Concurrent implantation of intra-aortic balloon pumping with extracorporeal membrane oxygenation improved survival of patients with postcardiotomy cardiogenic shock

Background Extra-corporeal membranous oxygenation (ECMO)and intra-aortic balloon pumping (IABP) are widely used in patients with severe circulatory failure. The decision to initiate ECMO and IABP on optimal occasion in postcardiotomy cardiogenic shock (PCS) remains controversial in the absence of guidelines.

Role of Intra-Aortic Balloon Pump in Off-Pump Coronary Artery Bypass —A Vettath Modification

Objective: Hemodynamic deterioration during positioning of the heart has been the most critical complication of off-pump coronary artery bypass surgery. Pre-operative use of intra-aortic balloon pump has been shown to prevent this complication in high risk patients. The role of balloon pump in high risk patients has been questioned by our group. We modified the role of balloon pump in our patients, thus avoiding the conversion to cardiopulmonary bypass. Methods: 4063 off-pump coronary bypass surgeries were performed by a single surgeon in our center, over thirteen years. 130 intra-aortic balloons used between July 2002 and December 2015 were removed from the the-ater, once the distal anastomosis was performed. We studied this group of patients for—time and need for insertion, duration of balloon used, local insertion problems and survival. Results: Initially, we inserted intra-aortic balloons in high risk patients. We observed that, patients with low ejection fraction and patients with critical left main coronary artery disease were not the ones who actually needed balloon pump support. It was the patients who had ongoing ischemia, with preserved left ventricular function, and ST depression intra-operatively, who needed balloon pump support to perform complete anatomical revascularization. Conclusions: Intra-aortic balloon pump has helped us to position the heart without hemodynamic instability, thereby avoiding conversion to cardio-pulmonary bypass. This enabled us to perform off-pump surgery in virtually all areas of the heart, thus maintaining perfect hemodynamics.

Effects on the renal artery blood flow during the intra-aortic balloonpumping was used

The effects of intra-aortic balloon pumping(IABP) on hemodynamic parameters inthe kidney were studied. The pulse produced by pumping activated the renal nervoussystem and reduced the renal vascular resistance. Therefore, the reduction of the renalvascular resistance is an important reason for the increase the renal blood flow duringintra-aortic balloon pumping.

Anticoagulation therapy in intra-aortic balloon counterpulsation： Does IABP really need anti-coagulation ？

Objective: To investigate if intra-aortic balloon pump(IABP) is contraindicated without anticoag-ulation therapy. Methods: Some 153 IABP patients in the King Abdulaziz Cardiac Center(KSA) were random-ly assigned into two groups. Anticoagulation group( Group A) consisted of 71 patients who were given heparin intravenously with target aPTT 50 - 70 seconds. Non-anticoagulation group( Group B) consisted of 82 patients without intravenous heparin during balloon pumping. Hematological parameters including platelet count, D-dimer, Plasminogen activator inhibitor-1 (PAI-1) and fibrinogen degradation products(FDP) were checked respectively at the point of baseline, 24 hours, 48 hours and 24 hours post IABP counterpulsation. Clot deposits on balloon surface, vascular complications from IABP including bleeding and limb ischemia were recorded.Results: Platelet count and PAI-1 level decreased at 24 hours and 48 hours in both groups ( P < 0.05) . D-dimer and FDP level increased at 24 hours and 48 hours in both groups( P < 0.05), but returned to the baseline level 24 hours post IABP removal( P > 0.05) . Three patients in Group A and 2 patients in Group B developed minor limb ischemia( P > 0.05). No major limb ischemia in either group. Two patients in Group A suffered major bleeding and required blood transfusion or surgical intervention, whereas no patient had major bleeding in Group B. Eight patients had minor bleeding in Group A, but only 2 patients in Group B ( P <0.05). No clot deposit developed on IABP surface in either group. Conclusion: IABP is safe without routine anticoagulation therapy. Selecting appropriate artery approach and early detection intervention are key methods for preventing complications.

