Based on the major gene and polygene mixed inheritance model for multiple correlated quantitative traits, the authors proposed a new joint segregation analysis method of major gene controlling multiple correlated quan...Based on the major gene and polygene mixed inheritance model for multiple correlated quantitative traits, the authors proposed a new joint segregation analysis method of major gene controlling multiple correlated quantitative traits, which include major gene detection and its effect and variation estimation. The effect and variation of major gene are estimated by the maximum likelihood method implemented via expectation-maximization （EM） algorithm. Major gene is tested with the likelihood ratio （LR） test statistic. Extensive simulation studies showed that joint analysis not only increases the statistical power of major gene detection but also improves the precision and accuracy of major gene effect estimates. An example of the plant height and the number of tiller of F2 population in rice cross Duonieai x Zhonghua 11 was used in the illustration. The results indicated that the genetic difference of these two traits in this cross refers to only one pleiotropic major gene. The additive effect and dominance effect of the major gene are estimated as -21.3 and 40.6 cm on plant height, and 22.7 and -25.3 on number of tiller, respectively. The major gene shows overdominance for plant height and close to complete dominance for number of tillers.展开更多
Joint location and scale models of the skew-normal distribution provide useful ex- tension for joint mean and variance models of the normal distribution when the data set under consideration involves asymmetric outcom...Joint location and scale models of the skew-normal distribution provide useful ex- tension for joint mean and variance models of the normal distribution when the data set under consideration involves asymmetric outcomes. This paper focuses on the maximum likelihood estimation of joint location and scale models of the skew-normal distribution. The proposed procedure can simultaneously estimate parameters in the location model and the scale model. Simulation studies and a real example are used to illustrate the proposed methodologies.展开更多
In this paper we reparameterize covariance structures in longitudinal data analysis through the modified Cholesky decomposition of itself. Based on this modified Cholesky decomposition, the within-subject covariance m...In this paper we reparameterize covariance structures in longitudinal data analysis through the modified Cholesky decomposition of itself. Based on this modified Cholesky decomposition, the within-subject covariance matrix is decomposed into a unit lower triangular matrix involving moving average coefficients and a diagonal matrix involving innovation variances, which are modeled as linear functions of covariates. Then, we propose a penalized maximum likelihood method for variable selection in joint mean and covariance models based on this decomposition. Under certain regularity conditions, we establish the consistency and asymptotic normality of the penalized maximum likelihood estimators of parameters in the models. Simulation studies are undertaken to assess the finite sample performance of the proposed variable selection procedure.展开更多
Normal mixture regression models are one of the most important statistical data analysis tools in a heterogeneous population. When the data set under consideration involves asymmetric outcomes, in the last two decades...Normal mixture regression models are one of the most important statistical data analysis tools in a heterogeneous population. When the data set under consideration involves asymmetric outcomes, in the last two decades, the skew normal distribution has been shown beneficial in dealing with asymmetric data in various theoretic and applied problems. In this paper, we propose and study a novel class of models： a skew-normal mixture of joint location, scale and skewness models to analyze the heteroscedastic skew-normal data coming from a heterogeneous population. The issues of maximum likelihood estimation are addressed. In particular, an Expectation-Maximization （EM） algorithm for estimating the model parameters is developed. Properties of the estimators of the regression coefficients are evaluated through Monte Carlo experiments. Results from the analysis of a real data set from the Body Mass Index （BMI） data are presented.展开更多
基金This research was supported by the National Natural Science Foundation of China to Xu Chenwu （39900080, 30270724 and 30370758）.
文摘Based on the major gene and polygene mixed inheritance model for multiple correlated quantitative traits, the authors proposed a new joint segregation analysis method of major gene controlling multiple correlated quantitative traits, which include major gene detection and its effect and variation estimation. The effect and variation of major gene are estimated by the maximum likelihood method implemented via expectation-maximization （EM） algorithm. Major gene is tested with the likelihood ratio （LR） test statistic. Extensive simulation studies showed that joint analysis not only increases the statistical power of major gene detection but also improves the precision and accuracy of major gene effect estimates. An example of the plant height and the number of tiller of F2 population in rice cross Duonieai x Zhonghua 11 was used in the illustration. The results indicated that the genetic difference of these two traits in this cross refers to only one pleiotropic major gene. The additive effect and dominance effect of the major gene are estimated as -21.3 and 40.6 cm on plant height, and 22.7 and -25.3 on number of tiller, respectively. The major gene shows overdominance for plant height and close to complete dominance for number of tillers.
基金Supported by the National Natural Science Foundation of China(11261025,11201412)the Natural Science Foundation of Yunnan Province(2011FB016)the Program for Middle-aged Backbone Teacher,Yunnan University
文摘Joint location and scale models of the skew-normal distribution provide useful ex- tension for joint mean and variance models of the normal distribution when the data set under consideration involves asymmetric outcomes. This paper focuses on the maximum likelihood estimation of joint location and scale models of the skew-normal distribution. The proposed procedure can simultaneously estimate parameters in the location model and the scale model. Simulation studies and a real example are used to illustrate the proposed methodologies.
文摘In this paper we reparameterize covariance structures in longitudinal data analysis through the modified Cholesky decomposition of itself. Based on this modified Cholesky decomposition, the within-subject covariance matrix is decomposed into a unit lower triangular matrix involving moving average coefficients and a diagonal matrix involving innovation variances, which are modeled as linear functions of covariates. Then, we propose a penalized maximum likelihood method for variable selection in joint mean and covariance models based on this decomposition. Under certain regularity conditions, we establish the consistency and asymptotic normality of the penalized maximum likelihood estimators of parameters in the models. Simulation studies are undertaken to assess the finite sample performance of the proposed variable selection procedure.
基金Supported by the National Natural Science Foundation of China(11261025,11561075)the Natural Science Foundation of Yunnan Province(2016FB005)the Program for Middle-aged Backbone Teacher,Yunnan University
文摘Normal mixture regression models are one of the most important statistical data analysis tools in a heterogeneous population. When the data set under consideration involves asymmetric outcomes, in the last two decades, the skew normal distribution has been shown beneficial in dealing with asymmetric data in various theoretic and applied problems. In this paper, we propose and study a novel class of models： a skew-normal mixture of joint location, scale and skewness models to analyze the heteroscedastic skew-normal data coming from a heterogeneous population. The issues of maximum likelihood estimation are addressed. In particular, an Expectation-Maximization （EM） algorithm for estimating the model parameters is developed. Properties of the estimators of the regression coefficients are evaluated through Monte Carlo experiments. Results from the analysis of a real data set from the Body Mass Index （BMI） data are presented.
