Background:Neuroinflammation is an essential event in Parkinson’s disease(PD).Identifying affordable and less invasive biomarkers to make an early diagnosis and monitor therapeutic strategies should be a priority amo...Background:Neuroinflammation is an essential event in Parkinson’s disease(PD).Identifying affordable and less invasive biomarkers to make an early diagnosis and monitor therapeutic strategies should be a priority among researchers.The study’s objective was to measure tear levels of cytokines in subjects with PD and their association with motor features and the presence of dry eye symptoms.Methods:A total of 16 subjects with PD and 16 age-and sex-matched controls were included.Movement Disorders Society-Unified Parkinson’s Disease Rating Scale(MDS-UPDRS),Hoehn and Yahr(HY)stage scale,Montreal Cognitive Assessment(MoCA),tear break-up time(TBUT),blink rate(BR),Dry Eye Questionnaire 5(DEQ-5)were examined,and pro-inflammatory cytokines[interleukin(IL)-1β,IL-6,IL-8,IL-10,IL-12p70 and tumor necrosis factor-alpha(TNF-α)]were quantified in tears using the BD Cytometric Bead Array Human Inflammatory Cytokine Kit.Results:Higher tear TNF-αwere quantified in PD compared to controls(2.94±3.95 vs.0.33±0.49 pg/mL,P=0.008).According to DEQ-5,50.0%(n=8)of PD subjects and 12.5%(n=2)controls had dry eye disease(DED).No differences were found in cytokines concentrations between PD patients with DED compared to those without DED.IL-8 was associated with the HY stage,TBUT,DEQ-5,and a better MoCA score.A higher BR correlated moderately with a lower HY stage(r=−0.645,P=0.007),and DED patients have lower BR in PD(12.14±2.54 vs.9.0±2.06 blinks/minute,P=0.031).Conclusions:PD patients have higher levels of TNF-αin tears than age-and sex-matched HC.IL-8 in tears may be both involved in the severity of the disease and in the development of DED in PD.In addition,our findings suggest that as HY stage increases,indicating a more advanced stage,BR decreases,indicating greater motor impairment.Conversely,the presence of DED is associated with higher levels of bradykinesia in PD patients,suggesting a potential relationship between DED and motor impairment severity.展开更多
Two Job’s tears cultivars, yy18-1 (high resistance to drought stress) and yy12-7 (susceptible to drought stress) were used to investigate the responses of seed germination, root and seedling growth, and seedling anti...Two Job’s tears cultivars, yy18-1 (high resistance to drought stress) and yy12-7 (susceptible to drought stress) were used to investigate the responses of seed germination, root and seedling growth, and seedling antioxidant characteristics to drought stress simulated by polyethylene glycol (PEG) 6000 solutions with 0, -0.05, -0.1, -0.15, and -0.2 MPa osmotic potentials. The results showed that the germination energy, germination rate, germination index, root and seedling lengths, root and seedling diameters, root and seedling fresh masses, root and seedling dry masses, and seedling relative water content (RWC) decreased with the decrease of the osmotic potential of PEG 6000 solution. The contents of hydrogen peroxide (H2O2), malondialdehyde (MDA), and proline in seedling increased with the decrease of the osmotic potential of PEG 6000 solution. The activities of peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) in seedling increased and then decreased with the decrease of osmotic potential of PEG 6000 solution. -0.1 MPa was the optimal osmotic potential of PEG 6000 solution simulated drought stress at germination stage for Job’s tears. The proline content and activities of POD and CAT were important mechanisms for the maintenance of drought resistance in Job’s tears seedling.展开更多
Gender discrimination has long been the problem that exists in the entire world,including China.However,as more and more people are focusing on the general gender discrimination,the group recognized an extension of su...Gender discrimination has long been the problem that exists in the entire world,including China.However,as more and more people are focusing on the general gender discrimination,the group recognized an extension of such discrimination-pregnancy discrimination in job hiring(the discrimination that women who are pregnant or have the inclination to pregnancy receive in hiring).The possible subtle pregnancy discrimination may be one of the main causes that lead to the declining fertility rate in China.The group decided to conduct an experiment to determine whether women are receiving more subtle discrimination in job hiring due to their identity as mother than men with children,men without children,and women without children.Using the form of questionary and resumes,the team found that Chinese women are indeed enduring subtle discrimination in work hiring.The experiment highlights the importance to promote further equality among women.However,there are some confounding variables,like the level of patient of the HR who reads the resume,affecting the ultimate result of the study.Keywords:gender discrimination,women’s career,Chinese job market,pregnancy discrimination,fertility rate in China.展开更多
