Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rode...Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.展开更多
Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model ...Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.展开更多
The benefits of regular physical activity are well known.Yet,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary setting.To investigate the incorporat...The benefits of regular physical activity are well known.Yet,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary setting.To investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course material.These synchronous sessions were co-taught by a group fitness instructor and an anatomy instructor.The fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously covered.After the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental wellbeing.Thirty participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce stress.The majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social connectedness.Overall,medical students saw benefit in PA based interventions to supplement MSK course concepts.Along with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.展开更多
The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions gen...The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely ignored.In this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list optimization.Technically,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)relationships.Then,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar portraits.Finally,we propose to optimize the recommendation list to obtain different exercise suggestions.After analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity.展开更多
Evaluating and selecting players to suit football clubs and decision-makers (coaches, managers, technical, and medical staff) is a difficult process from a managerial-financial and sporting perspective. Football is a ...Evaluating and selecting players to suit football clubs and decision-makers (coaches, managers, technical, and medical staff) is a difficult process from a managerial-financial and sporting perspective. Football is a highly competitive sport where sponsors and fans are attracted by success. The most successful players, based on their characteristics (criteria and sub-criteria), can influence the outcome of a football game at any given time. Consequently, the D-day of selection should employ a more appropriate approach to human resource management. To effectively address this issue, a detailed study and analysis of the available literature are needed to assist practitioners and professionals in making decisions about football player selection and hiring. Peer-reviewed journals were selected for collecting published papers between 2018 and 2023. A total of 66 relevant articles (journal articles, conference articles, book sections, and review articles) were selected for evaluation and analysis. The purpose of the study is to present a systematic literature review (SLR) on how to solve this problem and organize the published research papers that answer our four research questions.展开更多
BACKGROUND Inflammatory bowel disease(IBD)may limit physical activity due to intestinal or extraintestinal manifestations,fatigue,or exercise perception.We sought to evaluate the influence of IBD diagnosis on exercise...BACKGROUND Inflammatory bowel disease(IBD)may limit physical activity due to intestinal or extraintestinal manifestations,fatigue,or exercise perception.We sought to evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.We compared patient-reported and parent-reported perspectives.AIM To evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.METHODS Consecutive IBD outpatients(aged 10-18 years)and their parents completed parallel voluntary surveys.A validated,patient-reported functional activity scale,the Hospital for Special Surgery Pediatric Functional Activity Brief Scale(HSS Pedi-FABS)was used to assess children’s activity levels.RESULTS There were 149 completed surveys(75%response rate)with mean participant age of 16.5 years[standard deviation(SD)=4.0]and mean age at IBD diagnosis of 11.8 years(SD=3.4).Most patients(77%)were diagnosed within 12 mo of symptom onset.Current athletic participation was reported in 65%across 65 sports.Participation was greatest before(40%)rather than after(32%)IBD diagnosis,with no reported change in 28%.IBD negatively impacted play/performance in 45%but did not change play/performance in 44%.IBD treatment improved patients’desire to exercise(70%)and subjective capacity for aerobic exercise(72%).Patients and parents agreed that IBD subjects demonstrate normal capacity for aerobic exercise(0.40,95%CI:0.22-0.58)and that treatment improved both participatory desire(0.33,95%CI:0.12-0.54)and capacity for aerobic exercise(0.52,95%CI:0.31-0.71).Almost all(99%)viewed exercise as healthy,and most encouraged its practice.IBD patients demonstrated normal mean HSS Pedi-FABS scores.CONCLUSION After pediatric IBD diagnosis,most patients continue exercise and sports,with mean activity levels comparable to American youth.Treatment positively impacts participatory desire and aerobic capacity.Patients favor the role of exercise in IBD.展开更多
