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Requirements ranking based on crowd-sourcing high-end product USs
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作者 MA Yufeng DOU Yajie +2 位作者 XU Xiangqian JIA Qingyang TAN Yuejin 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2024年第1期94-104,共11页
Based on the characteristics of high-end products,crowd-sourcing user stories can be seen as an effective means of gathering requirements,involving a large user base and generating a substantial amount of unstructured... Based on the characteristics of high-end products,crowd-sourcing user stories can be seen as an effective means of gathering requirements,involving a large user base and generating a substantial amount of unstructured feedback.The key challenge lies in transforming abstract user needs into specific ones,requiring integration and analysis.Therefore,we propose a topic mining-based approach to categorize,summarize,and rank product requirements from user stories.Specifically,after determining the number of story categories based on py LDAvis,we initially classify“I want to”phrases within user stories.Subsequently,classic topic models are applied to each category to generate their names,defining each post-classification user story category as a requirement.Furthermore,a weighted ranking function is devised to calculate the importance of each requirement.Finally,we validate the effectiveness and feasibility of the proposed method using 2966 crowd-sourced user stories related to smart home systems. 展开更多
关键词 high-end product complex system crowd-sourcing user stories topic mining requirements ranking
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OPG/RANKL/RANK信号通路在脓毒症相关急性肾损伤小鼠中的研究
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作者 李辉 陈蔚霖 牛新荣 《海南医学院学报》 CAS 北大核心 2024年第3期168-174,共7页
目的:探讨骨保护素(OPG)/核因子⁃κB受体活化因子配体(RANKL)/核因子⁃κB受体激活因子(RANK)信号通路因子在脓毒症相关急性肾损伤(SA⁃AKI)小鼠中的改变及可能的作用,为SA⁃AKI的机制研究探索新的思路。方法:通过盲肠结扎穿孔手术(CLP)建... 目的:探讨骨保护素(OPG)/核因子⁃κB受体活化因子配体(RANKL)/核因子⁃κB受体激活因子(RANK)信号通路因子在脓毒症相关急性肾损伤(SA⁃AKI)小鼠中的改变及可能的作用,为SA⁃AKI的机制研究探索新的思路。方法:通过盲肠结扎穿孔手术(CLP)建立SA⁃AKI模型组(CLP组),对照组为假手术组(Sham组),只行开腹不做盲肠结扎穿孔操作。术后24 h采血并处死留取小鼠肾脏组织,用试剂盒检测血清Scr、BUN水平,酶联免疫测定法(ELISA)检验血清中IL⁃6、TNF⁃α、IL⁃1β水平,苏木精⁃伊红染色(HE)观测肾组织病理学变化,聚合酶链反应(RT⁃qPCR)和蛋白质印迹实验(Western blotting)检验小鼠肾组织中OPG、RANKL、RANK的mRNA和蛋白水平。结果:与Sham组对比,CLP组Scr、BUN、IL⁃6、TNF⁃α、IL⁃1β水平显著升高,差异均具有统计学意义(P<0.05);与Sham组对比,CLP组肾小球充血水肿,部分缺血皱缩,球囊间隙扩大,部分肾小管中可见坏死的上皮细胞,管腔扩大,肾间质水肿,少量炎性细胞浸润;与Sham组相比较,CLP组肾组织中OPG和RANK的mRNA表达显著上调,而RANKL的mRNA表达明显下降,差异均具有统计学意义(P<0.05);与Sham组相比较,CLP组肾脏组织中OPG及RANK的蛋白表达均升高,而RANKL的蛋白表达明显下降,差异均具有统计学意义(P<0.05)。结论:在脓毒症的小鼠模型中OPG及RANK表达升高,RANKL表达下降,表明OPG/RANKL/RANK信号通路可能参与了SA⁃AKI的病理生理过程。 展开更多
关键词 脓毒症 急性肾损伤 OPG/rankL/rank信号通路
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基于RANKL/RANK/OPG信号轴探讨骨痹通消颗粒对激素性股骨头坏死模型小鼠的治疗作用
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作者 方祥 周正新 +3 位作者 朱磊 芮仞 许茂玉 朱彩玉 《中国现代医学杂志》 CAS 2024年第7期27-33,共7页
目的观察骨痹通消颗粒对激素性股骨头坏死模型小鼠的治疗作用,并从核因子-κB受体活化因子配体/核因子-κB受体活化因子/骨保护素(RANKL/RANK/OPG)信号轴探讨其作用机制。方法采取腹腔注射脂多糖和臀肌注射醋酸泼尼松龙复制激素性股骨... 目的观察骨痹通消颗粒对激素性股骨头坏死模型小鼠的治疗作用,并从核因子-κB受体活化因子配体/核因子-κB受体活化因子/骨保护素(RANKL/RANK/OPG)信号轴探讨其作用机制。方法采取腹腔注射脂多糖和臀肌注射醋酸泼尼松龙复制激素性股骨头缺血坏死(SONFH)动物模型,经核磁共振鉴定后,将模型复制成功的60只小鼠分成模型(MC)组、骨痹通消颗粒(GBTX)组及通络生骨胶囊(PC)组,每组20只,另设12只正常小鼠作为空白对照(NC)组。分别予以对应组灌胃相应药物12周后麻醉状态下取材,观察各组小鼠治疗前后的一般行为;酶联免疫吸附试验(ELISA)检测各组小鼠的骨碱性磷酸酶(BALP)和I型氨基端延长肽(PINP)含量;Western blotting和实时荧光定量聚合酶链反应(qRT-qPCR)检测各组RANK、RANKL、OPG、磷脂酰肌醇特异性磷脂酶Cγ2(PLCγ2)、组织蛋白酶K(CTSK)、抗酒石酸酸性磷酸酶(TRAP)的蛋白和基因表达。结果核磁共振显示,模型复制成功后的小鼠左侧髋部呈高信号状态。与NC组比较,MC组BALP、PINP水平,以及OPG蛋白和基因相对表达量均降低(P<0.05),RANK、RANKL、PLCγ2、CTSK、TRAP蛋白和基因相对表达量均升高(P<0.05);与MC组比较,GBTX组和PC组BALP、PINP水平,以及OPG蛋白和基因相对表达量均升高(P<0.05),RANK、RANKL、PLCγ2、CTSK、TRAP蛋白和基因相对表达量均下降(P<0.05);与GBTX组比较,PC组OPG、RANK、RANKL、CTSK、TRAP蛋白和基因相对表达量,以及PLCγ2蛋白相对表达量差异均无统计学意义(P>0.05),而PC组PLCγ2基因相对表达量较GBTX组下降(P<0.05)。结论骨痹通消颗粒可能通过上调OPG表达,抑制RANK、RANKL、PLCγ2、CTSK和TRAP表达,从而改善股骨头坏死情况。 展开更多
关键词 激素性股骨头坏死 骨痹通消颗粒 rankL/rank/OPG信号轴
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脱氢胆酸调控OPG/RANK和TRAF3抑制破骨细胞分化
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作者 朱禹潼 张晓楠 +1 位作者 关溪 尚东 《中国骨质疏松杂志》 CAS CSCD 北大核心 2024年第1期12-16,共5页
目的探讨脱氢胆酸(dehydrocholic acid,DHCA)对破骨细胞(osteoclasts,OCs)分化及功能的影响。方法采用粒细胞-巨噬细胞集落刺激因子和核因子κB受体活化因子配体(receptor activator of nuclear factor kappa B(NF-κB)-ligand,RANKL)... 目的探讨脱氢胆酸(dehydrocholic acid,DHCA)对破骨细胞(osteoclasts,OCs)分化及功能的影响。方法采用粒细胞-巨噬细胞集落刺激因子和核因子κB受体活化因子配体(receptor activator of nuclear factor kappa B(NF-κB)-ligand,RANKL)诱导成熟骨髓来源的巨噬细胞分化为OCs。通过抗酒石酸酸性磷酸酶(tartrate-resistant acid phosphatase,TRAP/ACP5)染色,确定DHCA抑制OCs形成的最佳浓度。qRT-PCR检测OCs分化和功能相关基因TRAP/ACP5、组织蛋白酶K(cathepsin K,CTSK)和基质金属蛋白酶9(matrix metalloproteinase 9,MMP9)的基因表达。Western blot检测OCs中TNF受体相关因子3(TNF receptor-associated factor 3,TRAF3)、NF-κB受体活化因子(receptor activator of NF-κB,RANK)和骨保护素(osteoprotegerin,OPG)的蛋白水平。结果DHCA浓度为200μmol/L是抑制OCs形成的最佳剂量(P<0.01)。DHCA抑制OCs分化和功能相关基因ACP5、CTSK和MMP9的表达(P<0.01)。DHCA通过下调RANK蛋白和增加TRAF3和OPG蛋白的表达来抑制OCs的分化(P<0.01)。结论DHCA通过调控OPG/RANK和TRAF3抑制OCs分化,这可能是一种有效的骨质疏松前体药物。 展开更多
