Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca<sub>2+</sub> （4.5 mmol/L）, high K<sup>+</sup> （8.7 mmol/L） or tree radical generating system （FRGS...Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca<sub>2+</sub> （4.5 mmol/L）, high K<sup>+</sup> （8.7 mmol/L） or tree radical generating system （FRGS） significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-repertusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.展开更多
文摘Studies on the isolated rat heart perfusion model have proved that perfusion with high Ca<sub>2+</sub> （4.5 mmol/L）, high K<sup>+</sup> （8.7 mmol/L） or tree radical generating system （FRGS） significantly increases myocardial uptake of liposomes. Intravenous injection of liposomes covalently combined with antibody of rat myocardial cells obviously elevates the target action of liposomes to myocardium. Liposome-carried SOD for treatment of rat myocardial ischemia-repertusion injury is much more effective than simple SOD. The results evidence that the liposome as drug carrier for treatment of ischemic heart diseases shows a broad prospect for its clinical use.