Objective To explore the effects of exercise on dentate gyrus (DG) neurogenesis and the ability of learning and memory in hippocampus-lesioned adult rats. Methods Hippocampus lesion was produced by intrabippocampal ...Objective To explore the effects of exercise on dentate gyrus (DG) neurogenesis and the ability of learning and memory in hippocampus-lesioned adult rats. Methods Hippocampus lesion was produced by intrabippocampal microinjection of kainic acid (KA). Bromodeoxyuridine (BrdU) was used to label dividing cells. Y maze test was used to evaluate the ability of learning and memory. Exercise was conducted in the form of forced running in a motor-driven running wheel. The speed of wheel revolution was regulated at 3 kinds of intensity: lightly running, moderately running, or heavily running. Results Hippocampus lesion could increase the number of BrdU-labeled DG cells, moderately running after lesion could further enhance the number of BrdU-labeled cells and decrease the error number (EN) in Y maze test, while neither lightly running, nor heavily running had such effects. There was a negative correlation between the number of DG BrdU-labeled cells and the EN in the Y maze test after running. Conclusion Moderate exercise could enhance the DG neurogenesis and ameliorate the ability of learning and memory in hippocampus-lesioned rats.展开更多
The present study was designed to determine microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region in a rat model of middle cerebral artery occlusion. The rats were treated with ac...The present study was designed to determine microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region in a rat model of middle cerebral artery occlusion. The rats were treated with acupuncture at Baihui (GV 20), Qubin (GB 7), and Qianding (GV 21) points, in addition to exercise training. Results were compared with rats undergoing exercise training only. The Y-maze method and immunohistochemistry revealed decreased error frequency of passing through Y-maze, as well as significantly increased microtubule-associated protein-2 and synaptophysin expression, in the acupuncture with exercise training group compared with the model and exercise training groups after 5 weeks. Microtubule-associated protein-2 and synaptophysin expressions negatively correlated with error frequency of passing through the Y-maze. These results suggested that acupuncture combined with exercise training improved learning and memory functions in a rat model of cerebral infarction. The mechanisms of action were hypothesized to be associated with dendritic or synaptic plasticity in the ipsilateral hippocampal CA3 region.展开更多
Background: There is limited research on the association between opportunity cost of time and sports and exercise due to lack of data on opportunity cost of time. Using a sample of 14142 adults from Health Survey for ...Background: There is limited research on the association between opportunity cost of time and sports and exercise due to lack of data on opportunity cost of time. Using a sample of 14142 adults from Health Survey for England (2006), we develop and test a composite index of opportunity cost of time (to address the current issues with data constraint on opportunity cost of time) in order to explore the relationship between opportunity cost of time and sports participation. Methods: Probit regression models are fitted adjusting for a range of covariates. Opportunity cost of time is measured with two proxy measures: a) composite index (consisting of various indicators of wage earnings) constructed using principal component analysis;and b) education and employment, approach in the literature. We estimate the relative impact of the composite index compared with current proxy measures, on prediction of sports participation. Findings: Findings suggest that higher opportunity cost of time is associated with increased likelihood of sports participation, regardless of the time intensity of activity or the measure of opportunity cost of time used. The relative impacts of the two proxy measures are comparable. Sports and exercise was found to be positively correlated with income. Another important positive correlate of sports and exercise is participation in voluntary activity. The research and policy implications of our findings are discussed.展开更多
The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, rec...The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, recent evidence attests that neurotrophin receptor signalingmay have an important role, because the activation of this pathway leads to growth and differentiation of new neurons and synapses, supportsaxonal and dendritic growth, fosters synaptic plasticity, and preserves survival of existing neurons. In this review of published evidence, we highlightthat a positive relationship exists between physical exercise and circulating brain-derived neurotrophic factor levels and that the postexercisevariation of this molecule is associated with improvement of neurocognitive functioning. Less clear evidence has instead been published forother neurotrophins, such as nerve growth factor, neurotrophin-3, and neurotrophin-4. Overall, promotion of adequate volumes and intensities ofphysical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2—3 sessions/week lasting not less than 30 min)may hence be regarded as an inexpensive and safe strategy for boosting brain-derived neurotrophic factor release, thus preserving or restoringcognitive functions.展开更多
The differences of learning and memory between males and females have been well documented and confirmed by both human and animal studies. The sex differences in cognition started from early stage of neuronal developm...The differences of learning and memory between males and females have been well documented and confirmed by both human and animal studies. The sex differences in cognition started from early stage of neuronal development and last through entire lifespan. The major biological basis of the gender-dependent cognitive activity includes two major components: sex hormone and sex-related characteristics, such as sex- determining region of the Y chromosome (SRY) protein. However, the knowledge of how much biology of sex contributes to normal cogni- tive function and elite athletes in various sports are still pretty limited. In this review, we will be focusing on sex differences in spatial learning and memory -- especially the role of male- and female-type cognitive behaviors in sports.展开更多
Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical a...Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical ailments, such as cardiovascular diseases and diabetes.展开更多
Moderate exercise contributes to health, but excessive exercise may lead to physicalinjury or even endanger life. It is pressing for a device that can detect the intensity of exercise.Therefore, in order to enable rea...Moderate exercise contributes to health, but excessive exercise may lead to physicalinjury or even endanger life. It is pressing for a device that can detect the intensity of exercise.Therefore, in order to enable real-time detection of exercise intensity and mitigate the risks of harmfrom excessive exercise, a exercise intensity monitoring system based on the heart rate variability(HRV) from electrocardiogram (ECG) signal and linear features from phonocardiogram (PCG)signal is proposed. The main contributions include: First, accurate analysis of HRV is crucial forsubsequent exercise intensity detection. To enhance HRV analysis, we propose an R-peak detectorbased on encoder-decoder and temporal convolutional network (TCN). Experimental resultsdemonstrate that the proposed R-peak detector achieves an F1 score exceeding 0.99 on real high-intensity exercise ECG datasets. Second, an exercise fatigue monitoring system based on multi-signal feature fusion is proposed. Initially, utilizing the proposed R-peak detector for HRV extractionin exercise intensity detection,which outperforms traditional algorithms, with the system achieving a classification performance of 0.933 sensitivity, 0.802 specificity, and 0.960 accuracy. To further improve the system, we combine HRV with the linear features of PCG. Our exercise intensitydetection system achieves 90.2% specificity, 96.7% recall, and 98.1% accuracy in five-fold cross-validation.展开更多
Purpose:The aim of this study was to investigate the effects of flui replacement by water or sports drinks on serum heat shock protein 70(HSP70) levels and DNA damage during exercise at a high ambient temperature.M...Purpose:The aim of this study was to investigate the effects of flui replacement by water or sports drinks on serum heat shock protein 70(HSP70) levels and DNA damage during exercise at a high ambient temperature.Methods:Ten male college athletes with an athletic career ranging from 6 to 11 years were recruited from Yonsei University.The subjects ran on a treadmill at 75% of heart rate reserve during 4 different trials:thermoneutral temperature at 18℃(T),high ambient temperature at 32℃ without flui replacement(H),high ambient temperature at 32℃ with water replacement(HW),and high ambient temperature at 32℃ with sports drink replacement(HS).During each condition,blood samples were collected at the pre-exercise baseline(PEB),immediately after exercise(IAE),and60 min post-exercise.Results:Skin temperature significant y increased during exercise and was significant y higher in H compared to T and HS at IAE.Meanwhile,serum HSP70 was significant y increased in all conditions at IAE compared to PEB and was higher in H compared to T at the former time point.Significant y increased lymphocyte DNA damage(DNA in the tail,tail length,tail moment) was observed in all trials at IAE compared to PEB,and attenuated DNA damage(tail moment) was observed in HS compared to H at IAE.Conclusion:Acute exercise elevates serum HSP70 and induces lymphocyte DNA damage.Fluid replacement by sports drink during exercise at high ambient temperature can attenuate HSP response and DNA damage by preventing dehydration and reducing thermal stress.展开更多
Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT)...Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT) suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2'-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling.展开更多
Abstract: This study investigated the effects of three sport-specific high-intensity training units on cardiac biomarker alteration in elite athletes of dragon boating. Thirty six male (age 33 ± 9) and twenty ...Abstract: This study investigated the effects of three sport-specific high-intensity training units on cardiac biomarker alteration in elite athletes of dragon boating. Thirty six male (age 33 ± 9) and twenty nine female (age 31 ±8) elite athletes, members of the German national team, were examined in their final training camp preparing for world championship. At two time points blood panels (pre-training and one hour post-training) were collected and concentrations of high sensitive troponin T, N-terminal pro brain natriuretic peptide (NT-pro BNP), ereatine phosphokinase (CPK), MB-creatine kinase (CKMB) and myoglobin were assessed. After exercise, serum levels ofNT-pro BNP, CPK, myoglobin and CKMB increased significantly (P 〈 0.01 for each) with only few values exceeding the upper reference limits. High sensitive troponin T remained below the limit of detection both before and after exercise in all athletes. Significant gender-related differences were found with a higher increase ofNT-pro BNP levels in female athletes (P 〈 0.01) compared to males. In contrast, male athletes displayed a significant higher increase of CPK (P 〈 0.01) and myoglobin (P 〈 0.01) compared to female athletes. In conclusion, three high-intensity training units did not lead to elevated high sensitive troponin T concentrations in elite athletes of dragon boating but to significant increases ofNT-pro BNP, CPK and myoglobin levels. This suggests that high-intensity training units do not lead to a cardiac injury in these athletes.展开更多
