Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after ESD.AIM To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus post-ESD.METHODS Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential ESD.Endoscopic examinations occurred on days 7 and 21 post-ESD.In vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was assessed.Profibrotic signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after ESD.After treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal layer.Additionally,the expression of fibrotic effector molecules was notably inhibited.Mechanistically,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/3.In vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen I.The 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated pEsF.CONCLUSION KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

Kangfuxin Fluid on the Treatment of Ulcerative Colitis with Retention Enema： a Systematic Review

Objective： To systematically evaluate the effectiveness of Kangfuxin Fluid （KFX） in Ulcerative Colitis （UC） with retention enema. Methods： We searched The Cochanrane Library, Pubmed, EMbase, VIP, CNKI, CBM and WanFang Data from inception to December.2017, and retrospectively incorporated into the literature reference. And a systematic review of randomized controlled trials was performed. Meta-analysis was performed with RevMan5.3 software. Results： A total of 18 randomized controlled trials and 1417 patients were enrolled, among which 731 cases were in experimental group and 686 cases were in control group. The meta-analysis results revealed that the effectiveness of KFX on UC with retention enema was significantly superior to the controlled treatment （RR=1.22 95%CI： [1.16,1.27], Z=8.14, p〈0.00001）. And, the score of quality of life was significantly increased after KFX treatment （MD=11.12, 95% CI [7.00, 15.23], Z=5.30, p〈0.00001）. Conclusion： KFX on the treatment of UC with retention enema is potentially effective to improve patient＇s quality of life, and it is worth being popularized clinically. Depth researches and high quality randomized controlled trials on the efficacy of UC are necessary.

Effect of Kangfuxin solution on inflammatory, immune, oxidative indexes and vascular factors in patients with ulcerative colitis

Objective:To explore the effect of Kangfuxin solution on inflammatory, immune, oxidative indexes and vascular factorsin patients with ulcerative colitis.Methods: 172 cases of ulcerative colitis from August 2015 to February 2017 were selected and divided into control group (n=86) and observation group (n=86) according to random principle, the control group was treated with Mesalazin Enteric-coated Tablets, and the observation group was treated with enema by infusion of rectal drip on the basis of the control group, and the levels of the two groups of inflammatory factors, immune indexes, oxidation indexes and vascular factors were compared.Results: After treatment, the total effective rate of the observation group (88.37%) was significantly higher than that of the control group (73.26%) (P<0.05);the two groups of CRP and TNF-α were significantly lower than those before treatment (P<0.05), and the observation group was significantly lower than that of the control group (P<0.05);the two groups of CD4+, CD4+/CD8+ and SOD increased significantly compared with those before treatment (P<0.05), while CD8+, MDA and LOP were significantly lower than those before treatment (P<0.05), and the CD4+, CD4+/CD8+ and SOD in the observation group were significantly higher than those in the control group (P<0.05), while CD8+, MDA and LOP were significantly lower than those in the control group (P<0.05);The levels of VEGF and PDGF in both groups were significantly higher than those before treatment (P<0.05), and the levels of VEGF and PDG in observation group were significantly higher than those in control group (P<0.05).Conclusions:The combined treatment of Kangfuxin Liquid and mesalazine can significantly improve the clinical efficacy of the patients. The mechanism of its action is related to reducing the inflammatory response and enhancing the immune, antioxidant functionsand vascular factors. It is worthy of further study in clinical.

