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Application of Patient Simulators Combined with Internet plus Scenario Simulation Teaching Models on Intravenous Infusion Nursing Education in China
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作者 Ying Wu Yun Chen +5 位作者 Liuyan Zhang Guohua Huang Jinai He Yutong Li Yuzhen Renqing Zhijuan Zhan 《Journal of Biosciences and Medicines》 2024年第1期64-71,共8页
Objective: To explore the effectiveness of applying patient simulators combined with Internet Plus scenario simulation teaching models on intravenous (IV) infusion nursing education, and to provide scientific evidence... Objective: To explore the effectiveness of applying patient simulators combined with Internet Plus scenario simulation teaching models on intravenous (IV) infusion nursing education, and to provide scientific evidence for the implementation of advanced teaching models in future nursing education. Methods: Enrolled 60 nurses who took the IV infusion therapy training program in our hospital from January 2022 to December 2023 for research. 30 nurses who were trained in traditional teaching models from January to December 2022 were selected as the control group, and 30 nurses who were trained with simulation-based teaching models with methods including simulated patients, internet, online meetings which can be replayed and scenario simulation, etc. from January to December 2023 were selected as the experimental group. Evaluated the learning outcomes based on the Competency Inventory for Nursing Students (CINS), Problem-Solving Inventory (PSI), comprehensive learning ability, scientific research ability, and proficiency in the theoretical knowledge and practical skills of IV infusion therapy. Nursing quality, the incidence of IV infusion therapy complications and nurse satisfaction with different teaching models were also measured. Results: The scientific research ability, PSI scores, CINS scores, and comprehensive learning ability of the experimental group were better than those of the control group (P 0.05), and their assessment results of practical skills, nursing quality of IV infusion therapy during training, and satisfaction with teaching models were all better than those of the control group with statistical significance (P < 0.05). The incidence of IV infusion therapy complications in the experimental group was lower than that in the control group, indicating statistical significance (P < 0.05). Conclusions: Teaching models based on patient simulators combined with Internet Plus scenario simulation enable nursing students to learn more directly and practice at any time and in any place, and can improve their proficiency in IV infusion theoretical knowledge and skills (e.g. PICC catheterization), core competencies, problem-solving ability, comprehensive learning ability, scientific research ability and the ability to deal with complicated cases. Also, it helps provide high-quality nursing education, improve the nursing quality of IV therapy, reduce the incidence of related complications, and ensure the safety of patients with IV therapy. 展开更多
关键词 Specialty of intravenous Infusion Therapy Nursing Education Patient Simulators Internet Plus Scenario Simulation Teaching model
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Real-Time Analytical Solutions as Series Formulas and Heaviside off/on Switch Functions for Multiple Intermittent Intravenous Infusions in One- and Two-Compartment Models 被引量:2
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作者 Michalakis Savva 《Journal of Biosciences and Medicines》 2022年第1期150-189,共40页