关键词 脱氢胆酸 破骨细胞 OPG/rank TRAF3 骨质疏松
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Modified Computational Ranking Model for Cloud Trust Factor Using Fuzzy Logic
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作者 Lei Shen Ting Huang +1 位作者 Nishui Cai Hao Wu 《Intelligent Automation & Soft Computing》 SCIE 2023年第7期507-524,共18页
Through the use of the internet and cloud computing,users may access their data as well as the programmes they have installed.It is now more challenging than ever before to choose which cloud service providers to take... Through the use of the internet and cloud computing,users may access their data as well as the programmes they have installed.It is now more challenging than ever before to choose which cloud service providers to take advantage of.When it comes to the dependability of the cloud infrastructure service,those who supply cloud services,as well as those who seek cloud services,have an equal responsibility to exercise utmost care.Because of this,further caution is required to ensure that the appropriate values are reached in light of the ever-increasing need for correct decision-making.The purpose of this study is to provide an updated computational ranking approach for decision-making in an environment with many criteria by using fuzzy logic in the context of a public cloud scenario.This improved computational ranking system is also sometimes referred to as the improvised VlseKriterijumska Optimizacija I Kompromisno Resenje(VIKOR)method.It gives users access to a trustworthy assortment of cloud services that fit their needs.The activity that is part of the suggested technique has been broken down into nine discrete parts for your convenience.To verify these stages,a numerical example has been evaluated for each of the six different scenarios,and the outcomes have been simulated. 展开更多
关键词 CLOUD TRUST computational ranking VIKOR fuzzy
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Fusion of Feature Ranking Methods for an Effective Intrusion Detection System
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作者 Seshu Bhavani Mallampati Seetha Hari 《Computers, Materials & Continua》 SCIE EI 2023年第8期1721-1744,共24页
Expanding internet-connected services has increased cyberattacks,many of which have grave and disastrous repercussions.An Intrusion Detection System(IDS)plays an essential role in network security since it helps to pr... Expanding internet-connected services has increased cyberattacks,many of which have grave and disastrous repercussions.An Intrusion Detection System(IDS)plays an essential role in network security since it helps to protect the network from vulnerabilities and attacks.Although extensive research was reported in IDS,detecting novel intrusions with optimal features and reducing false alarm rates are still challenging.Therefore,we developed a novel fusion-based feature importance method to reduce the high dimensional feature space,which helps to identify attacks accurately with less false alarm rate.Initially,to improve training data quality,various preprocessing techniques are utilized.The Adaptive Synthetic oversampling technique generates synthetic samples for minority classes.In the proposed fusion-based feature importance,we use different approaches from the filter,wrapper,and embedded methods like mutual information,random forest importance,permutation importance,Shapley Additive exPlanations(SHAP)-based feature importance,and statistical feature importance methods like the difference of mean and median and standard deviation to rank each feature according to its rank.Then by simple plurality voting,the most optimal features are retrieved.Then the optimal features are fed to various models like Extra Tree(ET),Logistic Regression(LR),Support vector Machine(SVM),Decision Tree(DT),and Extreme Gradient Boosting Machine(XGBM).Then the hyperparameters of classification models are tuned with Halving Random Search cross-validation to enhance the performance.The experiments were carried out on the original imbalanced data and balanced data.The outcomes demonstrate that the balanced data scenario knocked out the imbalanced data.Finally,the experimental analysis proved that our proposed fusionbased feature importance performed well with XGBM giving an accuracy of 99.86%,99.68%,and 92.4%,with 9,7 and 8 features by training time of 1.5,4.5 and 5.5 s on Network Security Laboratory-Knowledge Discovery in Databases(NSL-KDD),Canadian Institute for Cybersecurity(CIC-IDS 2017),and UNSW-NB15,datasets respectively.In addition,the suggested technique has been examined and contrasted with the state of art methods on three datasets. 展开更多