Clinical observation and experimental study on Kangfuxin fluid in treating indwelling needle-related phlebitis

Objective To investigate the therapeutic effect of Kangfuxin Fluid on indwelling needle-related phlebitis by observation of clinical samples and pharmacological study.Methods Eighty-five patients with indwelling needle-related phlebitis in the neurosurgery department of a Grade A hospital in Shanxi Province from June 2019 to November 2021 were randomly divided into the study group(43 cases)and the vehicle group(42 cases).Patients in the study group were treated with KFX,and patients in the control group were treated with hydrocolloid dressing.The time for symptoms(such as redness and pain)to disappear was recorded.The effect of tissue repair was evaluated by the fin crosscutting model and the anti-inflammatory effect was evaluated by the inflammatory models.Q-PCR assay was used to detect the mRNA expression levels of IL-6 and TNF-αin LPS-stimulated zebrafish.The effect on promoting angiogenesis was evaluated by the inter-segmental blood vascular defect model of zebrafish.Results The curative effect of the study group was better than the control group.The pain resolution time and the swelling resolution time in the study group were(1.67±0.90)d and(2.25±0.92)d,respectively,shorter than those in the control group(P<0.05).KFX can improve the ISV index,increase the regeneration length of the fin,inhibit the migration of neutrophils in three inflammatory models and reduce the mRNA expression levels of IL-6 and TNF-αin LPS-stimulated zebrafish.Conclusion KFX exerts great clinical efficacy in the treatment of indwelling needle-induced phlebitis which may be associated with inflammation inhibition,angiogenesis promotion,and tissue repair.

Study on the clinical effect and safety of Kangfuxin liquid combined with microneedling in the treatment of facial skin photoaging

Background and Objectives:Microneedling has been introduced as a new technique to address the growing concern of facial skin photoaging.Kangfuxin liquid has been found to promote the process of skin wound repair,including reducing inflammatory response,improving immunity and enhancing antioxidant levels.In this prospective randomized double-blinded study,we wanted to explore the clinical efficacy and safety of Kangfuxin liquid combined with microneedling in treating facial skin photoaging.Methods:57 patients with facial skin photoaging were randomly divided into two groups.The treatment group(28 cases)received microneedle therapy with Kangfuxin liquid,while the control group(29 cases)received microneedle therapy with physiological saline.The treatment interval was 4 weeks,and a total of 3 treatments were performed.Compare the VISIA scores of facial photoaging features such as wrinkles,texture,pores,spots and ultraviolet pigmentation between two groups of patients before and after treatment,Global Score for Photoaging,satisfaction evaluation,and record the occurrence of adverse reactions.Results:After treatment,the treatment group showed more significant improvement in wrinkles,texture,pores,spots and ultraviolet pigmentation,and the Global Score for Photoaging was better than the control group(P<0.05).The satisfaction rate with improving skin in the treatment group was 85.71%,which was higher than 75.86%in the control group(P<0.05).Both groups did not experience adverse reactions such as skin infection,pigmentation or hypopigmentation,scar formation,or worsening of melasma.Conclusion:Kangfuxin liquid combined with microneedling therapy has a good improvement effect on facial skin photoaging,with a low incidence of adverse reactions and high patient satisfaction.It is worthy of clinical promotion.

Effects of Kangfuxin Solution (康复新液) Combined with Low-level Laser on Cytokines and Immune Function in Patients with Radiation-induced Oral Mucositis

Objective:To investigate the effect of Kangfuxin Solution(康复新液)combined with low-level laser therapy(LLLT)on cytokines and immune function in patients with radiation-induced oral mucositis.Methods:There were 84 nasopharyngeal carcinoma patients with oral mucositis after intensity-modulated radiation therapy(IMRT)were randomly divided into the control group(CG)and the observation group(OG),with 42 cases in each group.The CG was given LLLT,and the OG was treated with Kangfuxin Solution in addition to LLLT for 10 consecutive days.The healing time of oral mucosa,mucositis grading,oral pain scores,cytokines(interleukin-6,interleukin-1βand tumor necrosis factor-α)and T lymphocyte subsets were compared between the 2 groups before and after treatment.Results:The healing time of oral mucosa in the OG was(6.8±1.4)d,which was significantly shorter than(8.6±1.9)d in the CG(t=4.943,P<0.01).After treatment,the grading of oral mucositis in the OG was better than that in the CG,with a statistically significant difference(Z=2.942,P<0.05).The oral pain scores of the OG was lower than that in the CG at different time points after treatment,and the difference was statistically significant(t=8.207,11.017,P<0.01).After treatment,the levels of IL-6,IL-1βand TNF-αin peripheral blood of the OG were significantly lower than those in the CG(t=5.217,2.775,4.053,P<0.01).There were statistically significant differences in CD4+,CD8+and CD4+/CD8+between the OG and the CG after treatment(t=5.692,6.093,3.658,P<0.01).Conclusion:Kangfuxin Solution combined with LLLT can significantly shorten the healing time of oral mucosal,reduce the grading of oral mucositis,relieve oral pain,reduce inflammatory response and improve the immune function of patients.