Preoperative Intra-Aortic Balloon Counterpulsation in Coronary Artery Bypass Graft Patients with Severe Left Ventricular Dysfunction

Background: The intra-aortic balloon pumping (IABP) is the most used ventricular mechanical assist device. In recent years, the preoperative use in patients with severe ventricular dysfunction presents itself as a great benefic strategy to the postoperative recovery. This paper aim is to evaluate the IABP post-operative benefit in patients with severe ventricular dysfunction. Methods: From January 2011 to March 2016, 125 patients underwent a coronary artery bypass graft (CABG) with cardiopulmonary bypass and preoperative IABP in Teaching Hospital of the ABC Medical School and Hospital Estadual Mario Covas. The inclusion criteria were the presence of severe ischemic cardiomyopathy with left ventricular ejection fraction (LVEF) less than or equal to 40%, estimated by Doppler echocardiography using the Simpson method. The preoperative LVEF was 30.25% ± 8.53% and the diastolic diameter of the left ventricle (LVDD) 67.75 ± 16.37 mm. IABP was installed approximately 15 hours before the surgery. Results: The patients required the IABP for 2.4 ± 1.58 days, and vasoactive drugs, 4.8 ± 2.12 days. We performed 3.2 ± 1.9 grafts per patient and the total length of stay was 07 ± 5.52 days. Cardiopulmonary bypass time was 67 ± 10.95 minutes and anoxia time, 46.4 ± 10.06 minutes. Twelve patients (9.6%) had pneumonia and four (3.2%), atrial fibrillation. We observed a LVDD reduction to 63 ± 16.26 (p = 0.068) and LVEF enhancement to 36.50 ± 16.86 (p = 0.144). The data were analyzed statistically according to the Wilcoxon test. There were no deaths. Conclusion: The initial experience of the authors with the preoperative IABP in patients with severe left ventricular dysfunction suggests great benefit in post-operative recovery with im-provement of LVEF and reduction of LVDD.

1例急性心肌梗死患者经皮冠状动脉介入治疗术后中西医结合集束化护理

本文总结1例急性心肌梗死患者经皮冠状动脉介入治疗术后中西医结合集束化护理体会。在完善护理评估的基础上,制定基础护理方案。在密切监测病情的基础上,实施集束化护理措施,包括术后健康宣教、主动脉内球囊反搏(IABP)管路护理、皮肤护理、双心护理、睡眠护理,以及针对腹胀、胸闷憋喘症状的干预等,旨在有效缓解症状,减少并发症、后遗症等的发生,改善预后和患者生活质量。

Peri-operative application of intra-aortic balloon pumping reduced in-hospital mortality of patients with coronary artery disease and left ventricular dysfunction

Background:There are few reports of peri-operative application of intra-aortic balloon pumping(IABP)in patients with coronary artery disease(CAD)and different grades of left ventricular dysfunction.This study aimed to analyze the early outcomes of perioperative application of IABP in coronary artery bypass grafting(CABG)among patients with CAD and left ventricular dysfunction,and to provide a clinical basis for the peri-operative use of IABP.Methods:A retrospective analysis of 612 patients who received CABG in the General Hospital of People's Liberation Army between May 1995 and June 2014.Patients were assigned to an IABP or non-IABP group according to their treatments.Logistic regression analysis was performed to investigate the influence of peri-operative IABP implantation on in-hospital mortality.Further subgroup analysis was performed on patients with severe(ejection fraction[EF]≤35%)and mild(EF=36%-50%)left ventricular dysfunction.Results:Out of 612 included subjects,78 belonged to the IABP group(12.7%)and 534 to the non-IABP group.Pre-operative left ventricular EF(LVEF)and EuroSCOREII·predicted mortality was higher in the IABP group compared with the non-IABP group(P<0.001 in both cases),yet the two did not differ significantly in terms of post-operative in-hospital mortality(P=0.833).Regression analysis showed that IABP implantation,recent myocardial infarction,critical status,non-elective operation,and postoperative ventricular fibrillation were risk factors affecting in-hospital mortality(P<0.01 in all cases).Peri-operative IABP implantation was a protective factor against in-hospital mortality(P=0.0010).In both the severe and mild left ventricular dysfunction subgroups,peri-operative IABP implantation also exerted a protective role against mortality(P=0.0303 and P=0.0101,respectively).Conclusions:Peri-operative IABP implantation could reduce the in-hospital mortality and improve the surgical outcomes of patients with CAD with both severe and mild left ventricular dysfunction.