Pharmacokinetic compartment models are the only models that can extract pharmacokinetic parameters from data collected in clinical studies but their estimates lack accuracy, explanations and physiological significance... Pharmacokinetic compartment models are the only models that can extract pharmacokinetic parameters from data collected in clinical studies but their estimates lack accuracy, explanations and physiological significance. The objective of this work was to develop particular solutions to drug concentration and AUC in the form of mathematical series and Heaviside functions for repetitive intermittent infusions in the one- and two-compartment models, as a function of dose number and total time using differential calculus. It was demonstrated that the central and peripheral compartment volumes determined from regression analysis of the aminoglycoside antibiotic Sisomicin concentration in plasma represent the actual physiological body fluid volumes accessible by the drug. The drug peak time and peak concentration in the peripheral compartment were also calculated as a function of dose number. It is also shown that the time of intercompartmental momentary distribution equilibrium can be used to determine the drug’s apparent volume of distribution within any dosing interval in multi-compartment models. These estimates were used to carry out simulations of plasma drug concentration with time in the one-compartment model. In conclusion, the two-compartment open mammillary pharmacokinetic model was fully explained for the aminoglycoside antibiotic sisomicin through the new concept of the apparent volume of distribution. 展开更多
关键词 PHARMACOKINETICS Intermittent intravenous Infusion Multiple Doses Compartment models Heaviside Function Apparent Volume of Distribution
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Intravenous immunoglobulins in liver transplant patients: Perspectives of clinical immune modulation 被引量:6
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作者 Arno Kornberg 《World Journal of Hepatology》 CAS 2015年第11期1494-1508,共15页
Shortage of appropriate donor grafts is the foremost current problem in organ transplantation. As a logical consequence, waiting times have extended and pretransplant mortality rates were significantly increasing. The... Shortage of appropriate donor grafts is the foremost current problem in organ transplantation. As a logical consequence, waiting times have extended and pretransplant mortality rates were significantly increasing. The implementation of a priority-based liver allocation system using the model of end-stage liverdisease(MELD) score helped to reduce waiting list mortality in liver transplantation(LT). However, due to an escalating organ scarcity, pre-LT MELD scores have significantly increased and liver recipients became more complex in recent years. This has finally led to posttransplant decreasing survival rates, attributed mainly to elevated rates of infectious and immunologic complications. To meet this challenging development, an increasing number of extended criteria donor grafts are currently accepted, which may, however, aggravate the patients' infectious and immunologic risk profiles. The administration of intravenous immunoglobulins(IVIg) is an established treatment in patients with immune deficiencies and other antibody-mediated diseases. In addition, IVIg was shown to be useful in treatment of several disorders caused by deterioration of the cellular immune system. It proved to be effective in preventing hyperacute rejection in highly sensitized kidney and heart transplants. In the liver transplant setting, the administration of specific Ig against hepatitis B virus is current standard in post-LT antiviral prophylaxis. The mechanisms of action of IVIg are complex and not fully understood. However, there is increasing experimental and clinical evidence that IVIg has an immuno-balancing impact by a combination of immuno-supporting and immuno-suppressive properties. It may be suggested that, especially in the context of a worsening organ shortage with all resulting clinical implications, liver transplant patients should benefit from immuno-regulatory capabilities of IVIg. In this review, perspectives of immune modulation by IVIg and impact on outcome in liver transplant patients are described. 展开更多
