Purpose:This study aims to explore how network intermediaries influence collaborative innovation performance within inter-organizational technological collaboration networks.Design/methodology/approach:This study empl...Purpose:This study aims to explore how network intermediaries influence collaborative innovation performance within inter-organizational technological collaboration networks.Design/methodology/approach:This study employs a mixed-method approach,combining quantitative social network analysis with regression techniques to investigate the role of network intermediaries in collaborative innovation performance.Using a patent dataset of Chinese industrial enterprises,the research constructs the collaboration networks and analyzes their structural positions,particularly focusing on their role as intermediaries,characterized by betweenness centrality.Negative binomial regression analysis is employed to assess how these network characteristics shape innovation outcomes.Findings:The study reveals that firms in intermediary positions enhance collaborative innovation performance,but this effect is nuanced.A key finding is that network clustering negatively moderates the intermediary-innovation relationship.Highly clustered networks,while fostering local collaboration,may limit the innovation potential of intermediaries.On the other hand,relationship strength,measured by collaboration intensity and trust among firms,positively moderates the intermediary-innovation link.Research limitations:This study has several limitations that present opportunities for further research.The reliance on quantitative social network analysis may overlook the complexity of intermediaries’roles,and future studies could benefit from incorporating qualitative methods to better understand cultural and institutional factors.Additionally,cross-country comparisons are needed to assess the consistency of these dynamics in different contexts.Practical implications:The study offers practical insights for firms and policymakers.Organizations should strategically position themselves as network intermediaries to access diverse information and resources,thereby improving innovation performance.Building strong trust helps using network intermediary advantages.For firms in highly clustered networks,it is important to seek external partners to avoid limiting their exposure to new ideas and technologies.This research emphasizes the need to balance network diversity with relationship strength for sustained innovation.Originality/value:This research contributes to the literature by offering new insights into the role of network intermediaries,presenting a comprehensive framework for understanding the interaction between network dynamics and firm innovation.展开更多
PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expr...PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.展开更多
Robot technology is expected to reduce the burden of medical professionals, a concern in the super-aged society. The aim of this article is to determine the intermediary roles of Public Health Nurses (PHNs) in using C...Robot technology is expected to reduce the burden of medical professionals, a concern in the super-aged society. The aim of this article is to determine the intermediary roles of Public Health Nurses (PHNs) in using Communication Robots (CRs) in Community Health care. It is necessary to consider who will manage, and how to draw lines of responsibility when a problem occurs when using robots in the future. Regarding the mediator or intermediary role of PHNs in the use of CRs, PHNs are expected to be cognizant of varieties of robots for use with persons of diverse ages and health levels, as well as of robot performances. As one of the community healthcare workers who service the elderly living in the community, the role of PHNs as mediators or intermediaries is to pay attention to ethical and moral issues while working with CRs to manage the health of the community. Lack of understanding of the intermediary role might create possible ethico-moral issues in the future. Therefore, it is critical for PHNs to understand their role as intermediaries. In doing so, it is expected that older people at home will be able to live peaceful lives, as well as be physically and mentally healthy.展开更多
Healthcare for older adults with dementia is an important healthcare problem in Japan and in other developed countries. Importantly, healthcare workers in Japan are also getting older. In order to address solutions to...Healthcare for older adults with dementia is an important healthcare problem in Japan and in other developed countries. Importantly, healthcare workers in Japan are also getting older. In order to address solutions to this problem, using robots is being realized and is starting to assist healthcare and welfare practice needs. The aim of this study was to identify the characteristics of a transactive phenomenon in relationships among older adults with dementia, with nurses as intermediaries and with a cognitive skill-aid robot. Subjects were two institutionalized older adults who were diagnosed with dementia using Hasegawa’s Dementia Scale-Revised;a Kabochan (Nodding Kabochan) fixed with a remote-controlled speaker, Pechat (Kabochan with Pechat). Measurements of autonomic nervous activity were done using wearable electrocardiography attached to the subjects for four hours. Heart Rate Variability data were assessed at various frequency bands using a HRV software tool. In a continuously recorded data, interbeat (R-R) intervals were obtained for a 1-min segment using the maximum entropy method. In this study, the two major spectral components of HRV, the variances of the low-frequency (LF: 0.04 - 0.15 Hz) band and high-frequency (HF: 0.15 - 0.4 Hz) band, were calculated. Activities and behaviors of subjects transacting with Kabochan were observed by the expert nurses and video-recorded. Throughout the transaction period, observations were recorded of patients’ behavior, words uttered and over-all contents of the transactive conversation with the Kabochan or Kabochan with Pechat. Identified characteristics were transactive relationship phenomenon;changes in autonomic nervous system activity of persons with dementia are expressed as per one minute, linguistic response of elderly people, transactive relations among Kabochan, Kabochan with Pechat, and nurses as intermediaries. These were exhibited as Figures: Situation 1, A Sense of Fear, Situation 2, A Pleasant Sensation, and Situation 3, Misunderstanding and Confusion. It also showed that autonomic nervous system activity of persons with communication skills is actively changing in older adults with dementia. Conversation of adding Pechat to the Kabochan illustrated that nurses as intermediaries showed emotional conversations as established by effectively manipulating the Pechat. Also, it was revealed that if Kabochan with Pechat uttered words about patient’s personal information in a conversation, the patient felt a sense of fear. The researchers suggest that when developing future communication robot for elderly with dementia, it is necessary to consider, for an effective conversation, transactive relationships including nurses as intermediaries. The role functions of these intermediaries have been shown of high versatility, indicating that situations such as these can also be controlled by other healthcare providers such as by occupational therapists.展开更多
