Quality-adjusted time without symptoms or toxicity analysis of haploidentical-related donor vs.identical sibling donor hematopoietic stem cell transplantation in acute myeloid leukemia

Objective:We aimed to compare the quality-adjusted time without symptoms or toxicity(Q-TWiST)in acute myeloid leukemia(AML)patients who received haploidentical-related donor(HID)and identical sibling donor(ISD)hematopoietic stem cell transplantation(HSCT).Methods:Five clinical health states were defined:toxicity(TOX),acute graft-versus-host disease(GVHD),chronic GVHD(cGVHD),time without symptoms and toxicity(TWiST)and relapse(REL).The equation used in this study was as follows:Q-TWiST=UTOX×TOX+UTWiST×TWiST+UREL×REL+UaGVHD×aGVHD+UcGVHD×cGVHD.Results:A total of 239 AML patients were enrolled.We established a mathematical model,i.e.,Q-TWiST HID HSCT>Q-TWiST ISD HSCT,to explore the range of utility coefficients satisfying the inequality.Based on the raw data,the utility coefficient is equivalent to the following inequality:10.57067UTOX-46.27733UREL+105.9374+3.388078UaGVHD-210.8198UcGVHD>0.The model showed that when UTOX,UREL,and UaGVHD were within the range of 0-1,as well as when UcGVHD was within the range of 0-0.569,the inequality Q-TWiST HID HSCT>Q-TWiST ISD HSCT was valid.According to the results of the ChiCTR1800016972 study,the median coefficients of TOX,acute GVHD(aGVHD),and cGVHD were 0.56(0.41-0.76),0.56(0.47-0.72),and 0.54(0.37-0.79),respectively.We selected a series of specific examples of the coefficients,i.e.,UTOX=0.5,UREL=0.05,UaGVHD-0.5,and UcGVHD-0.5.The Q-TWiST values of ISD and HID HSCT were 896 and 900 d,respectively(P=0.470).Conclusions:We first observed that Q-TWiST was comparable between AML patients receiving HID HSCT and those receiving ISD HSCT.

Mechanism Study on the Effect of Retarder on Polyurethane Setting Time Based on Molecular Simulation

This study identified castor oil and phosphate ester as effective retarders through setting time,tensile,and flexural tests,and determined their optimal dosages.The mechanism by which phosphate ester affects the setting time of polyurethane was further investigated using molecular dynamics simulations.Fourier transform infrared spectroscopy was also employed to systematically study the physical and chemical interactions between phosphate esters and polyurethane materials.The results demonstrate that a 1%concentration of phosphate ester provides the most effective retarding effect with minimal impact on the strength of polyurethane.When phosphate ester is added to the B component of the two-component polyurethane system,its interaction energy with component A decreases,as do the diffusion coefficient and aggregation degree of component B on the surface of component A.This reduction in interaction slows the setting time.Additionally,the addition of phosphate ester to polyurethane leads to the disappearance or weakening of functional groups,indicating competitive interactions within the phosphate ester components that inhibit the reaction rate.

DecMamba:Mamba Utilizing Series Decomposition for Multivariate Time Series Forecasting

Multivariate time series forecasting iswidely used in traffic planning,weather forecasting,and energy consumption.Series decomposition algorithms can help models better understand the underlying patterns of the original series to improve the forecasting accuracy of multivariate time series.However,the decomposition kernel of previous decomposition-based models is fixed,and these models have not considered the differences in frequency fluctuations between components.These problems make it difficult to analyze the intricate temporal variations of real-world time series.In this paper,we propose a series decomposition-based Mamba model,DecMamba,to obtain the intricate temporal dependencies and the dependencies among different variables of multivariate time series.A variable-level adaptive kernel combination search module is designed to interact with information on different trends and periods between variables.Two backbone structures are proposed to emphasize the differences in frequency fluctuations of seasonal and trend components.Mamba with superior performance is used instead of a Transformer in backbone structures to capture the dependencies among different variables.A new embedding block is designed to capture the temporal features better,especially for the high-frequency seasonal component whose semantic information is difficult to acquire.A gating mechanism is introduced to the decoder in the seasonal backbone to improve the prediction accuracy.A comparison with ten state-of-the-art models on seven real-world datasets demonstrates that DecMamba can better model the temporal dependencies and the dependencies among different variables,guaranteeing better prediction performance for multivariate time series.

