In the last decade, three dimensional discontin- uous deformation analyses (3D DDA) has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a ...In the last decade, three dimensional discontin- uous deformation analyses (3D DDA) has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a linear displacement function to describe the block movement and deformation, which would cause block expansion under rigid body rotation and thus limit its capability to model block de- formation. In this paper, 3D DDA is coupled with tetrahe- dron finite elements to tackle these two problems. Tetrahe- dron is the simplest in the 3D domain and makes it easy to implement automatic discretization, even for complex topol- ogy shape. Furthermore, element faces will remain planar and element edges will remain straight after deformation for tetrahedron finite elements and polyhedral contact detection schemes can be used directly. The matrices of equilibrium equations for this coupled method are given in detail and an effective contact searching algorithm is suggested. Valida- tion is conducted by comparing the results of the proposed coupled method with that of physical model tests using one of the most common failure modes, i.e., wedge failure. Most of the failure modes predicted by the coupled method agree with the physical model results except for 4 cases out of the total 65 cases. Finally, a complex rockslide example demon- strates the robustness and versatility of the coupled method.展开更多
Excellent vacuum performance ensures a high beam transmission efficiency of the neutral beam injector (NBI). The vacuum performance is mainly determined by the cryoperformance of the cryopanel of the cryocondensatio...Excellent vacuum performance ensures a high beam transmission efficiency of the neutral beam injector (NBI). The vacuum performance is mainly determined by the cryoperformance of the cryopanel of the cryocondensation pumps which are the main vacuum pumps of NBI. In order to optimize the cryoperformance, the requirements for the temperature distribution and the heat load of the cryopanel are analysed and the factors that affect the cryopanel's temperature distribution are studied. The results indicate that the temperature difference of the cryopanel can be reduced by fabricating the cryopanel with high thermal conductivity material, increasing its thickness and cutting the distance between the two upward cooling pipes. The results may be applied to a cryopanel cooled by forced flow liquid helium.展开更多
OBJECTIVE: This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES: O...OBJECTIVE: This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES: Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were "transcranial magnetic stimulation", "TMS", "repetitive tran- scranial magnetic stimulation", and "hallucination". STUDY SELECTION: Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES: The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS: Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant (MD = -0.42, 95%C/: -0.64 to -0.20, P = 0.000 2). Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation (OR = 2.94, 95%C/: 1.39 to 6.24, P =0.005). No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms. Compared with sham stimulation, active repeti- tive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching. CONCLUSION: Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders,展开更多
This study evaluates the operational performance of all routes of Sajha Bus Yatayat operating inside Kathmandu valley using Data Envelopment Analysis (DEA) in terms of efficiency and effectiveness score. This approach...This study evaluates the operational performance of all routes of Sajha Bus Yatayat operating inside Kathmandu valley using Data Envelopment Analysis (DEA) in terms of efficiency and effectiveness score. This approach allows us to access the relative performance of transit system in absence of historical data and research to compare with. To explore the possibility of enhancing the performance, scenarios were created for relatively underperforming routes and long route problem by changing the most important input variable and output variables accordingly with regression model where it was relevant. Partial Least Squares (PLS) regression was used to determine the most influential input variables to the output variables. DEA was conducted to access the performance of all routes under these scenarios. Underperforming routes except the longest route under the first set of scenarios, emerge to be better performing efficiently without considerable negative deviation in effectiveness. The result of second set of scenarios for long route problem suggests that the longest route’s performance can be enhanced significantly upon proper route alignment. Scenarios development and evaluation can help lead transit companies to explore the strategies to facilitate operational performance enhancement.展开更多
To attain the volumetric information of the optic radiation in normal human brains, we per- formed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to...To attain the volumetric information of the optic radiation in normal human brains, we per- formed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are help- ful in the study of optic radiation fiber tract information.展开更多
Current research and ways of capturing mechanical energy are discussed in this paper. By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool, the amount of a vailable work that can be produc...Current research and ways of capturing mechanical energy are discussed in this paper. By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool, the amount of a vailable work that can be produced from capturing the pressure energy has been calculated. Based on the comprehensive thermodynamic analysis, two systems have been proposed to capture pressure energy of natural gas to generate electricity. In this study, the expression of exergy is given which can be used in evaluating purposes. A problem with this multidisciplinary study is the complicated boundary condition. In conclusion, a technical prospect on recoverable natural gas pressure energy has been presented based on total energy system theory.展开更多