关键词 Cyber security feature ranking IMBALANCE PREPROCESSING IDS SHAP
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Advanced DAG-Based Ranking(ADR)Protocol for Blockchain Scalability
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作者 Tayyaba Noreen Qiufen Xia Muhammad Zeeshan Haider 《Computers, Materials & Continua》 SCIE EI 2023年第5期2593-2613,共21页
In the past decade,blockchain has evolved as a promising solution to develop secure distributed ledgers and has gained massive attention.However,current blockchain systems face the problems of limited throughput,poor ... In the past decade,blockchain has evolved as a promising solution to develop secure distributed ledgers and has gained massive attention.However,current blockchain systems face the problems of limited throughput,poor scalability,and high latency.Due to the failure of consensus algorithms in managing nodes’identities,blockchain technology is considered inappropriate for many applications,e.g.,in IoT environments,because of poor scalability.This paper proposes a blockchain consensus mechanism called the Advanced DAG-based Ranking(ADR)protocol to improve blockchain scalability and throughput.The ADR protocol uses the directed acyclic graph ledger,where nodes are placed according to their ranking positions in the graph.It allows honest nodes to use theDirect Acyclic Graph(DAG)topology to write blocks and verify transactions instead of a chain of blocks.By using a three-step strategy,this protocol ensures that the system is secured against doublespending attacks and allows for higher throughput and scalability.The first step involves the safe entry of nodes into the system by verifying their private and public keys.The next step involves developing an advanced DAG ledger so nodes can start block production and verify transactions.In the third step,a ranking algorithm is developed to separate the nodes created by attackers.After eliminating attacker nodes,the nodes are ranked according to their performance in the system,and true nodes are arranged in blocks in topological order.As a result,the ADR protocol is suitable for applications in the Internet of Things(IoT).We evaluated ADR on EC2 clusters with more than 100 nodes and achieved better transaction throughput and liveness of the network while adding malicious nodes.Based on the simulation results,this research determined that the transaction’s performance was significantly improved over blockchains like Internet of Things Applications(IOTA)and ByteBall. 展开更多
关键词 Blockchain SCALABILITY directed acyclic graph advanced DAG-based ranking protocol
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Ranking of Web Pages in a Personalized Search
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作者 Mahmoud Abou Ghaly 《Journal of Computer and Communications》 2023年第2期89-101,共13页
The basic idea behind a personalized web search is to deliver search results that are tailored to meet user needs, which is one of the growing concepts in web technologies. The personalized web search presented in thi... The basic idea behind a personalized web search is to deliver search results that are tailored to meet user needs, which is one of the growing concepts in web technologies. The personalized web search presented in this paper is based on exploiting the implicit feedbacks of user satisfaction during her web browsing history to construct a user profile storing the web pages the user is highly interested in. A weight is assigned to each page stored in the user’s profile;this weight reflects the user’s interest in this page. We name this weight the relative rank of the page, since it depends on the user issuing the query. Therefore, the ranking algorithm provided in this paper is based on the principle that;the rank assigned to a page is the addition of two rank values R_rank and A_rank. A_rank is an absolute rank, since it is fixed for all users issuing the same query, it only depends on the link structures of the web and on the keywords of the query. Thus, it could be calculated by the PageRank algorithm suggested by Brin and Page in 1998 and used by the google search engine. While, R_rank is the relative rank, it is calculated by the methods given in this paper which depends mainly on recording implicit measures of user satisfaction during her previous browsing history. 展开更多
关键词 Implicit Feedback Personalized Search Web Page ranking User Profile
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The Effect of Coding Method on Cause-of-Death Rankings
