Yarn sensors have shown promising application prospects in wearable electronics owing to their shape adaptability, good flexibility, and weavability. However, it is still a critical challenge to develop simultaneously...Yarn sensors have shown promising application prospects in wearable electronics owing to their shape adaptability, good flexibility, and weavability. However, it is still a critical challenge to develop simultaneously structure stable, fast response, body conformal, mechanical robust yarn sensor using full microfibers in an industrial-scalable manner. Herein, a full-fiber auxetic-interlaced yarn sensor(AIYS) with negative Poisson’s ratio is designed and fabricated using a continuous, mass-producible, structure-programmable, and low-cost spinning technology. Based on the unique microfiber interlaced architecture, AIYS simultaneously achieves a Poisson’s ratio of-1.5, a robust mechanical property(0.6 c N/dtex), and a fast train-resistance responsiveness(0.025 s), which enhances conformality with the human body and quickly transduce human joint bending and/or stretching into electrical signals. Moreover, AIYS shows good flexibility, washability, weavability, and high repeatability. Furtherly, with the AIYS array, an ultrafast full-letter sign-language translation glove is developed using artificial neural network. The sign-language translation glove achieves an accuracy of 99.8% for all letters of the English alphabet within a short time of 0.25 s. Furthermore, owing to excellent full letter-recognition ability, real-time translation of daily dialogues and complex sentences is also demonstrated. The smart glove exhibits a remarkable potential in eliminating the communication barriers between signers and non-signers.展开更多
For a characteristic c-ray with interlaced overlap peak, and the case where its reliable and credible net count cannot be obtained using the current high-purity germanium(HPGe) multichannel γ-ray spectrum software, t...For a characteristic c-ray with interlaced overlap peak, and the case where its reliable and credible net count cannot be obtained using the current high-purity germanium(HPGe) multichannel γ-ray spectrum software, two new methods are proposed herein to obtain the γ-ray net peak count from the interlaced overlap peak in the HPGe cray spectrometer system, of which one is the symmetric conversion method based on Gaussian distribution and the other is where the energy average value of two close γ-rays is regarded as the γ-ray energy. The experimental results indicate that the two methods mentioned above are reliable and credible. This study is significant for the development of better γ-ray spectrum processing software for measuring complex γ-ray spectra concerning the nuclear reaction cross section, neutron activation analysis, and analysis of transuranium elements, using an HPGe detector.展开更多
An innovative perforation method of interlaced fixed perforation was put forward based on the analysis of the characteristics of fractures in various periods of perforation and conventional perforation modes.By conduc...An innovative perforation method of interlaced fixed perforation was put forward based on the analysis of the characteristics of fractures in various periods of perforation and conventional perforation modes.By conducting a large-scale perforation shooting experiments,we investigated the morphology,propagation mechanism and propagation law of the near-wellbore fractures generated during perforating processes under different fixed angle and interlaced angle combinations,and discussed the control method of near-wellbore fractures in different types of unconventional oil and gas reservoirs.The experimental results show that:(1)The interlaced fixed perforation strengthens the connectivity between the perforation tunnels not only in the same fixed plane but also in adjacent fixed planes,making it likely to form near-wellbore connected fractures which propagate in order.(2)Three kinds of micro-fractures will come up around the perforation tunnel during perforation,namely typeⅠradial micro-fracture,typeⅡoblique micro-fracture and typeⅢdivergent micro-fracture at the perforation tip,which are interconnected into complex near-wellbore fracture system.(3)Different types of perforation bullets under different combinations of fixed angles and interlaced angles result in different shapes of near-wellbore fractures propagating in different patterns.(4)By using the interlaced perforation on fixed planes,arranging fixed planes according to the spiral mode or the continuous"zigzag"shape,the desired near-wellbore fractures can be obtained,which is conducive to the manual control of main fractures in the fracturing of unconventional or complex conventional reservoirs.展开更多
In this study,a compact 2×2 interlaced sequentially rotated dual-polarized dielectric-resonator antenna array is proposed for 5.8 GHz applications.The array is composed of a novel unit elements that are made of r...In this study,a compact 2×2 interlaced sequentially rotated dual-polarized dielectric-resonator antenna array is proposed for 5.8 GHz applications.The array is composed of a novel unit elements that are made of rectangular dielectric resonator(RDR)coupled to an eye slot for generating the orthogonal modes,TEδx 21 and TE1yδ1 to acquire circular polarization(CP)radiation.For the purpose of miniaturization and achieving dual polarized resonance,the array is fed by two interlaced ports and each port excites two radiating elements.The first port feeds horizontal elements to obtain left hand circular polarization(LHCP).The second port feeds vertical elements to obtain right hand circular polarization(RHCP).A quarter-wave length transformer is employed to reduce the attenuation and consequently increase the array gain performance.The 35×35 mm2(0.676λ0×0.676λ0)gains were 8.4 and 8.2 dBi for port 1 and port 2,respectively,with port isolations of−33.51 dB.The design achieves a voltage standing-wave ratio(VSWR)<−10 dB and an axial ratio(AR)<−3 dB bandwidth of 2.48%(5.766 to 5.911 GHz)for LHCP at port 1 and a VSWR<−10 dB and AR<−3 dB bandwidth of 2.28%(5.788 to 5.922 GHz)for RHCP at port 2.The findings of the proposed design validate its use for ISM band applications.展开更多
