genes were applied to perform weighted gene co-suppression analyses,to establish a weighted co-expression network model.Furthermore,the protein-protein interaction network for differentially expressed genes from turquoise modules was built using Cytoscape(version 3.40)and the most highly correlated subnetwork was extracted from the protein-protein interaction network using the MCODE plugin.The predicted target genes for differentially expressed miRNAs were also identified using the online database starBase v3.0.A total of 3698 differentially expressed genes were identified.Gene ontology analysis demonstrated that differentially expressed genes that are related to hUMSC treatment of ischemic cerebral infarction are involved in endocytosis and inflammatory responses.We identified 12 differentially expressed miRNAs in middle cerebral artery occlusion rats after hUMSC treatment,and these differentially expressed miRNAs were mainly involved in signaling in inflammatory pathways,such as in the regulation of neutrophil migration.In conclusion,we have identified a number of differentially expressed genes and differentially expressed mRNAs,miRNA-mRNAs,and signaling pathways involved in the hUMSC treatment of ischemic cerebral infarction.Bioinformatics and interaction analyses can provide novel clues for further research into hUMSC treatment of ischemic cerebral infarction.展开更多
E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a mo...E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a modern structured MOODLE interactive course, designed for the needs of the laboratory course “Automotive Systems”. The study concerns Greek secondary vocational education pupils aged 18 and vocational training adult students aged 20 to 50 years. The multistage, equal size simple random cluster sample was used as a sampling method. Pupils and adult students of each cluster completed structured 10-question questionnaires both before and after attending the course. A total of 120 questionnaires were collected. In general, our findings disclosed that the majority of pupils and adult students had significantly improved their knowledge and skills from using MOODLE. They reported strengthening conventional teaching, using the new MOODLE technology. The satisfaction indices improved quite, with the differences in their mean values being statistically significant.展开更多
In 2013, World-Universe Model (WUM) proposed a principally different way to solve the problem of Newtonian Constant of Gravitation measurement precision. WUM revealed a self-consistent set of time-varying values of Pr...In 2013, World-Universe Model (WUM) proposed a principally different way to solve the problem of Newtonian Constant of Gravitation measurement precision. WUM revealed a self-consistent set of time-varying values of Primary Cosmological parameters of the World: Gravitation parameter, Hubble’s parameter, Age of the World, Temperature of the Microwave Background Radiation, and the concentration of Intergalactic plasma. Based on the inter-connectivity of these parameters, WUM solved the Missing Baryon problem and predicted the values of the following Cosmological parameters: gravitation G, concentration of Intergalactic plasma, relative energy density of protons in the Medium, and the minimum energy of photons, which were experimentally confirmed in 2015-2018. Between 2013 and 2018, the relative standard uncertainty of G measurements decreased x6. The set of values obtained by WUM was recommended for consideration in CODATA Recommended Values of the Fundamental Physical Constants 2014.展开更多
Taylor vortex flow between two concentric rotating cylinders with finite axial length includes various patterns of laminar and turbulent flows, and its behavior has attracted great interests. When mode bifurcation occ...Taylor vortex flow between two concentric rotating cylinders with finite axial length includes various patterns of laminar and turbulent flows, and its behavior has attracted great interests. When mode bifurcation occurs, quantitative parameters such as the volume-averaged energy change rapidly. It is important to visualize the behaviors of vortices. In this study, a three-dimensional visualization system with respect to time is devised. This system can change the viewpoint of flow visualization, and we can observe the track of a vortex from any point. The volume-averaged energy is projected to the track of the center of a vortex. The proposed system can help to investigate the relationship between the mode bifurcation process and the volume-averaged energy.展开更多
This brief review discusses the behavioral consequences of two pharmacologically selected lines of rats. Flinders Sensitive (FSL) and Flinders Resistant (FRL) Lines of rats were selected on the basis of differential h...This brief review discusses the behavioral consequences of two pharmacologically selected lines of rats. Flinders Sensitive (FSL) and Flinders Resistant (FRL) Lines of rats were selected on the basis of differential hypothermic and behavioral responses to the anticholinesterase, diisopropylfluorophosphate (DFP). FSL rats are more sensitive to the hypothermic effects of cholinergic, serotonergic, and dopaminergic agonists but less sensitive to the locomotor or stereotypic effects of dopamine agonists. FSL rats exhibit greater immobility in the forced swim test and reduced social interaction compared with FRL rats, but do