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作者 Peter Harteloh 《Open Journal of Statistics》 2023年第6期778-788,共11页
Background: Cause-of-death rankings are often used for planning or evaluating health policy measures. In the European Union, some countries produce cause-of-death statistics by a manual coding of death certificates, w... Background: Cause-of-death rankings are often used for planning or evaluating health policy measures. In the European Union, some countries produce cause-of-death statistics by a manual coding of death certificates, while other countries use an automated coding system. The outcome of these two different methods in terms of the selected underlying cause of death for statistics may vary considerably. Therefore, this study explores the effect of coding method on the ranking of countries by major causes of death. Method: Age and sex standardized rates were extracted for 33 European (related) countries from the cause-of-death registry of the European Statistical Office (Eurostat). Wilcoxon’s rank sum test was applied to the ranking of countries by major causes of death. Results: Statistically significant differences due to coding method were identified for dementia, stroke and pneumonia. These differences could be explained by a different selection of dementia or pneumonia as underlying cause of death and by a different certification practice for stroke. Conclusion: Coding method should be taken into account when constructing or interpreting rankings of countries by cause of death. 展开更多
关键词 Cause-of-Death Statistics Cause of Death ranking Automated Coding Manual Coding EPIDEMIOLOGY Health Policy
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New Ranking of Generalized Quadrilateral Shape Fuzzy Number Using Centroid Technique
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作者 A.Thiruppathi C.K.Kirubhashankar 《Intelligent Automation & Soft Computing》 SCIE 2023年第5期2253-2266,共14页
The output of the fuzzy set is reduced by one for the defuzzification procedure.It is employed to provide a comprehensible outcome from a fuzzy inference process.This page provides further information about the defuzzi... The output of the fuzzy set is reduced by one for the defuzzification procedure.It is employed to provide a comprehensible outcome from a fuzzy inference process.This page provides further information about the defuzzifica-tion approach for quadrilateral fuzzy numbers,which may be used to convert them into discrete values.Defuzzification demonstrates how useful fuzzy ranking systems can be.Our major purpose is to develop a new ranking method for gen-eralized quadrilateral fuzzy numbers.The primary objective of the research is to provide a novel approach to the accurate evaluation of various kinds of fuzzy inte-gers.Fuzzy ranking properties are examined.Using the counterexamples of Lee and Chen demonstrates the fallacy of the ranking technique.So,a new approach has been developed for dealing with fuzzy risk analysis,risk management,indus-trial engineering and optimization,medicine,and artificial intelligence problems:the generalized quadrilateral form fuzzy number utilizing centroid methodology.As you can see,the aforementioned scenarios are all amenable to the solution pro-vided by the generalized quadrilateral shape fuzzy number utilizing centroid methodology.It’s laid out in a straightforward manner that’s easy to grasp for everyone.The rating method is explained in detail,along with numerical exam-ples to illustrate it.Last but not least,stability evaluations clarify why the Gener-alized quadrilateral shape fuzzy number obtained by the centroid methodology outperforms other ranking methods. 展开更多
关键词 Fuzzy numbers quadrilateral fuzzy number ranking methods fuzzy risk analysis
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Google Scholar University Ranking Algorithm to Evaluate the Quality of Institutional Research
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作者 Noor Ul Sabah Muhammad Murad Khan +3 位作者 Ramzan Talib Muhammad Anwar Muhammad Sheraz Arshad Malik Puteri Nor Ellyza Nohuddin 《Computers, Materials & Continua》 SCIE EI 2023年第6期4955-4972,共18页
