Boro-germanate glasses containing copper, i.e., xCuO(1-x)[GeO2·B2O3] subjected to gamma irradiation, were studied by means of EPR. Comparisons were made with the xCuO·(1-x)[Na2B4O7] system. Irradiation induc...Boro-germanate glasses containing copper, i.e., xCuO(1-x)[GeO2·B2O3] subjected to gamma irradiation, were studied by means of EPR. Comparisons were made with the xCuO·(1-x)[Na2B4O7] system. Irradiation induced centers were detected. These are: electron trapped at a hydrogen compensated germanium ion centers; boron oxygen hole centers and electron trapped at an oxygen vacancy centers. Strong dependence of the paramagnetic irradiation-induced centers concentration on the CuO content of the sample was evidenced.展开更多
Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed pr...Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury. Here we investigated the effects of shikonin on carbon ion beam induced radiation brain injury in mice. Pretreatment with shikonin significantly increased the SOD and CAT activities and the ratio of GSH/GSSG in mouse brain tissues compared with irradiated group (P〈0.01), while obviously reduced the MDA and PCO contents and the RO$ levels derived from of the brain mitochondria.展开更多
The highly charged ion Ar^12+ with an energy of 3 Me V is used for irradiating metallic glass (Cu47Zr45Al8)98.5Y1.5 and polycrystalline metallic W at the irradiation fluences of 1× 10^14 ions/cm2, 1 × 10^...The highly charged ion Ar^12+ with an energy of 3 Me V is used for irradiating metallic glass (Cu47Zr45Al8)98.5Y1.5 and polycrystalline metallic W at the irradiation fluences of 1× 10^14 ions/cm2, 1 × 10^15 ions/cm^2 and 1 × 10^16 ions/cm^2. The main structure of metallic glass remains an amorphous phase under different irradiation fluences according to x-ray diffraction analysis. The scanning electron microscope observation on the morphologies indicates that no significant irradiation damage occurs on the surface and cross section of the metallic glass sample after different fluences of irradiation, while a large area of irregular cracks and holes were observed on the surface of metallic W at a fluence of 1 ×10^16 ions/cm^2, with cracks and channel impairments at a certain depth from the surface. The root-mean-square (rms) roughness of metallic glass increases with increasing fluence of Ar^12+, while the reflectance decreases with increasing irradiation fluence. A nano-hardness test shows that the hardness of metallic glass decreases after irradiation. Under certain a higher capability of resistance to Ar^12+ irradiation in conditions, metallic glass (Cu47 Zr45Al8 )98.5 Y1.5 exhibits comparison with polycrystalline W.展开更多
Eight lines of temperature-responsive leaf colormutants induced by applying 300 Gy Gamma-ray irradiation to Thermo-sensitive genic malesterile line 2177s,were obtained through con-tinuous selection in seven generation...Eight lines of temperature-responsive leaf colormutants induced by applying 300 Gy Gamma-ray irradiation to Thermo-sensitive genic malesterile line 2177s,were obtained through con-tinuous selection in seven generations..Theleaves of these lines started to become greenafter the fourth leaf extension,and except展开更多
Microtubules are involved in a variety of cellular functions such as cell division, intracellular transport, maintenance of cell polarity and flagella and ciliary motility. The heterogeneity of tubulin and microtubule...Microtubules are involved in a variety of cellular functions such as cell division, intracellular transport, maintenance of cell polarity and flagella and ciliary motility. The heterogeneity of tubulin and microtubule-associated proteins is responsible for these different microtubule functions. Many studies have confirmed that the structure and function of the different α-tubulin and β-tubulin subunits can affect the microtubule. The sperm axoneme microtubule has linear fiber filaments which are polymerized by heterodimeric a and β-tubulin, each with a molecular mass of approximately 50 kD[1].展开更多
Although 5-aminolevulinic acid(5-ALA)-mediated photodynamic therapy(PDT) has been demonstrated to be a novel and effective therapeutic modality for some human malignancies, its effect and mechanism on glioma are s...Although 5-aminolevulinic acid(5-ALA)-mediated photodynamic therapy(PDT) has been demonstrated to be a novel and effective therapeutic modality for some human malignancies, its effect and mechanism on glioma are still controversial. Previous studies have reported that 5-ALA-PDT induced necrosis of C6 rat glioma cells in vitro. The aim of this study was to further investigate the effect and mechanism of 5-ALA-PDT on C6 gliomas implanted in rats in vivo. Twenty-four rats bearing similar size of subcutaneously implanted C6 rat glioma were randomly divided into 3 groups: receiving 5-ALA-PDT(group A), laser irradiation(group B), and mock procedures but without any treatment(group C), respectively. The growth, histology, microvessel density(MVD), and apoptosis of the grafts in each group were determined after the treatments. As compared with groups B and C, the volume of tumor grafts was significantly reduced(P〈0.05), MVD was significantly decreased(P〈0.001), and the cellular necrosis was obviously increased in group A. There was no significant difference in apoptosis among the three groups. The in vivo studies confirmed that 5-ALA-PDT may be an effective treatment for gliomas by inhibiting the tumor growth. The mechanism underlying may involve increasing the cellular necrosis but not inducing the cellular apoptosis, which may result from the destruction of the tumor microvessels.展开更多
文摘Boro-germanate glasses containing copper, i.e., xCuO(1-x)[GeO2·B2O3] subjected to gamma irradiation, were studied by means of EPR. Comparisons were made with the xCuO·(1-x)[Na2B4O7] system. Irradiation induced centers were detected. These are: electron trapped at a hydrogen compensated germanium ion centers; boron oxygen hole centers and electron trapped at an oxygen vacancy centers. Strong dependence of the paramagnetic irradiation-induced centers concentration on the CuO content of the sample was evidenced.
