Clinical Analysis of Embryonic Posterior Cerebral Artery

Objective:To understand the clinical characteristics of patients with embryonic posterior cerebral artery and its correlation with abnormal vascular development.Methods:The clinical data of 396 patients with embryonic posterior cerebral artery confirmed by magnetic resonance angiography(MRA)and computed tomography angiography(CTA)were analyzed.Results:Two-hundred patients had clinical manifestations of posterior circulation ischemia,including recurrent dizziness,vertigo,and tinnitus;45 had headaches,97 had limb weakness,and 16 patients had syncope or impaired consciousness.Seventy-six patients with circulatory infarction were admitted to the hospital.There were 251 patients with history of hypertension,74 with diabetes,113 with hyperlipidemia,13 with dominant vertebral artery,10 with intracranial aneurysm,and 19 with absence of A1 segment of the anterior cerebral artery(considering developmental variation).Conclusion:Embryonic posterior cerebral artery develops abnormally during the embryonic period,often accompanied by abnormal vascular access.Due to abnormal hemodynamics,the incidence of posterior circulation ischemia,aneurysm,and infarction increases in such patients.

Influence of Clip Locations on Intraaneurysmal Flow Dynamics in Patient-specific Anterior Communicating Aneurysm Models with Different Aneurysmal Angle

To improve aneurysm treatment,this study examined the influence of clip locations on hemodynamic factors in patient-specific anterior communicating artery(ACoA)aneurysms with different aneurysmal angle.We proposed a simplified classification of ACoA aneurysms using aneurysmal angle,defined by the angle of pivot of the aneurysmal dome and the virtual two-dimensional plane created by both proximal A2 segments of anterior cerebral artery(ACA).ACoA aneurysms with three different aneurysmal angles,which are 15°,80°and 120°,were analyzed in our study.In this work,we obtained hemodynamics before and after clipping surgery with three clip locations based on clinical clipping strategies in three ACoA aneurysms with different aneurysm angles.Results showed that local high pressure occurs at impingement region of the ACoA aneurysm before clipping and new impingement region close to the clipping location after clipping treatment.For clipping the aneurysm with aneurysmal angle 15°and a wide neck,wall shear stress(WSS)distribution is more uniform when the clipping angle of two clips close to 180°comparing with other two angles.In addition,for clipping the aneurysm with aneurysmal angle 80°and 120°,local high pressure appears on new impingement region and high WSS distributes around the clipping location when the clip plane is normal to the direction of inflow of aneurysm from the dominance of A1 segment of ACA.Hence,we should avoid the impingement of inflow from the A1 segment and choose a favorable clipping location for the fastness of clip.The results of our study could preoperatively give a useful information to the decision of surgical plan.

Nomogram model for predicting oculomotor nerve palsy in patients with intracranial aneurysm

AIM:To explore the risk factors of oculomotor nerve palsy(ONP)in patients with intracranial aneurysm(IA)and develop a nomogram model for predicting ONP of IA patients.METHODS:A total of 329 IA patients were included.Logistic regression analysis was applied to identify independent factors,which were then integrated into the nomogram model.The performance of the nomogram model was evaluated by calibration cur ve,receiver operating curve(ROC),and decision curve analysis.RESULTS:Univariate and multivariate logistic regression analysis indicated posterior communicating artery(PCo A)aneur ysm[hazard ratio(HR)=17.13,P<0.001]and aneurysm diameter(HR=1.31,P<0.001)were independent risk factors of ONP in IA patients.Based on the results of logistic regression analysis,a nomogram model for predicting the ONP in IA patients was constructed.The calibration curve indicated the nomogram had a good agreement between the predictions and observations.The nomogram showed a high predictive accuracy and discriminative ability with an area under the curve(AUC)of 0.863.The decision curve analysis showed that the nomogram was powerful in the clinical decision.PCo A aneurysm(HR=3.38,P=0.015)was identified to be the only independent risk factor for ONP severity.CONCLUSION:PCo A aneurysm and aneurysm diameter are independent risk factors of ONP in IA patients.The nomogram established is performed reliably and accurately for predicting ONP.PCo A aneurysm is the only independent risk factor for ONP severity.

