General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junct...General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of consciousness. The general anesthetics sevoflurane and propofol were used. Intracerebroventricular administration of carbenoxolone, a gap junction blocker, significantly decreased the time to loss of the righting reflex （P 0.05）, but prolonged the time to recovery of the reflex （P 0.05）. Moreover, intracerebroventricular administration of carbenoxolone increased the sensitivity to sevoflurane, with a leftward shift of the loss of righting reflex dose-response curve, and decreased the 50% effective concentration of sevoflurane. These results suggest that the gap junction blocker carbenoxolone enhances propofol and sevoflurane-mediated general anesthesia.展开更多
A block copolymer consisting of polyfluorene (PF) and polytriarylamine (PTAA) functionalized with green emitting phenoxazine moiety at the junction point of two blocks was designed and prepared for electroluminescent ...A block copolymer consisting of polyfluorene (PF) and polytriarylamine (PTAA) functionalized with green emitting phenoxazine moiety at the junction point of two blocks was designed and prepared for electroluminescent application. PF homopolymer was synthesized by Suzuki coupling polymerization, and was reacted with brominated phenoxazine. In the presence of the resulting PF functionalized with phenoxazine, C-N coupling polymerization of 4-(4’-bromophenyl)-4’’-butyldiphenylamine was carried out to afford a triblock copolymer, PTAA-phenoxazine-PF-phenoxazine-PTAA (PF-Ph-PTAA). Two types of random copolymers were also synthesized with fluorene and phenoxazine (PF2) by Suzuki coupling polymerization for comparison. All the polymers were soluble in common organic solvents and readily formed thin films by a solution processing. Prepared polymers exhibited similar UV absorption and PL emission in chloroform solutions. In a film state, the existence of phenoxazine unit drastically changed PL spectra. Although the content of phenoxazine unit in PF-Ph-PTAA was relatively high (13 mol%), it showed similar PL spectrum to that of PF2(phenoxazine content, 0.2 mol%) indicating that phenoxazine unit is isolated in single polymer chain nevertheless the high content. EL device based on PF-Ph-PTAA showed green-emission, suggesting that emission sites predominantly located in the vicinity of phenoxazine moiety because of its shallow HOMO level.展开更多
残生微洋块,即正在俯冲消减或俯冲停滞的原大型洋壳板块的海底残余,位于俯冲消减系统的俯冲盘,一般被活动或死亡的洋中脊、海沟及转换断层所围限,但也存在例外,如里维拉(Rivera)微洋块与科科斯(Cocos)板块的边界。现今已确认的残生微洋...残生微洋块,即正在俯冲消减或俯冲停滞的原大型洋壳板块的海底残余,位于俯冲消减系统的俯冲盘,一般被活动或死亡的洋中脊、海沟及转换断层所围限,但也存在例外,如里维拉(Rivera)微洋块与科科斯(Cocos)板块的边界。现今已确认的残生微洋块有胡安·德·富卡(Juan de Fuca)、里维拉(Rivera)、瓜达卢佩(Guadalupe)等法拉隆(Farallon)板块的残余和位于南美洲和南极洲之间的菲尼克斯(Phoenix)微洋块。此类微洋块的边界以及恢复其演化过程主要是通过地形、重力异常、震源分布、磁异常条带、地震剖面和构造解释等手段辨析。洋中脊与俯冲带的相对位移使围限的洋壳板块面积整体或局部不断减小,当整块洋壳面积减小到10万平方千米以下时形成残生微洋块,其产生的动力机制为地幔对流驱动下的相邻板块之间的相互作用。较大的微洋块可能因新生洋壳的浮力等因素造成俯冲速度及方向的差异,破裂为数个更小的微洋块。残生微洋块的形成和演化与洋中脊、俯冲系统、板片窗形成及三节点的转化密不可分,研究其成因模式可为探索板块起源和动力提供参考。在板块俯冲过程中可能产生大洋汇聚边界并以此作为微洋块新的边界(如里维拉?科科斯边界),可与陆内变形带类比。展开更多
该文报道具有最小比导通电阻的~1.7 k V 4H-SiC结势垒肖特基二极管。首先通过数值仿真对结势垒肖特基(junction barrier Schottky,JBS)二极管的有源区和终端结构进行了优化设计。实验结果验证了场限环(floating guard ring,FGR)终端的...该文报道具有最小比导通电阻的~1.7 k V 4H-SiC结势垒肖特基二极管。首先通过数值仿真对结势垒肖特基(junction barrier Schottky,JBS)二极管的有源区和终端结构进行了优化设计。实验结果验证了场限环(floating guard ring,FGR)终端的优化设计结构具有较强的鲁棒性,能够抵抗工艺中环间距的变化以及钝化层中寄生电荷的影响。实验制作的4H-SiC结势垒肖特基二极管实现了2.5 mΩ·cm2的最小比导通电阻值,接近于理论值(2.4 mΩ·cm2),并且具有优秀的反向阻断特性,获得了最高1.75 k V的阻断电压(达到了95%的理论值)和83%的器件良率,从而实现了SiC JBS二极管品质因数的最高记录(U22B/Ron_sp=1 225 MW/cm)。展开更多
基金supported by the Natural Science Foundation of Hubei Province, No. 2010CHB01001
文摘General anesthetics induce loss of consciousness by inhibiting ascending arousal pathways, and they interfere with gap junction electrical coupling. The present study aimed to determine whether inhibition of gap junction-mediated signaling could influence general anesthetic-induced loss of consciousness. The general anesthetics sevoflurane and propofol were used. Intracerebroventricular administration of carbenoxolone, a gap junction blocker, significantly decreased the time to loss of the righting reflex （P 0.05）, but prolonged the time to recovery of the reflex （P 0.05）. Moreover, intracerebroventricular administration of carbenoxolone increased the sensitivity to sevoflurane, with a leftward shift of the loss of righting reflex dose-response curve, and decreased the 50% effective concentration of sevoflurane. These results suggest that the gap junction blocker carbenoxolone enhances propofol and sevoflurane-mediated general anesthesia.
