Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofo...Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofobject recognition in dark and harsh weather conditions.Design/methodology/approach – This paper adopts the fusion strategy of radar and camera linkage toachieve focus amplification of long-distance targets and solves the problem of low illumination by laser lightfilling of the focus point. In order to improve the recognition effect, this paper adopts the YOLOv8 algorithm formulti-scale target recognition. In addition, for the image distortion caused by bad weather, this paper proposesa linkage and tracking fusion strategy to output the correct alarm results.Findings – Simulated intrusion tests show that the proposed method can effectively detect human intrusionwithin 0–200 m during the day and night in sunny weather and can achieve more than 80% recognitionaccuracy for extreme severe weather conditions.Originality/value – (1) The authors propose a personnel intrusion monitoring scheme based on the fusion ofmillimeter wave radar and camera, achieving all-weather intrusion monitoring;(2) The authors propose a newmulti-level fusion algorithm based on linkage and tracking to achieve intrusion target monitoring underadverse weather conditions;(3) The authors have conducted a large number of innovative simulationexperiments to verify the effectiveness of the method proposed in this article.展开更多
Liver fibrosis is an important pathological precondition for hepatocellular carcinoma.The degree of hepatic fibrosis is positively correlated with liver cancer.Liver fibrosis is a series of pathological and physiologi...Liver fibrosis is an important pathological precondition for hepatocellular carcinoma.The degree of hepatic fibrosis is positively correlated with liver cancer.Liver fibrosis is a series of pathological and physiological process related to liver cell necrosis and degeneration after chronic liver injury,which finally leads to extracellular matrix and collagen deposition.The early detection and precise staging of fibrosis and cirrhosis are very important for early diagnosis and timely initiation of appropriate therapeutic regimens.The risk of severe liver fibrosis finally progressing to liver carcinoma is>50%.It is known that biopsy is the gold standard for the diagnosis and staging of liver fibrosis.However,this method has some limitations,such as the potential for pain,sampling variability,and low patient acceptance.Furthermore,the necessity of obtaining a tissue diagnosis of liver fibrosis still remains controversial.An increasing number of reliable non-invasive approaches are now available that are widely applied in clinical practice,mostly in cases of viral hepatitis,resulting in a significantly decreased need for liver biopsy.In fact,the noninvasive detection and evaluation of liver cirrhosis now has good accuracy due to current serum markers,ultrasound imaging,and magnetic resonance imaging quantification techniques.A prominent advantage of the non-invasive detection and assessment of liver fibrosis is that liver fibrosis can be monitored repeatedly and easily in the same patient.Serum biomarkers have the advantages of high applicability(>95%)and good reproducibility.However,their results can be influenced by different patient conditions because none of these markers are liver-specific.The most promising techniques appear to be transient elastography and magnetic resonance elastography because they provide reliable results for the detection of fibrosis in the advanced stages,and future developments promise to increase the reliability and accuracy of the staging of hepatic fibrosis.This article aims to describe the recent progress in the development of non-invasive assessment methods for the staging of liver fibrosis,with a special emphasize on computer-aided quantitative and deep learning methods.展开更多