not differ in saccharin intake, behavior in the elevated plus maze, or responses for rewarding brain self-stimulation. The exaggerated immobility and reduced social interaction are counteracted by chronic treatment with antidepressants. Because FSL rats were more sensitive to 5-HT1A receptor agonists, high (HDS) and low (LDS) 8-OH-DPATsensitive lines were selectively bred for differential hypothermic responses to the 5-HT1A receptor agonist, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT). HDS rats were also more sensitive to the hypothermic effects of oxotremorine, a cholinergic agonist, but selection for this response did not diverge with later selection. HDS rats exhibited greater immobility in the forced swim test than LDS rats and this correlated response could be seen early in selection (generation 3). HDS rats also showed reduced social interaction compared to LDS rats, but did not differ in behavior in the elevated plus maze. These findings confirm that selection for hypothermic responses to pharmacological agents do have behavioral consequences, notably the production of depressive-like phenotypes, which can be counteracted by chronic antidepressant treatment. Because increased 5-HT1A receptor sensitivity was common to both selected lines (FSL and HDS), neurobiological processes dependent on this receptor could contribute to the abnormal behaviors that manifest in these rat lines and thus suggesting a mechanism underlying depressive behaviors in humans. However, available human data are inconsistent with this hypothesis and suggest that other mechanisms underlie these behavioral abnormalities in HDS and FSL rats. These mechanisms as well as additional behavioral testing in these rat lines will be discussed.展开更多
Multimedia Interactive Informative Systems (MIIS) are software applications resulting from the convergence of multiples technologies such as audiovisual, computing and communication. They aim to transmit information t...Multimedia Interactive Informative Systems (MIIS) are software applications resulting from the convergence of multiples technologies such as audiovisual, computing and communication. They aim to transmit information to a large, diverse and dispersed public. As with other mass media, the fulfillment of MIIS goals depends largely on the quality of communication between the system and end users. Therefore, those systems should be developed in order to ensure that this quality requirement is satisfied. If MIIS are constructed according to usual software engineering practices, the analysis discipline of the development process includes requirements identification and specification;however, these techniques are focused on functional requirements, and they do not give much importance to non-functional requirements. In this paper, we propose a development process based on the production of videogames which has two different phases: preproduction and production. The first phase, corresponding to requirements identification, derives into the concept of system. In order to translate this concept into a specification, we propose the use of new communicational attributes and a MIIS metamodel. The establishment of MIIS non-functional specification is the result of analyzing class diagrams through quality attributes. In order to evaluate if the specifications are responding to communicational attributes, a functional prototype is built and evaluated with end users. The proposed methodology is applied to a real case study.展开更多
Six categories of systematic 2n-(n-k) designs derivable from the full 2k factorial experiment by the interactions-main effects assignment are available for carrying out 2n-(n-k) factorial experiments sequentially run ...Six categories of systematic 2n-(n-k) designs derivable from the full 2k factorial experiment by the interactions-main effects assignment are available for carrying out 2n-(n-k) factorial experiments sequentially run after the other such that main effects are protected against the linear/quadratic time trend and/or such that the number of factor level changes (i.e. cost) between the runs is minimal. Three of these six categories are of resolution at least III and three are of resolution at least IV. The three categories of designs within each resolution are: 1) minimum cost 2n-(n-k) designs, 2) minimum cost linear trend free 2n-(n-k) designs and 3) minimum cost linear and quadratic trend free 2n-(n-k) designs. This paper characterizes these six categories and documents their differences with regard to either time trend resistance of factor effects and/or the number of factor level changes. The paper introduces the last category of systematic 2n-(n-k) designs (i.e. the sixth) for the purpose of extending the design resolution from III into IV and also for raising the level of protection of main effects from the linear time trend into the quadratic, where a catalog of minimum cost linear and quadratic trend free 2n-(n-k) designs (of resolution at least IV) will be proposed. The paper provides for each design in any of the six categories: 1) the sequence of its runs in minimum number of factor level changes 2) the defining relation or its 2n-(n-k) alias structure and 3) the k independent generators needed for sequencing the 2n-(n-k) runs by the generalized foldover scheme. A comparison among these six categories of designs reveals that when the polynomial degree of the time trend increases from linear into quadratic and/or when the design’s resolution increases from III to IV, the number of factor level changes between the 2n-(n-k) runs increases. Also as the number of factors (i.e. n) increases, the design’s resolution decreases.展开更多
Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord ...Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans cannot.To analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus database.Gene ontology and protein-protein interaction networks were used to analyze the identified differentially expressed genes.Finally,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated neurons.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node connections.We also obtained the 10 hub genes with the highest correlation and the two modules with the highest score.The results showed that spectrin may promote axonal regeneration after spinal cord injury in zebrafish.Transforming growth factor beta signaling may inhibit repair after spinal cord injury in zebrafish.Focal adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in zebrafish.Bioinformatic analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals.展开更多
Nowadays with the improvement in the degree of emphasis on new energy, the wind power system has developed more and more rapidly over the world. Usually the wind plants are located in the remote areas which are far fr...Nowadays with the improvement in the degree of emphasis on new energy, the wind power system has developed more and more rapidly over the world. Usually the wind plants are located in the remote areas which are far from the load centers. Generally series compensated AC transmission and high voltage DC transmission are made use of to improve the transmission capacity as two main effective ways which can solve the problem of large scale wind power transmission. The paper describes the three kinds of impact varieties and impact mechanisms in the sub-synchronous oscillation phenomena of wind power system based on doubly fed induction generator (DFIG) wind generators. At last, we point out the important problem that should be stressed in the wind power system.展开更多
With the rapid and large-scale development of renewable energy, the lack of new energy power transportation or consumption, and the shortage of grid peak-shifting ability have become increasingly serious. Aiming to th...With the rapid and large-scale development of renewable energy, the lack of new energy power transportation or consumption, and the shortage of grid peak-shifting ability have become increasingly serious. Aiming to the severe wind power curtailment issue, the characteristics of interactive load are studied upon the traditional day-ahead dispatch model to mitigate the influence of wind power fluctuation. A multi-objective optimal dispatch model with the minimum operating cost and power losses is built. Optimal power flow distribution is available when both generation and demand side participate in the resource allocation. The quantum particle swarm optimization (QPSO) algorithm is applied to convert multi-objective optimization problem into single objective optimization problem. The simulation results of IEEE 30-bus system verify that the proposed method can effectively reduce the operating cost and grid loss simultaneously enhancing the consumption of wind power.展开更多
文摘Based on the traditional Human-Computer Interaction method which is mainly touch input system, the way of capturing the movement of people by using cameras is proposed. This is a convenient technique which can provide users more experience. In the article, a new way of detecting moving things is given on the basis of development of the image processing technique. The system architecture decides that the communication should be used between two different applications. After considered, named pipe is selected from many ways of communication to make sure that video is keeping in step with the movement from the analysis of the people moving. According to a large amount of data and principal knowledge, thinking of the need of actual project, a detailed system design and realization is finished. The system consists of three important modules: detecting of the people's movement, information transition between applications and video showing in step with people's movement. The article introduces the idea of each module and technique.
文摘Seismic oscillations of the “building-building” system which is interconnected buildings built close to each other, and “building-stack-like structure” system which is adjacent and connected in different ways to existing building are considered in the paper. Different types of connections, such as dampers, including the ones suggested by the authors, are studied. Seismic impact is given as a harmonic function and various existing accelerograms, including synthesized ones. Distinctive feature of this paper from previously published ones [1] [2] is the fact that the emphasis falls on the influence of soil-foundation interaction properties, which are described using various models of load-displacement connections. Calculation results are compared in the case of representation of the building as concentrated masses and spatial systems. Ways to reduce seismic response of buildings during the earthquakes are pointed out. Results of experimental studies are given in the paper and are compared with calculations.