The purpose of this study is to demonstrate MCF-7 cells’ dependence on calcium for growth and to exploit that dependence to improve chemotherapy efficacy. Fura-2 fluorescence imaging shows that MCF-7 cells maintain a...The purpose of this study is to demonstrate MCF-7 cells’ dependence on calcium for growth and to exploit that dependence to improve chemotherapy efficacy. Fura-2 fluorescence imaging shows that MCF-7 cells maintain a higher basal intracellular calcium concentration than non-tumorigenic MCF-10A cells. Blocking T-type calcium channels with mibefradil reduced MCF-7 intracellular calcium concentration. Flow cytometry shows that knocking down T-type calcium channel expression with siRNA caused an increase in MCF-7 cells in G1 phase and a decrease in cells in S phase. Proliferation assays of MCF-7 cells treated with EGTA and thapsigargin reveal the dependence of MCF-7 cell growth on extracellular and intracellular calcium sources, respectively. In vitro, interlaced treatment that alternated the T-type calcium channel blocker NNC-55-0396 with paclitaxel more effectively reduced MCF-7 cell number than chemotherapy alone. In a mouse in vivo model, interlaced mibefradil and paclitaxel more effectively reduced MCF-7 xenograft size than chemotherapy alone. These findings indicate that MCF-7 cells are dependent on calcium for proliferation, particularly in passing the G1/S cell cycle checkpoint. Further, this dependence on calcium can be exploited by alternating treatment with T-type calcium channel blockers with paclitaxel in an interlaced therapy scheme that increases the efficacy of the chemotherapy.展开更多
In this work, we make a representation of non-relativistic quantum theory based on foundations of paraconsistent annotated logic (PAL), a propositional and evidential logic with an associated lattice FOUR. We use the ...In this work, we make a representation of non-relativistic quantum theory based on foundations of paraconsistent annotated logic (PAL), a propositional and evidential logic with an associated lattice FOUR. We use the PAL version with annotation of two values (PAL2v), named paraquantum logic (PQL), where the evidence signals are normalized values and the intensities of the inconsistencies are represented by degrees of contradiction. Quantum mechanics is represented through mapping on the interlaced bilattices where this logical formalization allows annotation of two values in the format of degrees of evidence of probability. The Bernoulli probability distribution is used to establish probabilistic logical states that identify the superposition of states and quantum entanglement with the equations and determine the state vectors located inside the interlaced Bilattice. In the proposed logical probabilistic paraquantum logic model (pPQL Model), we introduce the operation of logical conflation into interlaced bilattice. We verify that in the pPQL Model, the operation of logical conflation is responsible for providing a suitable model for various phenomena of quantum mechanics, mainly the quantum entanglement. The results obtained from the entanglement equations demonstrate the formalization and completeness of paraquantum logic that allows for interpretations of similar phenomena of quantum mechanics, including EPR paradox and the wave-particle theory.展开更多
In architecture,interlace structural concept is considered as a new design approach for cosmopolitan cities with high density to minimize the land use and increase the interaction.With various architectural approach,l...In architecture,interlace structural concept is considered as a new design approach for cosmopolitan cities with high density to minimize the land use and increase the interaction.With various architectural approach,land resources can be minimized by this interlace concept for residential complexes.Such buildings will eliminate the reduction of land resource problem and on the other side safety measures in structural design is incorporated by interlace concept of buildings.This new concept can be constructed steel or reinforced concrete.In this paper,an analytical approach has been presented for these buildings in architecture and structural design.In the research,design considerations were taken for interlaced structures with reinforced concrete and steel.Components of steel structure,isolated footing,and columns.This paper is presenting a step wise process for interlaced structures.They are identification of project area,layout and model preparation,analysis and design of concrete interlaced structure,analysis and design of steel interlaced structure,drafting of the plans and costing and estimation of the structures.Comparison of both reinforced concrete and steel structures were carried out.The main aim of the paper is to provide a comparison between steel and concrete interlaced structure.A cost estimation was carried out to determine optimum design and construction for interlaced structures.展开更多