Education quality has undoubtedly become an important local and international benchmark for education,and an institute’s ranking is assessed based on the quality of education,research projects,theses,and dissertation... Education quality has undoubtedly become an important local and international benchmark for education,and an institute’s ranking is assessed based on the quality of education,research projects,theses,and dissertations,which has always been controversial.Hence,this research paper is influenced by the institutes ranking all over the world.The data of institutes are obtained through Google Scholar(GS),as input to investigate the United Kingdom’s Research Excellence Framework(UK-REF)process.For this purpose,the current research used a Bespoke Program to evaluate the institutes’ranking based on their source.The bespoke program requires changes to improve the results by addressing these methodological issues:Firstly,Redundant profiles,which increased their citation and rank to produce false results.Secondly,the exclusion of theses and dissertation documents to retrieve the actual publications to count for citations.Thirdly,the elimination of falsely owned articles from scholars’profiles.To accomplish this task,the experimental design referred to collecting data from 120 UK-REF institutes and GS for the present year to enhance its correlation analysis in this new evaluation.The data extracted from GS is processed into structured data,and afterward,it is utilized to generate statistical computations of citations’analysis that contribute to the ranking based on their citations.The research promoted the predictive approach of correlational research.Furthermore,experimental evaluation reported encouraging results in comparison to the previous modi-fication made by the proposed taxonomy.This paper discussed the limitations of the current evaluation and suggested the potential paths to improve the research impact algorithm. 展开更多
关键词 Google scholar institutes ranking research assessment exercise research excellence framework impact evaluation citation data
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Traffic Incident Management Performance Measures: Ranking Agencies on Roadway Clearance Time
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作者 Maroa Mumtarin Skylar Knickerbocker +1 位作者 Theresa Litteral Jonathan S. Wood 《Journal of Transportation Technologies》 2023年第3期353-368,共16页
This study develops a procedure to rank agencies based on their incident responses using roadway clearance times for crashes. This analysis is not intended to grade agencies but to assist in identifying agencies requi... This study develops a procedure to rank agencies based on their incident responses using roadway clearance times for crashes. This analysis is not intended to grade agencies but to assist in identifying agencies requiring more training or resources for incident management. Previous NCHRP reports discussed usage of different factors including incident severity, roadway characteristics, number of lanes involved and time of incident separately for estimating the performance. However, it does not tell us how to incorporate all the factors at the same time. Thus, this study aims to account for multiple factors to ensure fair comparisons. This study used 149,174 crashes from Iowa that occurred from 2018 to 2021. A Tobit regression model was used to find the effect of different variables on roadway clearance time. Variables that cannot be controlled directly by agencies such as crash severity, roadway type, weather conditions, lighting conditions, etc., were included in the analysis as it helps to reduce bias in the ranking procedure. Then clearance time of each crash is normalized into a base condition using the regression coefficients. The normalization makes the process more efficient as the effect of uncontrollable factors has already been mitigated. Finally, the agencies were ranked by their average normalized roadway clearance time. This ranking process allows agencies to track their performance of previous crashes, can be used in identifying low performing agencies that could use additional resources and training, and can be used to identify high performing agencies to recognize for their efforts and performance. 展开更多
关键词 Traffic Incident Management Roadway Clearance Time Performance Measures and ranking Agency Performance Evaluation Tobit Regression Model
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Multi-Criteria Decision-Making for Power Grid Construction Project Investment Ranking Based on the Prospect Theory Improved by Rewarding Good and Punishing Bad Linear Transformation
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作者 Shun Ma Na Yu +3 位作者 Xiuna Wang Shiyan Mei Mingrui Zhao Xiaoyu Han 《Energy Engineering》 EI 2023年第10期2369-2392,共24页
