Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity

The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of their unique familial,sporadic,and transmissible etiologies,all caused by a single agent:misfolded conformations of PrP.

Intrinsic and scattering attenuations of the Sichuan-Yunnan region in China from S coda waves

Seismic attenuation is a fundamental property of the Earth's media.Attenuation structure for the complicated geological structures with strong seismicity in the Sichuan-Yunnan region is poorly studied.In this study,we collected 108,399 waveforms of 11,517 local small earthquakes with magnitudes between 1.5 and 3.5 from January 2014 to September 2021 in the Sichuan-Yunnan region and its adjacent areas.We employed an envelope inversion technique for separating the intrinsic and scattering attenuations of the S coda wave,and obtained the intrinsic and scattering attenuation structures for frequencies between 0.25 and 8.00 Hz.The attenuation structures correlate well with the geological units,and some major faults mark the attenuation variations where historic large earthquakes have occurred.The regional average attenuation shows a negative frequency dependence.The average scattering attenuation has a faster descending rate than the average intrinsic attenuation,and is dominant at low frequencies,while at high frequencies the average intrinsic attenuation is stronger.The lateral variation in the intrinsic attenuation is consistent with the variation in heat flow,the scattering attenuation may be related to the scatter distribution and size.The total attenuation is consistent with the previous studies in this region,and the separate intrinsic and scattering attenuation may be useful in understanding regional tectonics and important in earthquake prevention and disaster reduction.

A novel DPSS filter optimization scheme to reduce the intrinsic interference of FBMC-QAM systems

In order to reduce the intrinsic interference of the filter bank multicarrier-quadrature amplitude modulation(FBMC-QAM)system,a novel filter optimization scheme based on discrete prolate spheroidal sequences(DPSS)is proposed.Firstly,a prototype filter function based on DPSS is designed,since the eigenvalue can be used as an indicator of the energy concentration of DPSS,so a threshold is set,and the sequence with the most concentrated energy is selected under the threshold,that is,the sequence with the eigenvalue higher than the threshold,and the prototype filter function is rewritten as a weighted sum function of multiple eigenvectors.Under the energy constraints of the filter,the relationship between the eigenvectors and the intrinsic interference function is established,and the function problem is transformed into an optimization problem for the weighted coefficients.Through the interior point method,the most suitable weight is found to obtain the minimum intrinsic interference result.Theoretical analysis and simulation results show that compared with the prototype filters such as Type1 and CaseC,the DPSS filter applying the proposed optimization algorithm can effectively suppress the intrinsic interference of the system and obtain a better bit error rate(BER)performance.

Experimental Study of the Influence of Intrinsic Parameters on the Thermal Reactivity of Sawdust, Polyethylene Terephthalate and Composite

Several works have been based on the study of thermal variations in biomass to derive more valuable products such as fuels capable of replacing oil in the event of a crisis or activated carbon used as an adsorbent material, widely used in industry for the elimination of unwanted materials, both in liquid and gaseous environments. A study of thermal parameters such as: heating speed, retention time, drying temperature, carbonization temperature, particle size, was carried out with the aim of determining the characteristic factors of the carbonization of Polyethylene terephthalate (PET), sawdust (SC) and sawdust/polyethylene terephthalate (CPS) mixture. The results of the immediate analysis revealed a very low level of ash in PET (0.013%) compared to the level of ash in sawdust (2.9%), as well as a high level of fixed carbon (82.960%), which suggests the presence of mineral oxides and a significant carbon matrix unlike PET, which indicates a very significant organic matrix (essentially made up of organic matter) with the absence of mineral oxides. The study of thermal parameters showed the water loss from Sawdust (SC) and the Sawdust/Polyethylene terephthalate (CPS) mixture, an increase with temperature, unlike that of PET whose variation is essentially zero. Without heat treatment, sawdust alone contains approximately 7% water. The optimal drying temperature for this study is 110˚C for a stay of 24 hours. It appears that the largest mass losses for the PET samples are between 87.19% and 96.05%, followed by that of the mixture, between 47.33% and 64.37%. And the lowest are observed, those of sawdust (from 24.02% to 62.6%). However, here we can say that the influence of the mass is not great, given the slight difference between the losses by temperature. The results of the study of the influence of grain size showed that the differences are insignificant, even if we vary the diameter of the grains from simple to triple. To better minimize physical constraints such as the intragranular diffusibility of the volatile matter and the homogeneity of the temperature in the grains, 75 μm particles are found to be optimal for our study. It can be noted when studying the heating rate that the mass loss at the end of the reaction is approximately the same depending on each precursor material. However, it has been demonstrated that the heating rate strongly influences the nature of the reaction products both for volatile materials and for the solid residue as well as on the kinetic parameters of the chemical reaction. Furthermore, the variation in apparent density shows a decrease as a function of the increase in the residence time of the materials in the reactor. As the carbonization time increases, the apparent density decreases. We note, for the lignocellulosic material, that the apparent density stabilizes after 60 minutes.

