In order to explore the effect of acupuncture preconditioning on rats＇ cell apoptosis with cardiac muscle re-perfusion damage and bcl-2mRNA genes, we used differentiating acupuncture and moxibustion preconditioning a...In order to explore the effect of acupuncture preconditioning on rats＇ cell apoptosis with cardiac muscle re-perfusion damage and bcl-2mRNA genes, we used differentiating acupuncture and moxibustion preconditioning among groups, then compared acupuncture and moxibustion preconditioning with ischemic preconditioning. The experimental results show that acupuncture and moxibustion preconditioning makes more bcl-2mRNA genes expressed and produces less cell apoptosis, furthermore, groups of acupuncture and moxibustion preconditioning for twice a day are more effective than those of ischemic ureconditioning.展开更多
AIM To study whether remote ischemic preconditioning(RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation(POAF).METHODS This was a prospective, single-center, single-blinded,randomized ...AIM To study whether remote ischemic preconditioning(RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation(POAF).METHODS This was a prospective, single-center, single-blinded,randomized controlled study. One hundred and two patients were randomized to receive RIPC(3 cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia) or no RIPC(control). Primary outcome was POAF lasting for five minutes or longer during the first seven days after surgery. Secondary outcomes included length of hospital stay, incidence of inpatient mortality, myocardial infarction, and stroke. RESULTS POAF occurred at a rate of 54% in the RIPC group and 41.2% in the control group(P = 0.23). No statistically significant differences were noted in secondary outcomes between the two groups. CONCLUSION This is the first study in the United States to suggest that RIPC does not reduce POAF in patients with elective or urgent cardiac surgery. There were no differences in adverse effects in either group. Further studies are required to assess the relationship between RIPC and POAF.展开更多
目的:探讨肢体远隔缺血预处理对胸腔镜体外循环心脏手术的肺保护作用及其机制。方法 :胸腔镜体外循环心脏手术患者81例,ASAⅡ～Ⅲ级,随机分为试验组(给予肢体远隔缺血预处理,n=41)和对照组(不给予肢体远隔缺血预处理,n=40)。采集患者术...目的:探讨肢体远隔缺血预处理对胸腔镜体外循环心脏手术的肺保护作用及其机制。方法 :胸腔镜体外循环心脏手术患者81例,ASAⅡ～Ⅲ级,随机分为试验组(给予肢体远隔缺血预处理,n=41)和对照组(不给予肢体远隔缺血预处理,n=40)。采集患者术中及术后临床指标,分别在手术开始前、手术结束后6、24 h采集桡动脉血检测氧合指数(PaO2/FiO2)、血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及丙二醛(MDA)水平。结果:两组患者术后机械通气时间试验组小于对照组,组内比较术后6、24 h血浆TNF-α、IL-6、MDA水平明显高于手术开始时的水平,术后6、24 h PaO2/FiO2明显低于手术开始时的水平;但是组间比较术后6、24 h血浆TNF-α、IL-6、MDA水平试验组低于对照组,术后6、24 h PaO2/FiO2试验组高于对照组,差异有统计学意义(P<0.05)。结论:肢体远隔缺血预处理对胸腔镜体外循环心脏手术中肺损伤具有一定的保护作用,是一种简单、有效的肺保护方法。展开更多
文摘In order to explore the effect of acupuncture preconditioning on rats＇ cell apoptosis with cardiac muscle re-perfusion damage and bcl-2mRNA genes, we used differentiating acupuncture and moxibustion preconditioning among groups, then compared acupuncture and moxibustion preconditioning with ischemic preconditioning. The experimental results show that acupuncture and moxibustion preconditioning makes more bcl-2mRNA genes expressed and produces less cell apoptosis, furthermore, groups of acupuncture and moxibustion preconditioning for twice a day are more effective than those of ischemic ureconditioning.
文摘AIM To study whether remote ischemic preconditioning(RIPC) has an impact on clinical outcomes, such as post-operative atrial fibrillation(POAF).METHODS This was a prospective, single-center, single-blinded,randomized controlled study. One hundred and two patients were randomized to receive RIPC(3 cycles of 5 min ischemia and 5 min reperfusion in the upper arm after induction of anesthesia) or no RIPC(control). Primary outcome was POAF lasting for five minutes or longer during the first seven days after surgery. Secondary outcomes included length of hospital stay, incidence of inpatient mortality, myocardial infarction, and stroke. RESULTS POAF occurred at a rate of 54% in the RIPC group and 41.2% in the control group(P = 0.23). No statistically significant differences were noted in secondary outcomes between the two groups. CONCLUSION This is the first study in the United States to suggest that RIPC does not reduce POAF in patients with elective or urgent cardiac surgery. There were no differences in adverse effects in either group. Further studies are required to assess the relationship between RIPC and POAF.
文摘目的:探讨肢体远隔缺血预处理对胸腔镜体外循环心脏手术的肺保护作用及其机制。方法 :胸腔镜体外循环心脏手术患者81例,ASAⅡ～Ⅲ级,随机分为试验组(给予肢体远隔缺血预处理,n=41)和对照组(不给予肢体远隔缺血预处理,n=40)。采集患者术中及术后临床指标,分别在手术开始前、手术结束后6、24 h采集桡动脉血检测氧合指数(PaO2/FiO2)、血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及丙二醛(MDA)水平。结果:两组患者术后机械通气时间试验组小于对照组,组内比较术后6、24 h血浆TNF-α、IL-6、MDA水平明显高于手术开始时的水平,术后6、24 h PaO2/FiO2明显低于手术开始时的水平;但是组间比较术后6、24 h血浆TNF-α、IL-6、MDA水平试验组低于对照组,术后6、24 h PaO2/FiO2试验组高于对照组,差异有统计学意义(P<0.05)。结论:肢体远隔缺血预处理对胸腔镜体外循环心脏手术中肺损伤具有一定的保护作用,是一种简单、有效的肺保护方法。
基金This work was supported by the National Natural Science Foundation of China (No. 30270550) and the Natural Science Foundationof Beijing(No. 7032044).