Background Data-driven event analysis has gradually become the backbone of modern competitive sports analysis. Competitive sports data analysis tasks increasingly use computer vision and machine-learning models for in...Background Data-driven event analysis has gradually become the backbone of modern competitive sports analysis. Competitive sports data analysis tasks increasingly use computer vision and machine-learning models for intelligent data analysis. Existing sports visualization systems focus on the player–team data visualization, which is not intuitive enough for team season win–loss data and game time-series data visualization and neglects the prediction of all-star players. Methods This study used an interactive visualization system designed with parallel aggregated ordered hypergraph dynamic hypergraphs, Calliope visualization data story technology,and i Storyline narrative visualization technology to visualize the regular statistics and game time data of players and teams. NPIPVis includes dynamic hypergraphs of a team’s wins and losses and game plot narrative visualization components. In addition, an integrated learning-based all-star player prediction model, SRR-voting, which starts from the existing minority and majority samples, was proposed using the synthetic minority oversampling technique and Random Under Sampler methods to generate and eliminate samples of a certain size to balance the number of allstar and average players in the datasets. Next, a random forest algorithm was introduced to extract and construct the features of players and combined with the voting integrated model to predict the all-star players, using GridSearch CV, to optimize the hyperparameters of each model in integrated learning and then combined with five-fold cross-validation to improve the generalization ability of the model. Finally, the SHapley Additive ex Planations(SHAP) model was introduced to enhance the interpretability of the model. Results The experimental results of comparing the SRR-voting model with six common models show that the accuracy, F1-score, and recall metrics are significantly improved, which verifies the effectiveness and practicality of the SRR-voting model. Conclusions This study combines data visualization and machine learning to design a National Basketball Association data visualization system to help the general audience visualize game data and predict all-star players;this can also be extended to other sports events or related fields.展开更多
Since traditional English teaching method, which merely focuses on language teaching but ignores communicative competence, severely impedes the development of students' oral ability. It is high time that English t...Since traditional English teaching method, which merely focuses on language teaching but ignores communicative competence, severely impedes the development of students' oral ability. It is high time that English teachers took measures to find a workable and valuable teaching method which can improve students' speaking proficiency effectively. Learning community theory provides a broad space for this, for it regards learning as a process which takes place in a community where the learners are sharing their experience towards knowledge building in an interactive and cooperative way.展开更多
基金supported by the National Institutes of Health,Nos.AA025919,AA025919-03S1,and AA025919-05S1(all to RAF).
文摘Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s disease.Adult hippocampal neurogenesis is reduced in patients with Alzheimer’s disease.Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s disease.However,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly understood.Recently,regulator of G protein signaling 6(RGS6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in mice.Here,we generated novel RGS6fl/fl;APP_(SWE) mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse model.We found that voluntary running in APP_(SWE) mice restored their hippocampal cognitive impairments to that of control mice.This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal neurogenesis.Adult hippocampal neurogenesis was reduced in sedentary APP_(SWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells.RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGS6-expressing neurons.Thus,RGS6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(SWE) mice,identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.
基金supported by China Rehabilitation Research Center,No.2021zx-03the Special Fund for Joint Training of Doctoral Students between the University of Health and Rehabilitation Sciences and China Rehabilitation Research Center,No.2020 kfdx-008(both to TZ)。
文摘Exercise-with-melatonin therapy has complementary and synergistic effects on spinal cord injury and Alzheimer's disease,but its effect on stroke is still poorly understood.In this study,we established a rat model of ischemic stroke by occluding the middle cerebral artery for 60 minutes.We treated the rats with exercise and melatonin therapy for 7 consecutive days.Results showed that exercise-with-melatonin therapy significantly prolonged sleep duration in the model rats,increased delta power values,and regularized delta power rhythm.Additionally,exercise-with-melatonin therapy improved coordination,endurance,and grip strength,as well as learning and memory abilities.At the same time,it led to higher hippocampal CA1 neuron activity and postsynaptic density thickness and lower expression of glutamate receptor 2 than did exercise or melatonin therapy alone.These findings suggest that exercise-withmelatonin therapy can alleviate sleep disorder and motor dysfunction by increasing glutamate receptor 2 protein expression and regulating hippocampal CA1 synaptic plasticity.
