Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the fir...Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the first consideration should be the protection of cardiac function.Based on the theory of intermingled phlegm,blood stasis and toxin of heart disease put forward by Master Lei Zhongyi,the dialectical treatment thinking of COVID-19 patients from the concept of damage of phlegm,blood stasis and toxin to the heart were discussed.During the diagnosis,critical stage and recovery period of COVID-19,expectorant and blood-activating agents,heat and detoxification agents can be added to promote lung and asthma,free Bizheng and remove blood stasis,calm the heart and calm the mind,and promote the recovery of cardiopulmonary functions.展开更多
目的:观察化痰散瘀汤治疗斑块型银屑病(痰瘀互结证)的临床疗效及临床作用机制。方法:将皮肤科斑块型银屑病(痰瘀互结证)患者80例按随机数字表法分为观察组与对照组各40例。对照组予阿维A胶囊+糠酸莫米松软膏治疗,观察组在此基础上予化...目的:观察化痰散瘀汤治疗斑块型银屑病(痰瘀互结证)的临床疗效及临床作用机制。方法:将皮肤科斑块型银屑病(痰瘀互结证)患者80例按随机数字表法分为观察组与对照组各40例。对照组予阿维A胶囊+糠酸莫米松软膏治疗,观察组在此基础上予化痰散瘀汤治疗。观察两组患者中医证候评分(皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错),银屑病皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分,皮肤病生活质量指数调查表(dermatology life quality index,DLQI)评分,血清免疫细胞因子干扰素γ(interferonγ,IFN-γ)、白细胞介素4(interleukin 4,IL-4)、白细胞介素17A(interleukin 17A,IL-17A)、白细胞介素10(interleukin-10,IL-10)、白细胞介素22(interleukin-22,IL-22)改善状况,并统计临床疗效及不良反应发生情况。结果:两组治疗后皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错积分均明显降低(P<0.05),且观察组治疗后中医证候积分明显低于对照组(P<0.05)。两组治疗后PASI及DLQI评分均明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。两组治疗后血清IFN-γ、IL-17A、IL-22水平均明显降低(P<0.05),IL-4及IL-10水平均明显升高(P<0.05),且观察组上述指标改善情况均优于对照组(P<0.05)。观察组总有效率[92.5%(37/40)]明显高于对照组[75.0%(30/40)](P<0.05)。两组治疗期间均未出现明显不良反应。结论:化痰散瘀汤能有效改善斑块型银屑病(痰瘀互结证)患者皮损状况,缓解瘙痒等临床症状,有助于提高生活质量,其可能与调节IFN-γ、IL-4、IL-17A、IL-10、IL-22等免疫细胞因子,纠正患者机体紊乱的免疫机能有关。展开更多
基金the Project of the Third National Master of Traditional Chinese Medicine of National Administration of Traditional Chinese Medicine/National Famous Traditional Chinese Medicine Inheritance Studio Construction(No.119(2018)of Education Letter of the State Office of Traditional Chinese Medicine).
文摘Novel coronavirus infection not only damages lung function,but also causes myocardial injury,elevated myocardial enzymes and heart failure,especially for patients with basic heart diseases who develop COVID-19,the first consideration should be the protection of cardiac function.Based on the theory of intermingled phlegm,blood stasis and toxin of heart disease put forward by Master Lei Zhongyi,the dialectical treatment thinking of COVID-19 patients from the concept of damage of phlegm,blood stasis and toxin to the heart were discussed.During the diagnosis,critical stage and recovery period of COVID-19,expectorant and blood-activating agents,heat and detoxification agents can be added to promote lung and asthma,free Bizheng and remove blood stasis,calm the heart and calm the mind,and promote the recovery of cardiopulmonary functions.
文摘目的:观察化痰散瘀汤治疗斑块型银屑病(痰瘀互结证)的临床疗效及临床作用机制。方法:将皮肤科斑块型银屑病(痰瘀互结证)患者80例按随机数字表法分为观察组与对照组各40例。对照组予阿维A胶囊+糠酸莫米松软膏治疗,观察组在此基础上予化痰散瘀汤治疗。观察两组患者中医证候评分(皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错),银屑病皮损面积和严重程度指数(psoriasis area and severity index,PASI)评分,皮肤病生活质量指数调查表(dermatology life quality index,DLQI)评分,血清免疫细胞因子干扰素γ(interferonγ,IFN-γ)、白细胞介素4(interleukin 4,IL-4)、白细胞介素17A(interleukin 17A,IL-17A)、白细胞介素10(interleukin-10,IL-10)、白细胞介素22(interleukin-22,IL-22)改善状况,并统计临床疗效及不良反应发生情况。结果:两组治疗后皮损颜色、皮损肥厚浸润、瘙痒、肌肤甲错积分均明显降低(P<0.05),且观察组治疗后中医证候积分明显低于对照组(P<0.05)。两组治疗后PASI及DLQI评分均明显降低(P<0.05),且观察组明显低于对照组(P<0.05)。两组治疗后血清IFN-γ、IL-17A、IL-22水平均明显降低(P<0.05),IL-4及IL-10水平均明显升高(P<0.05),且观察组上述指标改善情况均优于对照组(P<0.05)。观察组总有效率[92.5%(37/40)]明显高于对照组[75.0%(30/40)](P<0.05)。两组治疗期间均未出现明显不良反应。结论:化痰散瘀汤能有效改善斑块型银屑病(痰瘀互结证)患者皮损状况,缓解瘙痒等临床症状,有助于提高生活质量,其可能与调节IFN-γ、IL-4、IL-17A、IL-10、IL-22等免疫细胞因子,纠正患者机体紊乱的免疫机能有关。
