AimTo study effects of PVP K30 on the aque ou s solubility and dissolution properties of daidzein. Methods To measure the aqueous solubility and dissolution rates of daidzein in three diffe rent states (within solid d...AimTo study effects of PVP K30 on the aque ou s solubility and dissolution properties of daidzein. Methods To measure the aqueous solubility and dissolution rates of daidzein in three diffe rent states (within solid dispersions, physical mixtures and as a pure drug) and investigate drug-polymer interactions in the solid state using X-ray powder d iffraction and fourier-transform infrared spectroscopy. Results The negative values of the Gibbs free energy and enthalpy of transfer explaine d the spontaneous transfer of daidzein from phosphate buffer solution (PBS) to a solution of PVP in PBS. X-ray powder diffraction patterns showed that the drug was in the amorphous state (ratio of the drug ∶ PVP<1∶5) when dispers ed i n PVP K30. The infrared spectra indicated there exist interactions between the O H of daidzein and the C=O of PVP K30. Conclusionthe dispersion of daidzein in PVP K30 considerably enhances the solubility and dissolution rat e.展开更多
本设计实现了HIRFL-CSRe同步系统控制器DSP插件内的FPGA中的FIFO(First in first out)功能,数据入口是16位DSP总线,数据出口是16位DAC总线。其核心机制采用双缓冲"乒乓操作",并在FPGA内完成一次线性插值。程序采用VHDL硬件描...本设计实现了HIRFL-CSRe同步系统控制器DSP插件内的FPGA中的FIFO(First in first out)功能,数据入口是16位DSP总线,数据出口是16位DAC总线。其核心机制采用双缓冲"乒乓操作",并在FPGA内完成一次线性插值。程序采用VHDL硬件描述语言在Altera公司的现场可编程逻辑器件ACEX1K30上实现。FIFO实现机制完全自行设计,解决了传统异步FIFO由于读写时钟异步造成的空/满标志难以准确给出及数据输出时间不能精确保证的难题,满足了HIRFL-CSRe对于输出数据不间断(每微秒一个)的要求,并由于在FPGA内实现了一次线性插值,从而把从DSP中接收到的已插值数据量增加了一倍,在宏观上降低了DSP的数据运算量。模块经现场工作证实FIFO数据输出时间误差控制在40ns内,达到设计要求。展开更多
文摘AimTo study effects of PVP K30 on the aque ou s solubility and dissolution properties of daidzein. Methods To measure the aqueous solubility and dissolution rates of daidzein in three diffe rent states (within solid dispersions, physical mixtures and as a pure drug) and investigate drug-polymer interactions in the solid state using X-ray powder d iffraction and fourier-transform infrared spectroscopy. Results The negative values of the Gibbs free energy and enthalpy of transfer explaine d the spontaneous transfer of daidzein from phosphate buffer solution (PBS) to a solution of PVP in PBS. X-ray powder diffraction patterns showed that the drug was in the amorphous state (ratio of the drug ∶ PVP<1∶5) when dispers ed i n PVP K30. The infrared spectra indicated there exist interactions between the O H of daidzein and the C=O of PVP K30. Conclusionthe dispersion of daidzein in PVP K30 considerably enhances the solubility and dissolution rat e.
文摘本设计实现了HIRFL-CSRe同步系统控制器DSP插件内的FPGA中的FIFO(First in first out)功能,数据入口是16位DSP总线,数据出口是16位DAC总线。其核心机制采用双缓冲"乒乓操作",并在FPGA内完成一次线性插值。程序采用VHDL硬件描述语言在Altera公司的现场可编程逻辑器件ACEX1K30上实现。FIFO实现机制完全自行设计,解决了传统异步FIFO由于读写时钟异步造成的空/满标志难以准确给出及数据输出时间不能精确保证的难题,满足了HIRFL-CSRe对于输出数据不间断(每微秒一个)的要求,并由于在FPGA内实现了一次线性插值,从而把从DSP中接收到的已插值数据量增加了一倍,在宏观上降低了DSP的数据运算量。模块经现场工作证实FIFO数据输出时间误差控制在40ns内,达到设计要求。