文摘The benefits of regular physical activity are well known.Yet,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary setting.To investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(MSK)anatomy course material.These synchronous sessions were co-taught by a group fitness instructor and an anatomy instructor.The fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously covered.After the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving MSK anatomy knowledge,PA levels,and mental wellbeing.Thirty participants completed surveys;a majority agreed that the classes increased understanding of MSK concepts(90.0%)and activity levels(97.7%).Many(70.0%)felt that the classes helped reduce stress.The majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social connectedness.Overall,medical students saw benefit in PA based interventions to supplement MSK course concepts.Along with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.
基金supported by the Industrial Support Project of Gansu Colleges under Grant No.2022CYZC-11Gansu Natural Science Foundation Project under Grant No.21JR7RA114+1 种基金National Natural Science Foundation of China under Grants No.622760736,No.1762078,and No.61363058Northwest Normal University Teachers Research Capacity Promotion Plan under Grant No.NWNU-LKQN2019-2.
文摘The exercise recommendation system is emerging as a promising application in online learning scenarios,providing personalized recommendations to assist students with explicit learning directions.Existing solutions generally follow a collaborative filtering paradigm,while the implicit connections between students(exercises)have been largely ignored.In this study,we aim to propose an exercise recommendation paradigm that can reveal the latent connections between student-student(exercise-exercise).Specifically,a new framework was proposed,namely personalized exercise recommendation with student and exercise portraits(PERP).It consists of three sequential and interdependent modules:Collaborative student exercise graph(CSEG)construction,joint random walk,and recommendation list optimization.Technically,CSEG is created as a unified heterogeneous graph with students’response behaviors and student(exercise)relationships.Then,a joint random walk to take full advantage of the spectral properties of nearly uncoupled Markov chains is performed on CSEG,which allows for full exploration of both similar exercises that students have finished and connections between students(exercises)with similar portraits.Finally,we propose to optimize the recommendation list to obtain different exercise suggestions.After analyses of two public datasets,the results demonstrated that PERP can satisfy novelty,accuracy,and diversity.
文摘Evaluating and selecting players to suit football clubs and decision-makers (coaches, managers, technical, and medical staff) is a difficult process from a managerial-financial and sporting perspective. Football is a highly competitive sport where sponsors and fans are attracted by success. The most successful players, based on their characteristics (criteria and sub-criteria), can influence the outcome of a football game at any given time. Consequently, the D-day of selection should employ a more appropriate approach to human resource management. To effectively address this issue, a detailed study and analysis of the available literature are needed to assist practitioners and professionals in making decisions about football player selection and hiring. Peer-reviewed journals were selected for collecting published papers between 2018 and 2023. A total of 66 relevant articles (journal articles, conference articles, book sections, and review articles) were selected for evaluation and analysis. The purpose of the study is to present a systematic literature review (SLR) on how to solve this problem and organize the published research papers that answer our four research questions.
基金the National Institute of Health/National Institute of Diabetes and Digestive and Kidney Diseases,No.5P30DK34854
文摘BACKGROUND Inflammatory bowel disease(IBD)may limit physical activity due to intestinal or extraintestinal manifestations,fatigue,or exercise perception.We sought to evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.We compared patient-reported and parent-reported perspectives.AIM To evaluate the influence of IBD diagnosis on exercise and sports participation in a pediatric population.METHODS Consecutive IBD outpatients(aged 10-18 years)and their parents completed parallel voluntary surveys.A validated,patient-reported functional activity scale,the Hospital for Special Surgery Pediatric Functional Activity Brief Scale(HSS Pedi-FABS)was used to assess children’s activity levels.RESULTS There were 149 completed surveys(75%response rate)with mean participant age of 16.5 years[standard deviation(SD)=4.0]and mean age at IBD diagnosis of 11.8 years(SD=3.4).Most patients(77%)were diagnosed within 12 mo of symptom onset.Current athletic participation was reported in 65%across 65 sports.Participation was greatest before(40%)rather than after(32%)IBD diagnosis,with no reported change in 28%.IBD negatively impacted play/performance in 45%but did not change play/performance in 44%.IBD treatment improved patients’desire to exercise(70%)and subjective capacity for aerobic exercise(72%).Patients and parents agreed that IBD subjects demonstrate normal capacity for aerobic exercise(0.40,95%CI:0.22-0.58)and that treatment improved both participatory desire(0.33,95%CI:0.12-0.54)and capacity for aerobic exercise(0.52,95%CI:0.31-0.71).Almost all(99%)viewed exercise as healthy,and most encouraged its practice.IBD patients demonstrated normal mean HSS Pedi-FABS scores.CONCLUSION After pediatric IBD diagnosis,most patients continue exercise and sports,with mean activity levels comparable to American youth.Treatment positively impacts participatory desire and aerobic capacity.Patients favor the role of exercise in IBD.