Linearization of Intrinsically Nonlinear Oscillators

We show that an intrinsically nonlinear oscillator can always be transformed into a linear or harmonic oscillator by addition of a constant force, which shifts the equilibrium position of the oscillator.

Intrinsic Spin Angular Momentum of Electron Relation to the Discrete Indivisible Quantum of Time Kshana or Moment

The frequency of any periodic event can be defined in terms of units of Time. Planck constructed a unit of time called the Plank time from other physical constants. Vyasa defined a natural unit of time, kshana, or moment based on the motion of a fundamental particle. It is the time taken by an elementary particle, to change its direction from east to north. According to Vyasa, kshana is discrete, exceedingly small, indivisible, and is a constant time quantum. When the intrinsic spin angular momentum of an electron was related to the angular momentum of a simple thin circular plate, spherical shell, and solid sphere model of an electron, we found that the value of kshana in seconds was equal to ten to a power of minus twenty-one second. The disc model for the spinning electron provides an accurate value of the number of kshanas per second as determined previously and compared with other spinning models of electrons. These results indicate that the disk-like model of spinning electrons is the correct model for electrons. Vyasa’s definition of kshana opens the possibility of a new foundation for the theory of physical time, and perspectives in theoretical and philosophical research.

Intrinsic Self-Healing Chemistry for Next-Generation Flexible Energy Storage Devices

The booming wearable/portable electronic devices industry has stimulated the progress of supporting flexible energy storage devices.Excellent performance of flexible devices not only requires the component units of each device to maintain the original performance under external forces,but also demands the overall device to be flexible in response to external fields.However,flexible energy storage devices inevitably occur mechanical damages(extrusion,impact,vibration)/electrical damages(overcharge,over-discharge,external short circuit)during longterm complex deformation conditions,causing serious performance degradation and safety risks.Inspired by the healing phenomenon of nature,endowing energy storage devices with self-healing capability has become a promising strategy to effectively improve the durability and functionality of devices.Herein,this review systematically summarizes the latest progress in intrinsic self-healing chemistry for energy storage devices.Firstly,the main intrinsic self-healing mechanism is introduced.Then,the research situation of electrodes,electrolytes,artificial interface layers and integrated devices based on intrinsic self-healing and advanced characterization technology is reviewed.Finally,the current challenges and perspective are provided.We believe this critical review will contribute to the development of intrinsic self-healing chemistry in the flexible energy storage field.

Design of novel transition-metal-doped C_(4)N_(4) as highly effective electrocatalysts for nitrogen fixation with a new intrinsic descriptor

Electrocatalytic nitrogen reduction reaction(NRR) is an efficient and green way to produce ammonia,which offers an alternative option to the conventional Haber-Bosch process.Unfortunately,the large-scale industrial application of NRR processes is still hindered by poor Faraday efficiency and high overpotential,which need to be overcome urgently.Herein,combined with density functional theory and particle swarm optimization algorithm for the nitrogen carbide monolayer structural search(C_mN_(8-m),m=1-7),the surprising discovery is that single transition metal-atom-doped C_(4)N_(4) monolayers(TM@C_(4)N_(4)) could effectively accelerate nitrogen reduction reaction.TM@C_(4)N_(4)(TM=29 transition metals) as single-atom catalysts are evaluated via traditional multi-step screening method,and their structures,NRR activity,selectivity and solvation effect are investigated to evaluate their NRR performance,Through the screening steps,W@C_(4)N_(4) possesses the highest activity for NRR with a very low limiting potential of-0.29 V.Moreover,an intrinsic descriptor φ is proposed with machine learning,which shortens the screening process and provides a new idea for finding efficient SACs.This work not only offers promising catalysts W@C_(4)N_(4) for NRR process but also offers a new intrinsic and universal descriptor φ.