基金supported by the National Nature Science Foundation of China,No.32101020(to JL)the Natural Science Foundation of Shandong Province,Nos.ZR2020MC071(to JL),ZR2023MH327(to HZ)+1 种基金the Integrated Project of Major Research Plan of National Natural Science Foundation of China,No.92249303(to PL)the Natural Science Foundation of Qingdao,No.23-2-1-193-zyyd-jch(to HZ)。
文摘The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding domains.Variants of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully understood.Research has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic spines.However,the function of CNKSR2 in the cytoplasm remains to be elucidated.In this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of CNKSR2.Through a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the centrosome.We also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker CEP290.Subsequent colocalization analysis confirmed the centrosomal localization of CNKSR2.When we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal genes.This manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and motility.Furthermore,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum disorder.Our findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.
文摘Our paper presents a project that involves two research questions: does the choice of a related problem by the tutorial system allow the problem solving process which is blocked for the student to be restarted? What information about learning do related problems returned by the system provide us? We answer the first question according to the didactic engineering, whose mode of validation is internal and based on the confrontation between an a priori analysis and an a posteriori analysis that relies on data from experiments in schools. We consider the student as a subject whose adaptation processes are conditioned by the problem and the possible interactions with the computer environment, and also by his knowledge, usually implicit, of the institutional norms that condition his relationship with geometry. Choosing a set of good problems within the system is therefore an essential element of the learning model. Since the source of a problem depends on the student’s actions with the computer tool, it is necessary to wait and see what are the related to problems that are returned to him before being able to identify patterns and assess the learning. With the simultaneity of collecting and analysing interactions in each class, we answer the second question according to a grounded theory analysis. By approaching the problems posed by the system and the designs in play at learning blockages, our analysis links the characteristics of problems to the design components in order to theorize on the decisional, epistemological, representational, didactic and instrumental aspects of the subject-milieu system in interaction.
基金Supported by the National Key Research and Development Plan(2016YFB1001200)the Natural Science Foundation of China(U1435220,61232013)Natural Science Research Projects of Universities in Jiangsu Province(16KJA520003)
文摘Biography videos based on life performances of prominent figures in history aim to describe great mens' life.In this paper,a novel interactive video summarization for biography video based on multimodal fusion is proposed,which is a novel approach of visualizing the specific features for biography video and interacting with video content by taking advantage of the ability of multimodality.In general,a story of movie progresses by dialogues of characters and the subtitles are produced with the basis on the dialogues which contains all the information related to the movie.In this paper,JGibbsLDA is applied to extract key words from subtitles because the biography video consists of different aspects to depict the characters' whole life.In terms of fusing keywords and key-frames,affinity propagation is adopted to calculate the similarity between each key-frame cluster and keywords.Through the method mentioned above,a video summarization is presented based on multimodal fusion which describes video content more completely.In order to reduce the time spent on searching the interest video content and get the relationship between main characters,a kind of map is adopted to visualize video content and interact with video summarization.An experiment is conducted to evaluate video summarization and the results demonstrate that this system can formally facilitate the exploration of video content while improving interaction and finding events of interest efficiently.
基金The National Natural Science Foundation of China(No.51875332)the Capacity Building Projects of Some Local Universities of Shanghai Science and Technology Commission(No.18040501600).
文摘To improve the human-physical-virtual coordination and integration of the digital twin workshop,3D visual monitoring and human-computer interaction of the digital twin workshop was studied.First,a novel 6D model of the 3D visualization interactive system for digital twin workshops is proposed.As the traditional 5D digital twin model ignores the importance of human-computer interaction,a new dimension of the user terminal was added.A hierarchical real-time data-driven mapping model for the workshop production process is then proposed.Moreover,a real-time data acquisition method for the industrial Internet of things is proposed based on OPC UA(object linking and embedding for process control unified architecture).Based on the 6D model of the system,the process of creating a 3D visualization virtual environment based on virtual reality is introduced,in addition to a data-driven process based on the data management cloud platform.Finally,the 6D model of the system was confirmed using the blade rotor test workshop as the object,and a 3D visualization interactive system is developed.The results show that the system is more transparent,real-time,data-driven and more efficient,as well as promotes the coordination and integration of human-physical-virtual,which has practical significance for developing digital twin workshops.