Objective The purpose of this study was to evaluate the distribution of vascular endothelial growth factor(VEGF) and CD105-microvessel density(MVD) in invasive breast carcinomas. We also aimed to analyze the relations...Objective The purpose of this study was to evaluate the distribution of vascular endothelial growth factor(VEGF) and CD105-microvessel density(MVD) in invasive breast carcinomas. We also aimed to analyze the relationship between VEGF and MVD expression with other standard prognostic parameters associated with invasive breast cancer, such as size, grade, stage of the cancer, metastases, and tumor recurrence. Methods Immunohistochemistry via the Ultra Sensitive TM S-P method was used to detect VEGF and MVD expression in 128 cases of invasive breast carcinoma. Specimens were evaluated for CD105 expression. Positively stained microvessels were counted in dense vascular foci under 400× magnification. MVD in the peripheral area adjacent to the lesion and in the central area within the lesion in invasive breast carcinomas and benign leisions groups were also assessed. Fifty cases of benign breast disease tissue were selected as the control group.Results Results showed that 64.1% of invasive breast cancer samples were VEGF-positive, higher than in benign breast disease tissue(22.0%, P < 0.05). There was a positive correlation between VEGF overexpression and histological grade, lymph node metastasis, and distant metastasis of invasive breast cancer. VEGF expression was not related to age or size of the tumor(P > 0.05). MVD of the peripheral area adjacent to the lesion was significantly higher than those central area within the lesion in both invasive breast cancer and benign breast disease groups(P < 0.01 for each group). There were significant differences in the mean CD105-MVD, between invasive breast tumors with a histological grade of I or II and grade III; between tumors with lymph node or distant metastasis; and between patients with or without recurrence(P < 0.05). However, there was no difference in the mean MVD between the two age groups(≤ 50 years vs. > 50 years) or the two tumor diameter groups(≤ 2 cm vs. > 2 cm), P > 0.05.Conclusion Overexpression of VEGF and MVD may be important biological markers for invasion and lymph node and distant metastases of invasive breast cancer. Combined detection of the two tumor markers could provide better prognostic monitoring for disease recurrence and metastasis, as well as aid with clinical staging of breast tumors. Prediction of the risk for metastasis and recurrence, as well as recurrence patterns based on VEGF and MVD post-surgery, could aid design of better follow-up regimens and appropriate treatment strategies for breast cancer patients.展开更多
Oral cancer has a tendency to be detected at late stage which is detrimental to the patients because of its high mortality and morbidity rates. Early detection of oral cancer is therefore important to reduce the burde...Oral cancer has a tendency to be detected at late stage which is detrimental to the patients because of its high mortality and morbidity rates. Early detection of oral cancer is therefore important to reduce the burden of this devastating disease. In this review article, the most common oral precancerous lesions are discussed and the importance of early diagnosis is emphasized. In addition, the most common non-invasive oral cancer devices that can aid the general practitioners in early diagnosis are also discussed.展开更多
This paper proposes a resampling simulator that will calculate probabilities of detecting invasive species infesting hosts that occur in large numbers. Different methods were examined to determine the bias of observed...This paper proposes a resampling simulator that will calculate probabilities of detecting invasive species infesting hosts that occur in large numbers. Different methods were examined to determine the bias of observed cumulative distribution functions (c.d.f.s), generated from prototype resampling simulators. One involved seeing if they matched theoretical c.d.f.s, which were generated using formulae for calculating the probability of the union of many events (union formulae), which are known to be correct. Others involved assessing the bias of observed c.d.f.s, generated from using prototype resampling simulators operating on much larger simulated populations, when computation of theoretical c.d.f.s from the union formulae was not practical. Examples are given for using the proposed resampling simulator for detecting an invasive insect pest within the context of an invasive species management system.展开更多