Single-layer intrinsic 2H-phase LuX_(2)(X=Cl,Br,I)with large valley polarization and anomalous valley Hall effect

Manipulation of the valley degree of freedom provides a new path for quantum information technology,but the real intrinsic large valley-polarization materials are rarely reported up to date.Here,we perform first-principles calculations to predict a class of 2H-phase single layer(SL)materials LuX_(2)(X=Cl,Br,I)to be ideal candidates.SL-Lu X_(2)are ferrovalley materials with a giant valley-polarization of 55 meV–148 meV as a result of its large spin–orbital coupling(SOC)and intrinsic ferromagnetism(FM).The magnetic transition temperatures of SL-LuI_(2)and SL-LuCl2are estimated to be 89 K–124 K,with a sizable magnetic anisotropy at out-of-plane direction.Remarkably,the anomalous valley Hall effect(AVHE)can be controlled in SL-LuX_(2)when an external electric field is applied.Moreover,the intrinsic valleypolarization of SL-LuI_(2)is highly robust for biaxial strain.These findings provide a promising ferrovalley material system for the experimentation of valleytronics and subsequent applications.

Intrinsic kinetics of catalytic hydrogenation of 2-nitro-4-acetylamino anisole to 2-amino-4-acetylamino anisole over Raney nickel catalyst

The catalytic hydrogenation of 2-nitro-4-acetylamino anisole(NMA)is a less-polluting and efficient method to produce 2-amino-4-acetamino anisole(AMA).However,the kinetics of catalytic hydrogenation of NMA to AMA remains obscure.In this work,the kinetic models including power-law model and Langmuir-Hinshelwood-Hougen-Watson(LHHW)model of NMA hydrogenation to AMA catalyzed by Raney nickel catalyst were investigated.All experiments were carried out under the elimination of mass transfer resistance within the temperature range of 70–100°C and the hydrogen pressure of 0.8–1.5 MPa.The reaction was found to follow 0.52-order kinetics with respect to the NMA concentration and 1.10-order kinetics in terms of hydrogen pressure.Based on the LHHW model,the dual-site dissociation adsorption of hydrogen was analyzed to be the rate determining step.The research of intrinsic kinetics of NMA to AMA provides the guidance for the reactor design and inspires the catalyst modification.

How to make the "jump" on understanding the importance of the intrinsic foot muscles for propulsion

In this issue of the Journal of Sport and Health Science,Smith and colleagues1addressed a unique aspect of human locomotion;they evaluated the effects of the intrinsic foot musculature on the mechanical properties and energetic function of the human foot.By performing a controlled jumping experiment to mimic components of human locomotion.

Intrinsic Wave Velocity Propagation:A Novel Parameter for Assessing the Effect of Anthracycline Chemotherapy Agents on Cardiac Diastolic Function in Breast Cancer Patients

Objective Anthracycline chemotherapeutic agents have significant cardiotoxicity.The present study emphasized the effect of anthracycline chemotherapy drugs on left ventricular(LV)myocardial stiffness in breast cancer patients by measuring the intrinsic wave velocity propagation(IVP),and evaluating the potential clinical value of IVP in detecting early LV diastolic function impairment.Methods A total of 68 newly diagnosed breast cancer patients,who were treated with anthracycline-based chemotherapy,were analyzed.Transthoracic echocardiography was performed at baseline(T0),and after 1,2,3,4 and 8 chemotherapeutic cycles(T1,T2,T3,T4 and T5,respectively).Then,the IVP,LV strain parameters[global longitudinal strain(GLS),longitudinal peak strain rate at systole(LSRs),longitudinal peak strain rate at early diastole(LSRe),longitudinal peak strain rate at late diastole(LSRa),and the E/LSRe ratio],and conventional echocardiographic parameters were obtained and further analyzed.A relative reduction of>15%in GLS was considered a marker of early LV subclinical dysfunction.Results Compared to the T0 stage,IVP significantly increased at the T1 stage.However,there were no significant changes in GLS,LSRs,or LSRe between the T0 and T1 stages.These parameters significantly decreased from the T2 stage.LSRa started to significantly decrease at the T5 stage,and the E/LSRe ratio started to significantly increase at the T3 stage(all P<0.05).At the T0 stage,IVP(AUC=0.752,P<0.001)had a good predictive value for LV subclinical dysfunction after chemotherapy.Conclusions IVP is a potentially sensitive parameter for the early clinical assessment of anthracycline-related cardiac diastolic impairment.