A comparison of the effects of Kangfuxin liquid and watermelon frost spray for recurrent aphthous stomatitis:A meta-analysis

Through a meta-analysis,we comprehensively evaluated the clinical efficacy and safety of Kangfuxin liquid(KFXL)in patients with recurrent aphthous stomatitis(RAS).Randomized controlled clinical trials(RCTs)involving RAS patients treated with KFXL were systematically retrieved from several online databases from inception to December 2021.All the study selection,data extraction,and quality assessments were performed by two independent investigators using the Cochrane systematic review method.The total effective rate,VAS pain score,recurrence rate,and ulcer healing time were analyzed using Rev Man 5.3 software and Stata 16.0.A total of 17 studies consisting of 1703 patients were included in our investigation.The pooled result indicated that when compared with watermelon frost spray(WFS),KFXL had a significantly superior clinical effectiveness rate(logRR=0.19,95%CI:0.15 to 0.22,P<0.00001).Moreover,the ulcer healing time(MD=–1.63,95%CI=–2.32 to–0.93,P<0.00001),VAS pain score(MD=–1.81,95%CI:–2.65 to–0.97,P=0.00),and recurrence rate(logRR=–0.65,95%CI=–0.89 to 0.42,P<0.00001)of patients with RAS were also significantly improved after receiving the KFXL therapy.Our study revealed that KFXL was a more effective treatment for RAS than WFS,and it could significantly decrease the VAS pain score,recurrence rate,and ulcer healing time in patients.However,our study was limited by the quality of available literature,and further robust trials are needed for a more accurate analysis.

Kangfuxin(Periplaneta americana)Lotion for Adjunctive Treatment of Ulcerative Colitis:A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Objective: The objective of the study is to investigate the effect of Kangfuxin lotion as adjunctive therapy for treating ulcerative colitis(UC) through a systematic review and meta?analysis of randomized controlled trials(RCTs). Materials and Methods: RCTs comparing Kangfuxin lotion with no treatment, placebo, western medications or combination therapy for treatment of UC were included in this study. Two English and three Chinese electronic databases were searched. All searches ended in December 2017. Data and quality assessment carried out respectively. Rev Man 5.2 software(Copenhagen, The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) was used to analyze with effect estimate presented as mean difference(MD), risk ratio(RR) and 95% confidence interval(CI). Results: Fifteen trials with 1050 participants were included in this review. Overall, 13 trials were eligible for meta?analysis. Kangfuxin lotion combined with Mesalazine was better than Mesalazine on clinical cure rate(RR 1.45, 95% CI 1.24–1.70, 7 trials), recurrence rate of UC(RR 0.22, 95% CI 0.07–0.72, 2 trials), or endoscopic mucosal recovery(RR 8.05, 95% CI 2.64–24.57, 2 trials). And Kangfuxin lotion combined with triple live bacteria tablets(Bifidobacterium-Lactobacillus? Streptococcus thermophilus)was superior with regard to symptoms remission rate(RR 5.36, 95% CI 1.73–16.60, 3 trials), endoscopic disease activity score(MD-2.30, 95% CI-2.64–-1.96, 1 trial). There were no reports on the serious adverse events of Kangfuxin lotion. Conclusion: Kangfuxin lotion as adjunctive treatment appears more effective than medications alone on clinical cure rate, recurrence rate, endoscopic mucosal recovery and improvement rate of related symptoms.