Online customers execute transactions without inspecting products could expect to encounter risks of receiving products with unsatisfactory qualities,especially in food trans-actions.Thus quality supervision plays a k...Online customers execute transactions without inspecting products could expect to encounter risks of receiving products with unsatisfactory qualities,especially in food trans-actions.Thus quality supervision plays a key role in the establishment of trust as well as in the management of risk between online customers and sellers.Most papers in this field are in qualitative nature.In this paper,a quality supervision profit(QSP)model is formulated as a discrete-time optimal control problem.It is a quantitative approach,and it broadens the scope.of current research in the area.The quality efort level of online sellers(QELa)and the quality supervision level of the electronic intermediary(QSLm)are considered together with their cor-responding profit in the proposed model.The aim is to optimize an overall profit.A case study arising from Suichang's food traceability system(FTS)of farm produce online transaction is carried out in details.The results reveal that QELs,QSLm and the profit distribution coeffi-cient have a strong influence upon the profits of both sides.Finally,some concluding remarks,including potential further research topics,are given.展开更多
This paper intends to clarify the needs serendipity in creating new business. The authors will show that serendipity is capability method of finding potential needs and/or new markets. In economic society, potential n...This paper intends to clarify the needs serendipity in creating new business. The authors will show that serendipity is capability method of finding potential needs and/or new markets. In economic society, potential needs and/or new markets are only partially exposed, such as an iceberg. Serendipity is a capability that can expose the potential hidden part through accidental opportunity. Something more concrete can be formed from the exposed parts. The authors describe cases that demonstrate the usefulness of serendipity. In one case, a high-tech start-up had intended to use medical electronic equipment and/or industrial electronic equipment as the first application of their core technology. In these markets, they were competing with established major companies, so this start-up had difficulty entering these markets. However, a specific distributor found potential needs that were met by the start-up's products, and has created a new market by combining their core technology with social needs. The authors define serendipity capability by analyzing this case example and argue that serendipity can contribute to finding opportunities and solving social issues.展开更多
Since the New World Monetary Order,as designed and promoted at Bretton Woods,several policies were considered.As proposed by Hansen,Harrod,and post Keynesian,after the 60 years and after the Bretton Woods final collap...Since the New World Monetary Order,as designed and promoted at Bretton Woods,several policies were considered.As proposed by Hansen,Harrod,and post Keynesian,after the 60 years and after the Bretton Woods final collapse,a new monetary framework has been overlapping gradually most of the world financial transactions.Separately from the single global financial markets,without previous patterns and insight experiences,the new global landscape is posing new deep challenges in the present monetary stalemate.The removal of the gold benchmark on the first day of WWI(First World War)―The serious Gramm-Leach-Bliley Act 1999 repudiated the Glass-Sméagol Act.The removal caused the colossal crisis as the time deposits and unlimited monetary base expansions produced effects never seen in modern history―A colossal surge of the financial instrument market indexes and financial bubble blowing erupted.展开更多
With the development of network economy, e-commerce platform has increasingly become a worldwide trading places of various kinds of products and services. Therefore some scholars consider, intermediaries, under the ra...With the development of network economy, e-commerce platform has increasingly become a worldwide trading places of various kinds of products and services. Therefore some scholars consider, intermediaries, under the rapid development of information technology, will gradually withdrew from the historical stage. This article carried on the thorough analysis for the reasons of the existence of electronic intermediaries, and discusses the new development space and prospect of new middlemen, from the perspective of information asymmetry of the network environment.展开更多
This article analyzes the relationship between financial intermediary development and economic fluctuation in the last 50 years in China. It was found that a steady and long-term relation existed between these two var...This article analyzes the relationship between financial intermediary development and economic fluctuation in the last 50 years in China. It was found that a steady and long-term relation existed between these two variables, and that different aspects of the development of the financial intermediary system had different effects on the economic fluctuation. The improvement of the intermediary's efficiency can repress the economic fluctuation , but the increase of financial intermediaries can intensify the fluctuation. On that basis, some suggestions about the development of the financial intermediary are proposed in this essay.展开更多
基金supported by the National Social Science Fund of China(No.22FGLB035)Fujian Provincial Federation of Social Sciences(No.FJ2023B109).