IoT Empowered Early Warning of Transmission Line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data

Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power outages.Existing early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false alarms.To address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather forecast.Initially,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused data.Furthermore,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network model.Subsequently,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this coefficient.Finally,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.

Impact of time between meniscal injury and isolated meniscus repair on post-operative outcomes:A systematic review

BACKGROUND Meniscal tears are one of the most common knee injuries.After the diagnosis of a meniscal tear has been made,there are several factors physicians use to guide clinical decision-making.The influence of time between injury and isolated meniscus repair on patient outcomes is not well described.Assessing this relationship is important as it may influence clinical decision-making and can add to the preoperative patient education process.We hypothesized that increasing the time from injury to meniscus surgery would worsen postoperative outcomes.AIM To investigate the current literature for data on the relationship between time between meniscus injury and repair on patient outcomes.METHODS PubMed,Academic Search Complete,MEDLINE,CINAHL,and SPORTDiscus were searched for studies published between January 1,1995 and July 13,2023 on isolated meniscus repair.Exclusion criteria included concomitant ligament surgery,incomplete outcomes or time to surgery data,and meniscectomies.Patient demographics,time to injury,and postoperative outcomes from each study were abstracted and analyzed.RESULTS Five studies met all inclusion and exclusion criteria.There were 204(121 male,83 female)patients included.Three of five(60%)studies determined that time between injury and surgery was not statistically significant for postoperative Lysholm scores(P=0.62),Tegner scores(P=0.46),failure rate(P=0.45,P=0.86),and International Knee Documentation Committee scores(P=0.65).Two of five(40%)studies found a statistically significant increase in Lysholm scores with shorter time to surgery(P=0.03)and a statistically significant association between progression of medial meniscus extrusion ratio(P=0.01)and increasing time to surgery.CONCLUSION Our results do not support the hypothesis that increased time from injury to isolated meniscus surgery worsens postoperative outcomes.Decision-making primarily based on injury interval is thus not recommended.

水刀(Versajet^(TM))与传统小切口修剪治疗腋臭的有效性与安全性Meta分析

目的:对采用水刀与传统小切口修剪术两种术式治疗腋臭的疗效进行系统评价。方法:应用计算机检索知网、万方、维普、CBM、PubMed、Embase、Web Of Science等数据库,收集国内外有关水刀及传统小切口皮下修剪治疗腋臭的随机对照试验研究、临床对照研究。对纳入的文献进行质量评价并进行资料提取后,采用RevMan 5.4软件进行Meta分析。结果:最终共纳入7篇文献,其中中文5篇,英文2篇,共纳入662例患者,1324侧腋窝,其中水刀组340例(680侧腋窝),传统手术组322例(644侧腋窝)。Meta分析结果显示,水刀相对于传统手术治疗腋臭在术后早期并发症发生率(RR=0.28)、术后瘢痕发生率(RR=0.26)、术后满意度(非常满意,RR=1.43)上更有优势(P<0.05);水刀相对于传统手术治疗腋臭在治愈率(OR=1.36)上差异无统计学意义(P>0.05)。结论:水刀与传统手术治疗腋臭比较,在术后早期并发症发生率、术后瘢痕发生率、术后满意度(非常满意)上更有优势;在治愈率上两者差异无统计学意义。由于纳入的文献缺少RCT研究,且样本量偏少,需进一步开展更高质量的RCT加以验证。

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°C.We aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large cohort.Plasma samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline project.These samples were stored at-80°C for up to 6 years before being used in this study.Our results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage time.However,the level of total tau showed a negative correlation with sample storage time.Notably,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage time.This was not observed in individuals with cognitive impairment.Consequently,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage time.Therefore,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's disease.Furthermore,in cohort studies,it is important to consider the impact of storage time on the overall results.