Influence of preoperative coronary collateral circulation on in-hospital mortality in patients undergoing coronary artery bypass graft surgery with intra-aortic balloon pump support

Background Outcomes in patients requiring coronary artery bypass graft （CABG） surgery have been improved with devices such as the intra-aortic balloon pump （IABP）.Good coronary collateral circulation （CCC） has been shown to reduce mortality in patients with coronary artery disease （CAD）.We aimed to investigate whether poor preoperative CCC grade is a predictor of in-hospital mortality in CABG surgery requiring IABP support.Methods Fifty-five consecutive patients who were undergoing isolated first time on-pump CABG surgery with IABP support were enrolled into this study and CCC of those patients was evaluated.Results Twenty-seven patients had poor CCC and 28 patients had good CCC.In-hospital mortality rate in poor CCC group was significantly higher than good CCC group （14 （50％） vs.4 （13％）,P=0.013）.Preoperative hemoglobin level （OR：0.752; 95％ CI,0.571-0.991,P=0.043）,chronic obstructive pulmonary disease （OR：6.731; 95％ CI,1.159-39.085,P=0.034） and poor CCC grade （OR：5.750; 95％ CI,1.575-20.986,P=0.008） were associated with post-CABG in-hospital mortality.Poor CCC grade （OR：4.853; 95％ CI,1.124-20.952,P=0.034） and preoperative hemoglobin level （OR：0.624; 95％ CI,0.476-0.954,P=0.026） were independent predictors of in-hospital mortality after CABG.Conclusion Preoperative poor CCC and hemoglobin are predictors of in-hospital mortality after CABG with IABP support.

Efficacy and safety of intra-aortic balloon pump-assisted interventional therapy in different age groups of patients with acute coronary syndrome

Background Currently intra-aortic balloon pump （IABP） has been widely used in patients with acute coronary syndrome （ACS） who undergo percutaneous coronary intervention （PCI）. However, few studies have been done with regard to the clinical outcome and safety of IABP in assisting PCI in aged patients with ACS. The purpose of the present study was to evaluate the safety of tABP in different age groups of patients with ACS.Methods Data on 292 ACS patients who received IABP-assisted PCI in Shenyang General Hospital of People＇s Liberation Army were retrospectively analyzed. More specifically, the successful rate, mortality and complications associated with the treatment were compared between the senior （〉60 years old） and the non-senior （〈60 years old） groups of patients. Results The attack rate of non-ST segment elevation ACS was significantly higher in the senior group than in the non-senior group （38.8% vs 21.1%, P 〈0.01）. The incidence of the IABP-associated complications was not significantly different between both groups （P 〉0.05）.Conclusion The clinical outcome and safety of IABP-assisted PCI in the elderly patients were comparable to that for the non-elderly patients.