文摘Purpose:This study aims to explore how network intermediaries influence collaborative innovation performance within inter-organizational technological collaboration networks.Design/methodology/approach:This study employs a mixed-method approach,combining quantitative social network analysis with regression techniques to investigate the role of network intermediaries in collaborative innovation performance.Using a patent dataset of Chinese industrial enterprises,the research constructs the collaboration networks and analyzes their structural positions,particularly focusing on their role as intermediaries,characterized by betweenness centrality.Negative binomial regression analysis is employed to assess how these network characteristics shape innovation outcomes.Findings:The study reveals that firms in intermediary positions enhance collaborative innovation performance,but this effect is nuanced.A key finding is that network clustering negatively moderates the intermediary-innovation relationship.Highly clustered networks,while fostering local collaboration,may limit the innovation potential of intermediaries.On the other hand,relationship strength,measured by collaboration intensity and trust among firms,positively moderates the intermediary-innovation link.Research limitations:This study has several limitations that present opportunities for further research.The reliance on quantitative social network analysis may overlook the complexity of intermediaries’roles,and future studies could benefit from incorporating qualitative methods to better understand cultural and institutional factors.Additionally,cross-country comparisons are needed to assess the consistency of these dynamics in different contexts.Practical implications:The study offers practical insights for firms and policymakers.Organizations should strategically position themselves as network intermediaries to access diverse information and resources,thereby improving innovation performance.Building strong trust helps using network intermediary advantages.For firms in highly clustered networks,it is important to seek external partners to avoid limiting their exposure to new ideas and technologies.This research emphasizes the need to balance network diversity with relationship strength for sustained innovation.Originality/value:This research contributes to the literature by offering new insights into the role of network intermediaries,presenting a comprehensive framework for understanding the interaction between network dynamics and firm innovation.
基金support by the Ministerio Educación y CienciaMinisterio de Economía y Competitividad of Spain(until June 2013)
文摘PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.
文摘Robot technology is expected to reduce the burden of medical professionals, a concern in the super-aged society. The aim of this article is to determine the intermediary roles of Public Health Nurses (PHNs) in using Communication Robots (CRs) in Community Health care. It is necessary to consider who will manage, and how to draw lines of responsibility when a problem occurs when using robots in the future. Regarding the mediator or intermediary role of PHNs in the use of CRs, PHNs are expected to be cognizant of varieties of robots for use with persons of diverse ages and health levels, as well as of robot performances. As one of the community healthcare workers who service the elderly living in the community, the role of PHNs as mediators or intermediaries is to pay attention to ethical and moral issues while working with CRs to manage the health of the community. Lack of understanding of the intermediary role might create possible ethico-moral issues in the future. Therefore, it is critical for PHNs to understand their role as intermediaries. In doing so, it is expected that older people at home will be able to live peaceful lives, as well as be physically and mentally healthy.