Using the improved prospect theory with the linear transformations of rewarding good and punishing bad(RGPBIT),a new investment ranking model for power grid construction projects(PGCPs)is proposed.Given the uncertaint... Using the improved prospect theory with the linear transformations of rewarding good and punishing bad(RGPBIT),a new investment ranking model for power grid construction projects(PGCPs)is proposed.Given the uncertainty of each index value under the market environment,fuzzy numbers are used to describe qualitative indicators and interval numbers are used to describe quantitative ones.Taking into account decision-maker’s subjective risk attitudes,a multi-criteria decision-making(MCDM)method based on improved prospect theory is proposed.First,the[−1,1]RGPBIT operator is proposed to normalize the original data,to obtain the best andworst schemes of PGCPs.Furthermore,the correlation coefficients between interval/fuzzy numbers and the best/worst schemes are defined and introduced to the prospect theory to improve its value function and loss function,and the positive and negative prospect value matrices of the project are obtained.Then,the optimization model with the maximum comprehensive prospect value is constructed,the optimal attribute weight is determined,and the PGCPs are ranked accordingly.Taking four PGCPs of the IEEERTS-79 node system as examples,an illustration of the feasibility and effectiveness of the proposed method is provided. 展开更多
关键词 Power grid construction project investment ranking RGPBIT operator MCDM optimal weight
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Er,Cr:YSGG激光治疗对高糖环境下微螺钉周围炎症及对RANK/RANKL信号通路的影响
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作者 刘阳 牛家慧 《口腔颌面修复学杂志》 2024年第3期170-174,共5页
目的:探讨铒铬铱钪镓石榴石(Er,Cr:YSGG)激光治疗对高糖环境下微螺钉周围炎症治疗的疗效,并分析与RANK/RANKL信号通路的关系。方法:20只正常健康雄性新西兰兔随机分为A组(微螺钉周健康组)、B组(微螺钉周围炎症组)、C组(微螺钉周围炎症... 目的:探讨铒铬铱钪镓石榴石(Er,Cr:YSGG)激光治疗对高糖环境下微螺钉周围炎症治疗的疗效,并分析与RANK/RANKL信号通路的关系。方法:20只正常健康雄性新西兰兔随机分为A组(微螺钉周健康组)、B组(微螺钉周围炎症组)、C组(微螺钉周围炎症激光治疗组),皮下注射2%四氧嘧啶建立糖尿病模型,下颌双侧无牙区植入微螺钉种植体,3个月后,A组进行菌斑控制,B组、C组用丝线拴结于微螺钉种植体颈部基台处引入炎症,C组予以Er,Cr:YSGG激光治疗。记录菌斑指数、探诊深度、牙龈指数和龈沟液量;ELISA检测龈沟液炎性细胞白细胞介素1β(IL-1β)、肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)水平;CBCT检查微螺钉种植体周围炎周围骨吸收状态;Western blot检测牙龈组织中核因子κB(NF-κB)/NF-κB受体性活化因子(RANK)/NF-κB受体活化因子配体(RANKL)通路相关蛋白表达。结果:CBCT检查显示与A组比较,B组微螺钉种植体周围牙槽骨有明显的炎性吸收,微螺钉种植体-骨界面愈合差,骨附着不足;与B组比较,C组一侧牙槽骨有少量新生纤维成骨。与A组比较,B组PI、PD、GI水平较高,龈沟液量较多,龈沟液中IL-1β、TNF-α和IL-6水平较高,牙龈中NF-κBp65、RANK、RANKL蛋白表达水平较高(P<0.05);与B组比较,C组PI、PD、GI水平较低,龈沟液量较少,龈沟液中IL-1β、TNF-α和IL-6水平较低,牙龈中NF-κBp65、RANK、RANKL蛋白表达水平较低(P<0.05)。结论:Er,Cr:YSGG激光治疗糖尿病兔颌骨微螺钉种植体周围炎的疗效显著,且在NF-κB/RANK/RANKL通路表达调控上可能发挥一定作用。 展开更多
关键词 铒铬铱钪镓石榴石激光 糖尿病 微螺钉周围炎 核因子κB(NF-κB)/NF-κB受体性活化因子(rank)/NF-κB受体活化因子配体(rankL)通路
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Machine Learning for Hybrid Line Stability Ranking Index in Polynomial Load Modeling under Contingency Conditions
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作者 P.Venkatesh N.Visali 《Intelligent Automation & Soft Computing》 SCIE 2023年第7期1001-1012,共12页
In the conventional technique,in the evaluation of the severity index,clustering and loading suffer from more iteration leading to more com-putational delay.Hence this research article identifies,a novel progression f... In the conventional technique,in the evaluation of the severity index,clustering and loading suffer from more iteration leading to more com-putational delay.Hence this research article identifies,a novel progression for fast predicting the severity of the line and clustering by incorporating machine learning aspects.The polynomial load modelling or ZIP(constant impedances(Z),Constant Current(I)and Constant active power(P))is developed in the IEEE-14 and Indian 118 bus systems considered for analysis of power system security.The process of finding the severity of the line using a Hybrid Line Stability Ranking Index(HLSRI)is used for assisting the concepts of machine learning with J48 algorithm,infers the superior affected lines by adopting the IEEE standards in concern to be compensated in maintaining the power system stability.The simulation is performed in the WEKA environment and deals with the supervisor learning in order based on severity to ensure the safety of power system.The Unified Power Flow Controller(UPFC),facts devices for the purpose of compensating the losses by maintaining the voltage characteristics.The finite element analysis findings are compared with the existing procedures and numerical equations for authentications. 展开更多
关键词 CONTINGENCY hybrid line stability ranking index(HLSRI) machine learning(ML) unified power flow controller(UPFC) ZIP load modelling
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Low rank optimization for efficient deep learning:making a balance between compact architecture and fast training
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作者 OU Xinwei CHEN Zhangxin +1 位作者 ZHU Ce LIU Yipeng 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第3期509-531,F0002,共24页