Morphological predictors of posterior communicating artery aneurysms rupture

Objective: The conflicting findings of previous morphological studies on intracranial aneurysm rupture may be caused by the different locations of aneurysms. We aimed to determine the independent risk factors of aneurysm rupture by focusing on only posterior communicating artery(Pcom A) aneurysms. Methods: In 89 PcomA aneurysms(58 ruptured, 31 unruptured), clinical and morphological characteristics were compared between the ruptured and unruptured groups. Multivariate logistic regression analysis was performed to determine the independent predictors for the rupture status of PcomA aneurysms. Results: In univariate analyses, the aneurysm dome size, aspect ratio, size ratio,dome‐to‐neck ratio, and inflow angle were significant parameters. With multivariate analyses, only the aneurysm dome size and inflow angle were significantly associated with the rupture status of PcomA aneurysms. Conclusions: Morphology was related with rupture of PcomA aneurysms. The aneurysm dome size and inflow angle were found to be the independent parameters characterizing the rupture status of PcomA aneurysms.

Intentional Compartmentalized Embolization of Wide-neck Aneurysms Incorporating the Posterior Communicating Artery to Preserve Flow

Background:Endovascular coiling for wide-neck aneurysms with a branch arising from the aneurysmal sac is challenging and sometimes considered impossible.This study aims to present our experience in treating wide-neck internal carotid artery(ICA)aneurysms with a posterior communicating artery(PComA)arising from the sac using a strategy of stenting the ICA and intentional compartmentalization to preserve the flow in the PComA.Methods:Eight consecutive cases of wide-neck ICA aneurysms with a fetal-type PComA arising from the aneurysmal sac were embolized from January 2015 to June 2018 at the First Affiliated Hospital,College of Medicine,Zhejiang University.Demographics,angiographic technique,procedural complications and clinical outcomes were reviewed.Results:There were 2 men and 6 women ranging from 56 to 81 years of age.Of the 8 cases,3 were ruptured and 5 were unruptured aneurysms.Stents were successfully deployed in all 8 cases.Near-complete occlusion was achieved in 3 cases(37.5%),neck remnant in 4(50%)and sac remnant in one(12.5%)of the cases.One case suffered transient ischemic attack after procedure completion.The clinical outcome was favorable in all 8 cases(modified Rankin scale 0-1).No rebleeding occurred during clinical follow-up.Conclusion:Stent-assisted compartmentalized embolization is feasible and safe in the treatment of wide-neck ICA aneurysm with a PComA arising from the sac.

颈内动脉-后交通动脉瘤伴动眼神经麻痹大弹簧圈技术栓塞治疗的效果及安全性

目的分析颈内动脉-后交通动脉瘤伴动眼神经麻痹患者采用大弹簧圈技术栓塞治疗的效果及安全性。方法纳入2018-06—2021-06张家口市第一医院收治的98例颈内动脉-后交通动脉瘤伴动眼神经麻痹患者,对照组47例采用传统方式栓塞治疗,研究组51例采用大弹簧圈技术栓塞治疗。比较2组术后Raymond-Roy分级、动脉瘤填塞密度、动脉瘤复发、术后动眼神经恢复情况、动脉瘤术后GOS评分、术后并发症。结果研究组Raymond-Roy分级优于对照组(P<0.05)。研究组弹簧圈填塞密度高于对照组(P<0.05),动脉瘤复发率低于对照组(P<0.05)。研究组动眼神经恢复情况、发生死亡、植物生存、重残、轻残的情况与对照组相比无统计学差异(P>0.05),研究组恢复良好占比高于对照组(P<0.05)。2组术后并发症发生率无统计学差异(P>0.05)。研究组弹簧圈用量及弹簧圈费用均低于对照组(P<0.05)。结论大弹簧圈技术用于颈内动脉-后交通动脉瘤伴动眼神经麻痹患者的效果显著,能有效提高栓塞程度及密度,降低动脉瘤复发率,改善患者预后,安全性高,且能降低医疗费用。