Aimed at low accuracy of attitude determination because of using low-cost components which may result in non-linearity in integrated attitude determination systems, a novel attitude determination algorithm using vecto...Aimed at low accuracy of attitude determination because of using low-cost components which may result in non-linearity in integrated attitude determination systems, a novel attitude determination algorithm using vector observations and gyro measurements is presented. The various features of the unscented Kalman filter (UKF) and optimal-REQUEST (quaternion estimator) algorithms are introduced for attitude determination. An interlaced filtering method is presented for the attitude determination of nano-spacecraft by setting the quaternion as the attitude representation, using the UKF and optimal-REQUEST to estimate the gyro drifts and the quaternion, respectively. The optimal-REQUEST and UKF are not isolated from each other. When the optimal-REQUEST algorithm estimates the attitude quaternion, the gyro drifts are estimated by the UKF algorithm synchronously by using the estimated attitude quaternion. Furthermore, the speed of attitude determination is improved by setting the state dimension to three. Experimental results show that the presented method has higher performance in attitude determination compared to the UKF algorithm and the traditional interlaced filtering method and can estimate the gyro drifts quickly.展开更多
This paper presents a low-power small-area digitally controlled oscillator (DCO) using an inverters interlaced cascaded delay cell (IICDC). It uses a coarse-fine architecture with binary-weighted delay stages for ...This paper presents a low-power small-area digitally controlled oscillator (DCO) using an inverters interlaced cascaded delay cell (IICDC). It uses a coarse-fine architecture with binary-weighted delay stages for the delay range and resolution. The coarse-tuning stage of the DCO uses IICDC, which is power and area efficient with low phase noise, as compared with conventional delay cells. The ADPLL with a DCO is fabricated in the UMC 180-nm CMOS process with an active area of 0.071 mm2. The output frequency range is 140-600 MHz at the power supply of 1.8 V. The power consumption is 2.34 mW@ a 200 MHz output.展开更多
Based on the sequence of a novel expressed sequence tag (EST), the full-length cDNA of 1 017 nucleotides was cloned from Brassica napus cv. Xiangyou 15 through rapid amplification of cDNA ends (RACE). The gene was...Based on the sequence of a novel expressed sequence tag (EST), the full-length cDNA of 1 017 nucleotides was cloned from Brassica napus cv. Xiangyou 15 through rapid amplification of cDNA ends (RACE). The gene was designated as Bnhol34 (HQ585980), encoding a protein of 338 amino acids. BLAST analysis showed no high degree of sequence identity to any known gene. The calculated molecular weight of the Bnhol34 protein was 36.23 kDa, and the theoretical isoelectric point was 8.74. The Bnhol34 was also cloned from a high oleic acid mutant 854-1 through homologous cloning. There was no difference between the two Bnhol34 genes. Bnhol34 was localized in a tissue-specific manner in B. napus, and its expression level was about eight-fold greater in Xiangyou 15 seeds than in 854-1. The promoter region sequences of Bnhol34 were then isolated from Xiangyou 15 and 854-1, and a 93-bp deletion was found to occur in the Bnhol34 promoter region of 854-1. Three abscisic acid-responsive cis-elements (ABRE) were identified in the promoter region of Xiangyou 15. Real-time PCR analyses revealed that exogenous abscisic acid increased Bnhol34 expression by about four-fold in Xiangyou 15 seeds, yet did not change Bnhol34 expression in 854-1. It appeared that Bnhol34 might be abscisic acid insensitive in 854-1.展开更多
Wind and Window Flower is a special metaphorical love poem by Robert Frost. This tale of love actually presents a love journey of temptation, excitement, and disappointment. This paper tries to analysis the poem from ...Wind and Window Flower is a special metaphorical love poem by Robert Frost. This tale of love actually presents a love journey of temptation, excitement, and disappointment. This paper tries to analysis the poem from the perspective of the sound of the poetry, the metro and rhyme, the conceptual and rhetorical.展开更多
A novel silicon-on-insulator(SOI) high breakdown voltage(BV) power device with interlaced dielectric trenches(IDT) and N/P pillars is proposed. In the studied structure, the drift region is folded by IDT embedde...A novel silicon-on-insulator(SOI) high breakdown voltage(BV) power device with interlaced dielectric trenches(IDT) and N/P pillars is proposed. In the studied structure, the drift region is folded by IDT embedded in the active layer,which results in an increase of length of ionization integral remarkably. The crowding phenomenon of electric field in the corner of IDT is relieved by the N/P pillars. Both traits improve two key factors of BV, the ionization integral length and electric field magnitude, and thus BV is significantly enhanced. The electric field in the dielectric layer is enhanced and a major portion of bias is borne by the oxide layer due to the accumulation of inverse charges(holes) at the corner of IDT.The average value of the lateral electric field of the proposed device reaches 60 V/μm with a 10 μm drift length, which increases by 200% in comparison to the conventional SOI LDMOS, resulting in a breakdown voltage of 607 V.展开更多