文摘In this paper, we conduct research on the new modern English teaching mode in higher vocational colleges based on multimediaand interactive system. Multimedia can make the local conditions and customs of English-speaking countries, culture, art and life phenomenon,along with beautiful music and authentic English explanation, in order to real natural life scenes, abstract, boring of the learning content, becomevivid language communication environment, easy to stimulate students’ learning motivation, arouse their strong desire for knowledge, andthe thirst for knowledge into sustainable self-need, internalized learning motivation. Learning motivation is directly promote the inner power ofstudents in learning activities as point and level directly affect students’ learning behavior and academic achievement. Establishment situation,stimulate students’ curiosity and it is an effective way of training students’ learning motivations. This paper combines the related theories topropose the new perspective of the issues that will be meaningful.
基金supported by the National Key Research&Development Program of China,No.2016YFC1301600Program for Jilin University Science and Technology Innovation Team,No.2017TD-12(both to YY)
文摘In recent years,a large number of differentially expressed genes have been identified in human umbilical cord mesenchymal stem cell(hUMSC)transplants for the treatment of ischemic cerebral infarction.These genes are involved in various biochemical processes,but the role of microRNAs(miRNAs)in this process is still unclear.From the Gene Expression Omnibus(GEO)database,we downloaded two microarray datasets for GSE78731(messenger RNA(mRNA)profile)and GSE97532(miRNA profile).The differentially expressed genes screened were compared between the hUMSC group and the middle cerebral artery occlusion group.Gene ontology enrichment and pathway enrichment analyses were subsequently conducted using the online Database for Annotation,Visualization,and Integrated Discovery.Identified genes were applied to perform weighted gene co-suppression analyses,to establish a weighted co-expression network model.Furthermore,the protein-protein interaction network for differentially expressed genes from turquoise modules was built using Cytoscape(version 3.40)and the most highly correlated subnetwork was extracted from the protein-protein interaction network using the MCODE plugin.The predicted target genes for differentially expressed miRNAs were also identified using the online database starBase v3.0.A total of 3698 differentially expressed genes were identified.Gene ontology analysis demonstrated that differentially expressed genes that are related to hUMSC treatment of ischemic cerebral infarction are involved in endocytosis and inflammatory responses.We identified 12 differentially expressed miRNAs in middle cerebral artery occlusion rats after hUMSC treatment,and these differentially expressed miRNAs were mainly involved in signaling in inflammatory pathways,such as in the regulation of neutrophil migration.In conclusion,we have identified a number of differentially expressed genes and differentially expressed mRNAs,miRNA-mRNAs,and signaling pathways involved in the hUMSC treatment of ischemic cerebral infarction.Bioinformatics and interaction analyses can provide novel clues for further research into hUMSC treatment of ischemic cerebral infarction.
文摘E-learning platforms support education systems worldwide, transferring theoretical knowledge as well as soft skills. In the present study high-school pupils’, and adult students’ opinions were evaluated through a modern structured MOODLE interactive course, designed for the needs of the laboratory course “Automotive Systems”. The study concerns Greek secondary vocational education pupils aged 18 and vocational training adult students aged 20 to 50 years. The multistage, equal size simple random cluster sample was used as a sampling method. Pupils and adult students of each cluster completed structured 10-question questionnaires both before and after attending the course. A total of 120 questionnaires were collected. In general, our findings disclosed that the majority of pupils and adult students had significantly improved their knowledge and skills from using MOODLE. They reported strengthening conventional teaching, using the new MOODLE technology. The satisfaction indices improved quite, with the differences in their mean values being statistically significant.