胚胎型大脑后动脉伴发颅内动脉瘤的多层螺旋CT血管造影分析

目的:采用多层螺旋CT血管造影(CTA)分析胚胎型大脑后动脉(FTP)伴发颅内动脉瘤情况,探讨FTP是否为颅内动脉瘤危险因素。同时对比分析FTP伴发颅内动脉瘤与FTP未伴发颅内动脉瘤的相关临床资料。方法:3名医师复习155例头颅CTA的横断面、多平面重组(MPR)、容积再现(VR)图像,观察FTP是否存在及其分型,同时分析FTP患者与非FTP患者伴发颅内动脉瘤的部位、大小,是否存在蛛网膜下腔出血。电话回访FTP患者是否存在吸烟、高血压、冠心病和糖尿病病史。总结FTP发生率,采用χ2检验分析是否存在性别差异。分别总结FTP与非FTP患者伴发颅内动脉瘤的发生率。采用Fisher确切概率法比较FTP与非FTP患者伴发颅内动脉瘤的发生率,以及伴发颅内动脉瘤的FTP与未伴发颅内动脉瘤的FTP患者在年龄、性别、吸烟史、高血压、冠心病和糖尿病方面是否存在统计学差异。采用二项Logistic回归分析FTP是否为颅内动脉瘤危险因素。结果:FTP总体发生率为16.13%(25/155),男性为12.12%(12/99),女性为23.21%(13/56),其发生率无性别差异(P=0.071)。FTP患者伴发颅内动脉瘤的发生率为20%(5/25),全部为女性,非FTP患者伴发颅内动脉瘤的发生率为6.15%(8/135),FTP与非FTP在伴发颅内动脉瘤的发生率上存在统计学差异(P=0.038)。FTP是颅内动脉瘤发生的危险因素(P=0.031)。伴发颅内动脉瘤FTP患者与未伴发颅内动脉瘤FTP患者在性别、高血压、冠心病及糖尿病方面存在统计学差异(P<0.05),在年龄和吸烟史上不存在统计学差异(P>0.05)。结论:女性FTP患者在同时存在高血压、冠心病或糖尿病病史时,其伴发颅内动脉瘤的发生率明显增高。

累及小脑后下动脉椎动脉夹层动脉瘤的血管内介入治疗效果

目的：分析椎动脉夹层动脉瘤的血管内介入治疗中支架置入和双导管技术保护小脑后下动脉（PICA）的方法及其影像和临床随访结果。方法回顾性纳入首都医科大学宣武医院神经外科2012年1月至2014年12月收治的4例累及PICA的椎动脉夹层动脉瘤并经血管内治疗患者的临床资料。术后6个月复查全脑DSA，临床随访12～24个月。结果4例患者中，3例采用PICA-椎动脉支架置入技术，1例采用双向双导管技术保护PICA。对4例患者介入治疗技术方面均获成功，术后即刻造影显示PICA通畅，无缺血症状；6个月造影显示动脉瘤无复发，PICA通畅，无狭窄；12～24个月随访无新发神经功能缺损症状。结论在累及PICA的椎动脉夹层动脉瘤介入治疗中，使用P I C A-椎动脉支架置入技术和双向双导管技术能够安全、有效地保护P I C A。

血管内治疗胚胎型后交通动脉破裂动脉瘤的疗效分析

目的探讨保持胚胎型大脑后动脉（FPCA）通畅的后交通动脉动脉瘤（PCo AA）血管内治疗的可行性和有效性。方法回顾性纳入皖南医学院附属弋矶山医院2014年1月至2015年12月经血管内栓塞破裂PCo AA 14例,单纯弹簧圈栓塞6例,支架辅助弹簧圈栓塞宽颈PCo AA 3例,双导管辅助弹簧圈栓塞3例,支架辅助弹簧圈栓塞＋双导管技术1例,置入Y形支架1例。评价PCo AA即刻栓塞率（采用Raymond分级）、患者预后（术后6个月改良Rankin评分）、并发症、影像学随访结果等。结果弹簧圈和支架的置入技术成功率100%,支架均准确释放到位,无移位。动脉瘤即刻栓塞率Raymond分级显示,RaymondⅠ级8例;RaymondⅡ级4例;RaymondⅢ级2例。所有FPCA均保持通畅。术中有1例出现弹簧圈突入颈内动脉,其余无术中脑血管痉挛、支架内血栓形成、术中动脉瘤破裂等并发症。术后14例DSA随访3-24个月,3例复发,均为单纯弹簧圈栓塞的动脉瘤,未出现再出血和缺血并发症。术后6个月改良Rankin评分0-2分13例,4分1例。结论血管内栓塞治疗PCo AA并保持FPCA通畅是安全可行的。为保持FPCA的通畅,血管内治疗采用多种方式是必要的。