关键词 intravenous IMMUNOGLOBULINS Immunemodulation Hyperimmunoglobulin model of end-stageliver disease LIVER TRANSPLANTATION
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Japan's experience of energy saving and business model for low-carbon economy
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作者 Satoshi Watanabe Makoto Nishimura 《Chinese Journal of Population,Resources and Environment》 2013年第4期288-298,共11页
The purpose of this paper is to clarify the questions concerning stimulation of the innovation and the diffusion of energy saving or low-carbon.To do so,this paper explains using two cases of Japan-energy saving innov... The purpose of this paper is to clarify the questions concerning stimulation of the innovation and the diffusion of energy saving or low-carbon.To do so,this paper explains using two cases of Japan-energy saving innovation after the Oil Shock and the eco points system.For the case after the oil shock,we explain the energy saving trend after the Oil Shock and the factors statistically.Then we put forward the business model for the low-carbon economy.Furthermore,we analyze the case of the eco points system from 2009-2011 in Japan and explain the significance of the business model for diffusion of the low-carbon products. 展开更多
关键词 energy SAVING INNOVATION eco-point system BUSINESS model low-carbon ECONOMY JAPAN
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急性缺血性脑卒中静脉溶栓预后不良预警模型构建
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作者 林志超 潘思金 +1 位作者 谢玉龙 黄立安 《中国医学物理学杂志》 CSCD 2024年第4期421-425,共5页
目的:对急性缺血性脑卒中(AIS)静脉溶栓的预后不良影响因素进行分析,构建其不良预警模型为其并发症防治提供依据。方法:收集256例AIS患者,4.5 h内均行静脉溶栓及用药后1 h内进行DWI检查,治疗3个月后按MRS评分结果分为82例预后不良组(&g... 目的:对急性缺血性脑卒中(AIS)静脉溶栓的预后不良影响因素进行分析,构建其不良预警模型为其并发症防治提供依据。方法:收集256例AIS患者,4.5 h内均行静脉溶栓及用药后1 h内进行DWI检查,治疗3个月后按MRS评分结果分为82例预后不良组(>2分)和174例预后良好组(≤2分),采用Logistic回归分析预后不良影响因素,构建其预警模型及使用ROC曲线分析模型预测效能。结果:低DWI-ASPECTS和高NIHSS评分均是预后不良的危险因素(P=0.01)。ROC曲线显示,当NIHSS≥5分、DWI-ASPECTS<8分、NIHSS≥5分且DWI-ASPECTS<8分时,对静脉溶栓预后不良预测灵敏度、特异度、阳性率及阴性率分别为92%、47%、45%、92%,79%、80%、65%、89%,93%、73%、69%、94%,差别有统计学意义(P<0.01)。结论:AIS静脉溶栓预后不良危险因素是高基线NIHSS评分和低基线DWI-ASPECTS评分,联合构建其预后不良预警模型有助于防治静脉溶栓后并发症。 展开更多
关键词 急性缺血性脑卒中 静脉溶栓 NIHSS DWI-ASPECTS 预警模型
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Heat distribution model under hydrogen-rich low-carbon conditions in blast furnace
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作者 Gang Wang Jun Xu +2 位作者 Kun He Zhong-ping Zou Hao Bai 《Journal of Iron and Steel Research(International)》 SCIE EI CAS CSCD 2024年第3期584-594,共11页
Low carbon development of blast furnaces is one of the key technological directions in the current development of ironmaking.Owing to the differences in the physical and chemical properties of hydrogen and carbon,hydr... Low carbon development of blast furnaces is one of the key technological directions in the current development of ironmaking.Owing to the differences in the physical and chemical properties of hydrogen and carbon,hydrogen-rich media entering a blast furnace will change the heat distribution,thus affecting the stability of production.Accordingly,a heat distribution model was proposed to study the temperature distribution in a blast furnace,simultaneously considering gas-solid heat exchange,slag and iron melting,and chemical reactions.The model was used to analyze the temperature distribution of a 2300 m^(3) blast furnace and was verified via comparison with actual production data.Subsequently,the effects of the injection rate of