In mausoleum murals, existing bubbles are one kind of the most harmful defects for the repair and protection of relics. For this reason, it is necessary to detect bubbles, especially the ones with small size. A method...In mausoleum murals, existing bubbles are one kind of the most harmful defects for the repair and protection of relics. For this reason, it is necessary to detect bubbles, especially the ones with small size. A method to detect the small bubbles with enhanced terahertz (THz) images is proposed. To simulate the bubbles in the mausoleum murals, circular grooves have been hidden in the plaster and then measured by the THz reflected time domain spectroscopy imaging system. To observe the small bubbles in murals, a comprehensive enhancement algorithm is adopted to process the obtained THz images. With the enhanced method, the circular grooves in the murals can be observed clearly, even for the circular groove with a diameter of 1.5 mm. The results indicate that the proposed comprehensive method can be used to detect the tiny defects of murals.展开更多
智能电网的建设思路决定了远郊变电站异常入侵监测的无人化趋势,促进了变电站异常入侵智能检测方法的快速发展。现阶段尚未拥有该场景下异常入侵目标数据集,且现有的目标检测方法也未针对变电站边缘计算端进行轻量化优化设计,不适用于...智能电网的建设思路决定了远郊变电站异常入侵监测的无人化趋势,促进了变电站异常入侵智能检测方法的快速发展。现阶段尚未拥有该场景下异常入侵目标数据集,且现有的目标检测方法也未针对变电站边缘计算端进行轻量化优化设计,不适用于需要全天候实时监测的变电站边缘设备。针对上述问题,从实际应用需求出发,构建变电站异常入侵目标数据集(Dataset for Anomaly Invasion Targets in Substations,SAITD),基于YOLOv5s模型提出适用于变电站边缘检测设备的轻量化异常入侵目标检测网络YOLOv5-Substation。添加微小尺度目标特征提取层与上采样轻量化算子CARAFE,在扩大感受野的同时,充分保留特征图中多尺度目标的语义信息,从架构端提高原有模型的检测精度。基于知识蒸馏模型,使用网络剪枝(Network-slimming)策略对原有模型进行轻量化改进,在保证原模型检测精度的同时,加速模型推理。仿真实验表明,轻量化后的边缘端计算模型精度相较于YOLOv5s提高了3.3%,推理速度提升了41.9%,可为智能电网的全速运行提供强有力的数据基础、技术支撑与安全保障。展开更多
Lakes areas,which cause catastrophic damages in both commercial fishery and ecological systems.However,current assessment strategies may pose challenges for lake-wide abundance estimation and non-target anadromous spe...Lakes areas,which cause catastrophic damages in both commercial fishery and ecological systems.However,current assessment strategies may pose challenges for lake-wide abundance estimation and non-target anadromous species preservation.Here,we demonstrate an efficacious species-specific non-destructive sensing system based on porous ferroelectret nanogenerator for in-situ monitoring of lamprey spawning migration using their unique suction behavior.Simulations show that the porous structure enables a redistribution of surface charges under bidirectional deformations,which allows the detection of both positive and negative pressures.The quasi-piezoelectric effect is further validated by quantitative analysis in a wide pressure range of−50 to 60 kPa,providing detailed insights into transduction working principles.For reliable lamprey detection,a 4×4-pixel sensor array is developed and integrated with a complementary metal-oxide-semiconductor(CMOS)based signal processing array thus constituting a sensing panel capable of recording oral suction patterns in an underwater environment.展开更多
基金supported by the National Natural Science Foundation of China[U2268217].
文摘Purpose – The paper aims to solve the problem of personnel intrusion identification within the limits of highspeed railways. It adopts the fusion method of millimeter wave radar and camera to improve the accuracy ofobject recognition in dark and harsh weather conditions.Design/methodology/approach – This paper adopts the fusion strategy of radar and camera linkage toachieve focus amplification of long-distance targets and solves the problem of low illumination by laser lightfilling of the focus point. In order to improve the recognition effect, this paper adopts the YOLOv8 algorithm formulti-scale target recognition. In addition, for the image distortion caused by bad weather, this paper proposesa linkage and tracking fusion strategy to output the correct alarm results.Findings – Simulated intrusion tests show that the proposed method can effectively detect human intrusionwithin 0–200 m during the day and night in sunny weather and can achieve more than 80% recognitionaccuracy for extreme severe weather conditions.Originality/value – (1) The authors propose a personnel intrusion monitoring scheme based on the fusion ofmillimeter wave radar and camera, achieving all-weather intrusion monitoring;(2) The authors propose a newmulti-level fusion algorithm based on linkage and tracking to achieve intrusion target monitoring underadverse weather conditions;(3) The authors have conducted a large number of innovative simulationexperiments to verify the effectiveness of the method proposed in this article.
基金Supported by the High Technology Research and Development Programme of China (No. 2003AA1Z2070 ) and the National Natural Science Foundation of China (No. 90412013).