Thrombocytopenia in patients of acute coronary syndrome with intra-aortic balloon pumping placement

Background Thrombocytopenia is a common complication of IABP. Until now,there is no unified conclusions about the incidence,characteristics,risk factors and the prognosis of IABP related thrombocytopenia.Methods In this study,the data of patients with ACS undergoing PCI and IABP were retrospectively analyzed.All enrolled patients were divided into thrombocytopenia group and non-thrombocytopenia group according to the occurrence of thrombocytopenia after insertion of IABP. The baseline data of the two groups were compared,and the possible risk factors of thrombocytopenia and their impact on prognosis were analyzed by chi-square test and logistic regression analysis. Results Sixty-two patients were enrolled in this study. The rate ofIABP associated thrombocytopenia was 25.8%(16/62)of all patients. Older agewas an independent risk factor of IABP associated thrombocytopenia(OR:3.625;95% confidence interval:1.016-12.935;P=0.047). The incidence of TIMI bleeding events was higher in thrombocytopenia group[75.0%(12/16)vs. 43.5%(20/46),P=0.042]. The rate of in-hospital death was similar between the two groups[18.8%(3/16)vs. 17.4%(8/46),P=1.0]. Conclusion IABP associated thrombocytopenia occurs in 25.8% of patients with ACS undergoing PCI and correlates with increased TIMI bleeding events. Older age may predict IABP associated thrombocytopenia.

Superior mesenteric artery embolism as a fatal complication of intra-aortic balloon pump: A case report and literature review

INTRODUCTION The intra-aortic balloon pump(IABP)is commonly used as a cardiac assist device in various clinical situations,including cardiogenic shock,mechanical complications of acute myocardial infarction,high risk percutaneous coronary interventions(PCI),coronary artery bypass graft surgery and refractory unstable angina,etc.However,like other invasive devices,the use of IABP has been associated with some complications.The most frequently reported complications are hemorrhage and limb ischemia.Rare complications include infection,arterial perforation,aortic dissection and thrombocytopenia and bowel infarction.Arterial embolism of internal organs is a rare but fatal complication of IABP therapy.Sirbu et al.reported that 59%of patients who developed ischemic vascular complications due to IABP died1.

Clinical significance of intra-aortic balloon pumping on no-reflow phenomenon of primary percutaneous coronary intervention for acute myocardial infarction

Background Percutaneous coronary intervention （PCI） is used as a treatment for acute myocardial infarction （AMI）, and one of its major complications is the angiographic no-reflow phenomenon （NR）. Although intra-aortic balloon pumping （IABP） is sometimes used in such patients to increase the diastolic coronary blood flow, there is little available information regarding the effects of IABP on the angiographic no-reflow phenomenon. Method Twenty-two AMI patient with NR were performed primary PCI between January 2006 and December 2009, of which 12 patients were selected for IABP therapy and the left 10 were selected as the control group by group procedure of odd and even days; We observed the vasoactive substance in both groups on the days of 1, 2, 3, 5, 7, 10 after the different interventions, which include plasma renin activity （PRA）, angiotensin Ⅱ （ANG Ⅱ）, aldosterone （ALD）, adrenaline （E）, and noradrenalin （NE）; In addition, cardiac structure and cardiac ventricle systolic function including left atrium medial diameter （LAMD）, left ventricular medial diameter （LVMD） Finally, left ventricular ejection fraction （LVEF） were evaluated after 10 days, 3 months and 6 months; statistics was taken to analysis. Results According to the time concentration curve, vasoactive substance of the IABP group decreased faster than that of the control group, and this difference had statistical significance （P 〈 0.01 ） ; In terms of LAMD, LVMD, and LVEF, echocardiography difference of the IABP and the control group in 10 days, 3 months, and 6 months also showed statistical significance （P 〈 0.05）. Conclusions IABP can significantly reduce the release of vasoactive substances of NR in patients of primary PCI for AMI; LAMD, LVMD and LVEF in 10 days, 3 months, and 6 months can be improved using this method, which is conducive to recovery of heart function.