hydrogen-rich media,H2 concentration,and oxygen enrichment rate of the blast on the temperature distribution were investigated.Results indicated that the increase in the injection rate of the hydrogen-rich media decreased the amount of direct reduction and led to an increase in the furnace temperature.Furthermore,an increase in the oxygen enrichment rate led to a decrease in the furnace temperature,but could reduce the solid fuel ratio,while the change in H2 concentration had less effect on the temperature distribution.The combination of hydrogen-rich media injection and the increase in the oxygen enrichment rate would help to adjust the temperature distribution to the same level as the conventional blast furnace conditions. 展开更多
关键词 Heat distribution Blast furnace low-carbon condition Hydrogen enrichment Calculation model
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基于QOF模式构建的护理管理方案在白血病患者静脉治疗中的应用
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作者 张艳芳 温艳 +2 位作者 熊亚炜 马苹 程倩倩 《海南医学》 2024年第2期285-289,共5页
目的 探讨基于质量与结果管理框架(QOF)模式构建的护理管理方案在白血病患者静脉治疗中的应用效果。方法 本研究为回顾性研究,选取2020年1月至2021年5月漯河市中心医院收治的71例白血病患者作为对照组,采用常规管理模式下的静脉治疗护... 目的 探讨基于质量与结果管理框架(QOF)模式构建的护理管理方案在白血病患者静脉治疗中的应用效果。方法 本研究为回顾性研究,选取2020年1月至2021年5月漯河市中心医院收治的71例白血病患者作为对照组,采用常规管理模式下的静脉治疗护理管理方案,选取2021年6月至2022年10月71例采用基于QOF模式构建的护理管理方案护理的白血病患者作为观察组,两组患者在3个月化疗期间予以相应的护理。比较两组患者静脉输液穿刺工具使用情况、中心静脉置管后应用不当情况、留置静脉导管护理不当情况,同时比较两组患者护理3个月后的心理状态[采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评价]及生活质量[采用中文版癌症患者生命质量通用量表(FACT-G)评估]、留置静脉导管后的并发症情况和护理满意度。结果 观察组患者出现中心静脉置管不当发生率为1.41%,明显低于对照组的12.67%,差异具有统计学意义(P<0.05);观察组患者留置静脉导管不当发生率为4.23%,明显少于对照组的14.08%,差异均具有统计学意义(P<0.05);护理3个月后,两组患者的SAS、SDS评分均明显低于其治疗前,且观察组患者的SAS、SDS水平明显低于对照组,差异均具有统计学意义(P<0.05);护理3个月后,观察组患者的生活质量各维度评分明显高于对照组,差异均具有统计学意义(P<0.05);观察组患者的护理满意度为78.87%,明显高于对照组的54.93%,差异具有统计学意义(P<0.05)。结论 在白血病患者静脉治疗过程中,实施基于QOF管理模式构建的护理管理,能有效减少护理过程中中心静脉置管和留置静脉管使用不当情况,改善患者生活质量,有效降低静脉治疗的并发症发生率,提高护理满意度,是值得临床借鉴的有效管理方式。 展开更多
关键词 质量与结果管理框架管理模式 白血病 静脉治疗 护理管理方案 护理效果
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基于二房室模型的个体化给药方案设计的建模与仿真
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作者 关英子 刘畅 +2 位作者 张菲 庞留勇 王露 《信阳师范学院学报(自然科学版)》 CAS 2024年第2期216-221,共6页
利用脉冲微分方程,研究了多次静脉注射给药方式下,二房室模型血药浓度的变化规律,血药浓度在稳态情况下将呈现周期性变化。依据用药安全窗口,探讨了给药方案设计的具体流程和算法步骤。进一步地,结合通过实验测得的24位肿瘤患者单次静... 利用脉冲微分方程,研究了多次静脉注射给药方式下,二房室模型血药浓度的变化规律,血药浓度在稳态情况下将呈现周期性变化。依据用药安全窗口,探讨了给药方案设计的具体流程和算法步骤。进一步地,结合通过实验测得的24位肿瘤患者单次静脉注射氨甲蝶呤后不同时序的血药浓度数据,运用非线性回归分析的方法对24位患者药代动力学特异性参数进行了估计,并运用患者特异性参数值研究了患者个体之间的相似性和差异性。最后,基于不同患者的特异性参数值,给出了患者的个体化给药方案。 展开更多
关键词 二房室模型 静脉注射 个体化差异 给药方案设计
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急性缺血性卒中静脉溶栓后症状性颅内出血预测模型的系统评价
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作者 杨嘉欣 何春渝 +2 位作者 刘蕾 陈文博 谢艳 《中国卒中杂志》 北大核心 2024年第1期76-86,共11页
目的系统评价急性缺血性卒中静脉溶栓后症状性颅内出血预测模型的特征,为静脉溶栓临床决策提供参考。方法检索中国知网、万方数据知识服务平台、维普资讯、PubMed、Embase、Web of Science和The Cochrane Library数据库,收集急性缺血性... 目的系统评价急性缺血性卒中静脉溶栓后症状性颅内出血预测模型的特征,为静脉溶栓临床决策提供参考。方法检索中国知网、万方数据知识服务平台、维普资讯、PubMed、Embase、Web of Science和The Cochrane Library数据库,收集急性缺血性卒中静脉溶栓后症状性颅内出血预测模型相关研究信息,检索时限为建库至2022年12月18日。由2位研究员独立筛选文献、提取资料并评价偏倚风险后对纳入模型的基本特征和方法论进行系统评价。结果纳入20项研究,共30个预测模型。纳入模型ROC曲线的AUC值范围为0.42~0.94。24个(80%)预测模型的整体预测性能较好,模型对不同结局的定义和算法的区分度有明显差异。最常见的预测因子包括NIHSS评分、年龄、梗死的影像学征象或评分、血糖、收缩压和抗血小板药物。结论急性缺血性卒中静脉溶栓后症状性颅内出血预测模型呈现出建模算法多样化、模型性能更佳化、预测因素多元化等特点,但总体偏倚风险较高,未来研究还需要进一步校准模型。此外,应更加关注模型的更新与外部验证,提高其外推性及临床效用,从而发挥模型更大的临床价值。 展开更多
关键词 急性缺血性卒中 静脉溶栓 症状性颅内出血 预测模型 系统评价
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川崎病患儿静脉注射免疫球蛋白抵抗的影响因素评估及IVIGR风险预测模型构建
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作者 朱佳聪 张旭 《中国药师》 CAS 2024年第3期415-422,共8页