AQC柱前衍生高效液相色谱方法测定康复新液中游离氨基酸和总肽的含量

目的应用6-氨基喹啉基-N-羟基琥珀酰亚氨基氨基甲酸酯(AQC)柱前衍生化技术,建立康复新液中游离氨基酸和总肽的高效液相色谱(HPLC)含量测定方法,并以总肽含量为指标对市售样品进行检测。方法以十八烷基硅烷键合硅胶为填充剂(Kromasil 100-5 C18色谱柱);60%乙腈(A)-0.14 mol·L^(-1)三水合乙酸钠溶液,用磷酸调节pH值至5.0(B)为流动相,梯度洗脱;柱温:39℃;流速:1.0 mL·min^(-1),检测波长:248 nm。结果14种氨基酸均能达到良好的分离效果;门冬氨酸、谷氨酸、丝氨酸、组氨酸、甘氨酸、精氨酸、苏氨酸、丙氨酸、脯氨酸、缬氨酸、赖氨酸、异亮氨酸、亮氨酸和苯丙氨酸分别在2.0~99.7、3.4~168.5、2.8~139.6、4.0~201.4、4.8~238.1、6.7~336.9、3.3~167.5、9.7~487.3、4.1~202.5、4.4~221.6、5.4~270.5、3.3~166.8、4.8~240.8、4.7~236.6μg·mL^(-1)范围内呈现良好的线性关系(r=0.9995~1.0000);游离氨基酸的平均加样回收率(n=6)为86.8%~108.1%,RSD为2.8%~4.4%,总肽酸水解氨基酸的平均加样回收率(n=6)为83.2%~102.7%,RSD为0.1%~3.1%;仪器精密度、重复性、稳定性实验的RSD均小于5.0%。结论该方法与现行质量标准的紫外分光光度法比较,二者测定的总氨基酸含量结果基本一致,但前者的专属性、重现性更优;以具有生物活性的总肽为质控指标,针对性更强,可为康复新液的质量评价提供更科学、合理的方法。

康复新液在消化内镜术后患者中应用效果和安全性的Meta分析

目的系统评价康复新液联合常规治疗在消化内镜术后患者中的应用效果与安全性。方法计算机检索PubMed、Embase、Cochrane Library、CNKI、WanFang Data、VIP数据库,搜集关于消化内镜术后应用康复新液的随机对照试验(RCT),检索时限均从建库至2023年12月31日,由2名研究者独立筛选文献、提取数据并评价纳入研究的偏倚风险后,使用RevMan 5.3和Stata 14软件进行Meta分析。结果共纳入14个RCT,包括1359例患者。Meta分析结果显示,与常规治疗组相比,康复新液联用组可以提高术后溃疡完全愈合率[RR=1.32,95%CI(1.07,1.61),P=0.009]、术后临床症状缓解率[RR=1.20,95%CI(1.13,1.27),P<0.001],但2组的不良反应发生率差异无统计学意义(P>0.05)。亚组分析显示,康复新液联用组术后2周的溃疡完全愈合率高于常规治疗组[RR=1.56,95%CI(1.28,1.92),P<0.001],但2组术后4周的溃疡完全愈合率差异无统计学意义(P>0.05);康复新液口服给药组[RR=1.19,95%CI(1.11,1.27),P<0.001]或经内镜外用喷洒给药组[RR=1.23,95%CI(1.09,1.39),P<0.001]的临床症状缓解率均高于常规治疗组。结论消化内镜术后常规用药基础上联合康复新液治疗可进一步提高患者的临床疗效,尤其是促进术后2周内溃疡完全愈合、缓解术后临床症状方面效果较好,但能否降低药品不良反应发生率的证据不足。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