An elastic gridshell is an efficient constructive typology for crossing large spans with little material.A flat elastic grid is built before buckling the structure into shape,in active and post-formed bending.The desi...An elastic gridshell is an efficient constructive typology for crossing large spans with little material.A flat elastic grid is built before buckling the structure into shape,in active and post-formed bending.The design and structural analysis of such a structure requires a stage of form finding that can mainly be done:(1)With a physical model:either by a suspended net method,or an active bending model;(2)With a numerical model performed by dynamic relaxation.All these solutions have various biases and assumptions that make them reflect more or less the reality.These three methods have been applied by Happold and Liddell[1]during the design of the Frei Otto’s Mannheim Gridshell which has allowed us to compare the results,and to highlight the significant differences between digital and physical models.Based on our own algorithm called ELASTICA[2],our study focuses on:(1)Comparing the results of the ELASTICA’s numerical models to load tests on physical models;(2)The identification of the various factors that can influence the results and explain the observed differences,some of which are then studied;(3)Applying the results to build a full-scale interlaced lattice elastic gridshell based on the Japanese Kagome pattern.展开更多
According to the misfitting dislocation theory,a method of theoretical calculation was devel- oped for the specific energy of the semicoherent interface between microalloy carbonitrides and austenite matrix.The calcul...According to the misfitting dislocation theory,a method of theoretical calculation was devel- oped for the specific energy of the semicoherent interface between microalloy carbonitrides and austenite matrix.The calculating formulae were derived and the results were satisfactorily applied on the research works.展开更多
Cone-beam computed tornography (CBCT) has the notable features of high efficiency and high precision, and is widely used in areas such as medical imaging and industrial non-destructive testing. However, the presence...Cone-beam computed tornography (CBCT) has the notable features of high efficiency and high precision, and is widely used in areas such as medical imaging and industrial non-destructive testing. However, the presence of the ray scatter reduces the quality of CT images. By referencing the slit collimation approach, a scatter correction method for CBCT based on the interlacing-slit scan is proposed. Firstly, according to the characteristics of CBCT imaging, a scatter suppression plate with interlacing slits is designed and fabricated. Then the imaging of the scatter suppression plate is analyzed, and a scatter correction Calculation method for CBCT based on the image fusion is proposed, which can splice out a complete set of scatter suppression projection images according to the interlacing-slit projection images of the left and the right imaging regions in the scatter suppression plate, and simultaneously complete the scatter correction within the fiat panel detector (FPD). Finally, the overall process of scatter suppression and correction is provided. The experimental results show that this method can significantly improve the clarity of the slice images and achieve a good scatter correction.展开更多
Three series of CeO2/CuO samples were prepared by impregnation method and characterized by XRD, N2 adsorption-desorption, temperatureprogrammed reduction (TPR), XPS and TEM techniques. In comparison with the samples...Three series of CeO2/CuO samples were prepared by impregnation method and characterized by XRD, N2 adsorption-desorption, temperatureprogrammed reduction (TPR), XPS and TEM techniques. In comparison with the samples prepared with CuO as initial support, the samples with Cu(OH)2 as initial support have higher reducibilities and smaller relative TPR peak areas, and also larger specific surface areas at calcina- tion temperatures of 400 ℃--600 ℃. As a result, Cu(OH)2 is better than CuO as initial support for preferential oxidation of CO in excess H2 (CO-PROX). The best catalytic performance was achieved on the sample calcined at 600 ℃ and with an atomic ratio of Ce/Cu at 40%. XPS analyses indicate that more interface linkages Ce-O-Cu could be formed when it was calcined at 600 ℃. And the atomic ratio of Ce/Cu at 40% led to a proper reducibility for the sample as illustrated by the TPR measurements.展开更多
In this article,we consider a discrete right-definite Sturm-Liouville problems with two squared eigenparameter-dependent boundary conditions.By constructing some new Lagrange-type identities and two fundamental functi...In this article,we consider a discrete right-definite Sturm-Liouville problems with two squared eigenparameter-dependent boundary conditions.By constructing some new Lagrange-type identities and two fundamental functions,we obtain not only the existence,the simplicity,and the interlacing properties of the real eigenvalues,but also the oscillation properties,orthogonality of the eigenfunctions,and the expansion theorem.Finally,we also give a computation scheme for computing eigenvalues and eigenfunctions of specific eigenvalue problems.展开更多
Multiple complex networks, each with different properties and mutually fused, have the problems that the evolving process is time varying and non-equilibrium, network structures are layered and interlacing, and evolvi...Multiple complex networks, each with different properties and mutually fused, have the problems that the evolving process is time varying and non-equilibrium, network structures are layered and interlacing, and evolving characteristics are difficult to be measured. On that account, a dynamic evolving model of complex network with fusion nodes and overlap edges(CNFNOEs) is proposed. Firstly, we define some related concepts of CNFNOEs, and analyze the conversion process of fusion relationship and hierarchy relationship. According to the property difference of various nodes and edges, fusion nodes and overlap edges are subsequently split, and then the CNFNOEs is transformed