We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant I.Firstly,we prove two types of topological defects naturally inhering in the...We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant I.Firstly,we prove two types of topological defects naturally inhering in the inner differential structure of the Hopf mapping.One type is the four-dimensional point defects.展开更多
Due to a tremendous increase in mobile traffic,mobile operators have started to restructure their networks to offload their traffic.Newresearch directions will lead to fundamental changes in the design of future Fifth...Due to a tremendous increase in mobile traffic,mobile operators have started to restructure their networks to offload their traffic.Newresearch directions will lead to fundamental changes in the design of future Fifthgeneration(5G)cellular networks.For the formal reason,the study solves the physical network of the mobile base station for the prediction of the best characteristics to develop an enhanced network with the help of graph theory.Any number that can be uniquely calculated by a graph is known as a graph invariant.During the last two decades,innumerable numerical graph invariants have been portrayed and used for correlation analysis.In any case,no efficient assessment has been embraced to choose,how much these invariants are connected with a network graph.This paper will talk about two unique variations of the hexagonal graph with great capability of forecasting in the field of optimized mobile base station topology in setting with physical networks.Since K-banhatti sombor invariants(KBSO)and Contrharmonic-quadratic invariants(CQIs)are newly introduced and have various expectation characteristics for various variations of hexagonal graphs or networks.As the hexagonal networks are used in mobile base stations in layered,forms called honeycomb.The review settled the topology of a hexagon of two distinct sorts with two invariants KBSO and CQIs and their reduced forms.The deduced outcomes can be utilized for the modeling of mobile cellular networks,multiprocessors interconnections,microchips,chemical compound synthesis and memory interconnection networks.The results find sharp upper bounds and lower bounds of the honeycomb network to utilize the Mobile base station network(MBSN)for the high load of traffic and minimal traffic also.展开更多
We consider the following (1 + 3)-dimensional P(1,4)-invariant partial differential equations (PDEs): the Eikonal equation, the Euler-Lagrange-Born-Infeld equation, the homogeneous Monge-Ampère equation, the inho...We consider the following (1 + 3)-dimensional P(1,4)-invariant partial differential equations (PDEs): the Eikonal equation, the Euler-Lagrange-Born-Infeld equation, the homogeneous Monge-Ampère equation, the inhomogeneous Monge-Ampère equation. The purpose of this paper is to construct and classify the common invariant solutions for those equations. For this aim, we have used the results concerning construction and classification of invariant solutions for the (1 + 3)-dimensional P(1,4)-invariant Eikonal equation, since this equation is the simplest among the equations under investigation. The direct checked allowed us to conclude that the majority of invariant solutions of the (1 + 3)-dimensional Eikonal equation, obtained on the base of low-dimensional (dimL ≤ 3) nonconjugate subalgebras of the Lie algebra of the Poincaré group P(1,4), satisfy all the equations under investigation. In this paper, we present obtained common invariant solutions of the equations under study as well as the classification of those invariant solutions.展开更多
Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites...Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites x-1, x-2 (or x+1, x+2) are empty. It is nongradient and lacks invariant measures of product form. The purpose of this paper is to identify the invariant measures and to show that they satisfy both exponential decay of correlations and equivalence of ensembles. These properties will play a pivotal role in deriving the hydrodynamic limit.展开更多
An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is developed.The numerical scheme is explicit in time and the approximation in space is done with continuou...An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is developed.The numerical scheme is explicit in time and the approximation in space is done with continuous finite elements.The method is made invar-iant domain preserving for the Euler equations using convex limiting and is tested on vari-ous benchmarks.展开更多
For three-dimensional vector fields,the governing formula of invariant manifolds grown from a hyperbolic cycle is given in cylindrical coordinates.The initial growth directions depend on the Jacobians of Poincaré...For three-dimensional vector fields,the governing formula of invariant manifolds grown from a hyperbolic cycle is given in cylindrical coordinates.The initial growth directions depend on the Jacobians of Poincarémap on that cycle,for which an evolution formula is deduced to reveal the relationship among Jacobians of different Poincarésections.The evolution formula also applies to cycles in arbitrary finite n-dimensional autonomous continuous-time dynamical systems.Non-Möbiusian/Möbiusian saddle cycles and a dummy X-cycle are constructed analytically as demonstration.A real-world numeric example of analyzing a magnetic field timeslice on EAST is presented.展开更多
Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with a...Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with arbitrary functions for the(3+1)-dimensional Virasoro integrable model,including the interaction solution between a kink and a soliton,the lump-type solution and periodic solutions,have been studied analytically and graphically.展开更多
This is a survey of using NMSP method to study higher genus Gromov-Witten invariants of Calabi-Yau quintics.It emphasizes on how and why the various methods are introduced to solve several important conjectures for hi...This is a survey of using NMSP method to study higher genus Gromov-Witten invariants of Calabi-Yau quintics.It emphasizes on how and why the various methods are introduced to solve several important conjectures for higher genus Gromov-Witten invariants of Calabi-Yau quintics.展开更多
Some mathematical aspects of the Lie groups SU (2) and in realization by two pairs of boson annihilation and creation operators and in the parametrization by the vector parameter instead of the Euler angles and ...Some mathematical aspects of the Lie groups SU (2) and in realization by two pairs of boson annihilation and creation operators and in the parametrization by the vector parameter instead of the Euler angles and the vector parameter c of Fyodorov are developed. The one-dimensional root scheme of SU (2) is embedded in two-dimensional root schemes of some higher Lie groups, in particular, in inhomogeneous Lie groups and is represented in text and figures. The two-dimensional fundamental representation of SU (2) is calculated and from it the composition law for the product of two transformations and the most important decompositions of general transformations in special ones are derived. Then the transition from representation of SU (2) to of is made where in addition to the parametrization by vector the convenient parametrization by vector c is considered and the connections are established. The measures for invariant integration are derived for and for SU (2) . The relations between 3D-rotations of a unit sphere to fractional linear transformations of a plane by stereographic projection are discussed. All derivations and representations are tried to make in coordinate-invariant way.展开更多
The perturbation to Lie symmetry and adiabatic invariants are studied.Based on the concept of higher-order adiabatic invariants of mechanical systems with action of a small perturbation,the perturbation to Lie symmetr...The perturbation to Lie symmetry and adiabatic invariants are studied.Based on the concept of higher-order adiabatic invariants of mechanical systems with action of a small perturbation,the perturbation to Lie symmetryis studied,and Hojman adiabatic invariants of Hamilton system are obtained.An example is given to illustrate theapplication of the results.展开更多
It is a recent observation that entanglement classification for qubits is closely related to stochastic local operations and classical communication(SLOCC)invariants.Verstraete et al.[Phys.Rev.A 65(2002)052112]showed ...It is a recent observation that entanglement classification for qubits is closely related to stochastic local operations and classical communication(SLOCC)invariants.Verstraete et al.[Phys.Rev.A 65(2002)052112]showed that for pure states of four qubits there are nine different degenerate SLOCC entanglement classes.Li et al.[Phys.Rev.A 76(2007)052311]showed that there are at least 28 distinct true SLOCC entanglement classes for four qubits by means of the SLOCC invariant and semi-invariant.We give 16 different entanglement classes for four qubits by means of basic SLOCC invariants.展开更多
The theory of moving frames developed by Peter J Olver and M Fels has impor-tant applications to geometry, classical invariant theory. We will use this theory to classify joint invariants and joint differential invari...The theory of moving frames developed by Peter J Olver and M Fels has impor-tant applications to geometry, classical invariant theory. We will use this theory to classify joint invariants and joint differential invariants of some transformation groups.展开更多
In this paper, the authors get the characterizations of the integral and Car-leson type measure both associated with the invariant gradient for little a-Bloch functions in the unit ball of Cn. As a consequence, some r...In this paper, the authors get the characterizations of the integral and Car-leson type measure both associated with the invariant gradient for little a-Bloch functions in the unit ball of Cn. As a consequence, some results of Ouyang C H, Yang W S and Zhao R H in [4] and a result of Yang W S in [10] are extended.展开更多
BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate...BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains unclear.AIM To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver failure.METHODS We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong University.Peripheral blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow cytometry.Plasma levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex assay.RESULTS Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with HCs.More importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver failure.Circulating MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared with HCs.CONCLUSION Circulating MAIT cells may play an important role in the process of HBV-related liver failure and can be an important prognostic marker.展开更多