基金supported by Key Program of National Natural Science Foundation of China(U1432248)National Natural Science Foundation of China(11175222,11305226)
文摘Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury. Here we investigated the effects of shikonin on carbon ion beam induced radiation brain injury in mice. Pretreatment with shikonin significantly increased the SOD and CAT activities and the ratio of GSH/GSSG in mouse brain tissues compared with irradiated group (P〈0.01), while obviously reduced the MDA and PCO contents and the RO$ levels derived from of the brain mitochondria.
基金Supported by the National Natural Science Foundation of China under Grant Nos 11079012 and 11375037the National Basic Research Program of China under Grant No 2010CB832901
文摘The highly charged ion Ar^12+ with an energy of 3 Me V is used for irradiating metallic glass (Cu47Zr45Al8)98.5Y1.5 and polycrystalline metallic W at the irradiation fluences of 1× 10^14 ions/cm2, 1 × 10^15 ions/cm^2 and 1 × 10^16 ions/cm^2. The main structure of metallic glass remains an amorphous phase under different irradiation fluences according to x-ray diffraction analysis. The scanning electron microscope observation on the morphologies indicates that no significant irradiation damage occurs on the surface and cross section of the metallic glass sample after different fluences of irradiation, while a large area of irregular cracks and holes were observed on the surface of metallic W at a fluence of 1 ×10^16 ions/cm^2, with cracks and channel impairments at a certain depth from the surface. The root-mean-square (rms) roughness of metallic glass increases with increasing fluence of Ar^12+, while the reflectance decreases with increasing irradiation fluence. A nano-hardness test shows that the hardness of metallic glass decreases after irradiation. Under certain a higher capability of resistance to Ar^12+ irradiation in conditions, metallic glass (Cu47 Zr45Al8 )98.5 Y1.5 exhibits comparison with polycrystalline W.
文摘Eight lines of temperature-responsive leaf colormutants induced by applying 300 Gy Gamma-ray irradiation to Thermo-sensitive genic malesterile line 2177s,were obtained through con-tinuous selection in seven generations..Theleaves of these lines started to become greenafter the fourth leaf extension,and except
基金supported by grants from the National Basic Research Program of China(2010CB834202)The National Natural Science Foundation of China(10835011)the Scientific Technology Research Projects of Gansu Province(0702NKDA045,0806RJYA020)
文摘Microtubules are involved in a variety of cellular functions such as cell division, intracellular transport, maintenance of cell polarity and flagella and ciliary motility. The heterogeneity of tubulin and microtubule-associated proteins is responsible for these different microtubule functions. Many studies have confirmed that the structure and function of the different α-tubulin and β-tubulin subunits can affect the microtubule. The sperm axoneme microtubule has linear fiber filaments which are polymerized by heterodimeric a and β-tubulin, each with a molecular mass of approximately 50 kD[1].
基金supported by the grants from the National Natural Science Foundation of China(No.30973073,81172402 and 81372683)
文摘Although 5-aminolevulinic acid(5-ALA)-mediated photodynamic therapy(PDT) has been demonstrated to be a novel and effective therapeutic modality for some human malignancies, its effect and mechanism on glioma are still controversial. Previous studies have reported that 5-ALA-PDT induced necrosis of C6 rat glioma cells in vitro. The aim of this study was to further investigate the effect and mechanism of 5-ALA-PDT on C6 gliomas implanted in rats in vivo. Twenty-four rats bearing similar size of subcutaneously implanted C6 rat glioma were randomly divided into 3 groups: receiving 5-ALA-PDT(group A), laser irradiation(group B), and mock procedures but without any treatment(group C), respectively. The growth, histology, microvessel density(MVD), and apoptosis of the grafts in each group were determined after the treatments. As compared with groups B and C, the volume of tumor grafts was significantly reduced(P〈0.05), MVD was significantly decreased(P〈0.001), and the cellular necrosis was obviously increased in group A. There was no significant difference in apoptosis among the three groups. The in vivo studies confirmed that 5-ALA-PDT may be an effective treatment for gliomas by inhibiting the tumor growth. The mechanism underlying may involve increasing the cellular necrosis but not inducing the cellular apoptosis, which may result from the destruction of the tumor microvessels.