文摘In 2013, World-Universe Model (WUM) proposed a principally different way to solve the problem of Newtonian Constant of Gravitation measurement precision. WUM revealed a self-consistent set of time-varying values of Primary Cosmological parameters of the World: Gravitation parameter, Hubble’s parameter, Age of the World, Temperature of the Microwave Background Radiation, and the concentration of Intergalactic plasma. Based on the inter-connectivity of these parameters, WUM solved the Missing Baryon problem and predicted the values of the following Cosmological parameters: gravitation G, concentration of Intergalactic plasma, relative energy density of protons in the Medium, and the minimum energy of photons, which were experimentally confirmed in 2015-2018. Between 2013 and 2018, the relative standard uncertainty of G measurements decreased x6. The set of values obtained by WUM was recommended for consideration in CODATA Recommended Values of the Fundamental Physical Constants 2014.
文摘Taylor vortex flow between two concentric rotating cylinders with finite axial length includes various patterns of laminar and turbulent flows, and its behavior has attracted great interests. When mode bifurcation occurs, quantitative parameters such as the volume-averaged energy change rapidly. It is important to visualize the behaviors of vortices. In this study, a three-dimensional visualization system with respect to time is devised. This system can change the viewpoint of flow visualization, and we can observe the track of a vortex from any point. The volume-averaged energy is projected to the track of the center of a vortex. The proposed system can help to investigate the relationship between the mode bifurcation process and the volume-averaged energy.
文摘This brief review discusses the behavioral consequences of two pharmacologically selected lines of rats. Flinders Sensitive (FSL) and Flinders Resistant (FRL) Lines of rats were selected on the basis of differential hypothermic and behavioral responses to the anticholinesterase, diisopropylfluorophosphate (DFP). FSL rats are more sensitive to the hypothermic effects of cholinergic, serotonergic, and dopaminergic agonists but less sensitive to the locomotor or stereotypic effects of dopamine agonists. FSL rats exhibit greater immobility in the forced swim test and reduced social interaction compared with FRL rats, but do not differ in saccharin intake, behavior in the elevated plus maze, or responses for rewarding brain self-stimulation. The exaggerated immobility and reduced social interaction are counteracted by chronic treatment with antidepressants. Because FSL rats were more sensitive to 5-HT1A receptor agonists, high (HDS) and low (LDS) 8-OH-DPATsensitive lines were selectively bred for differential hypothermic responses to the 5-HT1A receptor agonist, 8-hydroxy-2-(di-N-propylamino)tetralin (8-OH-DPAT). HDS rats were also more sensitive to the hypothermic effects of oxotremorine, a cholinergic agonist, but selection for this response did not diverge with later selection. HDS rats exhibited greater immobility in the forced swim test than LDS rats and this correlated response could be seen early in selection (generation 3). HDS rats also showed reduced social interaction compared to LDS rats, but did not differ in behavior in the elevated plus maze. These findings confirm that selection for hypothermic responses to pharmacological agents do have behavioral consequences, notably the production of depressive-like phenotypes, which can be counteracted by chronic antidepressant treatment. Because increased 5-HT1A receptor sensitivity was common to both selected lines (FSL and HDS), neurobiological processes dependent on this receptor could contribute to the abnormal behaviors that manifest in these rat lines and thus suggesting a mechanism underlying depressive behaviors in humans. However, available human data are inconsistent with this hypothesis and suggest that other mechanisms underlie these behavioral abnormalities in HDS and FSL rats. These mechanisms as well as additional behavioral testing in these rat lines will be discussed.
文摘Multimedia Interactive Informative Systems (MIIS) are software applications resulting from the convergence of multiples technologies such as audiovisual, computing and communication. They aim to transmit information to a large, diverse and dispersed public. As with other mass media, the fulfillment of MIIS goals depends largely on the quality of communication between the system and end users. Therefore, those systems should be developed in order to ensure that this quality requirement is satisfied. If MIIS are constructed according to usual software engineering practices, the analysis discipline of the development process includes requirements identification and specification;however, these techniques are focused on functional requirements, and they do not give much importance to non-functional requirements. In this paper, we propose a development process based on the production of videogames which has two different phases: preproduction and production. The first phase, corresponding to requirements identification, derives into the concept of system. In order to translate this concept into a specification, we propose the use of new communicational attributes and a MIIS metamodel. The establishment of MIIS non-functional specification is the result of analyzing class diagrams through quality attributes. In order to evaluate if the specifications are responding to communicational attributes, a functional prototype is built and evaluated with end users. The proposed methodology is applied to a real case study.
