目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分...目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分对照组和试验组,每组各50例。对照组采用常规治疗,试验组常规治疗+健脾化痰祛湿法联合针刺周期疗法。治疗3个月后,观察比较两组患者临床疗效,治疗前后体质量指数(Body mass index,BMI)、腰臀比(Waist hip ratio,WHR)、子宫内膜容受性[子宫内膜厚度、子宫动脉血流搏动指数(Pulsatility index,PI)和子宫动脉阻力指数(Resistance index,RI)]和糖代谢指标[糖化血红蛋白(HbAlc)、空腹胰岛素(Fasting insulin,FINS)和胰岛素抵抗指数(Homeostasis model assessment-insulin resistance,HOMA-IR)]、脂肪代谢因子[脂联素(Adiponectin,APN)、廋素(Leptin,LEP)]水平。结果治疗后试验组总有效率为90.00%(45/50)明显高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者BMI指数及WHR比值均较治疗前降低,差异有统计学意义(P<0.05);且试验组BMI指数及WHR比值均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜厚度均较治疗前增厚、RI指数均较治疗前降低,差异有统计学意义(P<0.05);且试验组子宫内膜厚度较对照组增厚、RI指数较对照组降低,差异有统计学意义(P<0.05)。治疗后两组患者HbAlc、FINS及HOMA-IR水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组HbAlc、FINS及HOMA-IR水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者APN、LEP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组APN、LEP水平均较对照组降低,差异有统计学意义(P<0.05)。结论应用健脾化痰祛湿法联合针刺周期疗法治疗肥胖型PCOS可提高疗效,并能改善患者子宫内膜容受性和糖脂代谢因子。展开更多
Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chin...Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chinese medicine (TCM) combined with Western medicine for the treatment of ulcerative colitis(UC).Materials and Methods:The databases China National Knowledge Infrastructure,China Biology Medicinedisc(CBMdisc),WANFANG, VIP, and PubMed were searched for randomized controlled trials investigating the integration of the TCM methods of clearing heat,draining dampness, invigorating the spleen, and removing stasis, combined with Western medicine to treat UC from January 2009 to March 2019. Two reviewers independently conducted literature searches, screenings, data extractions, and literature bias evaluations. A meta-analysis was conducted using RevMan 5.3 and Stata 13.0 software. Results:In total, 15 studies involving 1289 patients were included. The results of the meta-analysis showed that the total effective rate of treatment in the experimental groups was higher than that of the control groups (relative risk [RR]=1.27, 95%confidence interval [CI]:1.21, 1.35, Z=8.74, P <0.00001). In the subgroup analysis, the total effective rate of oral TCM combined with Western medicine was higher than that of the control groups (RR=1.24, 95%CI:1.15, 1.33, Z=5.88, P <0.00001). The total effective rate of oral TCM with enemas combined with Western medicine was higher than that of the control group (RR=1.30, 95%CI:1.12, 1.50, Z=3.52, P=0.0004).The comparison between Western medicine alone and oral TCM combined with enteroscopy and Western medicine showed that the effective rate of enteroscopy (RR=1.18, 95%CI:1.05, 1.33, Z=2.86, P=0.004) and the symptom scores before and after treatment all improved more in the combined treatment groups than in those of the Western medicine group alone, with statistically significant differences (RR=-4.23, 95%CI:-4.93,-3.53, Z=11.84, P <0.00001). Conclusion:The integration of the TCM methods of heat clearing, dampness excreting, spleen strengthening, and stasis removing combined with Western medicine can significantly improve the cure rate of UC, and is an effective method to treat UC.展开更多
Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF). Met...Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF). Methods: Thirty-nine patients with CRF were divided into two groups at random: the 18 patients in group A (the control group) were treated with low protein diet and controlling blood pressure and 21 patients in group B (the treatment group) were treated similarly with that of the control group and additional CD. Levels of serous creatinine (SCr), blood urea nitrogen (BUN), blood albumin (Alb), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and hemoglobin (Hb) were checked every two months and the rate of progression of CRF was estimated by slope of the creatinine reciprocal (1/SCr) with time (months). Results: Levels of SCr and BUN in group B were lower and HDL higher than those in group A significantly, P<0.05. Mean slopes of the creatinine reciprocal with time in the two groups were markedly different, P<0.01. Conclusion: Additional CD treatment based upon the low protein diet and controlling blood pressure could retard the rate of progression of CRF evidently.展开更多