Deep neural networks(DNNs)have achieved great success in many data processing applications.However,high computational complexity and storage cost make deep learning difficult to be used on resource-constrained devices... Deep neural networks(DNNs)have achieved great success in many data processing applications.However,high computational complexity and storage cost make deep learning difficult to be used on resource-constrained devices,and it is not environmental-friendly with much power cost.In this paper,we focus on low-rank optimization for efficient deep learning techniques.In the space domain,DNNs are compressed by low rank approximation of the network parameters,which directly reduces the storage requirement with a smaller number of network parameters.In the time domain,the network parameters can be trained in a few subspaces,which enables efficient training for fast convergence.The model compression in the spatial domain is summarized into three categories as pre-train,pre-set,and compression-aware methods,respectively.With a series of integrable techniques discussed,such as sparse pruning,quantization,and entropy coding,we can ensemble them in an integration framework with lower computational complexity and storage.In addition to summary of recent technical advances,we have two findings for motivating future works.One is that the effective rank,derived from the Shannon entropy of the normalized singular values,outperforms other conventional sparse measures such as the?_1 norm for network compression.The other is a spatial and temporal balance for tensorized neural networks.For accelerating the training of tensorized neural networks,it is crucial to leverage redundancy for both model compression and subspace training. 展开更多
关键词 model compression subspace training effective rank low rank tensor optimization efficient deep learning
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World-Class Discipline Ranking 2023
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《评价与管理》 2023年第S01期60-118,共59页
On the basis of ESI data,all universities are ranked in 92 out of 105 world-class disciplines.There is no ESI data(either publications or citations)in the rest of 13 world-class disciplines.
关键词 ranked UNIVERSITIES PUBLICATIONS
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RPL-Based IoT Networks under Decreased Rank Attack:Performance Analysis in Static and Mobile Environments
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作者 Amal Hkiri Mouna Karmani +3 位作者 Omar Ben Bahri Ahmed Mohammed Murayr Fawaz Hassan Alasmari Mohsen Machhout 《Computers, Materials & Continua》 SCIE EI 2024年第1期227-247,共21页
The RPL(IPv6 Routing Protocol for Low-Power and Lossy Networks)protocol is essential for efficient communi-cation within the Internet of Things(IoT)ecosystem.Despite its significance,RPL’s susceptibility to attacks r... The RPL(IPv6 Routing Protocol for Low-Power and Lossy Networks)protocol is essential for efficient communi-cation within the Internet of Things(IoT)ecosystem.Despite its significance,RPL’s susceptibility to attacks remains a concern.This paper presents a comprehensive simulation-based analysis of the RPL protocol’s vulnerability to the decreased rank attack in both static andmobilenetwork environments.We employ the Random Direction Mobility Model(RDM)for mobile scenarios within the Cooja simulator.Our systematic evaluation focuses on critical performance metrics,including Packet Delivery Ratio(PDR),Average End to End Delay(AE2ED),throughput,Expected Transmission Count(ETX),and Average Power Consumption(APC).Our findings illuminate the disruptive impact of this attack on the routing hierarchy,resulting in decreased PDR and throughput,increased AE2ED,ETX,and APC.These results underscore the urgent need for robust security measures to protect RPL-based IoT networks.Furthermore,our study emphasizes the exacerbated impact of the attack in mobile scenarios,highlighting the evolving security requirements of IoT networks. 展开更多
关键词 RPL decreased rank attacks MOBILITY random direction model
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Test Case Generation Evaluator for the Implementation of Test Case Generation Algorithms Based on Learning to Rank
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作者 Zhonghao Guo Xinyue Xu Xiangxian Chen 《Computer Systems Science & Engineering》 2024年第2期479-509,共31页
