To investigate the effects of L-Tetrahydropalmatine (L-THP ) on neuron apoptosis during acute cerebral ischemia-reperfusion of rats and explore the effects of heat shock protein (HSP) on neuron apoptosis, Wistar rats ...To investigate the effects of L-Tetrahydropalmatine (L-THP ) on neuron apoptosis during acute cerebral ischemia-reperfusion of rats and explore the effects of heat shock protein (HSP) on neuron apoptosis, Wistar rats were randomly divided into 3 groups: normal group, ischemia- reperfusion group and treatment group. The condition of neuron apoptosis, the survival state of neuron, pathological changes under an electron microscope and the number of HSP70 positive cells were measured in all groups. Results showed that the apoptosis neuron number was increased obviously at the 24th h during reperfusion and was further increased at the 48th h, the 72th h. While the number of survival neurons was decreased gradually with the prolongation of reperfusion time. Treatment with L-THP could decrease the apoptosis neuron number but increase the survival neuron number and the HSP70 positive cell number. Our study suggested that L-THP could decrease apoptosis and necrosis of neuron, up-regulate the expression of HSP70 and protect the cerebral ischemic injury.展开更多
The culture of every nation is bound to develop and make progress along with social development and progress. This is true, too, of Tibetan culture. As China furthers the cause of building socialism with Chinese chara...The culture of every nation is bound to develop and make progress along with social development and progress. This is true, too, of Tibetan culture. As China furthers the cause of building socialism with Chinese characteristics, a new progressive culture will keep replacing an old and backward culture. Any attempt to impede and reverse such progress constitutes real destruction of a culture. Such an attempt can never succeed. Nor will the attempt of the Dalai Lama.展开更多
文摘To investigate the effects of L-Tetrahydropalmatine (L-THP ) on neuron apoptosis during acute cerebral ischemia-reperfusion of rats and explore the effects of heat shock protein (HSP) on neuron apoptosis, Wistar rats were randomly divided into 3 groups: normal group, ischemia- reperfusion group and treatment group. The condition of neuron apoptosis, the survival state of neuron, pathological changes under an electron microscope and the number of HSP70 positive cells were measured in all groups. Results showed that the apoptosis neuron number was increased obviously at the 24th h during reperfusion and was further increased at the 48th h, the 72th h. While the number of survival neurons was decreased gradually with the prolongation of reperfusion time. Treatment with L-THP could decrease the apoptosis neuron number but increase the survival neuron number and the HSP70 positive cell number. Our study suggested that L-THP could decrease apoptosis and necrosis of neuron, up-regulate the expression of HSP70 and protect the cerebral ischemic injury.
文摘The culture of every nation is bound to develop and make progress along with social development and progress. This is true, too, of Tibetan culture. As China furthers the cause of building socialism with Chinese characteristics, a new progressive culture will keep replacing an old and backward culture. Any attempt to impede and reverse such progress constitutes real destruction of a culture. Such an attempt can never succeed. Nor will the attempt of the Dalai Lama.