血管内栓塞与开颅夹闭治疗破裂后交通动脉瘤的对比研究

目的探讨血管内栓塞与开颅夹闭治疗破裂后交通动脉瘤(PCoAA)的有效性与安全性。方法回顾性分析122例破裂PCoAA病人的临床资料,按治疗方法不同,分为夹闭组32例和栓塞组90例,其中栓塞组又分为两个亚组:弹簧圈组46例、支架组44例。分析术后相关并发症,术后1、6个月mRS评分及影像学随访结果。结果栓塞组与夹闭组术中、术后症状性卒中并发症的发生率均无显著差异(P>0.05),两组术后1、6个月的预后良好率亦无显著差异(P>0.05)。动脉瘤复发率比较:夹闭组与栓塞组、夹闭组与弹簧圈组、支架组与弹簧圈组差异均有统计学意义(P<0.05),而夹闭组与支架组无明显差异(P>0.05)。结论栓塞与夹闭治疗Hunt-HessⅠ～Ⅲ级破裂PCoAA预后相当,支架组和夹闭组动脉瘤复发率明显低于弹簧圈组。

后交通动脉镜像动脉瘤的影像学特征及手术疗效

目的探讨后交通动脉(PCoA)镜像动脉瘤的影像学特征、手术时机与方法,以及显微外科手术的疗效。方法回顾性分析显微外科手术治疗的8例(16个)PCoA镜像动脉瘤患者的临床资料。采取早期与择期、一期与二期相结合的方法处理PCoA镜像动脉瘤。原则是先处理破裂动脉瘤,再处理未破裂动脉瘤。结果①PCoA镜像动脉瘤均位于颈内动脉—后交通动脉的分叉处,两侧动脉瘤的大小、形态完全对称(Ⅰ型)的有6例,不完全对称(Ⅱ型)的有2例。动脉瘤大小:0.5～1.5 cm的有9个,>1.5～2.0 cm的有5个,>2.0 cm的有2个。入院时Hunt-Hess分级Ⅱ级的有2例,Ⅲ级的有4例,Ⅳ级的有2例。②直接夹闭PCoA镜像动脉瘤15个,未处理的有1个。一期手术5例,均经双侧开颅,夹闭PCoA动脉瘤10个,对其中2例同时清除脑内血肿。二期手术2例,第1次手术夹闭一侧PCoA动脉瘤2个,对其中1例同时清除脑内血肿,第2次手术夹闭另一侧PCoA动脉瘤2个。夹闭一侧PCoA动脉瘤后,对侧动脉瘤未处理者1例。③依据格拉斯哥预后评分:良好的有6例,轻残的有1例,重残的有1例。随访3～48个月,动脉瘤无复发。结论显微外科手术治疗PCoA镜像动脉瘤效果显著,将PCoA镜像动脉瘤分为Ⅰ型和Ⅱ型,有助于判断出血的责任动脉瘤;根据动脉瘤的形态、患者Hunt-Hess分级及周身状况等选择一期或二期手术,可达到良好的效果。

小脑后下动脉远端动脉瘤的临床特征及手术治疗

目的探讨小脑后下动脉(PICA)远端动脉瘤的临床特征、诊断及手术治疗方法。方法回顾性分析2008年1月至2010年3月收治的8例PICA远端动脉瘤的临床表现、影像学特征、手术治疗及预后情况。结果所有病例均经显微手术治疗,其中经枕下正中入路手术6例,经枕下远外侧入路手术2例。动脉瘤瘤颈夹闭6例,动脉瘤孤立切除2例;脑室出血急性期行脑室外引流3例。随访3个月至2年,三维CT血管造影复查示5例患者动脉瘤消失,2例因脑积水加重行脑室-腹腔分流术。根据GOS评分,3分1例,4分1例,5分6例。结论 PICA远端动脉瘤以第四脑室内出血或小脑蚓部出血为主要表现,部分病人合并脑积水,诊断需行脑血管造影检查,一旦确诊应尽快手术治疗,效果较好。

3D-DSA评估颈内动脉-后交通动脉动脉瘤形成的形态学特征

目的分析颈内动脉眼动脉段与后交通动脉长轴方向的夹角（Apcom）、颈内动脉眼动脉段和后交通段的夹角（Aica）、颈内动脉后交通段与后交通动脉长轴的夹角（Apcom’）大小对颈内动脉-后交通动脉动脉瘤形成的影响。方法回顾性分析24例颈内动脉-后交通动脉动脉瘤（动脉瘤组）与22例非脑动脉瘤（对照组）的临床资料。通过三维血管重建技术获得满意的三维血管立体图像,从而测量其血管夹角参数。结果两组间Apcom、Aica和Apcom’、性别和年龄差异具有统计学意义（P〈0.05）。经Logistic回归分析显示仅Apcom（P=0.008）和Aica（P=0.007）与动脉瘤的发生具有独立相关性。Apcom曲线下面积（area under ROC curve,AUC）为0.799（95%CI：0.661～0.938）,最佳诊断界值为100.2°。Aica的AUC为0.764（95%CI：0.622～0.906）,最佳诊断界值为113.3°。结论 Apcom和Aica的大小与颈内动脉-后交通动脉动脉瘤形成具有相关性。