目的 探究川崎病(KD)患儿静脉注射免疫球蛋白抵抗(IVIGR)的影响因素,并构建IVIGR预测模型,为KD患儿风险分层护理提供依据。方法 纳入2020年4月至2023年4月在嘉兴市第二医院诊治的KD患儿为研究对象。根据KD患儿是否发生IVIGR分为IVIGR组... 目的 探究川崎病(KD)患儿静脉注射免疫球蛋白抵抗(IVIGR)的影响因素,并构建IVIGR预测模型,为KD患儿风险分层护理提供依据。方法 纳入2020年4月至2023年4月在嘉兴市第二医院诊治的KD患儿为研究对象。根据KD患儿是否发生IVIGR分为IVIGR组和非IVIGR组。采用逐步多因素Logistic回归探究KD患儿发生IVIGR的独立影响因素,构建KD患儿IVIGR预测模型。采用受试者工作特征曲线(ROC)、校准曲线和决策曲线评估IVIGR预测模型的预测能力、校准能力和临床净获益。结果 研究共纳入120例KD患儿,IVIG组22例,非IVIGR组98例。多因素Logistic回归结果显示,红细胞压积、总胆红素、乳酸脱氢酶和C-反应蛋白/白蛋白比值是KD患儿发生IVIGR的独立影响因素(P <0.05)。建立的KD患儿IVIGR风险预测模型ROC曲线下面积为0.858,具有良好的预测能力、校准能力和临床净获益。结论 IVIGR风险预测模型可用于KD患儿发生静脉注射IVIGR的预测,是实现风险分级护理的简单实用的工具。 展开更多
关键词 川崎病 静脉注射免疫球蛋白抵抗 风险预测模型 风险分层护理 受试者工作特征曲线 影响因素
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Analysis on the Influencing Factors of Low-carbon Economy and Its Mitigation Countermeasures in Sichuan Province 被引量:3
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作者 FU Miao-miao,YAO Jian College of Architecture and Environment,Sichuan University,Chengdu 610065,China 《Meteorological and Environmental Research》 CAS 2011年第11期49-52,71,共5页
[Objective]The study aimed to analyze the influencing factors of low-carbon economy and its mitigation countermeasures in Sichuan Province.[Method]Taking Sichuan Province as an example,an extended STIRPAT model was es... [Objective]The study aimed to analyze the influencing factors of low-carbon economy and its mitigation countermeasures in Sichuan Province.[Method]Taking Sichuan Province as an example,an extended STIRPAT model was established firstly,then the impacts of population,economy and technology on carbon emissions from 2000 to 2009 were analyzed econometrically by using the principal component analysis method.Finally,some corresponding countermeasures to reduce carbon dioxide emissions were put forward.[Result]At present,population scale had the greatest influence on carbon emissions in Sichuan Province,then energy consumption per industrial added value and the proportion of industrial added value to GDP.In addition,the influence of population scale on carbon emissions was still greater than that of population structure,and technical factor also has certain explanatory power on carbon emissions.Some countermeasures,like controlling population growth,advocating low-carbon life style and consumption model,paying more attention to the strategic adjustment of industrial structure to gradually reduce the proportion of high-carbon industries,encouraging energy consumption and emissions reduction plus scientific and technological innovation in a new energy technology filed,could be adopted to reduce carbon dioxide emissions,so as to adjust to the development of low-carbon economy in Sichuan Province.[Conclusion]The research could provide references for the establishment of policies for reducing carbon emissions. 展开更多
关键词 Sichuan Province low-carbon economy Influencing factors Mitigation countermeasures STIRPAT model Principal component analysis China
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A Reevaluation of Prazosin Pharmacokinetics in a Two-Compartment Model, the Apparent Volume of Distribution and Comparative Simulations in the One-Compartment Model 被引量:2
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作者 Michalakis Savva Xudong Yuan 《Journal of Biosciences and Medicines》 2022年第1期108-140,共33页
Published clinical data of Prazosin were reevaluated pharmacokinetically using explicit solutions to drug concentration as a function of total time for IV bolus injection, intermittent intravenous infusion and oral ro... Published clinical data of Prazosin were reevaluated pharmacokinetically using explicit solutions to drug concentration as a function of total time for IV bolus injection, intermittent intravenous infusion and oral routes of administration in an open two-compartment model. In a novel way, the apparent volume of distribution was estimated from a two-compartment model and found to be close to the total body water suggesting that Prazosin is distributed in all tissues both extracellularly and