康复新液联合沙利度胺防治鼻咽癌患者放射性口腔黏膜炎的临床效果

目的 探究康复新液联合沙利度胺预防鼻咽癌(NPC)患者放射性口腔黏膜炎(ROM)的临床效果。方法选取2021—2022年就诊于南昌大学第二附属医院的NPC患者60例,采用随机数字表法分为试验组和对照组,各30例。对照组自放疗开始,每日使用复方漱口液含漱和沙利度胺片口服,试验组在对照组基础上加用康复新液,2组均治疗至放疗结束。比较2组ROM发生情况、放射口腔受量、客观缓解率及不良反应的发生情况。结果 第4、6、8周时,试验组ROM的发生率显著低于对照组(P<0.05),且整个放疗期间试验组3、4级ROM的发生率也低于对照组(P<0.05)。2组口腔照射剂量体积的平均剂量、V30、V40、V50、V55、客观缓解率及不良反应发生率比较,差异均无统计学意义(P>0.05)。结论 康复新液联合沙利度胺可降低NPC患者ROM的发生率并减轻其严重程度。

康复新漱口液辅助治疗对牙周炎合并糖尿病患者口腔菌群和龈沟液相关因子的影响

目的:探讨康复新漱口液辅助治疗对牙周炎合并糖尿病患者口腔菌群和龈沟液相关因子的影响。方法:选取2022年6月-2022年10月于笔者医院接受治疗的98例牙周炎合并糖尿病患者为研究对象,按照随机数字表法将其分为对照组和观察组,每组49例。所有患者均接受牙周基础治疗,在此基础上对照组给予双氧水治疗,观察组在对照组基础上采用康复新漱口液辅助治疗,两组均治疗4周。比较两组患者临床治疗效果及治疗前后牙周相关指标。结果:观察组总有效率为91.84%,高于对照组的77.55%(P<0.05);治疗后,两组PLI、PD、SBI和AL均降低(P<0.05),且观察组均低于对照组(P<0.05);治疗后,观察组Td、Pi、Tf和Pg均低于对照组和治疗前(P<0.05);治疗后,两组TNF-α、IL-6、hs-CRP均降低(P<0.05),且观察组均低于对照组(P<0.05)。结论:给予牙周炎合并糖尿病患者康复新漱口液辅助治疗可改善患者牙周状态,降低口腔菌群水平,减轻炎性状态。

Analysis and monitoring of drug therapy in a patient with peptic ulcer complicated by infection:A case report

BACKGROUND The role of primary-level medical pharmacists in medical institutions in China is limited;therefore,it is necessary to explore the role of pharmacists in the process of drug treatment.CASE SUMMARY A Chinese pharmacist participated in the complete treatment of a patient with a duodenal ulcer.The rationale for drug treatment was evaluated,and adjustments were made to the antacid and anti-infective regimen,as well as the dose and frequency of administration.Body temperature,routine blood examination,and adverse drug reactions were strictly monitored.During treatment,the pharmacist recommended anti-infective therapy with ampicillin-sulbactam,which effectively controlled the infection.Additionally,the pharmacist suggested changing famotidine to lansoprazole for acid suppression and gastroprotective treatment,combined with Chinese patent medicine such as Kangfuxin Liquid.This is the first case report of a pharmacist in primary-level medical institutions adjusting drug use for patients with duodenal ulcer and pulmonary infection.CONCLUSION A pharmacist participated in the treatment process,provided individualized medication adjustment,and achieved good clinical results.