to interlacing layered complex networks(ILCN). Secondly,the node degree saturation and attraction factors are defined. On that basis, the evolution algorithm and the local world evolution model for ILCN are put forward. Moreover, four typical situations of nodes evolution are discussed, and the degree distribution law during evolution is analyzed by means of the mean field method.Numerical simulation results show that nodes unreached degree saturation follow the exponential distribution with an error of no more than 6%; nodes reached degree saturation follow the distribution of their connection capacities with an error of no more than 3%; network weaving coefficients have a positive correlation with the highest probability of new node and initial number of connected edges. The results have verified the feasibility and effectiveness of the model, which provides a new idea and method for exploring CNFNOE's evolving process and law. Also, the model has good application prospects in structure and dynamics research of transportation network, communication network, social contact network,etc.展开更多
基金supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (NRF-2020R1A2C3003344 and NRF-2020R1A4A2002728)
文摘Yarn sensors have shown promising application prospects in wearable electronics owing to their shape adaptability, good flexibility, and weavability. However, it is still a critical challenge to develop simultaneously structure stable, fast response, body conformal, mechanical robust yarn sensor using full microfibers in an industrial-scalable manner. Herein, a full-fiber auxetic-interlaced yarn sensor(AIYS) with negative Poisson’s ratio is designed and fabricated using a continuous, mass-producible, structure-programmable, and low-cost spinning technology. Based on the unique microfiber interlaced architecture, AIYS simultaneously achieves a Poisson’s ratio of-1.5, a robust mechanical property(0.6 c N/dtex), and a fast train-resistance responsiveness(0.025 s), which enhances conformality with the human body and quickly transduce human joint bending and/or stretching into electrical signals. Moreover, AIYS shows good flexibility, washability, weavability, and high repeatability. Furtherly, with the AIYS array, an ultrafast full-letter sign-language translation glove is developed using artificial neural network. The sign-language translation glove achieves an accuracy of 99.8% for all letters of the English alphabet within a short time of 0.25 s. Furthermore, owing to excellent full letter-recognition ability, real-time translation of daily dialogues and complex sentences is also demonstrated. The smart glove exhibits a remarkable potential in eliminating the communication barriers between signers and non-signers.
基金supported by the National Natural Science Foundation of China(Nos.11575090,11605099)the Young Key Teachers Training Program of He’nan Higher Education in China(No.2015GGJS-258)
文摘For a characteristic c-ray with interlaced overlap peak, and the case where its reliable and credible net count cannot be obtained using the current high-purity germanium(HPGe) multichannel γ-ray spectrum software, two new methods are proposed herein to obtain the γ-ray net peak count from the interlaced overlap peak in the HPGe cray spectrometer system, of which one is the symmetric conversion method based on Gaussian distribution and the other is where the energy average value of two close γ-rays is regarded as the γ-ray energy. The experimental results indicate that the two methods mentioned above are reliable and credible. This study is significant for the development of better γ-ray spectrum processing software for measuring complex γ-ray spectra concerning the nuclear reaction cross section, neutron activation analysis, and analysis of transuranium elements, using an HPGe detector.
基金Supported by the China National Science and Technology Major Project(2017ZX05009-003).
文摘An innovative perforation method of interlaced fixed perforation was put forward based on the analysis of the characteristics of fractures in various periods of perforation and conventional perforation modes.By conducting a large-scale perforation shooting experiments,we investigated the morphology,propagation mechanism and propagation law of the near-wellbore fractures generated during perforating processes under different fixed angle and interlaced angle combinations,and discussed the control method of near-wellbore fractures in different types of unconventional oil and gas reservoirs.The experimental results show that:(1)The interlaced fixed perforation strengthens the connectivity between the perforation tunnels not only in the same fixed plane but also in adjacent fixed planes,making it likely to form near-wellbore connected fractures which propagate in order.(2)Three kinds of micro-fractures will come up around the perforation tunnel during perforation,namely typeⅠradial micro-fracture,typeⅡoblique micro-fracture and typeⅢdivergent micro-fracture at the perforation tip,which are interconnected into complex near-wellbore fracture system.(3)Different types of perforation bullets under different combinations of fixed angles and interlaced angles result in different shapes of near-wellbore fractures propagating in different patterns.(4)By using the interlaced perforation on fixed planes,arranging fixed planes according to the spiral mode or the continuous"zigzag"shape,the desired near-wellbore fractures can be obtained,which is conducive to the manual control of main fractures in the fracturing of unconventional or complex conventional reservoirs.
基金The author would like to thank the Deanship of Scientific Research at Majmaah University for supporting this work under Project Number R-2022-71.