intracellularly. In addition, extracting the value of the apparent volume of distribution from a two-compartment model allowed comparative simulations in the one-compartment model. It is shown that dosage calculations of Prazosin intermittent infusion can be safely performed using the simpler one-compartment model equations. Lastly, several additional time-dependent pharmacokinetic parameters e.g., the peak time in the central and peripheral compartment and non-steady state and steady state peak concentration and AUC were determined using series equations for all three routes of administration, as a function of dose number and total time upon multiple drug administrations in the two-compartment model. It is also the first time that steady-state plasma drug concentration equations were derived in a two-compartment mammillary model. 展开更多
关键词 PRAZOSIN PHARMACOKINETICS intravenous Bolus Intermittent Infusion Oral Dose Multiple Doses Compartment model Apparent Volume of Distribution
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Modeling of Microstructure Evolution and Mechanical Properties of Steel Plates Produced by Thermo-Mechanical Control Process and Its On-line Application 被引量:1
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作者 Yunbo XU, Yongmei YU, Xianghua LIU and Guodong WANGState Key Laboratory of Rolling Technology and Automation, Northeastern University, P.O. Box 105, Shenyang 110004, ChinaPh.D., 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2005年第1期13-16,共4页
An integrated metallurgical model was developed to predict microstructure evolution and mechanical properties of low-carbon steel plates produced by TMCP. The metallurgical phenomena occurring during TMCP and mechanic... An integrated metallurgical model was developed to predict microstructure evolution and mechanical properties of low-carbon steel plates produced by TMCP. The metallurgical phenomena occurring during TMCP and mechanical properties were predicted for different process parameters. In the later passes full recrystallization becomes difficult to occur and higher residual strain remains in austenite after rolling. For the reasonable temperature and cooling schedule, yield strength of 30 mm plain carbon steel plate can reach 310 MPa. The first on-line application of prediction and control of microstructure and properties (PCMP) in the medium plate production was achieved. The predictions of the system are in good agreement with measurements. 展开更多
关键词 Thermo-mechanical control process Metallurgical model low-carbon steel Prediction and control of microstructure and properties On-line application
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Optimization and Regulation Policy for Land Use Changes Based on Low-carbon Emission in Developed Regions of China 被引量:1
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作者 Degui YU Qun WU 《Asian Agricultural Research》 2017年第6期67-76,共10页
Land use and cover change(LUCC) is one of the important causes of the Earth’s carbon cycle imbalances resulting from failure in optimizing land use. The solution to this problem has been the hotspot of research in la... Land use and cover change(LUCC) is one of the important causes of the Earth’s carbon cycle imbalances resulting from failure in optimizing land use. The solution to this problem has been the hotspot of research in land and environmental science. We took 'low carbon', 'energy saving' and 'high-efficiency' as the goals of land use optimization,and integrated Markov-CA(Cellular Automaton),the Grid-Fractal model and GIS,in order to study carbon emission objective function,to establish a simulation method for land use spatial allocation optimization,to evaluate the effect of the method on carbon emissions. Regulation policy on three types of land use spatial allocation was proposed,including 'low-carbon type', 'low-carbon-economic type' and 'economic type'. We applied the method to analyze the land use spatial allocation in Taixing City of the 'Yangtze River Delta' regions in China,and obtained the following results:(i) The three optimization types would improve carbon emissions by 3. 