Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is difficu...Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is difficult.In recent years,many surgeons have performed electrophysiological monitoring to effectively reduce the occurrence of post-operative neurological complications.Modern electrophysiological monitoring technology has advanced considerably,leading to the development of many monitoring methods,such as SSEPs,MEPs,DCM,and EMG,to monitor intramedullary tumors.However,electrophysiological monitoring in tumor resection is still being studied.In this article,we discussed the different monitoring methods and their role in monitoring intramedullary tumors by reviewing previous studies.Intratumorally tumors need to be monitored for a summary of the condition of the patient.Only by using various monitoring methods flexibly and through clear communication between surgeons and neurophysiological experts can good decisions be made during surgery and positive surgical results be achieved.展开更多
Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researc...Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researches for IMSCT treatment using nanomedicine.To fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT treatment.In this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of MSCs.Owing to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery.展开更多
Background Cavernous malformations of the spinal cord are a rare type of vascular malformation,comprising approximately 5 to 16%of all vascular lesions in the spinal cord.Depending on their origin position,these malfo...Background Cavernous malformations of the spinal cord are a rare type of vascular malformation,comprising approximately 5 to 16%of all vascular lesions in the spinal cord.Depending on their origin position,these malformations can be distributed in different locations within the spinal canal.Although intramedullary cavernous malformations have been reported in the literature,they are exceedingly rare.Furthermore,highly calcified or ossified intramedullary cavernous spinal malformations are even rarer.Case presentation Here,we present a case report of a 28-year-old woman diagnosed with a thoracic intramedullary cavernous malformation.The patient had been experiencing progressive numbness in her distal limbs for a period of 2 months.During routine lung computed tomography screening for COVID-19,a hyperdense mass was noted in the patient’s spinal canal.Magnetic resonance imaging revealed a mulberry-shaped intramedullary mass at the T1-2 level.The patient underwent surgical treatment,during which the entire lesion was successfully removed,resulting in a gradual improvement of her symptoms.Histological examination confirmed the presence of cavernous malformations with calcification.Conclusions Intramedullary cavernous malformations with calcification are rare and special type that should be treated surgically in the early stage without significant neurological impairment before rebleeding or enlargement of the lesion can occur.展开更多
文摘Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is difficult.In recent years,many surgeons have performed electrophysiological monitoring to effectively reduce the occurrence of post-operative neurological complications.Modern electrophysiological monitoring technology has advanced considerably,leading to the development of many monitoring methods,such as SSEPs,MEPs,DCM,and EMG,to monitor intramedullary tumors.However,electrophysiological monitoring in tumor resection is still being studied.In this article,we discussed the different monitoring methods and their role in monitoring intramedullary tumors by reviewing previous studies.Intratumorally tumors need to be monitored for a summary of the condition of the patient.Only by using various monitoring methods flexibly and through clear communication between surgeons and neurophysiological experts can good decisions be made during surgery and positive surgical results be achieved.
基金supported by the National Nature Science Foundation of China(Nos.31872756 and 32071387)Six Talent Peaks Project in Jiangsu Province(No.JY-079)333 High-level Talent Development Project in Jiangsu Province。
文摘Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researches for IMSCT treatment using nanomedicine.To fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT treatment.In this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of MSCs.Owing to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery.
基金National Natural Science Foundation of China(81891004)Beijing Hospitals Authority Clinical medicine Development of special funding support.(XMLX202109)
文摘Background Cavernous malformations of the spinal cord are a rare type of vascular malformation,comprising approximately 5 to 16%of all vascular lesions in the spinal cord.Depending on their origin position,these malformations can be distributed in different locations within the spinal canal.Although intramedullary cavernous malformations have been reported in the literature,they are exceedingly rare.Furthermore,highly calcified or ossified intramedullary cavernous spinal malformations are even rarer.Case presentation Here,we present a case report of a 28-year-old woman diagnosed with a thoracic intramedullary cavernous malformation.The patient had been experiencing progressive numbness in her distal limbs for a period of 2 months.During routine lung computed tomography screening for COVID-19,a hyperdense mass was noted in the patient’s spinal canal.Magnetic resonance imaging revealed a mulberry-shaped intramedullary mass at the T1-2 level.The patient underwent surgical treatment,during which the entire lesion was successfully removed,resulting in a gradual improvement of her symptoms.Histological examination confirmed the presence of cavernous malformations with calcification.Conclusions Intramedullary cavernous malformations with calcification are rare and special type that should be treated surgically in the early stage without significant neurological impairment before rebleeding or enlargement of the lesion can occur.