The complex and varied relationships between supply a nd demand among different enterprises calls for an effective way to evaluate and maintain reliability in supply chain management. Individually, enterprises purs ue...The complex and varied relationships between supply a nd demand among different enterprises calls for an effective way to evaluate and maintain reliability in supply chain management. Individually, enterprises purs ue maximum benefit strategy while cooperating with others. This behavior may res ult in the weakening of needed reliability in supply chain or, in more serious c ases, sever the supply chain. Although reliability of supply chain is the bases to ensuring long-term benefit, a systematic way of handling reliability issues in supply chain management has drawn little attention. The main objective of thi s paper is to define reliability in supply chain management and to develop a fuz zy operational model based on two factors: serial and parallel, to research it.展开更多
How to allocate a resource efficiently and fairly attracts the attention of both researchers and practitioners. Data envelopment analysis(DEA) has been brought to bear on its solution. The existing literature applie...How to allocate a resource efficiently and fairly attracts the attention of both researchers and practitioners. Data envelopment analysis(DEA) has been brought to bear on its solution. The existing literature applies Gini coefficient to measure the fairness in the resource allocation process. However, the Gini coefficient is inapplicable in many applications. This paper proposes a novel centralized resource allocation model based on DEA that considers both the efficiency and the fairness. This paper adopts a notion of fairness, namely α-fairness that is well studied in welfare economics and is of practical significance. The new model integratesα-fairness with DEA to support resource allocation decisions. It aids decision makers in making a trade-off between the efficiency and the fairness. An illustrative application is used to validate the proposed approach.展开更多
To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients (1...To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients (1-17 years old) who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 (range, 2-7) days after surgery for 10 (range, 7-23) days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients's clinical symptoms have no influences on neurofunctional outcomes.展开更多
This paper introduced characteristics of refractories and step of simulation. During simulation,firstly analyzed mechanism of technology; secondly described the mechanism as quadratic equation; thirdly designed and ex...This paper introduced characteristics of refractories and step of simulation. During simulation,firstly analyzed mechanism of technology; secondly described the mechanism as quadratic equation; thirdly designed and executed experiment; later made regression equation and optimization; then found technical conflict; finally analyzed and resolved the conflict. Doing repeatedly like this,resolved difficult problems.展开更多
Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological beh...Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis;infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD);thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form展开更多
User-analysis techniques are mainly used to recommend friends and information. This paper discusses the data characteristics of microblog users and describes a multidimensional user rec- ommendation algorithm that tak...User-analysis techniques are mainly used to recommend friends and information. This paper discusses the data characteristics of microblog users and describes a multidimensional user rec- ommendation algorithm that takes into account microblog length, relativity between microblog and users, and familiarity between users. The experimental results show that this multidi- mensional algorithm is more accurate than a traditional recom- mendation algorithm.展开更多
Cyber losses in terms of number of records breached under cyber incidents commonly feature a significant portion of zeros, specific characteristics of mid-range losses and large losses, which make it hard to model the...Cyber losses in terms of number of records breached under cyber incidents commonly feature a significant portion of zeros, specific characteristics of mid-range losses and large losses, which make it hard to model the whole range of the losses using a standard loss distribution. We tackle this modeling problem by proposing a three-component spliced regression model that can simultaneously model zeros, moderate and large losses and consider heterogeneous effects in mixture components. To apply our proposed model to Privacy Right Clearinghouse (PRC) data breach chronology, we segment geographical groups using unsupervised cluster analysis, and utilize a covariate-dependent probability to model zero losses, finite mixture distributions for moderate body and an extreme value distribution for large losses capturing the heavy-tailed nature of the loss data. Parameters and coefficients are estimated using the Expectation-Maximization (EM) algorithm. Combining with our frequency model (generalized linear mixed model) for data breaches, aggregate loss distributions are investigated and applications on cyber insurance pricing and risk management are discussed.展开更多
基金supported by the Key Project of Chinese National Programs for Fundamental Research and Development(2010CB731502)the National Natural Science Foundation of China(50978745)
文摘In the last decade, three dimensional discontin- uous deformation analyses (3D DDA) has attracted more and more attention of researchers and geotechnical engineers worldwide. The original DDA formulation utilizes a linear displacement function to describe the block movement and deformation, which would cause block expansion under rigid body rotation and thus limit its capability to model block de- formation. In this paper, 3D DDA is coupled with tetrahe- dron finite elements to tackle these two problems. Tetrahe- dron is the simplest in the 3D domain and makes it easy to implement automatic discretization, even for complex topol- ogy shape. Furthermore, element faces will remain planar and element edges will remain straight after deformation for tetrahedron finite elements and polyhedral contact detection schemes can be used directly. The matrices of equilibrium equations for this coupled method are given in detail and an effective contact searching algorithm is suggested. Valida- tion is conducted by comparing the results of the proposed coupled method with that of physical model tests using one of the most common failure modes, i.e., wedge failure. Most of the failure modes predicted by the coupled method agree with the physical model results except for 4 cases out of the total 65 cases. Finally, a complex rockslide example demon- strates the robustness and versatility of the coupled method.