大柴胡汤联合短波紫外线与康复新液治疗小儿溃疡性口腔炎疗效观察

目的:观察大柴胡汤联合短波紫外线与康复新液治疗小儿溃疡性口腔炎的临床疗效。方法:将92例溃疡性口腔炎患儿采用抽签法分为对照组和研究组,各46例.对照组予短波紫外线联合康复新液治疗,研究组在对照组基础上予大柴胡汤治疗。比较两组患者临床疗效、中医证候积分、相关症状改善情况及血清C反应蛋白(C-reaction protein,CRP)、白细胞介素6(interleukin-6,IL-6)、IL-10、肿瘤坏死因子α(tumor necrosis factor α,TNF-α)表达水平及不良反应发生情况。结果:研究组总有效率为93.5%(43/46),高于对照组的80.4%(37/46)(P<0.05);中医证候积分低于对照组(P<0.05);相关症状改善优于对照组(P<0.05);血清CRP、IL-6、IL-10、TNF-α表达均低于对照组(P<0.05);患者潮热及口苦不良反应发生率高于对照组(P<0.05),但总的不良反应发生率两组比较差异无统计学意义(P>0.05)。结论:与单纯短波紫外线联合康复新液治疗比较,大柴胡汤联合短波紫外线与康复新液治疗小儿溃疡性口腔炎疗效更优,能够改善中医证候及症状,降低血清CRP、IL-6、IL-10、TNF-α表达水平,安全性好。

康复新液联合重组人干扰素α-2b治疗慢性宫颈炎的效果

目的分析康复新液联合重组人干扰素α-2b治疗慢性宫颈炎的效果。方法随机抽取平顶山第一人民医院2019年1月至2022年12月收治的800例慢性宫颈炎患者,采用摸红蓝球法分为联合组(400例)与单一组(400例)。单一组接受重组人干扰素α-2b,联合组在单一组基础上接受康复新液。对比两组疗效、临床症状缓解时间(阴道分泌物增多、外阴瘙痒、性交后出血)、宫颈修复时间、不良反应发生率、生活质量。结果联合组总有效率[96.75%(387/400)]较单一组[86.50%(346/400)]高(P<0.05)。与单一组比,联合组阴道分泌物增多、外阴瘙痒、性交后出血缓解时间及宫颈修复时间较短(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。治疗后与单一组比,联合组的患者生活质量评分较高(P<0.05)。结论采用康复新液、重组人干扰素α-2b联合治疗慢性宫颈炎,可改善临床症状,提高生活质量,临床效果和安全性确切。

康复新液联合rb-bFGF凝胶对放射性皮炎患者皮肤恢复情况及炎性反应的影响

目的探究康复新液联合牛碱性成纤维细胞生长因子(rb-bFGF)凝胶治疗放射性皮炎的效果。方法选取2020年3月—2023年3月荣成市人民医院收治的96例放射性皮炎患者为研究对象,按随机数字表法将其分为对照组(n=48)和观察组(n=48)。对照组采用rb-bFGF凝胶治疗,观察组采用康复新液联合rb-bFGF凝胶治疗。比较两组患者的临床疗效、炎性反应、皮肤恢复情况及不良反应发生情况。结果观察组的治疗总有效率为93.75%,高于对照组的79.17%,差异有统计学意义(P<0.05)。治疗后,观察组的白细胞介素-6、C反应蛋白水平均低于对照组,组间差异有统计学意义(P<0.05)。观察组各项症状消失时间均短于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论康复新液联合rb-bFGF凝胶治疗放射性皮炎的效果确切,可减轻患者的炎性反应,促进其皮肤愈合,且安全性较好。