Single-Molecule Confinement Induced Intrinsic Multi-Electron Redox-Activity to Enhance Supercapacitor Performance

Aggregation of polyoxometalates(POM)is largely responsible for the reduced performance of POM-based energy-storage systems.To address this challenge,here,the precise confinement of single Keggin-type POM molecule in a porous carbon(PC)of unimodal super-micropore(micro-PC)is realized.Such precise single-molecule confinement enables sufficient activity center exposure and maximum electron-transfer from micro-PC to POM,which well stabilizes the electron-accepting molecules and thoroughly activates its inherent multi-electron redox-activity.In particular,the redox-activities and electron-accepting properties of the confined POM molecule are revealed to be super-micropore pore size-dependent by experiment and spectroscopy as well as theoretical calculation.Meanwhile,the molecularly dispersed POM molecules confined steadily in the“cage”of micro-PC exhibit unprecedented large-negative-potential stability and multiple-peak redox-activity at an ultra-low loading of~11.4 wt%.As a result,the fabricated solid-state supercapacitor achieves a remarkable areal capacitance,ultrahigh energy and power density of 443 mF cm^(-2),0.12 mWh cm^(-2)and 21.1 mW cm^(-2),respectively.This work establishes a novel strategy for the precise confinement of single POM molecule,providing a versatile approach to inducing the intrinsic activity of POMs for advanced energy-storage systems.

The Inner Structure of the Intrinsic Electron and the Origin of Self-Mass

A brief review and analysis of two historical models of the electron, the charged spinning sphere and Goudsmit and Uhlenbeck’s concept, is presented. It is shown that the enormous potential of classical electrodynamics has been underutilized in particle physics. Such observation leads to discovery of a principal component in the electron inner structure—the charged c-ring. The intrinsic (fundamental) electron model based on the charged c-ring successfully explains the ontology of the charge fractionation in quantum chromodynamics and the formation of Cooper pairs in superconductivity. The c-ring properties are explained on the basis of the General Compton Conditions as defined. Properties of the charged c-ring include the explanation of the boundary conditions, electro-magnetostatic field configuration, self-mass, spin, magnetic moment, and the gyromagnetic ratio. The self-mass of the intrinsic electron is 100% electro-magnetostatic and it is shown how to compute its value. The classical-quantum divide no longer exists. Relation between the intrinsic electron and the electron is fundamentally defined. The electron is the composite fermion consisting of the intrinsic electron and the neutrino. The ontology of the anomaly in the electron magnetic moment is demonstrated—it is due to the addition of the neutrino magnetic moment to the overall electron magnetic moment. The intrinsic electron replaces the W? boson in particle physics, resulting in a fundamental implication for the Standard Model.

The Intrinsic Electron with Its Properties Such as Inner Structure and Self-Mass Is in Conflict with Quantum Field Theory

The quantum field theory (QFT) is one of branches of the Standard Model. According to QFT, quantum fields are the primary entities and particles are the excitations of these fields, coming in discrete lumps with no inner structures and with properties assigned by declaration. Such view is in conflict with the observed vacuum energy density, 140 orders of magnitudes less than required by the QFT. In addition, such view is challenged by Aphysical Quantum Mechanics (AQM), a deeper quantum theory. According to AQM, the fundamental understanding of quantum reality is expanded by the addition of two fundamental categories, aphysical and elementary consciousness of elementary particles. Based on AQM and as an example, the total ontology of the intrinsic (fundamental) electron is presented with its inner structure of perfect geometry consisting of the physical charged c-ring and aphysical cylinder, and with its properties such as self-mass, spin, magneto-electrostatic field configuration and magnetic moment. The position parameter in the inner structure demonstrates that there are no two identical intrinsic electrons in the Universe thus placing a question mark over the QFT principle of indistinguishability.

Doped-Chamber Deposition of Intrinsic Microcrystalline Silicon Thin Films and Its Application in Solar Cells

A series of microcrystalline silicon thin films were fabricated by very high frequency plasma enhanced chemical vapor deposition （VHF-PECVD） at different silane concentrations in a P chamber. Through analysis of the structural and electrical properties of these materials,we conclude that the photosensitivity slightly decreased then increased as the silane concentration increased,while the crystalline volume fraction indicates the opposite change. Results of XRD indicate that thin films have a （220） preferable orientation under certain conditions. Microcrystalline silicon solar cells with conversion efficiency 4. 7% and micromorph tandem solar cells 8.5% were fabricated by VHF-PECVD （p layer and i layer of microcrystalline silicon solar cells were deposited in P chamber）, respectively.