The perturbation of symmetries of the free Birkhoff system undersmall excitation is discussed.The concept of high-order adiabatic invariant is pre-sented,and the form of adiabatic invariants and the conditions for the...The perturbation of symmetries of the free Birkhoff system undersmall excitation is discussed.The concept of high-order adiabatic invariant is pre-sented,and the form of adiabatic invariants and the conditions for their existence aregiven.Then these results are generalized to the constrained Birkhoff system.Oneexample is presented to illustrate these results.展开更多
Perturbation to Noether quasi-symmetry and adiabatic invariants for the nonholonomic system on time scales are studied. Firstly, some properties of time scale calculus are reviewed. Secondly, the differential equation...Perturbation to Noether quasi-symmetry and adiabatic invariants for the nonholonomic system on time scales are studied. Firstly, some properties of time scale calculus are reviewed. Secondly, the differential equations of motion for the nonholonomic system on time scales, Noether quasi-symmetry and conserved quantity are given. Thirdly, perturbation to Noether quasi-symmetry and adiabatic invariants, which are the main results of this paper, are investigated. The main results are achieved by two steps, the first step is to obtain adiabatic invariants without transforming the time, and the next is to obtain adiabatic invariants under the infinitesimal transformations of both the time and the coordinates. And in the end, an example is given to illustrate the methods and results.展开更多
In order to further study the dynamical behavior of nonconservative systems,we study the conserved quantities and the adiabatic invariants of fractional Brikhoffian systems with four kinds of different fractional deri...In order to further study the dynamical behavior of nonconservative systems,we study the conserved quantities and the adiabatic invariants of fractional Brikhoffian systems with four kinds of different fractional derivatives based on Herglotz differential variational principle.Firstly,the conserved quantities of Herglotz type for the fractional Brikhoffian systems based on Riemann-Liouville derivatives and their existence conditions are established by using the fractional Pfaff-Birkhoff-d Alembert principle of Herglotz type.Secondly,the effects of small perturbations on fractional Birkhoffian systems are studied,the conditions for the existence of adiabatic invariants for the Birkhoffian systems of Herglotz type based on Riemann-Liouville derivatives are established,and the adiabatic invariants of Herglotz type are obtained.Thirdly,the conserved quantities and adiabatic invariants for the fractional Birkhoffian systems of Herglotz type under other three kinds of fractional derivatives are established,namely Caputo derivative,Riesz-Riemann-Liouville derivative and Riesz-Caputo derivative.Finally,an example is given to illustrate the application of the results.展开更多
Mice have frequently been used to model human diseases involving immune dysregulation such as autoimmune and inflammatory diseases.These models help elucidatethe mechanisms underlying the disease and in the developmen...Mice have frequently been used to model human diseases involving immune dysregulation such as autoimmune and inflammatory diseases.These models help elucidatethe mechanisms underlying the disease and in the development of novel therapies.However,if mice are deficient in certain cells and/or effectors associated with human diseases,how can their functions be investigated in this species?Mucosal-associated invariant T(MAIT)cells,a novel innate-like T cell family member,are a good example.MAIT cells are abundant in humans but scarce in laboratory mice.MAIT cells harbor an invariant T cell receptor and recognize nonpeptidic antigens vitamin B2metabolites from bacteria and yeasts.Recent studies have shown that MAIT cells play a pivotal role in human diseases such as bacterial infections and autoimmune and inflammatory diseases.MAIT cells possess granulysin,a human-specific effector molecule,but granulysin and its homologue are absent in mice.Furthermore,MAIT cells show poor proliferation in vitro.To overcome these problems and further our knowledge of MAIT cells,we have established a method to expand MAIT cells via induced pluripotent stem cells(iP SCs).In this review,we describe recent advances in the field of MAIT cell research and our approach for human disease modeling with iP SCderived MAIT cells.展开更多
Mucosal-associated invariant T(MAIT)cells have been described in liver and nonliver diseases,and they have been ascribed antimicrobial,immune regulatory,protective,and pathogenic roles.The goals of this review are to ...Mucosal-associated invariant T(MAIT)cells have been described in liver and nonliver diseases,and they have been ascribed antimicrobial,immune regulatory,protective,and pathogenic roles.The goals of this review are to describe their biological properties,indicate their involvement in chronic liver disease,and encourage investigations that clarify their actions and therapeutic implications.English abstracts were identified in PubMed by multiple search terms,and bibliographies were developed.MAIT cells are activated by restricted non-peptides of limited diversity and by multiple inflammatory