文摘A block copolymer consisting of polyfluorene (PF) and polytriarylamine (PTAA) functionalized with green emitting phenoxazine moiety at the junction point of two blocks was designed and prepared for electroluminescent application. PF homopolymer was synthesized by Suzuki coupling polymerization, and was reacted with brominated phenoxazine. In the presence of the resulting PF functionalized with phenoxazine, C-N coupling polymerization of 4-(4’-bromophenyl)-4’’-butyldiphenylamine was carried out to afford a triblock copolymer, PTAA-phenoxazine-PF-phenoxazine-PTAA (PF-Ph-PTAA). Two types of random copolymers were also synthesized with fluorene and phenoxazine (PF2) by Suzuki coupling polymerization for comparison. All the polymers were soluble in common organic solvents and readily formed thin films by a solution processing. Prepared polymers exhibited similar UV absorption and PL emission in chloroform solutions. In a film state, the existence of phenoxazine unit drastically changed PL spectra. Although the content of phenoxazine unit in PF-Ph-PTAA was relatively high (13 mol%), it showed similar PL spectrum to that of PF2(phenoxazine content, 0.2 mol%) indicating that phenoxazine unit is isolated in single polymer chain nevertheless the high content. EL device based on PF-Ph-PTAA showed green-emission, suggesting that emission sites predominantly located in the vicinity of phenoxazine moiety because of its shallow HOMO level.
文摘残生微洋块,即正在俯冲消减或俯冲停滞的原大型洋壳板块的海底残余,位于俯冲消减系统的俯冲盘,一般被活动或死亡的洋中脊、海沟及转换断层所围限,但也存在例外,如里维拉(Rivera)微洋块与科科斯(Cocos)板块的边界。现今已确认的残生微洋块有胡安·德·富卡(Juan de Fuca)、里维拉(Rivera)、瓜达卢佩(Guadalupe)等法拉隆(Farallon)板块的残余和位于南美洲和南极洲之间的菲尼克斯(Phoenix)微洋块。此类微洋块的边界以及恢复其演化过程主要是通过地形、重力异常、震源分布、磁异常条带、地震剖面和构造解释等手段辨析。洋中脊与俯冲带的相对位移使围限的洋壳板块面积整体或局部不断减小,当整块洋壳面积减小到10万平方千米以下时形成残生微洋块,其产生的动力机制为地幔对流驱动下的相邻板块之间的相互作用。较大的微洋块可能因新生洋壳的浮力等因素造成俯冲速度及方向的差异,破裂为数个更小的微洋块。残生微洋块的形成和演化与洋中脊、俯冲系统、板片窗形成及三节点的转化密不可分,研究其成因模式可为探索板块起源和动力提供参考。在板块俯冲过程中可能产生大洋汇聚边界并以此作为微洋块新的边界(如里维拉?科科斯边界),可与陆内变形带类比。
基金The National High Technology Research and Development of China 863 Program(2014AA041402)Scientific Funds for Outstanding Young Scientists of China(51225701)~~
文摘该文报道具有最小比导通电阻的~1.7 k V 4H-SiC结势垒肖特基二极管。首先通过数值仿真对结势垒肖特基(junction barrier Schottky,JBS)二极管的有源区和终端结构进行了优化设计。实验结果验证了场限环(floating guard ring,FGR)终端的优化设计结构具有较强的鲁棒性,能够抵抗工艺中环间距的变化以及钝化层中寄生电荷的影响。实验制作的4H-SiC结势垒肖特基二极管实现了2.5 mΩ·cm2的最小比导通电阻值,接近于理论值(2.4 mΩ·cm2),并且具有优秀的反向阻断特性,获得了最高1.75 k V的阻断电压(达到了95%的理论值)和83%的器件良率,从而实现了SiC JBS二极管品质因数的最高记录(U22B/Ron_sp=1 225 MW/cm)。