As China’s CPI is soaring almost in all walks of life in the past months, more and more people began to adopt online transanctions to save household expense, especially the Spring Festival holiday is approaching,
The phenomenon of Cenozoic migrant worker shortage is a realism problem of China's enterprise, and Cenozoic migrant worker has become an important force occupied the social structure. So the study of Cenozoic migr...The phenomenon of Cenozoic migrant worker shortage is a realism problem of China's enterprise, and Cenozoic migrant worker has become an important force occupied the social structure. So the study of Cenozoic migrant worker's status and the demand is imperative. Understand employees' both psychological and physiological satisfaction of enterprises' environmental factors, and make some corresponding changes is of great help to reduce the employee turnover rate. This paper commenced to research from the Cenozoic migrant worker 's characteristics, analyzed conditions and puts forward the corresponding countermeasures.展开更多
Considering the independent optimization requirement for each demander of modernmanufacture, we explore the application of noncooperative game in production scheduling research,and model scheduling problem as competit...Considering the independent optimization requirement for each demander of modernmanufacture, we explore the application of noncooperative game in production scheduling research,and model scheduling problem as competition of machine resources among a group of selfish jobs.Each job has its own performance objective. For the single machine, multi-jobs and non-preemptivescheduling problem, a noncooperative game model is established. Based on the model, many prob-lems about Nash equilibrium solution, such as the existence, quantity, properties of solution space,performance of solution and algorithm are discussed. The results are tested by numerical example.展开更多
Under the condition of asymmetric information,the Spence 's Job Market Signaling Model is generally applied to inspect the design capability of a designer and his labor and efforts to be invested; however,since th...Under the condition of asymmetric information,the Spence 's Job Market Signaling Model is generally applied to inspect the design capability of a designer and his labor and efforts to be invested; however,since the"prior probability"and "posterior probability"have great uncertainties,the practical effect of this model is poor. On the basis of analyzing reverse selection questions,this paper provides a design capability screening model,which can make a designer automatically expose his hidden information so that necessary actions can be taken as required by the owner to realize risk sharing. A calculation example is finally given to demonstrate that the new model is helpful for an owner to select a designer with high professional level and to lead the designer to work hard,so it is of significant application value.展开更多
基金supported by Hospital Fundacion Nuestra Senora de la Luz,Private Assistance Institution.
文摘Background:Neuroinflammation is an essential event in Parkinson’s disease(PD).Identifying affordable and less invasive biomarkers to make an early diagnosis and monitor therapeutic strategies should be a priority among researchers.The study’s objective was to measure tear levels of cytokines in subjects with PD and their association with motor features and the presence of dry eye symptoms.Methods:A total of 16 subjects with PD and 16 age-and sex-matched controls were included.Movement Disorders Society-Unified Parkinson’s Disease Rating Scale(MDS-UPDRS),Hoehn and Yahr(HY)stage scale,Montreal Cognitive Assessment(MoCA),tear break-up time(TBUT),blink rate(BR),Dry Eye Questionnaire 5(DEQ-5)were examined,and pro-inflammatory cytokines[interleukin(IL)-1β,IL-6,IL-8,IL-10,IL-12p70 and tumor necrosis factor-alpha(TNF-α)]were quantified in tears using the BD Cytometric Bead Array Human Inflammatory Cytokine Kit.Results:Higher tear TNF-αwere quantified in PD compared to controls(2.94±3.95 vs.0.33±0.49 pg/mL,P=0.008).According to DEQ-5,50.0%(n=8)of PD subjects and 12.5%(n=2)controls had dry eye disease(DED).No differences were found in cytokines concentrations between PD patients with DED compared to those without DED.IL-8 was associated with the HY stage,TBUT,DEQ-5,and a better MoCA score.A higher BR correlated moderately with a lower HY stage(r=−0.645,P=0.007),and DED patients have lower BR in PD(12.14±2.54 vs.9.0±2.06 blinks/minute,P=0.031).Conclusions:PD patients have higher levels of TNF-αin tears than age-and sex-matched HC.IL-8 in tears may be both involved in the severity of the disease and in the development of DED in PD.In addition,our findings suggest that as HY stage increases,indicating a more advanced stage,BR decreases,indicating greater motor impairment.Conversely,the presence of DED is associated with higher levels of bradykinesia in PD patients,suggesting a potential relationship between DED and motor impairment severity.