cytokines.Diverse pro-inflammatory,anti-inflammatory,and immune regulatory cytokines are released;infected cells are eliminated;and memory cells emerge.Circulating MAIT cells are hyper-activated,immune exhausted,dysfunctional,and depleted in chronic liver disease.This phenotype lacks disease-specificity,and it does not predict the biological effects.MAIT cells have presumed protective actions in chronic viral hepatitis,alcoholic hepatitis,non-alcoholic fatty liver disease,primary sclerosing cholangitis,and decompensated cirrhosis.They have pathogenic and pro-fibrotic actions in autoimmune hepatitis and mixed actions in primary biliary cholangitis.Local factors in the hepatic microenvironment(cytokines,bile acids,gut-derived bacterial antigens,and metabolic by-products)may modulate their response in individual diseases.Investigational manipulations of function are warranted to establish an association with disease severity and outcome.In conclusion,MAIT cells constitute a disease-nonspecific,immune response to chronic liver inflammation and infection.Their pathological role has been deduced from their deficiencies during active liver disease,and future investigations must clarify this role,link it to outcome,and explore therapeutic interventions.展开更多
基金supported by the Natural Science Foundation of Beijing(Grant No.Z180007)the National Natural Science Foundation of China(Grant Nos.1157200511874003,and 51672018)。
文摘We propose a method to construct Hopf insulators based on the study of topological defects from the geometric perspective of Hopf invariant I.Firstly,we prove two types of topological defects naturally inhering in the inner differential structure of the Hopf mapping.One type is the four-dimensional point defects.
基金funded by the Deanship of Scientific Research(DSR),King Abdul-Aziz University,Jeddah,Saudi Arabia under Grant No.(RG−11–611–43).
文摘Due to a tremendous increase in mobile traffic,mobile operators have started to restructure their networks to offload their traffic.Newresearch directions will lead to fundamental changes in the design of future Fifthgeneration(5G)cellular networks.For the formal reason,the study solves the physical network of the mobile base station for the prediction of the best characteristics to develop an enhanced network with the help of graph theory.Any number that can be uniquely calculated by a graph is known as a graph invariant.During the last two decades,innumerable numerical graph invariants have been portrayed and used for correlation analysis.In any case,no efficient assessment has been embraced to choose,how much these invariants are connected with a network graph.This paper will talk about two unique variations of the hexagonal graph with great capability of forecasting in the field of optimized mobile base station topology in setting with physical networks.Since K-banhatti sombor invariants(KBSO)and Contrharmonic-quadratic invariants(CQIs)are newly introduced and have various expectation characteristics for various variations of hexagonal graphs or networks.As the hexagonal networks are used in mobile base stations in layered,forms called honeycomb.The review settled the topology of a hexagon of two distinct sorts with two invariants KBSO and CQIs and their reduced forms.The deduced outcomes can be utilized for the modeling of mobile cellular networks,multiprocessors interconnections,microchips,chemical compound synthesis and memory interconnection networks.The results find sharp upper bounds and lower bounds of the honeycomb network to utilize the Mobile base station network(MBSN)for the high load of traffic and minimal traffic also.
文摘We consider the following (1 + 3)-dimensional P(1,4)-invariant partial differential equations (PDEs): the Eikonal equation, the Euler-Lagrange-Born-Infeld equation, the homogeneous Monge-Ampère equation, the inhomogeneous Monge-Ampère equation. The purpose of this paper is to construct and classify the common invariant solutions for those equations. For this aim, we have used the results concerning construction and classification of invariant solutions for the (1 + 3)-dimensional P(1,4)-invariant Eikonal equation, since this equation is the simplest among the equations under investigation. The direct checked allowed us to conclude that the majority of invariant solutions of the (1 + 3)-dimensional Eikonal equation, obtained on the base of low-dimensional (dimL ≤ 3) nonconjugate subalgebras of the Lie algebra of the Poincaré group P(1,4), satisfy all the equations under investigation. In this paper, we present obtained common invariant solutions of the equations under study as well as the classification of those invariant solutions.
基金Supported in part by the National Natural Science Foundation of China(11731012, 11871425, 12271475)Fundamental Research Funds for Central Universities grant(2020XZZX002-03)。
文摘Consider a generalized model of the facilitated exclusion process, which is a onedimensional exclusion process with a dynamical constraint that prevents the particle at site x from jumping to x+1 (or x-1) if the sites x-1, x-2 (or x+1, x+2) are empty. It is nongradient and lacks invariant measures of product form. The purpose of this paper is to identify the invariant measures and to show that they satisfy both exponential decay of correlations and equivalence of ensembles. These properties will play a pivotal role in deriving the hydrodynamic limit.