文摘In this study,a compact 2×2 interlaced sequentially rotated dual-polarized dielectric-resonator antenna array is proposed for 5.8 GHz applications.The array is composed of a novel unit elements that are made of rectangular dielectric resonator(RDR)coupled to an eye slot for generating the orthogonal modes,TEδx 21 and TE1yδ1 to acquire circular polarization(CP)radiation.For the purpose of miniaturization and achieving dual polarized resonance,the array is fed by two interlaced ports and each port excites two radiating elements.The first port feeds horizontal elements to obtain left hand circular polarization(LHCP).The second port feeds vertical elements to obtain right hand circular polarization(RHCP).A quarter-wave length transformer is employed to reduce the attenuation and consequently increase the array gain performance.The 35×35 mm2(0.676λ0×0.676λ0)gains were 8.4 and 8.2 dBi for port 1 and port 2,respectively,with port isolations of−33.51 dB.The design achieves a voltage standing-wave ratio(VSWR)<−10 dB and an axial ratio(AR)<−3 dB bandwidth of 2.48%(5.766 to 5.911 GHz)for LHCP at port 1 and a VSWR<−10 dB and AR<−3 dB bandwidth of 2.28%(5.788 to 5.922 GHz)for RHCP at port 2.The findings of the proposed design validate its use for ISM band applications.
文摘The purpose of this study is to demonstrate MCF-7 cells’ dependence on calcium for growth and to exploit that dependence to improve chemotherapy efficacy. Fura-2 fluorescence imaging shows that MCF-7 cells maintain a higher basal intracellular calcium concentration than non-tumorigenic MCF-10A cells. Blocking T-type calcium channels with mibefradil reduced MCF-7 intracellular calcium concentration. Flow cytometry shows that knocking down T-type calcium channel expression with siRNA caused an increase in MCF-7 cells in G1 phase and a decrease in cells in S phase. Proliferation assays of MCF-7 cells treated with EGTA and thapsigargin reveal the dependence of MCF-7 cell growth on extracellular and intracellular calcium sources, respectively. In vitro, interlaced treatment that alternated the T-type calcium channel blocker NNC-55-0396 with paclitaxel more effectively reduced MCF-7 cell number than chemotherapy alone. In a mouse in vivo model, interlaced mibefradil and paclitaxel more effectively reduced MCF-7 xenograft size than chemotherapy alone. These findings indicate that MCF-7 cells are dependent on calcium for proliferation, particularly in passing the G1/S cell cycle checkpoint. Further, this dependence on calcium can be exploited by alternating treatment with T-type calcium channel blockers with paclitaxel in an interlaced therapy scheme that increases the efficacy of the chemotherapy.
文摘In this work, we make a representation of non-relativistic quantum theory based on foundations of paraconsistent annotated logic (PAL), a propositional and evidential logic with an associated lattice FOUR. We use the PAL version with annotation of two values (PAL2v), named paraquantum logic (PQL), where the evidence signals are normalized values and the intensities of the inconsistencies are represented by degrees of contradiction. Quantum mechanics is represented through mapping on the interlaced bilattices where this logical formalization allows annotation of two values in the format of degrees of evidence of probability. The Bernoulli probability distribution is used to establish probabilistic logical states that identify the superposition of states and quantum entanglement with the equations and determine the state vectors located inside the interlaced Bilattice. In the proposed logical probabilistic paraquantum logic model (pPQL Model), we introduce the operation of logical conflation into interlaced bilattice. We verify that in the pPQL Model, the operation of logical conflation is responsible for providing a suitable model for various phenomena of quantum mechanics, mainly the quantum entanglement. The results obtained from the entanglement equations demonstrate the formalization and completeness of paraquantum logic that allows for interpretations of similar phenomena of quantum mechanics, including EPR paradox and the wave-particle theory.
文摘In architecture,interlace structural concept is considered as a new design approach for cosmopolitan cities with high density to minimize the land use and increase the interaction.With various architectural approach,land resources can be minimized by this interlace concept for residential complexes.Such buildings will eliminate the reduction of land resource problem and on the other side safety measures in structural design is incorporated by interlace concept of buildings.This new concept can be constructed steel or reinforced concrete.In this paper,an analytical approach has been presented for these buildings in architecture and structural design.In the research,design considerations were taken for interlaced structures with reinforced concrete and steel.Components of steel structure,isolated footing,and columns.This paper is presenting a step wise process for interlaced structures.They are identification of project area,layout and model preparation,analysis and design of concrete interlaced structure,analysis and design of steel interlaced structure,drafting of the plans and costing and estimation of the structures.Comparison of both reinforced concrete and steel structures were carried out.The main aim of the paper is to provide a comparison between steel and concrete interlaced structure.A cost estimation was carried out to determine optimum design and construction for interlaced structures.
基金co-supported by the National Natural Science Foundation of China (Nos. 61004140, 61004129, 60825305, 61104198, 60904093)National Basic Research Program of China (No. 2009CB7240 0101C)
文摘Aimed at low accuracy of attitude determination because of using low-cost components which may result in non-linearity in integrated attitude determination systems, a novel attitude determination algorithm using vector observations and gyro measurements is presented. The various features of the unscented Kalman filter (UKF) and optimal-REQUEST (quaternion estimator) algorithms are introduced for attitude determination. An interlaced filtering method is presented for the attitude determination of nano-spacecraft by setting the quaternion as the attitude representation, using the UKF and optimal-REQUEST to estimate the gyro drifts and the quaternion, respectively. The optimal-REQUEST and UKF are not isolated from each other. When the optimal-REQUEST algorithm estimates the attitude quaternion, the gyro drifts are estimated by the UKF algorithm synchronously by using the estimated attitude quaternion. Furthermore, the speed of attitude determination is improved by setting the state dimension to three. Experimental results show that the presented method has higher performance in attitude determination compared to the UKF algorithm and the traditional interlaced filtering method and can estimate the gyro drifts quickly.