Application of intra-aortic balloon pumping on no-reflow phenomenon in primary PCI for STEMI

Background To investigate the effect of intra-aortic balloon pumping （IABP） on no-reflow phenomenon primary percutaneous coronary intervention （PCI） for ST-Elevation Myocardial Infarction （STEMI）. Methods Clinical data of 22 acute myocardial infarction patients after PCI with angiographic no-reflow phenomenon were retrospectively analyzed between January 2006 and December 2009.12 patients underwent IABP, other 10 patients as control group. We observed difference of cardiac structure, brain natriuretic peptide （BNP） and ventricular systolic function between two group, as well as cardiac injury markers （MYO,CK-MB, cTnI） in both groups on the days of 1, 2, 3, 5, 7, 10 after the different interventions. In addition, cardiac structure and ventricular systolic function including left atrium medial diameter （LAMD）, left ventricular medial diameter （LVMD）, left ventricular ejection fraction （LVEF） was evaluated after 10 days, 3 months,6 months Finally, statistics was used to analysis the data. Results The several vasoactive substances as well as cardiac injury markers and LAMD, LVMD, LVEF of 10 days, 3 months, 6 months of IABP group were significant difference with control group significant difference （P 〉 0.0 PCI with angiographic no-reflo （P 〈 0.05）. 5）. Conclusions w phenomenon, BNP targets of IABP group compared with the control group no IABP has effects on prognosis in STEMI patients who performed which is conducive to recovery of heart function.

A comparative analysis of intra-aortic balloon pump in off-pump patients undergoing coronary artery bypass grafting at different perioperative stages

Background Intra-aortic balloon pump （IABP） has been widely used at present. We can use it at different stages of perioperative period in off-pump coronary artery bypass grafting （CABG）. However, when to used it was seldom confirmed. Methods From January 2008 to June 2012, the 89 coronary heart disease （CHD） patients accepted implantation of IABP at different stages of off-pump CABG, preoperative and postoperative ventricular systolic function, left ventricular remodeling situation and the changes of myocardial enzymes were evaluated. Results All the patients had left heart insufficiency and muhivessel disease. Their postoperative left ventricular systolic function and ventricular remodeling were significantly improved while myocardial enzymes decreased with preoperative interventional implantation of IABP. The perioperative mortality was 7.86% （7/89）. No patients had complication of IABP. Conclusion Earlier IABP implantation at preoperation is useful to improve heart function, improve the tolerability of surgery, reduce the incidence of postoperative low cardiac output syndrome （LCOS） and decrease the mortality.

1650例男性患者冠状动脉旁路移植术围术期临床回顾性研究

目的冠状动脉旁路移植术(coronary artery bypass grafting,CABG)是治疗冠状动脉粥样硬化性心脏病(以下简称冠心病)主要手段之一,主要手术方式包括体外循环下冠状动脉旁路移植术(on-pump CABG,ONCABG)和非体外循环下冠状动脉旁路移植术(off-pump CABG,OPCABG)。本文拟通过回顾性分析1 650例男性患者施行OPCABG和不停跳ONCABG临床资料进行两种手术方式的临床效果分析。方法采用首都医科大学附属北京安贞医院麻醉科2007年至2009年CABG数据库的有关数据。比较OPCABG组和不停跳ONCABG组近期疗效,并分别以术后死亡和术后应用连续性肾脏替代治疗(continuous renal replacement treatment,CRRT)为因变量进行Logistic危险因素回归分析。结果 OPCABG组搭桥时间和总手术时间均小于ONCABG组(P<0.01)。OPCABG组搭桥数大于3的病例明显多于ONCABG组(20.9%vs 13.3%)(P<0.01),应用CRRT(1.33%vs 3.98%)和主动脉内球囊反搏(3.23%vs 6.63%)患者的比例较ONCABG组显著减少(P≤0.01),两组术后院内病死率差异无统计学意义。CABG术后发生院内死亡的独立危险因素为术前左室射血分数(left ventricular ejection fraction,LVEF)<40%(P=0.000,OR=8.321)、年龄>70岁(P=0.003,OR=4.870)和术后应用CRRT(P=0.000,OR=45.500)。术后应用CRRT的独立危险因素为术前高血压病史(P=0.049,OR=2.665)、术前肾功能异常(P=0.045,OR=3.598),OPCABG可以减少2/3的术后CRRT的使用率(P=0.008,OR=0.333)。结论 OPCABG可以降低术后CRRT和IABP的使用率,缩短手术时间。因此在年龄>70岁,术前肾脏功能下降,心功能差等患者施行OPCABG手术对早期恢复是有益的。