文摘Objective To explore the effects of exercise on dentate gyrus (DG) neurogenesis and the ability of learning and memory in hippocampus-lesioned adult rats. Methods Hippocampus lesion was produced by intrabippocampal microinjection of kainic acid (KA). Bromodeoxyuridine (BrdU) was used to label dividing cells. Y maze test was used to evaluate the ability of learning and memory. Exercise was conducted in the form of forced running in a motor-driven running wheel. The speed of wheel revolution was regulated at 3 kinds of intensity: lightly running, moderately running, or heavily running. Results Hippocampus lesion could increase the number of BrdU-labeled DG cells, moderately running after lesion could further enhance the number of BrdU-labeled cells and decrease the error number (EN) in Y maze test, while neither lightly running, nor heavily running had such effects. There was a negative correlation between the number of DG BrdU-labeled cells and the EN in the Y maze test after running. Conclusion Moderate exercise could enhance the DG neurogenesis and ameliorate the ability of learning and memory in hippocampus-lesioned rats.
文摘The present study was designed to determine microtubule-associated protein-2 and synaptophysin expression in the hippocampal CA3 region in a rat model of middle cerebral artery occlusion. The rats were treated with acupuncture at Baihui (GV 20), Qubin (GB 7), and Qianding (GV 21) points, in addition to exercise training. Results were compared with rats undergoing exercise training only. The Y-maze method and immunohistochemistry revealed decreased error frequency of passing through Y-maze, as well as significantly increased microtubule-associated protein-2 and synaptophysin expression, in the acupuncture with exercise training group compared with the model and exercise training groups after 5 weeks. Microtubule-associated protein-2 and synaptophysin expressions negatively correlated with error frequency of passing through the Y-maze. These results suggested that acupuncture combined with exercise training improved learning and memory functions in a rat model of cerebral infarction. The mechanisms of action were hypothesized to be associated with dendritic or synaptic plasticity in the ipsilateral hippocampal CA3 region.
文摘Background: There is limited research on the association between opportunity cost of time and sports and exercise due to lack of data on opportunity cost of time. Using a sample of 14142 adults from Health Survey for England (2006), we develop and test a composite index of opportunity cost of time (to address the current issues with data constraint on opportunity cost of time) in order to explore the relationship between opportunity cost of time and sports participation. Methods: Probit regression models are fitted adjusting for a range of covariates. Opportunity cost of time is measured with two proxy measures: a) composite index (consisting of various indicators of wage earnings) constructed using principal component analysis;and b) education and employment, approach in the literature. We estimate the relative impact of the composite index compared with current proxy measures, on prediction of sports participation. Findings: Findings suggest that higher opportunity cost of time is associated with increased likelihood of sports participation, regardless of the time intensity of activity or the measure of opportunity cost of time used. The relative impacts of the two proxy measures are comparable. Sports and exercise was found to be positively correlated with income. Another important positive correlate of sports and exercise is participation in voluntary activity. The research and policy implications of our findings are discussed.
基金supported by a postdoctoral contract granted by Subprograma Atraccio de Talent-Contractes Postdoctorals de la Universitat de Valencia
文摘The many important benefits of physical exercise also encompass maintenance or improvement of cognitive functions. Among the variousmechanisms underlying the association between physical exercise and brain health, recent evidence attests that neurotrophin receptor signalingmay have an important role, because the activation of this pathway leads to growth and differentiation of new neurons and synapses, supportsaxonal and dendritic growth, fosters synaptic plasticity, and preserves survival of existing neurons. In this review of published evidence, we highlightthat a positive relationship exists between physical exercise and circulating brain-derived neurotrophic factor levels and that the postexercisevariation of this molecule is associated with improvement of neurocognitive functioning. Less clear evidence has instead been published forother neurotrophins, such as nerve growth factor, neurotrophin-3, and neurotrophin-4. Overall, promotion of adequate volumes and intensities ofphysical exercise (i.e., approximately 3 months of moderate-intensity aerobic exercise, with 2—3 sessions/week lasting not less than 30 min)may hence be regarded as an inexpensive and safe strategy for boosting brain-derived neurotrophic factor release, thus preserving or restoringcognitive functions.