文摘Two Job’s tears cultivars, yy18-1 (high resistance to drought stress) and yy12-7 (susceptible to drought stress) were used to investigate the responses of seed germination, root and seedling growth, and seedling antioxidant characteristics to drought stress simulated by polyethylene glycol (PEG) 6000 solutions with 0, -0.05, -0.1, -0.15, and -0.2 MPa osmotic potentials. The results showed that the germination energy, germination rate, germination index, root and seedling lengths, root and seedling diameters, root and seedling fresh masses, root and seedling dry masses, and seedling relative water content (RWC) decreased with the decrease of the osmotic potential of PEG 6000 solution. The contents of hydrogen peroxide (H2O2), malondialdehyde (MDA), and proline in seedling increased with the decrease of the osmotic potential of PEG 6000 solution. The activities of peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and glutathione reductase (GR) in seedling increased and then decreased with the decrease of osmotic potential of PEG 6000 solution. -0.1 MPa was the optimal osmotic potential of PEG 6000 solution simulated drought stress at germination stage for Job’s tears. The proline content and activities of POD and CAT were important mechanisms for the maintenance of drought resistance in Job’s tears seedling.
文摘Gender discrimination has long been the problem that exists in the entire world,including China.However,as more and more people are focusing on the general gender discrimination,the group recognized an extension of such discrimination-pregnancy discrimination in job hiring(the discrimination that women who are pregnant or have the inclination to pregnancy receive in hiring).The possible subtle pregnancy discrimination may be one of the main causes that lead to the declining fertility rate in China.The group decided to conduct an experiment to determine whether women are receiving more subtle discrimination in job hiring due to their identity as mother than men with children,men without children,and women without children.Using the form of questionary and resumes,the team found that Chinese women are indeed enduring subtle discrimination in work hiring.The experiment highlights the importance to promote further equality among women.However,there are some confounding variables,like the level of patient of the HR who reads the resume,affecting the ultimate result of the study.Keywords:gender discrimination,women’s career,Chinese job market,pregnancy discrimination,fertility rate in China.
文摘As China’s CPI is soaring almost in all walks of life in the past months, more and more people began to adopt online transanctions to save household expense, especially the Spring Festival holiday is approaching,
文摘The phenomenon of Cenozoic migrant worker shortage is a realism problem of China's enterprise, and Cenozoic migrant worker has become an important force occupied the social structure. So the study of Cenozoic migrant worker's status and the demand is imperative. Understand employees' both psychological and physiological satisfaction of enterprises' environmental factors, and make some corresponding changes is of great help to reduce the employee turnover rate. This paper commenced to research from the Cenozoic migrant worker 's characteristics, analyzed conditions and puts forward the corresponding countermeasures.
文摘Considering the independent optimization requirement for each demander of modernmanufacture, we explore the application of noncooperative game in production scheduling research,and model scheduling problem as competition of machine resources among a group of selfish jobs.Each job has its own performance objective. For the single machine, multi-jobs and non-preemptivescheduling problem, a noncooperative game model is established. Based on the model, many prob-lems about Nash equilibrium solution, such as the existence, quantity, properties of solution space,performance of solution and algorithm are discussed. The results are tested by numerical example.
基金Sponsored by State Key Laboratory of Subtropical Building Science,Autonomous Research Topics(Grant No.x2tjc7100870)
文摘Under the condition of asymmetric information,the Spence 's Job Market Signaling Model is generally applied to inspect the design capability of a designer and his labor and efforts to be invested; however,since the"prior probability"and "posterior probability"have great uncertainties,the practical effect of this model is poor. On the basis of analyzing reverse selection questions,this paper provides a design capability screening model,which can make a designer automatically expose his hidden information so that necessary actions can be taken as required by the owner to realize risk sharing. A calculation example is finally given to demonstrate that the new model is helpful for an owner to select a designer with high professional level and to lead the designer to work hard,so it is of significant application value.