文摘Liver fibrosis is an important pathological precondition for hepatocellular carcinoma.The degree of hepatic fibrosis is positively correlated with liver cancer.Liver fibrosis is a series of pathological and physiological process related to liver cell necrosis and degeneration after chronic liver injury,which finally leads to extracellular matrix and collagen deposition.The early detection and precise staging of fibrosis and cirrhosis are very important for early diagnosis and timely initiation of appropriate therapeutic regimens.The risk of severe liver fibrosis finally progressing to liver carcinoma is>50%.It is known that biopsy is the gold standard for the diagnosis and staging of liver fibrosis.However,this method has some limitations,such as the potential for pain,sampling variability,and low patient acceptance.Furthermore,the necessity of obtaining a tissue diagnosis of liver fibrosis still remains controversial.An increasing number of reliable non-invasive approaches are now available that are widely applied in clinical practice,mostly in cases of viral hepatitis,resulting in a significantly decreased need for liver biopsy.In fact,the noninvasive detection and evaluation of liver cirrhosis now has good accuracy due to current serum markers,ultrasound imaging,and magnetic resonance imaging quantification techniques.A prominent advantage of the non-invasive detection and assessment of liver fibrosis is that liver fibrosis can be monitored repeatedly and easily in the same patient.Serum biomarkers have the advantages of high applicability(>95%)and good reproducibility.However,their results can be influenced by different patient conditions because none of these markers are liver-specific.The most promising techniques appear to be transient elastography and magnetic resonance elastography because they provide reliable results for the detection of fibrosis in the advanced stages,and future developments promise to increase the reliability and accuracy of the staging of hepatic fibrosis.This article aims to describe the recent progress in the development of non-invasive assessment methods for the staging of liver fibrosis,with a special emphasize on computer-aided quantitative and deep learning methods.
基金Supported by grants from the Medicine and Health Care Science and Technology Development Plan Projects Foundation of Shandong Province(No.2014WS0282,2014WSA11003)the Application Technology Research and Development Project Foundation in Rizhao City(No.2014SZSH002)the Scientific Research Projects of Jining Medical College(No.JY2013KJ051)
文摘Objective The purpose of this study was to evaluate the distribution of vascular endothelial growth factor(VEGF) and CD105-microvessel density(MVD) in invasive breast carcinomas. We also aimed to analyze the relationship between VEGF and MVD expression with other standard prognostic parameters associated with invasive breast cancer, such as size, grade, stage of the cancer, metastases, and tumor recurrence. Methods Immunohistochemistry via the Ultra Sensitive TM S-P method was used to detect VEGF and MVD expression in 128 cases of invasive breast carcinoma. Specimens were evaluated for CD105 expression. Positively stained microvessels were counted in dense vascular foci under 400× magnification. MVD in the peripheral area adjacent to the lesion and in the central area within the lesion in invasive breast carcinomas and benign leisions groups were also assessed. Fifty cases of benign breast disease tissue were selected as the control group.Results Results showed that 64.1% of invasive breast cancer samples were VEGF-positive, higher than in benign breast disease tissue(22.0%, P < 0.05). There was a positive correlation between VEGF overexpression and histological grade, lymph node metastasis, and distant metastasis of invasive breast cancer. VEGF expression was not related to age or size of the tumor(P > 0.05). MVD of the peripheral area adjacent to the lesion was significantly higher than those central area within the lesion in both invasive breast cancer and benign breast disease groups(P < 0.01 for each group). There were significant differences in the mean CD105-MVD, between invasive breast tumors with a histological grade of I or II and grade III; between tumors with lymph node or distant metastasis; and between patients with or without recurrence(P < 0.05). However, there was no difference in the mean MVD between the two age groups(≤ 50 years vs. > 50 years) or the two tumor diameter groups(≤ 2 cm vs. > 2 cm), P > 0.05.Conclusion Overexpression of VEGF and MVD may be important biological markers for invasion and lymph node and distant metastases of invasive breast cancer. Combined detection of the two tumor markers could provide better prognostic monitoring for disease recurrence and metastasis, as well as aid with clinical staging of breast tumors. Prediction of the risk for metastasis and recurrence, as well as recurrence patterns based on VEGF and MVD post-surgery, could aid design of better follow-up regimens and appropriate treatment strategies for breast cancer patients.
基金supported by Open Fund of State Key Laboratory of Oral Diseases, Sichuan University
文摘Oral cancer has a tendency to be detected at late stage which is detrimental to the patients because of its high mortality and morbidity rates. Early detection of oral cancer is therefore important to reduce the burden of this devastating disease. In this review article, the most common oral precancerous lesions are discussed and the importance of early diagnosis is emphasized. In addition, the most common non-invasive oral cancer devices that can aid the general practitioners in early diagnosis are also discussed.