基于“Just-in-Time”动态精准对接产业需求的化工过程开发与设计课程改革与实例

化学工业是国民经济的基础产业和支柱产业,而化工过程开发与设计在化工生产中扮演着至关重要的角色,是调整产业结构、优化产业布局、提高自主创新能力及发展循环经济的重要基础和支撑。本文创新性地提出基于准时制“Just-in-Time”动态精准对接产业需求的教学模式,结合环戊烯绿色催化氧化制戊二酸技术开发对化工过程开发与设计课程进行教学改革,并构建了一种高校化工专业课程建设与产业需求精准对接的动态调整机制,寄望为校企协同育人提供参考和借鉴。

“Culture time”板块教学中跨文化意识培养的策略

在新课程改革的大环境中,文化意识成为英语学科核心素养的重要组成部分。语言是文化的载体,语言与文化是相互依赖、相互影响、相互制约的。学习语言的过程也是学习文化的过程。文章主要结合译林版英语五、六年级教材中的Culture time板块的教学案例,探讨如何在英语课堂教学实践中丰富文化素材、发掘其中的文化元素和领略中西方文化异同,以帮助学生有效学习文化知识,拓宽文化视野,培养文化意识。

Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

The grain size of TiAl alloy castings prepared by traditional casting process is coarse,thus showing poor mechanical properties.In this study,a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was introduced.This research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings,employing both experimental approaches and ProCast simulation methodologies.The findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed grains.Under the condition of pouring temperature of 1,600℃,rotation speed of 800 r·min^(-1) and pouring time of 6 s,the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa,and the tensile strength at 800℃ reaches 705 MPa,which is significantly higher than that of traditional as-cast Ti-Al alloy.

基于互信息和Just-in-Time优化的回声状态网络

为了提高回声状态网络(ESN)的适应性,提出基于互信息(MI)和Just-in-Time(JIT)的优化方法,对ESN的输入伸缩参数以及输出层进行优化,所得网络称为MI-JIT-ESN.ESN的优化方法分为两部分:一是基于网络输入与输出之间的互信息,对网络的多个输入伸缩参数进行调整;二是基于JIT优化的局部输出层,对ESN的隐层输出数据进行局部重新建模,从而提升ESN输出层的回归拟合精度.将MI-JIT-ESN应用于青霉素补料分批发酵过程建模.结果显示,MI-JIT优化方法能提高模型的适应性,并优于其他比较方法.

4种植物源性成分多重real-time PCR检测方法的建立及其在食用淀粉中的应用

建立一种可同时快速检测红薯、木薯、马铃薯、玉米源性成分的多重实时聚合酶链式反应(real-time polymerase chain reaction,real-time PCR)方法。分别以红薯g3pdh基因、木薯g3pdh基因、马铃薯UGPase基因、玉米zSSIIb基因为靶基因设计特异性引物和TaqMan探针,以18S rRNA基因为内参基因,建立多重real-time PCR方法,开展方法学验证,并对不同掺入比例模拟样品和实际淀粉样品进行检测。结果显示,该方法具有高通量、特异性强、灵敏度高等优点。与15种非目标源性均无交叉反应;对目标DNA的检测灵敏度可达到3×10^(-3) ng/μL,且具有良好的线性关系和扩增效率;对淀粉样品的检出限可达0.1%,对50份实际样品进行检测,结果与参比方法一致,说明建立的多重real-time PCR法可用于食用淀粉种类掺假鉴别检测。

WINTERTIME MIDDLE EAST SUBTROPICAL WESTERLY JET STREAM INTERANNUAL VARIATION CHARACTERISTICS AND ITS POSSIBLE PHYSICAL FACTORS

Using National Centers for Environmental Prediction/Department of Energy(NCEP/DOE) monthly reanalysis data and an extended reconstruction of the sea surface temperature data provided by National Oceanic and Atmospheric Administration, the basic characteristics of the interannual variation in the wintertime Middle East subtropical westerly jet stream(MEJ) and its possible physical factors are studied. The results show that the climatological mean MEJ axis extends southwestward-northeastward and that its center lies in the northwest part of the Arabian Peninsula. The south-north shift of the MEJ axis and its intensity show obvious interannual variations that are closely related to the ElNio-Southern Oscillation(ENSO) and the mid-high latitude atmospheric circulation. The zonal symmetric response of the Asian jet to the ENSO-related tropical convective forcing causes the MEJ axis shift, and the Arctic Oscillation(AO)causes the middle-western MEJ axis shift. Due to the influences of both the zonal symmetric response of the Asian jet to the ENSO-related tropical convective forcing and the dynamical role of the AO, an east-west out-of-phase MEJ axis shift is observed. Furthermore, the zonal asymmetric response to the ENSO-related tropical convective forcing can lead to an anomalous Mediterranean convergence(MC) in the high troposphere. The MC anomaly excites a zonal wave train along the Afro-Asian jet, which causes the middle-western MEJ axis shift. Under the effects of both the zonal symmetric response to the ENSO-related tropical convective forcing and the wave train along the Afro-Asian jet excited by the MC anomaly, an east-west in-phase MEJ axis shift pattern is expressed. Finally, the AO affects the MEJ intensity, whereas the East Atlantic(EA) teleconnection influences the middle-western MEJ intensity. Under the dynamical roles of the AO and EA, the change in the MEJ intensity is demonstrated.