21%,1. 80% and 0. 36% respectively in 2020,compared with 2010;(ii) The actual planning for 2020 was close to the 'low-carbon-economic type';(iii) The optimization method and regulation policy,combining local optimization and global control,could meet the sustainable multi-objective requirements for low-carbon constraints of land use spatial allocation. The result of this research could also serve as a reference for exploration into patterns of regional low-carbon land use and measures for energy saving and emission reduction. 展开更多
关键词 Regulation policy Land use optimization low-carbon emission Markov-CA model Developed regions of China
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Research on the model of regional green innovation system in China:A case study of Shandong province
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作者 LI Hong-fei CI Fu-yi SHI Jia-lu 《Ecological Economy》 2020年第2期146-160,共15页
Taking Shandong province,one of China’s first batch of circular economy pilot provinces,as an example,this paper summarizes some types of regional green innovation system models through the cases study and retrospect... Taking Shandong province,one of China’s first batch of circular economy pilot provinces,as an example,this paper summarizes some types of regional green innovation system models through the cases study and retrospective reasoning and retrospective approaches.The models mentioned above include(1)the innovation system model of green animal husbandry in coastal small towns,(2)the green innovation system model in intravenous industry park,(3)the green innovation system model in coastal hi-tech industrial development zone based on the development of eco-industrial and low-carbon industries,(4)the green innovation system model in coastal economic&technological development area based on the development of ecological arterial industry and the ecological intravenous industry through the waste recycle inside and outside the area,(5)the green innovation system model of coastal harbor economic and technological development area based on constructing tiny-medium-macro circulation,(6)the green innovation system of reformed coastal economic and technological development zone turning to the recycling marine industry innovation,and(7)the green innovation system model of high-tech industry development zone tending to recycling innovation of biological industry.This paper aims to analyze the characteristics of these models,the formation mechanism,and further to discuss their implications for greening the same type of regional innovation systems. 展开更多
关键词 green innovation system low-carbon development circular economy model Shandong provinces
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院前院内协同救治模式对急性脑梗死患者的效果观察 被引量:1
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作者 刘艳 胡丽萍 +7 位作者 刘科位 郭先彬 蔡俊秀 潘敏 唐婕 龚清涛 李志国 王力 《实用临床医药杂志》 2023年第22期110-113,共4页
目的观察院前院内协同救治模式对急性脑梗死患者的效果。方法选取67例急性脑梗死患者为研究对象,根据救治模式分为观察组(n=37)与对照组(n=30)。对照组采取传统救治模式,观察组采取院前院内协同救治模式。比较2组静脉溶栓时间效率、早... 目的观察院前院内协同救治模式对急性脑梗死患者的效果。方法选取67例急性脑梗死患者为研究对象,根据救治模式分为观察组(n=37)与对照组(n=30)。对照组采取传统救治模式,观察组采取院前院内协同救治模式。比较2组静脉溶栓时间效率、早期神经功能恢复情况及氧化应激指标。结果2组患者发病到就诊时间的差异无统计学意义(P>0.05);观察组患者就诊到溶栓时间及就诊到签署静脉溶栓知情同意书时间均短于对照组,差异有统计学意义(P<0.05)。入院时,2组患者美国国立卫生研究院卒中量表(NIHSS)评分差异无统计学意义(P>0.05);入院后7 d、溶栓后90 d时,观察组患者NIHSS评分均低于对照组,差异有统计学意义(P<0.05)。2组患者血清谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)水平差异无统计学意义(P>0.05);观察组患者血清超氧化物歧化酶(SOD)水平高于对照组,差异有统计学意义(P<0.05)。对照组有1例患者死亡,病死率为3.33%;观察组中未发生死亡情况。结论院前院内协同救治模式可有效提升急性脑梗死患者静脉溶栓时间效率,减轻神经功能损伤,降低氧化应激反应程度及死亡风险。 展开更多