基金supported in part by a“Computational R&D in Support of Stockpile Stewardship”Grant from Lawrence Livermore National Laboratorythe National Science Foundation Grants DMS-1619892+2 种基金the Air Force Office of Scientifc Research,USAF,under Grant/contract number FA9955012-0358the Army Research Office under Grant/contract number W911NF-15-1-0517the Spanish MCINN under Project PGC2018-097565-B-I00
文摘An invariant domain preserving arbitrary Lagrangian-Eulerian method for solving non-linear hyperbolic systems is developed.The numerical scheme is explicit in time and the approximation in space is done with continuous finite elements.The method is made invar-iant domain preserving for the Euler equations using convex limiting and is tested on vari-ous benchmarks.
基金supported by National Magnetic Confined Fusion Energy R&D Program of China(No.2022YFE03030001)National Natural Science Foundation of China(Nos.12275310 and 12175277)+1 种基金the Science Foundation of Institute of Plasma Physics,Chinese Academy of Sciences(No.DSJJ-2021-01)the Collaborative Innovation Program of Hefei Science Center,CAS(No.2021HSCCIP019).
文摘For three-dimensional vector fields,the governing formula of invariant manifolds grown from a hyperbolic cycle is given in cylindrical coordinates.The initial growth directions depend on the Jacobians of Poincarémap on that cycle,for which an evolution formula is deduced to reveal the relationship among Jacobians of different Poincarésections.The evolution formula also applies to cycles in arbitrary finite n-dimensional autonomous continuous-time dynamical systems.Non-Möbiusian/Möbiusian saddle cycles and a dummy X-cycle are constructed analytically as demonstration.A real-world numeric example of analyzing a magnetic field timeslice on EAST is presented.
文摘Lie symmetry analysis is applied to a(3+1)-dimensional Virasoro integrable model and the corresponding similarity reduction equations are obtained with the different infinitesimal generators.Invariant solutions with arbitrary functions for the(3+1)-dimensional Virasoro integrable model,including the interaction solution between a kink and a soliton,the lump-type solution and periodic solutions,have been studied analytically and graphically.
基金Supported by Hong Kong GRF16301515,GRF16301717,GRF16304119 and GRF16306222。
文摘This is a survey of using NMSP method to study higher genus Gromov-Witten invariants of Calabi-Yau quintics.It emphasizes on how and why the various methods are introduced to solve several important conjectures for higher genus Gromov-Witten invariants of Calabi-Yau quintics.
文摘Some mathematical aspects of the Lie groups SU (2) and in realization by two pairs of boson annihilation and creation operators and in the parametrization by the vector parameter instead of the Euler angles and the vector parameter c of Fyodorov are developed. The one-dimensional root scheme of SU (2) is embedded in two-dimensional root schemes of some higher Lie groups, in particular, in inhomogeneous Lie groups and is represented in text and figures. The two-dimensional fundamental representation of SU (2) is calculated and from it the composition law for the product of two transformations and the most important decompositions of general transformations in special ones are derived. Then the transition from representation of SU (2) to of is made where in addition to the parametrization by vector the convenient parametrization by vector c is considered and the connections are established. The measures for invariant integration are derived for and for SU (2) . The relations between 3D-rotations of a unit sphere to fractional linear transformations of a plane by stereographic projection are discussed. All derivations and representations are tried to make in coordinate-invariant way.
文摘The perturbation to Lie symmetry and adiabatic invariants are studied.Based on the concept of higher-order adiabatic invariants of mechanical systems with action of a small perturbation,the perturbation to Lie symmetryis studied,and Hojman adiabatic invariants of Hamilton system are obtained.An example is given to illustrate theapplication of the results.
基金Supported by the National Natural Science Foundation of China under Grant No 10902083Shaanxi Natural Science Foundation under Contract No 2009JM1007.
文摘It is a recent observation that entanglement classification for qubits is closely related to stochastic local operations and classical communication(SLOCC)invariants.Verstraete et al.[Phys.Rev.A 65(2002)052112]showed that for pure states of four qubits there are nine different degenerate SLOCC entanglement classes.Li et al.[Phys.Rev.A 76(2007)052311]showed that there are at least 28 distinct true SLOCC entanglement classes for four qubits by means of the SLOCC invariant and semi-invariant.We give 16 different entanglement classes for four qubits by means of basic SLOCC invariants.