基金National Natural Science Foundation of China(No.10575105)
文摘Excellent vacuum performance ensures a high beam transmission efficiency of the neutral beam injector (NBI). The vacuum performance is mainly determined by the cryoperformance of the cryopanel of the cryocondensation pumps which are the main vacuum pumps of NBI. In order to optimize the cryoperformance, the requirements for the temperature distribution and the heat load of the cryopanel are analysed and the factors that affect the cryopanel's temperature distribution are studied. The results indicate that the temperature difference of the cryopanel can be reduced by fabricating the cryopanel with high thermal conductivity material, increasing its thickness and cutting the distance between the two upward cooling pipes. The results may be applied to a cryopanel cooled by forced flow liquid helium.
基金financially sponsored by the Special Funding of Henan Health Science and Technology Innovation Talent Project,No.4173(2010-2015)Xinxiang Medical University of High-Level Personnel of Scientific Research Projects,No.08BSKYQD-004the Key Projects of Science and Technology Research of Department of Education in Henan,No.13A320869
文摘OBJECTIVE: This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES: Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were "transcranial magnetic stimulation", "TMS", "repetitive tran- scranial magnetic stimulation", and "hallucination". STUDY SELECTION: Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES: The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS: Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant (MD = -0.42, 95%C/: -0.64 to -0.20, P = 0.000 2). Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation (OR = 2.94, 95%C/: 1.39 to 6.24, P =0.005). No significant differences were found between active repetitive transcranial magnetic stimulation and sham stimulation for positive or negative symptoms. Compared with sham stimulation, active repeti- tive transcranial magnetic stimulation had equivocal outcome in cognitive function and commonly caused headache and facial muscle twitching. CONCLUSION: Repetitive transcranial magnetic stimulation is a safe and effective treatment for auditory hallucination in schizophrenia spectrum disorders,
文摘This study evaluates the operational performance of all routes of Sajha Bus Yatayat operating inside Kathmandu valley using Data Envelopment Analysis (DEA) in terms of efficiency and effectiveness score. This approach allows us to access the relative performance of transit system in absence of historical data and research to compare with. To explore the possibility of enhancing the performance, scenarios were created for relatively underperforming routes and long route problem by changing the most important input variable and output variables accordingly with regression model where it was relevant. Partial Least Squares (PLS) regression was used to determine the most influential input variables to the output variables. DEA was conducted to access the performance of all routes under these scenarios. Underperforming routes except the longest route under the first set of scenarios, emerge to be better performing efficiently without considerable negative deviation in effectiveness. The result of second set of scenarios for long route problem suggests that the longest route’s performance can be enhanced significantly upon proper route alignment. Scenarios development and evaluation can help lead transit companies to explore the strategies to facilitate operational performance enhancement.
文摘To attain the volumetric information of the optic radiation in normal human brains, we per- formed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are help- ful in the study of optic radiation fiber tract information.
基金Supported by Tianjin Institute of Urban Construction(03046)
文摘Current research and ways of capturing mechanical energy are discussed in this paper. By the aid of the comprehensive thermodynamic analysis and Aspen simulation tool, the amount of a vailable work that can be produced from capturing the pressure energy has been calculated. Based on the comprehensive thermodynamic analysis, two systems have been proposed to capture pressure energy of natural gas to generate electricity. In this study, the expression of exergy is given which can be used in evaluating purposes. A problem with this multidisciplinary study is the complicated boundary condition. In conclusion, a technical prospect on recoverable natural gas pressure energy has been presented based on total energy system theory.
文摘The complex and varied relationships between supply a nd demand among different enterprises calls for an effective way to evaluate and maintain reliability in supply chain management. Individually, enterprises purs ue maximum benefit strategy while cooperating with others. This behavior may res ult in the weakening of needed reliability in supply chain or, in more serious c ases, sever the supply chain. Although reliability of supply chain is the bases to ensuring long-term benefit, a systematic way of handling reliability issues in supply chain management has drawn little attention. The main objective of thi s paper is to define reliability in supply chain management and to develop a fuz zy operational model based on two factors: serial and parallel, to research it.