基金supported by the American Health Assistance Foundation(G2006-118)the National Institutes of Health(R01AG032441-01 and R01AG025888)
文摘The differences of learning and memory between males and females have been well documented and confirmed by both human and animal studies. The sex differences in cognition started from early stage of neuronal development and last through entire lifespan. The major biological basis of the gender-dependent cognitive activity includes two major components: sex hormone and sex-related characteristics, such as sex- determining region of the Y chromosome (SRY) protein. However, the knowledge of how much biology of sex contributes to normal cogni- tive function and elite athletes in various sports are still pretty limited. In this review, we will be focusing on sex differences in spatial learning and memory -- especially the role of male- and female-type cognitive behaviors in sports.
文摘Exercise is a potent force of nature with significant potential for extending longevity and boosting physical fitness. It is also be- ing increasingly used as a prophylactic and curative measure for various physical ailments, such as cardiovascular diseases and diabetes.
基金the National Natural Science Foundation of China(No.62301056)the Fundamental Research Funds for Central Universities(No.2022QN005).
文摘Moderate exercise contributes to health, but excessive exercise may lead to physicalinjury or even endanger life. It is pressing for a device that can detect the intensity of exercise.Therefore, in order to enable real-time detection of exercise intensity and mitigate the risks of harmfrom excessive exercise, a exercise intensity monitoring system based on the heart rate variability(HRV) from electrocardiogram (ECG) signal and linear features from phonocardiogram (PCG)signal is proposed. The main contributions include: First, accurate analysis of HRV is crucial forsubsequent exercise intensity detection. To enhance HRV analysis, we propose an R-peak detectorbased on encoder-decoder and temporal convolutional network (TCN). Experimental resultsdemonstrate that the proposed R-peak detector achieves an F1 score exceeding 0.99 on real high-intensity exercise ECG datasets. Second, an exercise fatigue monitoring system based on multi-signal feature fusion is proposed. Initially, utilizing the proposed R-peak detector for HRV extractionin exercise intensity detection,which outperforms traditional algorithms, with the system achieving a classification performance of 0.933 sensitivity, 0.802 specificity, and 0.960 accuracy. To further improve the system, we combine HRV with the linear features of PCG. Our exercise intensitydetection system achieves 90.2% specificity, 96.7% recall, and 98.1% accuracy in five-fold cross-validation.
基金supported by the Dong-A University research fund
文摘Purpose:The aim of this study was to investigate the effects of flui replacement by water or sports drinks on serum heat shock protein 70(HSP70) levels and DNA damage during exercise at a high ambient temperature.Methods:Ten male college athletes with an athletic career ranging from 6 to 11 years were recruited from Yonsei University.The subjects ran on a treadmill at 75% of heart rate reserve during 4 different trials:thermoneutral temperature at 18℃(T),high ambient temperature at 32℃ without flui replacement(H),high ambient temperature at 32℃ with water replacement(HW),and high ambient temperature at 32℃ with sports drink replacement(HS).During each condition,blood samples were collected at the pre-exercise baseline(PEB),immediately after exercise(IAE),and60 min post-exercise.Results:Skin temperature significant y increased during exercise and was significant y higher in H compared to T and HS at IAE.Meanwhile,serum HSP70 was significant y increased in all conditions at IAE compared to PEB and was higher in H compared to T at the former time point.Significant y increased lymphocyte DNA damage(DNA in the tail,tail length,tail moment) was observed in all trials at IAE compared to PEB,and attenuated DNA damage(tail moment) was observed in HS compared to H at IAE.Conclusion:Acute exercise elevates serum HSP70 and induces lymphocyte DNA damage.Fluid replacement by sports drink during exercise at high ambient temperature can attenuate HSP response and DNA damage by preventing dehydration and reducing thermal stress.