基金Supported by National Natural Science Foundation of China(10801045)Supported by the Foundation of Henan Educational Committee(2007110002)Supported by the Foundation of Henan Technology Commit tee(082300410020)
文摘The theory of moving frames developed by Peter J Olver and M Fels has impor-tant applications to geometry, classical invariant theory. We will use this theory to classify joint invariants and joint differential invariants of some transformation groups.
文摘In this paper, the authors get the characterizations of the integral and Car-leson type measure both associated with the invariant gradient for little a-Bloch functions in the unit ball of Cn. As a consequence, some results of Ouyang C H, Yang W S and Zhao R H in [4] and a result of Yang W S in [10] are extended.
基金Supported by National Natural Science Foundation of China,No.81600449Nantong Science and Technology Bureau,No.MS22018007,No.MSZ18130,and No.JCZ18036+2 种基金Six Peak Talents in Jiangsu Province,No.YY-177Project of Jiangsu Province Youth Medical Talent Development,No.QNRC2016400and Project of Nantong Youth Medical Talent Development,No.05.
文摘BACKGROUND Liver failure has high mortality and poor prognosis,and establishing new reliable markers for predicting its prognosis is necessary.Mucosal-associated invariant T(MAIT)cells are a novel population of innate-like lymphocytes involved in inflammatory liver disease,and their potential role in liver failure remains unclear.AIM To investigate alteration of circulating MAIT cells and assess its prognostic value in patients with hepatitis B virus(HBV)-related liver failure.METHODS We recruited 55 patients with HBV-related liver failure,48 patients with chronic hepatitis B and 40 healthy controls(HCs)from Nantong Third People’s Hospital Affiliated to Nantong University.Peripheral blood mononuclear cells were isolated,and the percentage and number of circulating MAIT cells were detected by flow cytometry.Plasma levels of interleukin(IL)-7,IL-12p70,IL-18 and interferon-αwere measured by Luminex assay.RESULTS Circulating MAIT cells were significantly decreased in HBV-related liver failure patients(percentage:2.00±1.22 vs 5.19±1.27%,P<0.0001;number:5.47±4.93 vs 84.43±19.59,P<0.0001)compared with HCs.More importantly,there was a significant reduction of MAIT cells in patients with middle/late-stage compared with early-stage liver failure.Circulating MAIT cells partially recovered after disease improvement,both in percentage(4.01±1.21 vs 2.04±0.95%,P<0.0001)and in cell count(17.24±8.56 vs 7.41±4.99,P<0.0001).The proportion(2.29±1.01 vs 1.58±1.38%,P<0.05)and number(7.30±5.70 vs 2.94±1.47,P<0.001)of circulating MAIT cells were significantly higher in the survival group than in the dead/liver transplantation group,and the Kaplan–Meier curve showed that lower expression of circulating MAIT cells(both percentage and cell count)predicted poor overall survival(P<0.01).Also,the levels of IL-12(20.26±5.42 pg/mL vs 17.76±2.79 pg/mL,P=0.01)and IL-18(1470.05±1525.38 pg/mL vs 362.99±109.64 pg/mL,P<0.0001)were dramatically increased in HBV-related liver failure patients compared with HCs.CONCLUSION Circulating MAIT cells may play an important role in the process of HBV-related liver failure and can be an important prognostic marker.
基金The project supported by the National Natural Science Foundation(19972010)the Doctoral Program Foundation of Institution of Higher Education of Chinathe Natural Science Foundation of Henan Province
文摘The perturbation of symmetries of the free Birkhoff system undersmall excitation is discussed.The concept of high-order adiabatic invariant is pre-sented,and the form of adiabatic invariants and the conditions for their existence aregiven.Then these results are generalized to the constrained Birkhoff system.Oneexample is presented to illustrate these results.