文摘Healthcare for older adults with dementia is an important healthcare problem in Japan and in other developed countries. Importantly, healthcare workers in Japan are also getting older. In order to address solutions to this problem, using robots is being realized and is starting to assist healthcare and welfare practice needs. The aim of this study was to identify the characteristics of a transactive phenomenon in relationships among older adults with dementia, with nurses as intermediaries and with a cognitive skill-aid robot. Subjects were two institutionalized older adults who were diagnosed with dementia using Hasegawa’s Dementia Scale-Revised;a Kabochan (Nodding Kabochan) fixed with a remote-controlled speaker, Pechat (Kabochan with Pechat). Measurements of autonomic nervous activity were done using wearable electrocardiography attached to the subjects for four hours. Heart Rate Variability data were assessed at various frequency bands using a HRV software tool. In a continuously recorded data, interbeat (R-R) intervals were obtained for a 1-min segment using the maximum entropy method. In this study, the two major spectral components of HRV, the variances of the low-frequency (LF: 0.04 - 0.15 Hz) band and high-frequency (HF: 0.15 - 0.4 Hz) band, were calculated. Activities and behaviors of subjects transacting with Kabochan were observed by the expert nurses and video-recorded. Throughout the transaction period, observations were recorded of patients’ behavior, words uttered and over-all contents of the transactive conversation with the Kabochan or Kabochan with Pechat. Identified characteristics were transactive relationship phenomenon;changes in autonomic nervous system activity of persons with dementia are expressed as per one minute, linguistic response of elderly people, transactive relations among Kabochan, Kabochan with Pechat, and nurses as intermediaries. These were exhibited as Figures: Situation 1, A Sense of Fear, Situation 2, A Pleasant Sensation, and Situation 3, Misunderstanding and Confusion. It also showed that autonomic nervous system activity of persons with communication skills is actively changing in older adults with dementia. Conversation of adding Pechat to the Kabochan illustrated that nurses as intermediaries showed emotional conversations as established by effectively manipulating the Pechat. Also, it was revealed that if Kabochan with Pechat uttered words about patient’s personal information in a conversation, the patient felt a sense of fear. The researchers suggest that when developing future communication robot for elderly with dementia, it is necessary to consider, for an effective conversation, transactive relationships including nurses as intermediaries. The role functions of these intermediaries have been shown of high versatility, indicating that situations such as these can also be controlled by other healthcare providers such as by occupational therapists.
基金Supported by Zhejiang Provincial basic public welfare research project of China(LGN19C040001)。
文摘Online customers execute transactions without inspecting products could expect to encounter risks of receiving products with unsatisfactory qualities,especially in food trans-actions.Thus quality supervision plays a key role in the establishment of trust as well as in the management of risk between online customers and sellers.Most papers in this field are in qualitative nature.In this paper,a quality supervision profit(QSP)model is formulated as a discrete-time optimal control problem.It is a quantitative approach,and it broadens the scope.of current research in the area.The quality efort level of online sellers(QELa)and the quality supervision level of the electronic intermediary(QSLm)are considered together with their cor-responding profit in the proposed model.The aim is to optimize an overall profit.A case study arising from Suichang's food traceability system(FTS)of farm produce online transaction is carried out in details.The results reveal that QELs,QSLm and the profit distribution coeffi-cient have a strong influence upon the profits of both sides.Finally,some concluding remarks,including potential further research topics,are given.
文摘This paper intends to clarify the needs serendipity in creating new business. The authors will show that serendipity is capability method of finding potential needs and/or new markets. In economic society, potential needs and/or new markets are only partially exposed, such as an iceberg. Serendipity is a capability that can expose the potential hidden part through accidental opportunity. Something more concrete can be formed from the exposed parts. The authors describe cases that demonstrate the usefulness of serendipity. In one case, a high-tech start-up had intended to use medical electronic equipment and/or industrial electronic equipment as the first application of their core technology. In these markets, they were competing with established major companies, so this start-up had difficulty entering these markets. However, a specific distributor found potential needs that were met by the start-up's products, and has created a new market by combining their core technology with social needs. The authors define serendipity capability by analyzing this case example and argue that serendipity can contribute to finding opportunities and solving social issues.
文摘Since the New World Monetary Order,as designed and promoted at Bretton Woods,several policies were considered.As proposed by Hansen,Harrod,and post Keynesian,after the 60 years and after the Bretton Woods final collapse,a new monetary framework has been overlapping gradually most of the world financial transactions.Separately from the single global financial markets,without previous patterns and insight experiences,the new global landscape is posing new deep challenges in the present monetary stalemate.The removal of the gold benchmark on the first day of WWI(First World War)―The serious Gramm-Leach-Bliley Act 1999 repudiated the Glass-Sméagol Act.The removal caused the colossal crisis as the time deposits and unlimited monetary base expansions produced effects never seen in modern history―A colossal surge of the financial instrument market indexes and financial bubble blowing erupted.
文摘With the development of network economy, e-commerce platform has increasingly become a worldwide trading places of various kinds of products and services. Therefore some scholars consider, intermediaries, under the rapid development of information technology, will gradually withdrew from the historical stage. This article carried on the thorough analysis for the reasons of the existence of electronic intermediaries, and discusses the new development space and prospect of new middlemen, from the perspective of information asymmetry of the network environment.
文摘This article analyzes the relationship between financial intermediary development and economic fluctuation in the last 50 years in China. It was found that a steady and long-term relation existed between these two variables, and that different aspects of the development of the financial intermediary system had different effects on the economic fluctuation. The improvement of the intermediary's efficiency can repress the economic fluctuation , but the increase of financial intermediaries can intensify the fluctuation. On that basis, some suggestions about the development of the financial intermediary are proposed in this essay.