[Objective] The paper was to establish the guinea pig model of uterine leiomyoma by intragastric administration of estrogen and to discuss the effect of different doses and administration cycles on formation of uterin...[Objective] The paper was to establish the guinea pig model of uterine leiomyoma by intragastric administration of estrogen and to discuss the effect of different doses and administration cycles on formation of uterine leiomyoma. [Method] Mature female guinea pigs were divided into short term model group and long term model group, and intragastrically administrated with estradiol valerate at the dose of 0.1 mg/100 g body weight twice a week for 6 and 8 weeks respectively. Guinea pigs intragastrically administrated with equal volume of normal saline were set as con- trol. After 6 or 8 weeks, the guinea pigs were sacrificed. The serum levels of estrogen and progesterone were measured by ELISA and the leiomyoma formation rate was measured. Histological changes were compared between treatment group and control group with HE staining. [Results] The leiomyoma formation rate was 30% in short term model group and 40% in long term model group. The overall leiomyoma formation rate was 35%. The serum level of estrogen in model animals increased significantly and the progesterone level decreased in long term model group. Histopathological examination confirmed that the guinea pig model of uterine leiomyoma was established successfully. [Conclusions] Intragastric administration of estrogen is a simple and effective method for establishing guinea pigs model of uterine leiomyoma.展开更多
The purpose of this research is to show the instability and the security risks of the information system in Burkina-Faso public administration. In this paper, witnessing unsatisfactory services such as government mess...The purpose of this research is to show the instability and the security risks of the information system in Burkina-Faso public administration. In this paper, witnessing unsatisfactory services such as government messaging (mailer.gov.bf) as well as G-cloud services which are the government cloud were studied. The behavior of user agents on the administration’s IT infrastructures which could expose the information system to security risks was also studied. The expected result shows evidence of the weakness of the public administration information system and provides some recommendation.展开更多
文摘[Objective] The paper was to establish the guinea pig model of uterine leiomyoma by intragastric administration of estrogen and to discuss the effect of different doses and administration cycles on formation of uterine leiomyoma. [Method] Mature female guinea pigs were divided into short term model group and long term model group, and intragastrically administrated with estradiol valerate at the dose of 0.1 mg/100 g body weight twice a week for 6 and 8 weeks respectively. Guinea pigs intragastrically administrated with equal volume of normal saline were set as con- trol. After 6 or 8 weeks, the guinea pigs were sacrificed. The serum levels of estrogen and progesterone were measured by ELISA and the leiomyoma formation rate was measured. Histological changes were compared between treatment group and control group with HE staining. [Results] The leiomyoma formation rate was 30% in short term model group and 40% in long term model group. The overall leiomyoma formation rate was 35%. The serum level of estrogen in model animals increased significantly and the progesterone level decreased in long term model group. Histopathological examination confirmed that the guinea pig model of uterine leiomyoma was established successfully. [Conclusions] Intragastric administration of estrogen is a simple and effective method for establishing guinea pigs model of uterine leiomyoma.
文摘The purpose of this research is to show the instability and the security risks of the information system in Burkina-Faso public administration. In this paper, witnessing unsatisfactory services such as government messaging (mailer.gov.bf) as well as G-cloud services which are the government cloud were studied. The behavior of user agents on the administration’s IT infrastructures which could expose the information system to security risks was also studied. The expected result shows evidence of the weakness of the public administration information system and provides some recommendation.