经肱动脉与经股动脉路径进行主动脉内球囊反搏术治疗急性心肌梗死合并心源性休克患者的对比研究

目的评估急性心肌梗死(acute myocardial infarction,AMI)合并心源性休克(cardiogenic shock,CS)患者经肱动脉与股动脉路径进行主动脉内球囊反搏术(TBA-IABP与TFA-IABP)的有效性及安全性。方法纳入2010年6月至2011年12月期间在广东医学院附属医院行TBA-IABP及TFA-IABP治疗的AMI合并CS患者95例,将患者随机分为TBA-IABP组(46例)和TFAIABP组(49例)。比较两组患者住院期间临床事件的发生率。结果与TFA-IABP组相比,TBAIABP组IABP开始工作至CS缓解时间、总住院时间、穿刺点压迫时间均降低[(44±10.6)h比(65±12.5)h;(154±26.6)h比(236±34.2)h;(3±1.6)min比(25±10.2)min,P均<0.05];TBA-IABP组迷走神经反射、血肿和假性动脉瘤发生率也较TFA-IABP组低(2%比10%;2%比8%;0比4%,P均<0.05);相应TBA-IABP组CS抢救成功率明显高于TFA-IABP组(87%比73%,P=0.047)。TBA-IABP组有2例出现轻度远端肢体血运欠佳,但经解痉镇痛症状缓解。结论对AMI合并CS患者,TBA-IABP的血管并发症发生少,且CS抢救成功率高,其机制可能与TBAIABP有利于局部压迫止血、无体位限制(患者可半坐卧位)、患者痛苦小和心理压力轻(减少交感神经张力)有关,作为可选择的血管路径之一。

主动脉内球囊反搏置入辅助急诊冠状动脉介入治疗老年急性心肌梗死伴心源性休克的分析

目的:研究主动脉内球囊反搏术(IABP)辅助急诊经皮冠状动脉介入治疗(PCI)老年急性ST段抬高心肌梗死(ASTEMI)合并心源性休克(CS)患者的短期预后。方法:回顾性选择首都医科大学附属北京安贞医院心内科,自2015年1月至2016年12月,收治并应用IABP辅助急诊PCI治疗的STEMI合并CS的79例老年患者,同期选择未应用IABP辅助治疗的STEMI合并CS的75例老年患者作为对照组,比较两组术前、术中和术后情况的变化以及随访30 d时的病死率,并应用Kaplan-Meier生存分析评价两组的生存情况。结果:入选的154例患者中,男性85例,女性69例,平均年龄(69.4±9.3)岁,入院平均动脉压为(58.9±13.5)mmHg。两组间术前平均动脉压、CK-MB值、cTnI值、血肌酐、氧和指数、血肌酐、进门-球囊扩张时间、术后CK-MB和cTnI峰值、心电图ST段回落、完全血管化比例等,差异均有统计学意义(P<0.05)。两组患者血管活性药物使用时间、有创机械通气比例、住院时间、急性肾损伤、再发心肌梗死差异均有统计学意义(P<0.05)。随访30d时,死亡31例。Kaplan-Meier生存分析两组间的中位生存时间差异有统计学意义(P<0.05)。结论:IABP辅助PCI治疗老年ASTEMI急性冠状动脉综合征合并CS有助于改善短期患者的血流动力学。但IABP组患者基础心功能差,短期病死率高。因此需更多高质量、大规模的随机对照临床研究验证IABP辅助治疗老年ASTEMI的长期效果。