文摘This paper presents a low-power small-area digitally controlled oscillator (DCO) using an inverters interlaced cascaded delay cell (IICDC). It uses a coarse-fine architecture with binary-weighted delay stages for the delay range and resolution. The coarse-tuning stage of the DCO uses IICDC, which is power and area efficient with low phase noise, as compared with conventional delay cells. The ADPLL with a DCO is fabricated in the UMC 180-nm CMOS process with an active area of 0.071 mm2. The output frequency range is 140-600 MHz at the power supply of 1.8 V. The power consumption is 2.34 mW@ a 200 MHz output.
基金supported by the National Natural Science Foundation of China(31000722and31201240)the Scientific Research Fund of Pre-State Key Laboratory for Germplasm Innovation and Resource Utilization of Crops in China(10KFXM01)
文摘Based on the sequence of a novel expressed sequence tag (EST), the full-length cDNA of 1 017 nucleotides was cloned from Brassica napus cv. Xiangyou 15 through rapid amplification of cDNA ends (RACE). The gene was designated as Bnhol34 (HQ585980), encoding a protein of 338 amino acids. BLAST analysis showed no high degree of sequence identity to any known gene. The calculated molecular weight of the Bnhol34 protein was 36.23 kDa, and the theoretical isoelectric point was 8.74. The Bnhol34 was also cloned from a high oleic acid mutant 854-1 through homologous cloning. There was no difference between the two Bnhol34 genes. Bnhol34 was localized in a tissue-specific manner in B. napus, and its expression level was about eight-fold greater in Xiangyou 15 seeds than in 854-1. The promoter region sequences of Bnhol34 were then isolated from Xiangyou 15 and 854-1, and a 93-bp deletion was found to occur in the Bnhol34 promoter region of 854-1. Three abscisic acid-responsive cis-elements (ABRE) were identified in the promoter region of Xiangyou 15. Real-time PCR analyses revealed that exogenous abscisic acid increased Bnhol34 expression by about four-fold in Xiangyou 15 seeds, yet did not change Bnhol34 expression in 854-1. It appeared that Bnhol34 might be abscisic acid insensitive in 854-1.
文摘Wind and Window Flower is a special metaphorical love poem by Robert Frost. This tale of love actually presents a love journey of temptation, excitement, and disappointment. This paper tries to analysis the poem from the perspective of the sound of the poetry, the metro and rhyme, the conceptual and rhetorical.
基金Project supported by the Guangxi Natural Science Foundation of China(Grant Nos.2013GXNSFAA019335 and 2015GXNSFAA139300)Guangxi Experiment Center of Information Science of China(Grant No.YB1406)+2 种基金Guangxi Key Laboratory of Wireless Wideband Communication and Signal Processing of China,Key Laboratory of Cognitive Radio and Information Processing(Grant No.GXKL061505)Guangxi Key Laboratory of Automobile Components and Vehicle Technology of China(Grant No.2014KFMS04)the National Natural Science Foundation of China(Grant Nos.61361011,61274077,and 61464003)
文摘A novel silicon-on-insulator(SOI) high breakdown voltage(BV) power device with interlaced dielectric trenches(IDT) and N/P pillars is proposed. In the studied structure, the drift region is folded by IDT embedded in the active layer,which results in an increase of length of ionization integral remarkably. The crowding phenomenon of electric field in the corner of IDT is relieved by the N/P pillars. Both traits improve two key factors of BV, the ionization integral length and electric field magnitude, and thus BV is significantly enhanced. The electric field in the dielectric layer is enhanced and a major portion of bias is borne by the oxide layer due to the accumulation of inverse charges(holes) at the corner of IDT.The average value of the lateral electric field of the proposed device reaches 60 V/μm with a 10 μm drift length, which increases by 200% in comparison to the conventional SOI LDMOS, resulting in a breakdown voltage of 607 V.
文摘An elastic gridshell is an efficient constructive typology for crossing large spans with little material.A flat elastic grid is built before buckling the structure into shape,in active and post-formed bending.The design and structural analysis of such a structure requires a stage of form finding that can mainly be done:(1)With a physical model:either by a suspended net method,or an active bending model;(2)With a numerical model performed by dynamic relaxation.All these solutions have various biases and assumptions that make them reflect more or less the reality.These three methods have been applied by Happold and Liddell[1]during the design of the Frei Otto’s Mannheim Gridshell which has allowed us to compare the results,and to highlight the significant differences between digital and physical models.Based on our own algorithm called ELASTICA[2],our study focuses on:(1)Comparing the results of the ELASTICA’s numerical models to load tests on physical models;(2)The identification of the various factors that can influence the results and explain the observed differences,some of which are then studied;(3)Applying the results to build a full-scale interlaced lattice elastic gridshell based on the Japanese Kagome pattern.