文摘Six categories of systematic 2n-(n-k) designs derivable from the full 2k factorial experiment by the interactions-main effects assignment are available for carrying out 2n-(n-k) factorial experiments sequentially run after the other such that main effects are protected against the linear/quadratic time trend and/or such that the number of factor level changes (i.e. cost) between the runs is minimal. Three of these six categories are of resolution at least III and three are of resolution at least IV. The three categories of designs within each resolution are: 1) minimum cost 2n-(n-k) designs, 2) minimum cost linear trend free 2n-(n-k) designs and 3) minimum cost linear and quadratic trend free 2n-(n-k) designs. This paper characterizes these six categories and documents their differences with regard to either time trend resistance of factor effects and/or the number of factor level changes. The paper introduces the last category of systematic 2n-(n-k) designs (i.e. the sixth) for the purpose of extending the design resolution from III into IV and also for raising the level of protection of main effects from the linear time trend into the quadratic, where a catalog of minimum cost linear and quadratic trend free 2n-(n-k) designs (of resolution at least IV) will be proposed. The paper provides for each design in any of the six categories: 1) the sequence of its runs in minimum number of factor level changes 2) the defining relation or its 2n-(n-k) alias structure and 3) the k independent generators needed for sequencing the 2n-(n-k) runs by the generalized foldover scheme. A comparison among these six categories of designs reveals that when the polynomial degree of the time trend increases from linear into quadratic and/or when the design’s resolution increases from III to IV, the number of factor level changes between the 2n-(n-k) runs increases. Also as the number of factors (i.e. n) increases, the design’s resolution decreases.
基金supported by the State Key Program of National Natural Science Foundation of China,No.81330042(to SQF)the International Cooperation Program of the National Natural Science Foundation of China,No.81620108018(to SQF)
文摘Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans cannot.To analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus database.Gene ontology and protein-protein interaction networks were used to analyze the identified differentially expressed genes.Finally,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated neurons.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node connections.We also obtained the 10 hub genes with the highest correlation and the two modules with the highest score.The results showed that spectrin may promote axonal regeneration after spinal cord injury in zebrafish.Transforming growth factor beta signaling may inhibit repair after spinal cord injury in zebrafish.Focal adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in zebrafish.Bioinformatic analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals.
文摘Nowadays with the improvement in the degree of emphasis on new energy, the wind power system has developed more and more rapidly over the world. Usually the wind plants are located in the remote areas which are far from the load centers. Generally series compensated AC transmission and high voltage DC transmission are made use of to improve the transmission capacity as two main effective ways which can solve the problem of large scale wind power transmission. The paper describes the three kinds of impact varieties and impact mechanisms in the sub-synchronous oscillation phenomena of wind power system based on doubly fed induction generator (DFIG) wind generators. At last, we point out the important problem that should be stressed in the wind power system.
文摘With the rapid and large-scale development of renewable energy, the lack of new energy power transportation or consumption, and the shortage of grid peak-shifting ability have become increasingly serious. Aiming to the severe wind power curtailment issue, the characteristics of interactive load are studied upon the traditional day-ahead dispatch model to mitigate the influence of wind power fluctuation. A multi-objective optimal dispatch model with the minimum operating cost and power losses is built. Optimal power flow distribution is available when both generation and demand side participate in the resource allocation. The quantum particle swarm optimization (QPSO) algorithm is applied to convert multi-objective optimization problem into single objective optimization problem. The simulation results of IEEE 30-bus system verify that the proposed method can effectively reduce the operating cost and grid loss simultaneously enhancing the consumption of wind power.