预防性应用IABP治疗高危冠心病的有效性和安全性

目的:观察高危冠心病患者预防性应用经主动脉内球囊反搏(IABP)治疗的有效性和安全性。方法:入选符合高危冠心病患者59例,分为IABP组(预防性使用IABP,n=23)和非IABP组(未使用或被动型使用IABP,n=36),IABP组PCI前常规预防性的植入IABP,非IABP组未植入IABP或因病情恶化被动性植入IABP。术中术后观察指标:1IABP相关的并发症(血小板下降、贫血、下肢栓塞、坠积性肺炎等);2恶性心律失常、心力衰竭、心源性休克的发生率;31年内主要不良心血管事件(MACE)发生率。结果:IABP组贫血和坠积性肺炎或栓塞的发生率显著高于非IABP组(P<0.05),两组血小板下降的比例无明显差异;IABP组发生心力衰竭、心源性休克和恶性心律失常的比例显著低于非IABP组(P<0.05);两组再发心绞痛或非致死性心肌梗死和再次血运重建发生率无显著差异,IABP组1年内病死率显著低于非IABP组(P<0.05)。结论:高危冠心病患者预防性应用IABP能有效地改善血流动力学,增加冠脉灌注,减少心力衰竭、恶性心律失常和心源性休克的发生,提高了高危冠心病患者1年的存活率,且并未发生与IABP植入相关的严重并发症。

急诊IABP循环支持脱机时间对AMI并泵衰竭患者心功能的影响

目的探讨急诊主动脉球囊反搏术(IABP)循环支持脱机时间对急性心肌梗死(AMI)并泵衰竭患者心功能的影响。方法选择湖南省人民医院2011年1月—2014年10月收治的AMI并泵衰竭行急诊IABP循环支持辅助介入治疗50例,根据脱机时间分为观察组(IABP循环支持7 d后脱机)和对照组(IABP循环支持3 d后脱机),比较两组治疗前、治疗3 d、治疗7 d后血流动力学指标以及治疗前、治疗7 d后心功能指标及治疗结束后随访12个月时心功能指标、并发症、生存情况。结果治疗3 d后两组平均动脉压(MAP)、血氧饱和度(SaO_2)均较治疗前明显提高,心率(HR)较治疗前明显下降(P<0.05);对照组MAP、SaO_2高于观察组,HR低于观察组(P<0.05)。观察组治疗7 d后与治疗3 d后比较MAP、SaO_2升高、HR则降低(P<0.05)。治疗7 d后及随访12个月时两组左室射血分数(LVEF)、左室收缩末期容积指数(LVEDVI)、左室舒张末期容积指数(LVESVI)均高于治疗前(P<0.05),且观察组均高于对照组(P<0.05),观察组随访12个月时上述指标均高于治疗7 d后(P<0.05)。随访12个月时出现并发症及死亡例数观察组、对照组分别为6例(23.1%)、10例(38.5%)及4例(16.7%)、10例(41.7%),差异无统计学意义(P>0.05)。结论急诊IABP循环支持治疗AMI并泵衰竭安全有效,能明显改善患者的血流动力学指标,且延长IABP脱机时间能显著改善患者的心功能。

低浓度肝素钠冲管液预防IABP管道阻塞的临床观察

了解低浓度肝素钠冲管液对急性心肌梗死合并心源性休克患者使用IABP球囊辅助治疗的管道阻塞及相关血栓事件、出血风险的情况。我们选取2009年1月～2013年9月急性心肌梗死合并心源性休克患者使用IABP球囊应用肝素钠冲管液患者70例,其中包括实验组35例：应用0.9%NS加如入肝素钠稀释至浓度为10 000 u/L,对照组35例：应用0.9%生理盐水加入肝素钠稀释至浓度为（25 000μ/L）。观察术后IABP管道通畅及下肢动脉血栓形成情况,出血事件发生率。两组均未发现管道堵塞及下肢动脉血栓形成情况,但实验组总体出血事件的发生率明显较少。提示：较低浓度肝素钠冲管液（10 000 u/L）与常规浓度冲管液（25 000μ/L）相比在急性心肌梗死合并心源性休克IABP术后相关血栓事件无明显增加,但后者的出血风险较低。