小脑后下动脉瘤的显微外科治疗

目的探讨小脑后下动脉瘤(PICA)的显微外科治疗方法。方法分析首都医科大学附属北京天坛医院从1997年5月到2005年5月收治的19例经显微外科手术治疗的小脑后下动脉瘤患者的临床表现、外科治疗和预后情况。结果19例患者中以出血为首发症状者有15例,其中蛛网膜下腔出血5例,脑内出血3例,脑室内出血3例,蛛网膜下腔出血合并脑室内出血4例。占位为首发症状者4例。19例患者均经全脑数控减影血管造影术(DSA)检查证实诊断,其中囊状动脉瘤17例,梭状2例,发生于第1段5例,第3段1例,第4段2例,第5段11例,其中有5例合并其他血管发育异常。手术入路采用后正中开颅15例,远外侧开颅4例;采用动脉瘤夹闭术8例,动脉瘤夹闭切除术9例,动脉瘤夹闭并动静脉畸形切除术1例,动脉瘤夹闭切除并动静脉瘘切除术1例。有2例患者术后出现较轻的并发症。结论PICA动脉瘤发病率低,临床表现多为出血和占位,脑内出血及脑室内出血发生率高,多为囊状动脉瘤。动脉瘤部位以PICA第1段和第5段多见,易并发其他血管发育异常。开颅方式与动脉瘤所在区段有关,手术方式与动脉瘤形态及蒂宽有关,应尽量同时处理并发的其他血管发育异常,显微外科手术治疗效果良好。

颈内动脉-后交通动脉分叉部动脉瘤与动脉圆锥周围血管的形态学差异研究

目的分析颈内动脉-后交通动脉(ICA-PComA)分叉部动脉瘤与动脉圆锥周围血管的形态学特点。方法以22个ICA-PComA动脉瘤(动脉瘤组)与20个动脉圆锥(动脉圆锥组)为研究对象,通过3D-DSA对颈内动脉交通段直径(Dica)、后交通动脉起始部直径(Dpcom)、颈内动脉与后交通动脉起始部夹角角度(Apcom)及颈内动脉眼段-床突段转折处角度(Aica)等进行测量。采用两独立样本t检验及Logistic回归对结果进行统计分析;对与动脉瘤发生具有相关性的参数进行受试者工作特线曲线(ROC)分析。结果两组Dpcom、Aica和Apcom差异有统计学意义(P<0.05);Apcom减小导致动脉瘤发生概率增加。Apcom的ROC曲线下面积为0.913,最佳诊断界值为52.25°。结论Apcom对ICA-PComA动脉瘤与动脉圆锥的鉴别及对动脉瘤的预测具有重要参考价值。

小脑后下动脉远端动脉瘤破裂的血管内治疗

目的总结小脑后下动脉（posteriorinferiorcerebellarartery，PICA）远端动脉瘤破裂的临床特征及血管内治疗方法。方法回顾性分析11例破裂PICA远端动脉瘤病人的临床资料。术前Hunt—Hess分级：Ⅰ级1例。Ⅱ级5例，Ⅲ级4例．Ⅳ级1例。全部以单纯弹簧圈行血管内治疗。结果单纯闭塞动脉瘤7例，同时闭塞动脉瘤及载瘤动脉4例。所有病人随访1～4年，术后2年复发1例，再次行血管内治疗；术后1年载瘤动脉再通1例，但仍未见动脉瘤复发；余9例动脉瘤均栓塞完全。术后1年改良rankin评分（modifled rankin scale，MRS）：0分2例，1分8例，2分1例。结论对于PICA远端动脉瘤，以单纯弹簧圈闭塞动脉瘤或者同时闭塞动脉瘤和载瘤动脉均可行、且安全，能有效预防短、中期再出血，但需定期DSA随访以防复发。