文摘目的观察肥胖型多囊卵巢综合征(Polycystic ovarian syndrome,PCOS)患者应用健脾化痰祛湿法联合针刺周期疗法的临床疗效。方法选取2019年6月—2021年6月期间在南阳市第二人民医院中医妇科就诊的肥胖型PCOS患者100例,采用简单随机化法分对照组和试验组,每组各50例。对照组采用常规治疗,试验组常规治疗+健脾化痰祛湿法联合针刺周期疗法。治疗3个月后,观察比较两组患者临床疗效,治疗前后体质量指数(Body mass index,BMI)、腰臀比(Waist hip ratio,WHR)、子宫内膜容受性[子宫内膜厚度、子宫动脉血流搏动指数(Pulsatility index,PI)和子宫动脉阻力指数(Resistance index,RI)]和糖代谢指标[糖化血红蛋白(HbAlc)、空腹胰岛素(Fasting insulin,FINS)和胰岛素抵抗指数(Homeostasis model assessment-insulin resistance,HOMA-IR)]、脂肪代谢因子[脂联素(Adiponectin,APN)、廋素(Leptin,LEP)]水平。结果治疗后试验组总有效率为90.00%(45/50)明显高于对照组74.00%(37/50),差异有统计学意义(P<0.05)。治疗后两组患者BMI指数及WHR比值均较治疗前降低,差异有统计学意义(P<0.05);且试验组BMI指数及WHR比值均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者子宫内膜厚度均较治疗前增厚、RI指数均较治疗前降低,差异有统计学意义(P<0.05);且试验组子宫内膜厚度较对照组增厚、RI指数较对照组降低,差异有统计学意义(P<0.05)。治疗后两组患者HbAlc、FINS及HOMA-IR水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组HbAlc、FINS及HOMA-IR水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者APN、LEP水平均较治疗前降低,差异有统计学意义(P<0.05);且试验组APN、LEP水平均较对照组降低,差异有统计学意义(P<0.05)。结论应用健脾化痰祛湿法联合针刺周期疗法治疗肥胖型PCOS可提高疗效,并能改善患者子宫内膜容受性和糖脂代谢因子。
基金financially supported by Project of China-Japanese Friendship Hospital,the study on the pathogenesis of UC with syndrome of retention of dampness heat in large intestine based on relevant pathways of “bacteria–intestine–brain axis”(2019-JYB-JS-020)。
文摘Objective:The objective of this study was to systematically evaluate the clinical efficacy of the integration method of heat-clearing, dampness-excreting,spleen-strengthening, and stasis-removing from traditional Chinese medicine (TCM) combined with Western medicine for the treatment of ulcerative colitis(UC).Materials and Methods:The databases China National Knowledge Infrastructure,China Biology Medicinedisc(CBMdisc),WANFANG, VIP, and PubMed were searched for randomized controlled trials investigating the integration of the TCM methods of clearing heat,draining dampness, invigorating the spleen, and removing stasis, combined with Western medicine to treat UC from January 2009 to March 2019. Two reviewers independently conducted literature searches, screenings, data extractions, and literature bias evaluations. A meta-analysis was conducted using RevMan 5.3 and Stata 13.0 software. Results:In total, 15 studies involving 1289 patients were included. The results of the meta-analysis showed that the total effective rate of treatment in the experimental groups was higher than that of the control groups (relative risk [RR]=1.27, 95%confidence interval [CI]:1.21, 1.35, Z=8.74, P <0.00001). In the subgroup analysis, the total effective rate of oral TCM combined with Western medicine was higher than that of the control groups (RR=1.24, 95%CI:1.15, 1.33, Z=5.88, P <0.00001). The total effective rate of oral TCM with enemas combined with Western medicine was higher than that of the control group (RR=1.30, 95%CI:1.12, 1.50, Z=3.52, P=0.0004).The comparison between Western medicine alone and oral TCM combined with enteroscopy and Western medicine showed that the effective rate of enteroscopy (RR=1.18, 95%CI:1.05, 1.33, Z=2.86, P=0.004) and the symptom scores before and after treatment all improved more in the combined treatment groups than in those of the Western medicine group alone, with statistically significant differences (RR=-4.23, 95%CI:-4.93,-3.53, Z=11.84, P <0.00001). Conclusion:The integration of the TCM methods of heat clearing, dampness excreting, spleen strengthening, and stasis removing combined with Western medicine can significantly improve the cure rate of UC, and is an effective method to treat UC.
文摘Objective: To investigate the effect of Chinese drugs (CD) that invigorate Spleen to remove Dampness and activate the blood circulation to eliminate Turbid for retarding progression of chronic renal failure (CRF). Methods: Thirty-nine patients with CRF were divided into two groups at random: the 18 patients in group A (the control group) were treated with low protein diet and controlling blood pressure and 21 patients in group B (the treatment group) were treated similarly with that of the control group and additional CD. Levels of serous creatinine (SCr), blood urea nitrogen (BUN), blood albumin (Alb), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and hemoglobin (Hb) were checked every two months and the rate of progression of CRF was estimated by slope of the creatinine reciprocal (1/SCr) with time (months). Results: Levels of SCr and BUN in group B were lower and HDL higher than those in group A significantly, P<0.05. Mean slopes of the creatinine reciprocal with time in the two groups were markedly different, P<0.01. Conclusion: Additional CD treatment based upon the low protein diet and controlling blood pressure could retard the rate of progression of CRF evidently.