In software testing,the quality of test cases is crucial,but manual generation is time-consuming.Various automatic test case generation methods exist,requiring careful selection based on program features.Current evalu... In software testing,the quality of test cases is crucial,but manual generation is time-consuming.Various automatic test case generation methods exist,requiring careful selection based on program features.Current evaluation methods compare a limited set of metrics,which does not support a larger number of metrics or consider the relative importance of each metric to the final assessment.To address this,we propose an evaluation tool,the Test Case Generation Evaluator(TCGE),based on the learning to rank(L2R)algorithm.Unlike previous approaches,our method comprehensively evaluates algorithms by considering multiple metrics,resulting in a more reasoned assessment.The main principle of the TCGE is the formation of feature vectors that are of concern by the tester.Through training,the feature vectors are sorted to generate a list,with the order of the methods on the list determined according to their effectiveness on the tested assembly.We implement TCGE using three L2R algorithms:Listnet,LambdaMART,and RFLambdaMART.Evaluation employs a dataset with features of classical test case generation algorithms and three metrics—Normalized Discounted Cumulative Gain(NDCG),Mean Average Precision(MAP),and Mean Reciprocal Rank(MRR).Results demonstrate the TCGE’s superior effectiveness in evaluating test case generation algorithms compared to other methods.Among the three L2R algorithms,RFLambdaMART proves the most effective,achieving an accuracy above 96.5%,surpassing LambdaMART by 2%and Listnet by 1.5%.Consequently,the TCGE framework exhibits significant application value in the evaluation of test case generation algorithms. 展开更多
关键词 Test case generation evaluator learning to rank RFLambdaMART
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Study of the OPG/RANKL/RANK signaling pathway in mice treated with sepsis-related acute kidney injury
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作者 LI Hui CHEN Wei-lin NIU Xinrong 《Journal of Hainan Medical University》 CAS 2024年第3期8-14,共7页
Objective:The objective of this study was to investigate the alterations and potential implications of the Osteoprotegerin(OPG)/Receptor Activator of Nuclear Factor-kappa B Ligand(RANKL)/Receptor Activator of Nuclear ... Objective:The objective of this study was to investigate the alterations and potential implications of the Osteoprotegerin(OPG)/Receptor Activator of Nuclear Factor-kappa B Ligand(RANKL)/Receptor Activator of Nuclear Factor-kappa B(RANK)signaling pathway factors in a murine model of sepsis-associated acute kidney injury(SA-AKI).This research aimed to offer novel insights into the mechanistic exploration of SA-AKI.Methods:The SA-AKI model group(CLP group)was established through cecal ligation and puncture surgery(CLP),while the control group consisted of sham-operated animals(Sham group)subjected only to laparotomy without cecal ligation and puncture.Blood samples were collected 24 h post-surgery,and murine kidney tissues were harvested upon euthanasia.Serum levels of Serum Creatinine(Scr)and Blood Urea Nitrogen(BUN)were quantified using assay kits.Furthermore,serum levels of interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and interleukin-1 beta(IL-1β)were assessed through enzyme-linked immunosorbent assay(ELISA).Renal tissue pathological alterations were examined employing hematoxylin-eosin staining(HE),and the mRNA and protein levels of OPG,RANKL,and RANK in murine kidney tissues were determined via reverse transcription-quantitative polymerase chain reaction(RT-qPCR)and Western blotting.Results:Comparative analysis revealed that,in comparison to the Sham group,the CLP group demonstrated a significant elevation in the levels of Scr,BUN,IL-6,TNF-α,and IL-1β,with statistically significant disparities(all P<0.05).Histopathological examination of the CLP group's kidneys unveiled glomerular congestion,edema,partial ischemic wrinkling,enlargement of interstitial spaces,the presence of necrotic epithelial cells in select renal tubules,tubular luminal dilation,varying degrees of interstitial edema,and infiltration by a limited number of inflammatory cells.In parallel,relative to the Sham group,the CLP group exhibited substantial upregulation in mRNA expression of OPG and RANK in renal tissues,while RANKL mRNA expression experienced marked downregulation,with statistically significant distinctions(all P<0.05).Moreover,in comparison with the Sham group,the CLP group demonstrated an elevation in protein expression of OPG and RANK in kidney tissues,whereas RANKL protein expression displayed significant downregulation,with statistically significant differences(all P<0.05).Conclusion:In a murine sepsis model,augmented expression of OPG and RANK,coupled with diminished RANKL expression,suggests the potential involvement of the OPG/RANKL/RANK signaling pathway in the pathophysiological progression of SA-AKI. 展开更多
关键词 SEPSIS Acute kidney injury OPG/rankL/rank signaling pathway
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