文摘This paper proposes a resampling simulator that will calculate probabilities of detecting invasive species infesting hosts that occur in large numbers. Different methods were examined to determine the bias of observed cumulative distribution functions (c.d.f.s), generated from prototype resampling simulators. One involved seeing if they matched theoretical c.d.f.s, which were generated using formulae for calculating the probability of the union of many events (union formulae), which are known to be correct. Others involved assessing the bias of observed c.d.f.s, generated from using prototype resampling simulators operating on much larger simulated populations, when computation of theoretical c.d.f.s from the union formulae was not practical. Examples are given for using the proposed resampling simulator for detecting an invasive insect pest within the context of an invasive species management system.
基金supported by the 973 Program of China under Grant No.2013CBA01702National Natural Science Foundation of China under Grant No.11474206,No.91233202,No.11374216,and No.11404224+3 种基金Program for New Century Excellent Talents in University under Grant No.NCET-12-0607Scientific Research Project of Beijing Education Commission under Grant No.KM201310028005Specialized Research Fund for the Doctoral Program of Higher Education under Grant No.20121108120009the Beijing Youth Top-Notch Talent Training Plan under Grant No.CIT&TCD201504080
文摘In mausoleum murals, existing bubbles are one kind of the most harmful defects for the repair and protection of relics. For this reason, it is necessary to detect bubbles, especially the ones with small size. A method to detect the small bubbles with enhanced terahertz (THz) images is proposed. To simulate the bubbles in the mausoleum murals, circular grooves have been hidden in the plaster and then measured by the THz reflected time domain spectroscopy imaging system. To observe the small bubbles in murals, a comprehensive enhancement algorithm is adopted to process the obtained THz images. With the enhanced method, the circular grooves in the murals can be observed clearly, even for the circular groove with a diameter of 1.5 mm. The results indicate that the proposed comprehensive method can be used to detect the tiny defects of murals.
文摘智能电网的建设思路决定了远郊变电站异常入侵监测的无人化趋势,促进了变电站异常入侵智能检测方法的快速发展。现阶段尚未拥有该场景下异常入侵目标数据集,且现有的目标检测方法也未针对变电站边缘计算端进行轻量化优化设计,不适用于需要全天候实时监测的变电站边缘设备。针对上述问题,从实际应用需求出发,构建变电站异常入侵目标数据集(Dataset for Anomaly Invasion Targets in Substations,SAITD),基于YOLOv5s模型提出适用于变电站边缘检测设备的轻量化异常入侵目标检测网络YOLOv5-Substation。添加微小尺度目标特征提取层与上采样轻量化算子CARAFE,在扩大感受野的同时,充分保留特征图中多尺度目标的语义信息,从架构端提高原有模型的检测精度。基于知识蒸馏模型,使用网络剪枝(Network-slimming)策略对原有模型进行轻量化改进,在保证原模型检测精度的同时,加速模型推理。仿真实验表明,轻量化后的边缘端计算模型精度相较于YOLOv5s提高了3.3%,推理速度提升了41.9%,可为智能电网的全速运行提供强有力的数据基础、技术支撑与安全保障。
基金supported in part by the National Natural Science Foundation of China(Nos.U21A20519 and 62103369)the Michigan State University Foundation Strategic Partnership(No.16-SPG-Full-3236),and the Great Lakes Fishery Commission(No.2018_TAN_54069).
文摘Lakes areas,which cause catastrophic damages in both commercial fishery and ecological systems.However,current assessment strategies may pose challenges for lake-wide abundance estimation and non-target anadromous species preservation.Here,we demonstrate an efficacious species-specific non-destructive sensing system based on porous ferroelectret nanogenerator for in-situ monitoring of lamprey spawning migration using their unique suction behavior.Simulations show that the porous structure enables a redistribution of surface charges under bidirectional deformations,which allows the detection of both positive and negative pressures.The quasi-piezoelectric effect is further validated by quantitative analysis in a wide pressure range of−50 to 60 kPa,providing detailed insights into transduction working principles.For reliable lamprey detection,a 4×4-pixel sensor array is developed and integrated with a complementary metal-oxide-semiconductor(CMOS)based signal processing array thus constituting a sensing panel capable of recording oral suction patterns in an underwater environment.