基金Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited)the National Natural Science Foundation of China+1 种基金the Areas of Excellence (AoE) Scheme Established under the University Grants Committee of the Hong Kong and AoE Matching Fund from the University of Hong Kong, No. 21609101the Fundamental Research Funds for the Central Universities, No. 09ykpy25, 09ykpy31
文摘Intermediate level of stress is beneficial for brain functions, whereas extreme low level or high level of stress is deleterious. We have previously shown that chronic exposure to high doses of corticosterone (CORT) suppressed hippocampal plasticity and physical exercise in terms of running counteracted the detrimental effects of CORT treatment. We aimed to study whether a mild stress, that mimicked by a treatment with low CORT dose, improved hippocampal plasticity in terms of hippocampal cell proliferation and dendritic remodeling, and to examine whether running with CORT treatment showed an additive effect on improving hippocampal plasticity. The rats were treated with 20 mg/kg CORT for 14 days with or without running, followed by Morris water maze test or forced swim test. The hippocampal proliferating cells was labeled by intraperitoneal injection of 5-bromo-2'-deoxyuridine. The dendritic morphology was analyzed using Golgi staining method. Treatment with 20 mg/kg CORT alone yielded a higher number of hippocampal cell proliferation and significantly increased dendritic branching compared to vehicle-treated non-runners, but had no behavioral effects. In contrast, CORT treatment with running showed an additive increase in hippocampal cell proliferation and dendritic remodeling that was associated with improved spatial learning and decreased depression-like behavior; however, there was no additive improvement in behavior compared to vehicle-treated runners. These findings suggest that mild stress does not always cause detrimental effect on the brain, and combining mild stress with running could promote hippocampal plasticity via inducing cell proliferation and dendritic remodeling.
文摘Abstract: This study investigated the effects of three sport-specific high-intensity training units on cardiac biomarker alteration in elite athletes of dragon boating. Thirty six male (age 33 ± 9) and twenty nine female (age 31 ±8) elite athletes, members of the German national team, were examined in their final training camp preparing for world championship. At two time points blood panels (pre-training and one hour post-training) were collected and concentrations of high sensitive troponin T, N-terminal pro brain natriuretic peptide (NT-pro BNP), ereatine phosphokinase (CPK), MB-creatine kinase (CKMB) and myoglobin were assessed. After exercise, serum levels ofNT-pro BNP, CPK, myoglobin and CKMB increased significantly (P 〈 0.01 for each) with only few values exceeding the upper reference limits. High sensitive troponin T remained below the limit of detection both before and after exercise in all athletes. Significant gender-related differences were found with a higher increase ofNT-pro BNP levels in female athletes (P 〈 0.01) compared to males. In contrast, male athletes displayed a significant higher increase of CPK (P 〈 0.01) and myoglobin (P 〈 0.01) compared to female athletes. In conclusion, three high-intensity training units did not lead to elevated high sensitive troponin T concentrations in elite athletes of dragon boating but to significant increases ofNT-pro BNP, CPK and myoglobin levels. This suggests that high-intensity training units do not lead to a cardiac injury in these athletes.
基金Supported by the National Natural Science Foundation of China(61862018)the Subject of the Training Plan for Thousands of Young and Middle-aged Backbone Teachers in Guangxi Colleges and Universities(2020QGRW017)。
文摘Background Data-driven event analysis has gradually become the backbone of modern competitive sports analysis. Competitive sports data analysis tasks increasingly use computer vision and machine-learning models for intelligent data analysis. Existing sports visualization systems focus on the player–team data visualization, which is not intuitive enough for team season win–loss data and game time-series data visualization and neglects the prediction of all-star players. Methods This study used an interactive visualization system designed with parallel aggregated ordered hypergraph dynamic hypergraphs, Calliope visualization data story technology,and i Storyline narrative visualization technology to visualize the regular statistics and game time data of players and teams. NPIPVis includes dynamic hypergraphs of a team’s wins and losses and game plot narrative visualization components. In addition, an integrated learning-based all-star player prediction model, SRR-voting, which starts from the existing minority and majority samples, was proposed using the synthetic minority oversampling technique and Random Under Sampler methods to generate and eliminate samples of a certain size to balance the number of allstar and average players in the datasets. Next, a random forest algorithm was introduced to extract and construct the features of players and combined with the voting integrated model to predict the all-star players, using GridSearch CV, to optimize the hyperparameters of each model in integrated learning and then combined with five-fold cross-validation to improve the generalization ability of the model. Finally, the SHapley Additive ex Planations(SHAP) model was introduced to enhance the interpretability of the model. Results The experimental results of comparing the SRR-voting model with six common models show that the accuracy, F1-score, and recall metrics are significantly improved, which verifies the effectiveness and practicality of the SRR-voting model. Conclusions This study combines data visualization and machine learning to design a National Basketball Association data visualization system to help the general audience visualize game data and predict all-star players;this can also be extended to other sports events or related fields.
文摘Since traditional English teaching method, which merely focuses on language teaching but ignores communicative competence, severely impedes the development of students' oral ability. It is high time that English teachers took measures to find a workable and valuable teaching method which can improve students' speaking proficiency effectively. Learning community theory provides a broad space for this, for it regards learning as a process which takes place in a community where the learners are sharing their experience towards knowledge building in an interactive and cooperative way.