文摘According to the misfitting dislocation theory,a method of theoretical calculation was devel- oped for the specific energy of the semicoherent interface between microalloy carbonitrides and austenite matrix.The calculating formulae were derived and the results were satisfactorily applied on the research works.
基金supported by the National Science and Technology Major Project of the Ministry of Industry and Information Technology of China(Grant No.2012ZX04007021)the Young Scientists Fund of the National Natural Science Foundation of China(Grant No.51105315)+1 种基金the Natural Science Basic Research Program of Shaanxi Province,China(Grant No.2013JM7003)the Northwestern Polytechnical University Foundation for Fundamental Research,China(Grant Nos.3102014KYJD022 and JC20120226)
文摘Cone-beam computed tornography (CBCT) has the notable features of high efficiency and high precision, and is widely used in areas such as medical imaging and industrial non-destructive testing. However, the presence of the ray scatter reduces the quality of CT images. By referencing the slit collimation approach, a scatter correction method for CBCT based on the interlacing-slit scan is proposed. Firstly, according to the characteristics of CBCT imaging, a scatter suppression plate with interlacing slits is designed and fabricated. Then the imaging of the scatter suppression plate is analyzed, and a scatter correction Calculation method for CBCT based on the image fusion is proposed, which can splice out a complete set of scatter suppression projection images according to the interlacing-slit projection images of the left and the right imaging regions in the scatter suppression plate, and simultaneously complete the scatter correction within the fiat panel detector (FPD). Finally, the overall process of scatter suppression and correction is provided. The experimental results show that this method can significantly improve the clarity of the slice images and achieve a good scatter correction.
文摘Three series of CeO2/CuO samples were prepared by impregnation method and characterized by XRD, N2 adsorption-desorption, temperatureprogrammed reduction (TPR), XPS and TEM techniques. In comparison with the samples prepared with CuO as initial support, the samples with Cu(OH)2 as initial support have higher reducibilities and smaller relative TPR peak areas, and also larger specific surface areas at calcina- tion temperatures of 400 ℃--600 ℃. As a result, Cu(OH)2 is better than CuO as initial support for preferential oxidation of CO in excess H2 (CO-PROX). The best catalytic performance was achieved on the sample calcined at 600 ℃ and with an atomic ratio of Ce/Cu at 40%. XPS analyses indicate that more interface linkages Ce-O-Cu could be formed when it was calcined at 600 ℃. And the atomic ratio of Ce/Cu at 40% led to a proper reducibility for the sample as illustrated by the TPR measurements.
基金The authors are supported by National Natural Sciences Foundation of China(11961060,11671322)the Key Project of Natural Sciences Foundation of Gansu Province(18JR3RA084).
文摘In this article,we consider a discrete right-definite Sturm-Liouville problems with two squared eigenparameter-dependent boundary conditions.By constructing some new Lagrange-type identities and two fundamental functions,we obtain not only the existence,the simplicity,and the interlacing properties of the real eigenvalues,but also the oscillation properties,orthogonality of the eigenfunctions,and the expansion theorem.Finally,we also give a computation scheme for computing eigenvalues and eigenfunctions of specific eigenvalue problems.
基金supported by the National Natural Science Foundation of China(615730176140149961174162)
文摘Multiple complex networks, each with different properties and mutually fused, have the problems that the evolving process is time varying and non-equilibrium, network structures are layered and interlacing, and evolving characteristics are difficult to be measured. On that account, a dynamic evolving model of complex network with fusion nodes and overlap edges(CNFNOEs) is proposed. Firstly, we define some related concepts of CNFNOEs, and analyze the conversion process of fusion relationship and hierarchy relationship. According to the property difference of various nodes and edges, fusion nodes and overlap edges are subsequently split, and then the CNFNOEs is transformed to interlacing layered complex networks(ILCN). Secondly,the node degree saturation and attraction factors are defined. On that basis, the evolution algorithm and the local world evolution model for ILCN are put forward. Moreover, four typical situations of nodes evolution are discussed, and the degree distribution law during evolution is analyzed by means of the mean field method.Numerical simulation results show that nodes unreached degree saturation follow the exponential distribution with an error of no more than 6%; nodes reached degree saturation follow the distribution of their connection capacities with an error of no more than 3%; network weaving coefficients have a positive correlation with the highest probability of new node and initial number of connected edges. The results have verified the feasibility and effectiveness of the model, which provides a new idea and method for exploring CNFNOE's evolving process and law. Also, the model has good application prospects in structure and dynamics research of transportation network, communication network, social contact network,etc.