Stream-coordinate structure of oceanic jets based on merged altimeter data

The jet structure of the Southern Ocean front south of Australia is studied in stream-coordinate with a new altimeter product—Absolute Dynamic Topography (ADT) from AVISO. The accuracy of the ADT data is validated with the mooring data from a two-year subantarctic-front experiment. It is demonstrated that the ADT is consistent with in-situ measurements and captures the meso-scale activity of the Antarctic Circumpolar Current (ACC). Stream-coordinate analysis of ADT surface geostrophic flows finds that ACC jets exhibit large spatio-temporal variability and do not correspond to particular streamfunction values. In the circumpolar scope ACC jets display a transient fragmented pattern controlled by topographic features. The poleward shift of jet in streamfunction space, as revealed by a streamwise correlation method, indicates the presence of meridional fluxes of zonal momentum. Such cross-stream eddy fluxes concentrate the broad ACC baroclinic flow into narrow jets. Combined with a recent discovery of gravest empirical mode (GEM) in the thermohaline fields, the study clarifies the interrelationship among front, jet and streamfunction in the Southern Ocean.

A Novel Time-aware Frame Adjustment Strategy for RFID Anti-collision

Recently,object identification with radio frequency identification(RFID)technology is becoming increasingly popular.Identification time is a key performance metric to evaluate the RFID system.The present paper analyzes the deficiencies of the state-of-the-arts algorithms and proposes a novel sub-frame-based algorithm with adaptive frame breaking policy to lower the tag identification time for EPC global C1 Gen2 UHF RFID standard.Through the observation of slot statistics in a sub-frame,the reader estimates the tag quantity and efficiently calculates an optimal frame size to fit the unread tags.Only when the expected average identification time in the calculated frame size is less than that in the previous frame size,the reader starts the new frame.Moreover,the estimation of the proposed algorithm is implemented by the look-up tables,which allows dramatically reduction in the computational complexity.Simulation results show noticeable throughput and time efficiency improvements of the proposed solution over the existing approaches.

Support vector regression modeling in recursive just-in-time learning framework for adaptive soft sensing of naphtha boiling point in crude distillation unit

Prediction of primary quality variables in real time with adaptation capability for varying process conditions is a critical task in process industries.This article focuses on the development of non-linear adaptive soft sensors for prediction of naphtha initial boiling point(IBP)and end boiling point(EBP)in crude distillation unit.In this work,adaptive inferential sensors with linear and non-linear local models are reported based on recursive just in time learning(JITL)approach.The different types of local models designed are locally weighted regression(LWR),multiple linear regression(MLR),partial least squares regression(PLS)and support vector regression(SVR).In addition to model development,the effect of relevant dataset size on model prediction accuracy and model computation time is also investigated.Results show that the JITL model based on support vector regression with iterative single data algorithm optimization(ISDA)local model(JITL-SVR:ISDA)yielded best prediction accuracy in reasonable computation time.

Numerical simulation of flow field and residence time of nanoparticles in a 1000-ton industrial multi-jet combustion reactor