关键词 院前院内协同救治模式 急性脑梗死 静脉溶栓 神经功能 氧化应激
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基于Miller能力金字塔模型的中等长度导管置管培训方案实施
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作者 王刚 潘月帅 +6 位作者 高祀龙 程华伟 张业玲 徐静 吕伯瀚 钟政 魏丽丽 《护理学杂志》 CSCD 北大核心 2023年第18期89-92,共4页
目的培养院级中等长度导管置管护士,提高静脉治疗质量。方法基于Miller能力金字塔模型构建中等长度导管置管护士培训方案,进行中等长度导管置管规范化培训及考核。结果共培训48名护士,通过认证考核的护士31名,认证通过率为64.58%。中等... 目的培养院级中等长度导管置管护士,提高静脉治疗质量。方法基于Miller能力金字塔模型构建中等长度导管置管护士培训方案,进行中等长度导管置管规范化培训及考核。结果共培训48名护士,通过认证考核的护士31名,认证通过率为64.58%。中等长度导管置管1736例次,成功率为96.34%,带管患者均无置管并发症发生。结论基于Miller能力金字塔模型的中等长度导管置管护士培训可规范中等长度导管置管操作技术,提高静脉治疗质量。 展开更多
关键词 中等长度导管 Miller能力金字塔模型 培训方案 静脉治疗 资格认证
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急性脑梗死静脉溶栓后继发出血转化危险因素分析及预测模型构建 被引量:4
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作者 李令培 马新安 +2 位作者 张超 江四清 汤其强 《新乡医学院学报》 CAS 2023年第4期366-370,共5页
目的探讨急性脑梗死静脉溶栓后继发出血转化(HT)的危险因素及预测模型。方法选择2018年1月至2021年6月于淮北市人民医院行静脉溶栓治疗的555例急性脑梗死患者为研究对象,根据患者治疗后是否继发HT分为HT组(n=35)和非HT组(n=520)。查阅2... 目的探讨急性脑梗死静脉溶栓后继发出血转化(HT)的危险因素及预测模型。方法选择2018年1月至2021年6月于淮北市人民医院行静脉溶栓治疗的555例急性脑梗死患者为研究对象,根据患者治疗后是否继发HT分为HT组(n=35)和非HT组(n=520)。查阅2组患者的病历资料,统计患者的性别、年龄、心房颤动、体质量指数(BMI)、服用抗凝药物情况、是否吸烟、是否有高血尿酸、高血压、高脂血症以及美国国立卫生研究院卒中量表(NIHSS)评分和活化部分凝血活酶时间(APTT),对可能影响HT的因素进行单因素及多因素logistic回归分析。根据HT多因素logistic回归分析结果,应用R软件建立预测急性脑梗死静脉溶栓后继发HT的列线图预测模型;绘制受试者操作特征(ROC)曲线,分析该模型在急性脑梗死静脉溶栓后继发HT中的预测区分度,采用rms包绘制校准曲线,检验评估列线图模型的准确度。结果单因素及多因素logistic分析显示,急性脑梗死静脉溶栓治疗患者HT的发生与高血尿酸、高血压、高血脂、性别及BMI无关(P>0.05)。急性脑梗死静脉溶栓治疗患者HT的发生与年龄、心房颤动、服用抗凝药物、吸烟、APTT及NIHSS评分有关(P<0.05)。急性脑梗死静脉溶栓后继发HT的风险预测列线图模型显示,心房颤动得分为63.0分,服用抗凝药物得分为37.6分,APTT得分71.5分,NIHSS评分得分为60.0分,模型具有良好的区分度。列线图模型预测急性脑梗死静脉溶栓后继发HT的ROC曲线下面积为0.867,95%置信区间为0.785~0.931,校准图线图上列线图模型的校准曲线为斜率接近1的直线,列线图校准度良好。结论急性脑梗死静脉溶栓后继发HT发生率较高,影响因素较多,构建的预测模型具有较高的预测效能,区分度良好,能为临床预防急性脑梗死静脉溶栓后继发HT提供参考依据。 展开更多
关键词 急性脑梗死 静脉溶栓 出血转化 影响因素 预测模型 受试者操作特征曲线
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基于柯式模型构建静脉治疗专科护士实践培训效果评价体系 被引量:3
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作者 李丹丹 乔远静 +5 位作者 刘佳欣 王旭 夏玉雪 梁文娜 秦光雅 冯梦轩 《护理学报》 北大核心 2023年第10期73-78,共6页
目的构建静脉治疗专科护士实践培训效果评价体系,为评价临床实践教学效果提供客观、量化、系统的参考依据。方法以柯式模型为依据,通过分析静脉治疗专科护士培训基地实践培训大纲内容,结合文献研究法、德尔菲(Delphi)法、层次分析法确... 目的构建静脉治疗专科护士实践培训效果评价体系,为评价临床实践教学效果提供客观、量化、系统的参考依据。方法以柯式模型为依据,通过分析静脉治疗专科护士培训基地实践培训大纲内容,结合文献研究法、德尔菲(Delphi)法、层次分析法确定静脉治疗专科护士实践培训效果评价体系及指标权重。结果纳入18名函询专家,2轮函询的应答率均为100%,专家群体权威系数为0.960;第1轮函询结果一、二、三级指标协调系数分别为0.322、0.215、0.151,第2轮函询结果一、二、三级指标协调系数分别为0.358、0.270、0.256,显著性检验均有统计学意义(P<0.001)。最终构建包含4个一级指标、15个二级指标、67个三级指标的静脉治疗实践培训效果评价体系。结论函询专家的积极性、权威性、意见集中程度及协调程度均较高,构建的静脉治疗实践培训效果评价体系科学合理,可为静脉治疗专科护士的培训、考核、管理提供理论指导。 展开更多
关键词 静脉治疗 专科护士 评价指标 德尔菲法 柯式模型
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儿童重症腺病毒性肺炎风险模型的构建及静脉注射免疫球蛋白治疗时机的前瞻性研究
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作者 蔡莎 朱春晖 +3 位作者 陈方根 刘飞 高美玲 熊艳 《中国当代儿科杂志》 CAS CSCD 北大核心 2023年第6期619-625,共7页
目的构建儿童重症腺病毒性肺炎(adenoviral pneumonia,AVP)的风险评分模型,并探讨静脉注射免疫球蛋白(intravenous immunoglobulin,IVIG)治疗重症AVP的合适时机。方法回顾性分析1046例AVP患儿的临床资料,运用多因素logistic回归法建立重... 目的构建儿童重症腺病毒性肺炎(adenoviral pneumonia,AVP)的风险评分模型,并探讨静脉注射免疫球蛋白(intravenous immunoglobulin,IVIG)治疗重症AVP的合适时机。方法回顾性分析1046例AVP患儿的临床资料,运用多因素logistic回归法建立重症AVP风险预测模型。选取102例AVP患儿验证该模型。再前瞻性纳入75例年龄≤14岁且经该模型判定为有可能发展为重症AVP的患儿,按就诊顺序分为A、B、C 3组,每组各25例。A组:仅予对症支持治疗;B组:除对症支持治疗外,在进展为重症AVP前予IVIG治疗,1 g/(kg·d),连续2 d;C组:除对症支持治疗外,在进展为重症AVP后予IVIG治疗,1 g/(kg·d),连续2 d。比较A、B、C 3组治疗后的疗效及相关实验室指标。结果年龄<18.5个月、基础病、热程>6.5 d、血红蛋白<84.5 g/L、谷丙转氨酶>113.5 U/L、合并细菌感染6个变量进入重症AVP风险预测模型。该模型的受试者操作特征曲线下面积为0.862,灵敏度为0.878,特异度为0.848。Hosmer-Lemeshow检验显示模型预测值和实际观测值间的一致性较好(P>0.05)。治疗后,B组发热时间和住院时间最短,住院费用最低,治疗有效率最高,并发症发生率最低,白细胞计数最低,白细胞介素(interleukin,IL)-1、IL-2、IL-6、IL-8、IL-10水平最低,肿瘤坏死因子α水平最高(P<0.05)。结论该研究构建的重症AVP风险模型对预测重症AVP的发生具有良好的价值;在AVP患儿进展为重症前予IVIG治疗效果更好。 展开更多
关键词 腺病毒性肺炎 风险模型 静脉注射免疫球蛋白 儿童
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