基金Supported by the National Natural Science Foundation of China(11802193,11572212)the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(18KJB130005)+2 种基金the Jiangsu Government Scholarship for Overseas Studiesthe Science Research Foundation of Suzhou University of Science and Technology(331812137)the Natural Science Foundation of Suzhou University of Science and Technology
文摘Perturbation to Noether quasi-symmetry and adiabatic invariants for the nonholonomic system on time scales are studied. Firstly, some properties of time scale calculus are reviewed. Secondly, the differential equations of motion for the nonholonomic system on time scales, Noether quasi-symmetry and conserved quantity are given. Thirdly, perturbation to Noether quasi-symmetry and adiabatic invariants, which are the main results of this paper, are investigated. The main results are achieved by two steps, the first step is to obtain adiabatic invariants without transforming the time, and the next is to obtain adiabatic invariants under the infinitesimal transformations of both the time and the coordinates. And in the end, an example is given to illustrate the methods and results.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11972241,11572212,and 11272227)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20191454)the Innovation Program for Postgraduade in Higher Education Institutions of Jiangsu Province,China(Grant No.KYCX192013)。
文摘In order to further study the dynamical behavior of nonconservative systems,we study the conserved quantities and the adiabatic invariants of fractional Brikhoffian systems with four kinds of different fractional derivatives based on Herglotz differential variational principle.Firstly,the conserved quantities of Herglotz type for the fractional Brikhoffian systems based on Riemann-Liouville derivatives and their existence conditions are established by using the fractional Pfaff-Birkhoff-d Alembert principle of Herglotz type.Secondly,the effects of small perturbations on fractional Birkhoffian systems are studied,the conditions for the existence of adiabatic invariants for the Birkhoffian systems of Herglotz type based on Riemann-Liouville derivatives are established,and the adiabatic invariants of Herglotz type are obtained.Thirdly,the conserved quantities and adiabatic invariants for the fractional Birkhoffian systems of Herglotz type under other three kinds of fractional derivatives are established,namely Caputo derivative,Riesz-Riemann-Liouville derivative and Riesz-Caputo derivative.Finally,an example is given to illustrate the application of the results.
文摘Mice have frequently been used to model human diseases involving immune dysregulation such as autoimmune and inflammatory diseases.These models help elucidatethe mechanisms underlying the disease and in the development of novel therapies.However,if mice are deficient in certain cells and/or effectors associated with human diseases,how can their functions be investigated in this species?Mucosal-associated invariant T(MAIT)cells,a novel innate-like T cell family member,are a good example.MAIT cells are abundant in humans but scarce in laboratory mice.MAIT cells harbor an invariant T cell receptor and recognize nonpeptidic antigens vitamin B2metabolites from bacteria and yeasts.Recent studies have shown that MAIT cells play a pivotal role in human diseases such as bacterial infections and autoimmune and inflammatory diseases.MAIT cells possess granulysin,a human-specific effector molecule,but granulysin and its homologue are absent in mice.Furthermore,MAIT cells show poor proliferation in vitro.To overcome these problems and further our knowledge of MAIT cells,we have established a method to expand MAIT cells via induced pluripotent stem cells(iP SCs).In this review,we describe recent advances in the field of MAIT cell research and our approach for human disease modeling with iP SCderived MAIT cells.
文摘Mucosal-associated invariant T(MAIT)cells have been described in liver and nonliver diseases,and they have been ascribed antimicrobial,immune regulatory,protective,and pathogenic roles.The goals of this review are to describe their biological properties,indicate their involvement in chronic liver disease,and encourage investigations that clarify their actions and therapeutic implications.English abstracts were identified in PubMed by multiple search terms,and bibliographies were developed.MAIT cells are activated by restricted non-peptides of limited diversity and by multiple inflammatory cytokines.Diverse pro-inflammatory,anti-inflammatory,and immune regulatory cytokines are released;infected cells are eliminated;and memory cells emerge.Circulating MAIT cells are hyper-activated,immune exhausted,dysfunctional,and depleted in chronic liver disease.This phenotype lacks disease-specificity,and it does not predict the biological effects.MAIT cells have presumed protective actions in chronic viral hepatitis,alcoholic hepatitis,non-alcoholic fatty liver disease,primary sclerosing cholangitis,and decompensated cirrhosis.They have pathogenic and pro-fibrotic actions in autoimmune hepatitis and mixed actions in primary biliary cholangitis.Local factors in the hepatic microenvironment(cytokines,bile acids,gut-derived bacterial antigens,and metabolic by-products)may modulate their response in individual diseases.Investigational manipulations of function are warranted to establish an association with disease severity and outcome.In conclusion,MAIT cells constitute a disease-nonspecific,immune response to chronic liver inflammation and infection.Their pathological role has been deduced from their deficiencies during active liver disease,and future investigations must clarify this role,link it to outcome,and explore therapeutic interventions.