小脑后下动脉瘤的临床特点及CT血管成像的诊断作用

目的探讨小脑后下动脉瘤的临床特点及CT血管成像(CTA)的诊断作用。方法回顾性分析11例小脑后下动脉瘤患者的临床及CTA资料。结果本组患者中表现颅内出血10例,其中第四脑室出血4例、第四脑室合并蛛网膜下腔出血2例、全脑室系统出血1例、小脑半球出血3例;表现为后颅窝占位症状1例。CTA显示动脉瘤位于小脑后下动脉起始部8例、小脑后下动脉远端3例;其中囊状动脉瘤7例,梭形动脉瘤4例。手术所见动脉瘤的部位、形态、大小及其周边结构等与CTA检查结果基本一致。结论小脑后下动脉瘤多表现为第四脑室出血和小脑出血,CTA可清楚地显示小脑后下动脉瘤,对诊断有重要作用。

后交通动脉动脉瘤夹闭术中瘤夹的选择和应用

目的探讨开颅夹闭后交通动脉动脉瘤(PCoAA)的手术中,动脉瘤夹的选择规律和使用方式。方法回顾性分析2007年1月—2011年6月,北京大学第一医院开颅手术夹闭的46例PCoAA患者的临床资料。根据动脉瘤颈与载瘤动脉的关系对动脉瘤进行分型,分析瘤颈的位置、术中动脉瘤夹的型号及放置方式等。术后对患者以门诊、电话、DSA进行随访4个月至4年。结果①将46例PCoAA分为颈内动脉、后交通动脉、分叉型3种类型。其中分叉型22例、颈内动脉型19例、后交通动脉型5例。动脉瘤的位置(按时钟模式的12个钟点方向)位于1个钟点的2例,跨2个钟点的34例,跨3个钟点的10例。②对37个动脉瘤选用弯型动脉瘤夹、6个选用直型、2个选用成角度跨血管型(90°)、1个选用枪型。瘤夹长度54.3%(25/46)的为6～7 mm,另有21.7%(10/46)的长度为5～7 mm。对后交通动脉型及分叉型动脉瘤夹放置均采用平行于血管方向,而对颈内动脉型动脉瘤,垂直血管放置瘤夹13例,平行于血管放置瘤夹6例。③术后随访显示,患者均无动脉瘤复发及破裂的临床表现。对12例行DSA随访,显示动脉瘤颈均夹闭完全,无动脉瘤残留。结论 PCoAA夹闭术中,确认动脉瘤颈的位置,辨别瘤周血管的解剖关系,对动脉瘤夹的选择和放置至关重要。首选弯型动脉瘤夹,能提高完全夹闭PCoAA的成功率。

显微手术治疗颈内-后交通动脉瘤53例

目的探讨显微手术治疗颈内-后交通动脉瘤的方法、时机、并发症以及术中动脉瘤破裂和多发动脉瘤的处理。方法采用常规翼点及其改良入路,显微手术夹闭颈内-后交通动脉瘤51例,其中1例双侧后交通动脉瘤从一侧入路夹闭;行动脉瘤孤立术2例。结果本组51例均顺利夹闭瘤颈。术中有6例出现动脉瘤破裂,其中2例因动脉瘤无法夹闭而行动脉瘤孤立术,1例患者术后死亡,总死亡率1.89%(1/53)。结论显微手术仍具有介入治疗无法替代的优点,早期手术不仅可以降低等待手术期间再次出血的机率,还有利于动眼神经麻痹的恢复。

复合手术与常规夹闭术治疗颈内动脉后交通动脉破裂动脉瘤的疗效对比研究

目的对比研究复合手术和常规夹闭术治疗颈内动脉后交通动脉破裂动脉瘤的疗效。方法 60例颈内动脉后交通动脉破裂动脉瘤随机分成复合组和对照组,每组30例。复合组患者术中在实时造影技术及球囊临时阻断技术辅助下完成对动脉瘤的夹闭,对照组患者在显微镜下进行开颅动脉瘤夹闭术,比较两组患者术后疗效的差异。结果复合组动脉瘤完全夹闭率(100%)与对照组(86.7%)无明显差异(P>0.05)。复合组术中动脉瘤破裂率(3.3%)、术后动脉瘤复发率(0%)、术后颅内血肿发生率(0%)、术后偏瘫发生率(0%)均显著低于对照组(分别为26.7%、12.0%、16.7%和16.7%;P<0.05)。出院时,按GOS评分评估预后,复合组恢复良好23例,中残5例,重残2例;对照组恢复良好14例,中残5例,重残7例,植物生存2例,死亡2例;复合组预后明显优于对照组(P<0.05)。结论与常规夹闭术相比,复合手术能明显改善颈内后交通动脉破裂动脉瘤的预后,提高手术安全性,降低术后并发症的发生率。