Construction analysis on integral lifting of steel structure by the vector form intrinsic finite element

A newnumerical method based on vector form intrinsic finite element（VFIFE） is proposed to simulate the integral lifting process of steel structures. First, in order to verify the validity of the VFIFE method, taking the steel gallery between the integrated building and the attached building of Nanjing M obile Communication Buildings for example, the static analysis was carried out and the corresponding results were compared with the results achieved by the traditional finite element method. Then, according to the characteristics of dynamic construction of steel structure integral lifting, the tension cable element was employed to simulate the behavior of dynamic construction. The VFIFE method avoids the iterative solution of the stiffness matrix and the singularity problems. Therefore, it is simple to simulate the complete process of steel structure lifting construction.Finally, by using the VFIFE, the displacement and internal force time history curves of the steel structures under different lifting speeds are obtained. The results show that the lifting speed has influence on the lifting force, the internal force, and the displacement of the structure. In the case of normal lifting speed, the dynamic magnification factor of 1. 5 is safe and reasonable for practical application.

Facile preparation and efficient MnxCoy porous nanosheets for the sustainable catalytic process of soot

The pursuit of high-performance is worth considerable effort in catalysis for energy efficiency and environmental sustainability. To develop redox catalysts with superior performance for soot combustion, a series of Mn_(x)Co_(y) oxides were synthesized using MgO template substitution.This method greatly improves the preparation and catalytic efficiency and is more in line with the current theme of green catalysts and sustainable development. The resulting Mn_(1)Co_(2.3) has a strong activation capability of gaseous oxygen due to a high concentration of Co^(3+) and Mn^(3+). The Mn doping enhanced the intrinsic activity by prompting oxygen vacancy formation and gaseous oxygen adsorption. The nanosheet morphology with abundant mesoporous significantly increased the solid–solid contact efficiency and improved the adsorption capability of gaseous reactants. The novel design of Mn_(1)Co_(2.3)oxide enhanced its catalytic performance through a synergistic effect of Mn doping and the porous nanosheet morphology, showing significant potential for the preparation of high-performance soot combustion catalysts.

Transcriptome profiling and RXR gene family identification reveals the molecular mechanism of rapid aging after spawning of cuttlefish Sepiella japonica

Sepiella japonica is a worldwide marine cuttlefish species of high economic value.S.japonica routinely modifying behaviors in reproductive life,such as rapid aging until death after spawning,has been recognized in artificial breeding.However,reproductive behavior at the level of genes is rarely reported,thus,the research on the genetic basis of behavior,reproduction,and artificial breeding was limited.We applied RNA-seq in different stages of reproduction to investigate the reason of rapid aging after spawning,pre-maturity,pre-spawning after maturity,and post-spawning.The retinoid X receptor(RXR)gene family in S.japonica was identified,and 1343–1452 differentially expressed genes(DEGs)in all 3 stages of reproductive life were identified from pairwise m RNA comparisons.Furthermore,through the GO term and KEGG analysis,S.japonica could handle neuronal development and network formation before maturity and have a functional degradation of neural communication,signal transduction,vision,and gene expression after spawning.Eight Sj RXRαs have been identified and they played different roles in growth development or reproduction.Therefore,the regulation of several channels and receptors is the intrinsic molecular mechanism of rapid aging after spawning in S.japonica.This study revealed the survival strategy and provided fundamental data on the level of genes for understanding the reproductive behavior and the reproduction of S.japonica.

Coupled Cross-Flow/in-Line Vortex-Induced Vibration Responses of a Catenary-Type Riser Subjected to Uniform Flows

A three-dimensional numerical scheme was developed to investigate the vortex-induced vibration(VIV)of a catenary-type riser(CTR)in the in-line(IL)and cross-flow(CF)directions.By using the vector form intrinsic finite element method,the CTR was discretized into a finite number of spatial particles whose motions satisfy Newton’s second law.The Van der Pol oscillator was used to simulate the effect of vortex shedding.The coupling equations of structural vibration and wake oscillator were solved using an explicit central differential algorithm.The numerical model was verified with the published results.The VIV characteristics of the CTR subjected to uniform flows,including displacement,frequency,standing wave,traveling wave,motion trajectory,and energy transfer,were studied comprehensively.The numerical results revealed that the multimode property occurs in the CF-and IL-direction VIV responses of the CTR.An increase in the flow velocity has slight effects on the maximum VIV displacement.Due to structural nonlin-earity,the double-frequency relationship in the CF and IL directions is rarely captured.Therefore,the vibration trajectories display the shape of an inclined elliptical orbit.Moreover,the negative energy region is inconspicuous under the excitation of the uniform flow.