In this work,by establishing a three-dimensional physical model of a 1000-ton industrial multi-jet combustion reactor,a hexahedral structured grid was used to discretize the model.Combined with realizable k–εmodel,eddy-dissipation-concept,discrete-ordinate radiation model,hydrogen 19-step detailed reaction mechanism,air age user-defined-function,velocity field,temperature field,concentration field and gas arrival time in the reactor were numerically simulated.The Euler–Lagrange method combined with the discrete-phase-model was used to reveal the flow characteristics of particles in the reactor,and based on this,the effects of the reactor aspect ratios,central jet gas velocity and particle size on the flow field characteristics and particle back-mixing degree in the reactor were investigated.The results show that with the decrease of aspect ratio in the combustion reactors,the velocity and temperature attenuation in the reactor are intensified,the vortex phenomenon is aggravated,and the residence time distribution of nanoparticles is more dispersed.With the increase in the central jet gas velocities in reactors,the vortex lengthens along the axis,the turbulence intensity increases,and the residence time of particles decreases.The back-mixing degree and residence time of particles in the reactor also decrease with the increase in particle size.The simulation results can provide reference for the structural regulation of nanoparticles and the structural design of combustion reactor in the process of gas combustion synthesis.

Impact of the Preceding Boreal Winter Southern Annular Mode on the Summertime Somali Jet

One of the major high-latitude circulation systems in the Southern Hemisphere is the Southern Annular Mode(SAM). Its effect on the Somali Jet(SMJ), which connects the Southern and Northern hemispheres, cannot be ignored. The present reported results show that time series of both the Southern Annular Mode Index(SAMI) during the preceding winter and the summertime Somali Jet intensity Index(SMJI) display a significant increasing trend and have similar interdecadal variation. The latter was rather strong around 1960, then became weaker up to the mid-1980 s, before starting to strengthen again. The lead-lag correlations of monthly mean SAMI with the following summertime SMJI showed significant positive correlations in November, December, and January. There are thus connections across two seasons between the SAM and the SMJ. The influence of the winter SAM on the summer SMJ was explored via analyses of SST anomalies in the Southern Indian Ocean. During strong(weak) SAM/SMJ years, the SST east of Madagascar is colder(warmer) while the SST west of Australia is warmer(colder), corresponding to the positive(negative) Southern Indian Ocean Dipole-like(SIODL) event. Subsequently, the SIODL excites an anticyclone located over the Arabian Sea in summer through air-sea coupling from winter to summer, which causes an increase in the summer SMJ intensity. The anticyclone/high branch of the SAM over the Southern Hemisphere subtropics and the cyclone/low over the east coast of Madagascar play an important role in the formation of Southern Indian Ocean "bridge" from winter to summer.

ICON/MIGHTI与TIMED/SABER探测温度数据的对比

ICON卫星为临近空间环境特性研究、建模和预报提供了新数据.通过对ICON/MIGHTI与TIMED/SABER在90~105 km高度探测温度数据的比较,计算两者的年平均温度偏差和均方根误差,同时分析月平均温度偏差在不同月份中随高度和纬度的分布情况,为MIGHTI和SABER温度探测数据在临近空间大气建模和预报应用提供参考依据.结果表明,MIGHTI和SABER的温度垂直廓线变化趋势基本吻合,数值上有所差异.在12°S-42°N范围内,MIGHTI探测温度与SABER相比,在90~93 km时偏低,偏差最大值约2.5 K,在93~105 km偏高,偏差的绝对值最大约10 K.在不同季节,白天的温度偏差通常高于夜晚.SABER和MIGHTI的月平均温度偏差随季节和纬度的变化显著,夏季时的月平均温度偏差最大,且温度的均方根误差最大.

Switching mechanism and optimisation research on a pressure-attitude adaptive adjusting coal seam water jet slotter

To investigate the attitude-switching mechanisms of existing jet slotters,which integrate drilling,punching and slotting operations,and to improve its fracture ability,we used the power bond diagram theory to analyse the dynamic flow pressure,and force of slotters.A mathematical model was developed for the dynamic characteristics of slotter systems.Furthermore,to study the effect of the main characteristic parameters on the ability of the nozzle to erode sandstone,multi-orthogonal experiments were carried out.And the optimised slots were applied in later practical operations.The research results show that the inlet fluid passed through the time-varying orifice to generate pressure differential thrust,which overcame the spring force,pushed the valve core to open the side nozzle,and closed the rear cavity channel thereby realising the switch of the slotter attitude.An optimal plan was established to balance the diameter,depth,and volume of punching,and a rock-breaking plan was developed for the slotter.Subsequently,the optimised water jet slotter was practically used in coal seam gas drainage.Compared with conventional dense drilling,water jet slotting technology significantly improves the ability,efficiency,and effect of increasing the permeability of the coal seam.