基金supported by the National Natural Science Foundation of China(7117118171301155)+1 种基金the Fundamental Research Fundsfor the Central Universities(WK2040160008J2014HGBZ0172)
文摘How to allocate a resource efficiently and fairly attracts the attention of both researchers and practitioners. Data envelopment analysis(DEA) has been brought to bear on its solution. The existing literature applies Gini coefficient to measure the fairness in the resource allocation process. However, the Gini coefficient is inapplicable in many applications. This paper proposes a novel centralized resource allocation model based on DEA that considers both the efficiency and the fairness. This paper adopts a notion of fairness, namely α-fairness that is well studied in welfare economics and is of practical significance. The new model integratesα-fairness with DEA to support resource allocation decisions. It aids decision makers in making a trade-off between the efficiency and the fairness. An illustrative application is used to validate the proposed approach.
文摘To investigate the effect of early rehabilitation on neurofunctional outcome after surgery in chil- dren with spinal tumors, this study reviewed the medical charts and radiographic records of 70 pediatric patients (1-17 years old) who received spinal tumor surgical removal. The peddiatric patients received rahabilitation treatment at 4 (range, 2-7) days after surgery for 10 (range, 7-23) days. Results from the Modified McCormick Scale, Functional Independence Measure for Chil- dren, American Spinal Injury Association Impairment Scale and Karnofsky Performance Status Scale demonstrated that the sensory function, motor function and activity of daily living of pedi- atric children who received early rehabilitation were significantly improved. Results also showed that tumor setting and level localization as well as patients's clinical symptoms have no influences on neurofunctional outcomes.
基金funded by the Twelfth Five-year National Science and Technology Support Project(2013BAE03B01-01B)
文摘This paper introduced characteristics of refractories and step of simulation. During simulation,firstly analyzed mechanism of technology; secondly described the mechanism as quadratic equation; thirdly designed and executed experiment; later made regression equation and optimization; then found technical conflict; finally analyzed and resolved the conflict. Doing repeatedly like this,resolved difficult problems.
文摘Investigation of charge-transfer (CT) complexes of drugs has been recognized as an important phenomenon in understanding of the drug-receptor binding mechanism. Structural, thermal, morpholo-gical and biological behavior of CT complexes formed between drug quinidine (Qui) as a donor and quinol (QL), picric acid (PA) or dichlorodicyanobenzoquinone (DDQ) as acceptors were reported. The newly synthesized CT complexes have been spectroscopically characterized via elemental analysis;infrared (IR), Raman, 1H NMR and electronic absorption spectroscopy; powder X-ray diffraction (PXRD);thermogravimetric (TG) analysis and scanning electron microscopy (SEM). It was found that the obtained complexes are nanoscale, semi-crystalline particles, thermally stable and spontaneous. The molecular composition of the obtained complexes was determined using spectrophotometric titration method and was found to be 1:1 ratios (donor:acceptor). Finally, the biological activities of the obtained CT complexes were tested for their antibacterial activities. The results obtained herein are satisfactory for estimation of drug Qui in the pharmaceutical form
文摘User-analysis techniques are mainly used to recommend friends and information. This paper discusses the data characteristics of microblog users and describes a multidimensional user rec- ommendation algorithm that takes into account microblog length, relativity between microblog and users, and familiarity between users. The experimental results show that this multidi- mensional algorithm is more accurate than a traditional recom- mendation algorithm.
文摘Cyber losses in terms of number of records breached under cyber incidents commonly feature a significant portion of zeros, specific characteristics of mid-range losses and large losses, which make it hard to model the whole range of the losses using a standard loss distribution. We tackle this modeling problem by proposing a three-component spliced regression model that can simultaneously model zeros, moderate and large losses and consider heterogeneous effects in mixture components. To apply our proposed model to Privacy Right Clearinghouse (PRC) data breach chronology, we segment geographical groups using unsupervised cluster analysis, and utilize a covariate-dependent probability to model zero losses, finite mixture distributions for moderate body and an extreme value distribution for large losses capturing the heavy-tailed nature of the loss data. Parameters and coefficients are estimated using the Expectation-Maximization (EM) algorithm. Combining with our frequency model (generalized linear mixed model) for data breaches, aggregate loss distributions are investigated and applications on cyber insurance pricing and risk management are discussed.