止痛如神汤加减方联合康复新液灌肠治疗气滞血瘀型混合痔术后肛门疼痛的临床效果

目的:观察止痛如神汤加减方联合康复新液灌肠治疗气滞血瘀型混合痔术后肛门疼痛的临床效果。方法:选择2021年1月—2022年12月在崇州市人民医院收治的100例混合痔患者,按照随机数字表法分为A组、B组、C组三组。A组30例,予常规西医治疗;B组35例,在A组基础上予康复新液灌肠治疗;C组35例,在B组基础上,予止痛如神汤加减方治疗。三组术后1 d、7 d均评价创面水肿、创面肉芽组织生长情况,通过数字疼痛评分法(NRS)评价肛门疼痛情况,记录三组患者肛门水肿消退时间、创面分泌物消失时间、创面愈合时间,检测三组肿瘤坏死因子α(TNF-α)、表皮生长因子(EGF)、β-内啡肽(β-EP)、白细胞介素-22(IL-22)、纤维连接蛋白(FN)、血管内皮生长因子(VEGF)水平,术前、术后1个月测量患者直肠肛管抑制反射阈值、肛管静息压、肛管高压带长度。结果:C组创面水肿、NRS评分较A组、B组低(P<0.05),创面肉芽组织生长评分较A组、B组高(P<0.05);C组创面分泌物消失时间、肛门水肿消退时间、创面愈合时间较A组、B组短(P<0.05);C组直肠肛管抑制反射阈值、肛管静息压较A组、B组高(P<0.05),C组肛管高压带长度较A组、B组短(P<0.05);C组TNF-α、IL-22水平较A组、B组低(P<0.05),C组β-EP、EGF、FN、VEGF水平较A组、B组高(P<0.05)。结论:止痛如神汤加减方联合康复新液灌肠可抑制炎症因子水平,调节疼痛介质及EGF、FN、VEGF指标,缓解肛门疼痛,促进创面愈合,提升肛门功能。

康复新液联合PPI治疗反流性食管炎的疗效及安全性Meta分析

目的纳入系统评价康复新液联合质子泵抑制剂(Proton pump inhibitor,PPI)治疗反流性食管炎(Reflux esophagitis,RE)相较于单独使用PPI的疗效和安全性评价。方法以康复新液、反流性食管炎、反流性食道炎、KangFuXin、reflux esophagitis等为检索词在CNKI、WanFang Data、VIP、Embase、Web of Science、PubMed和The Cochrane Library数据库检索康复新液联合PPI治疗RE的随机对照研究,采用RevMan 5.4软件进行Meta分析。结果共纳入25项研究,统计分析结果显示康复新液联合PPI治疗RE较单独PPI治疗能显著提高临床有效率(95%CI:1.15,1.24)、胃镜下有效率(95%CI:1.14,1.22),血清胃泌素(95%CI:1.15,2.03)和胃动素的分泌(95%CI:0.96,1.39),降低复发率(95%CI:0.20,0.61),且不会增高不良反应发生率(95%CI:0.33~0.79),此外,不同PPI种类以及患者年龄高低对临床有效率无显著影响,而不同内镜下诊断标准对内镜下有效率也无显著影响。结论康复新液联合PPI治疗RE较单独PPI治疗能取得更好的疗效且减少疾病复发,并不会额外造成不良反应的发生。

口服血凝酶及康复新液对急性非静脉曲张性上消化道出血患者止血效果的研究

背景急性非静脉曲张性上消化道出血(acute nonvariceal upper gastrointestinal bleeding,ANVUGIB)是临床危急病症,病死率、复发率均较高,但临床尚未形成统一治疗意见,相关研究仍是临床关注重点.本研究尝试联合口服血凝酶及康复新液以提升治疗效果.目的探究口服血凝酶及康复新液在ANVUGIB患者中的应用效果.方法选取2022-03/2024-04义乌市中心医院消化内科的132例ANVUGIB患者,以随机数字表法分为3组,A组接受常规治疗,B组基于A组,给予血凝酶治疗,C组基于B组,给予康复新液治疗.对比3组即时止血有效率、出血停止时间、黑便消失时间、住院时间、再出血率、凝血酶原时间(prothrombin time,PT)、皮质醇(cortisol,Cor)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、抗利尿激素(antidiuretic hormone,ADH)、D-二聚体(D-dimer,D-D)、纤维蛋白原(fibrinogen,FIB)、胃泌素、血红蛋白、凝固角(coagulation angle,α)、反应时间(reaction time,R)、最大振幅(maximum amplitude,MA)及不良反应.结果C组即时止血有效率95.45%(42/44)大于A组65.91%(29/44)、B组81.82%(36/44)(P<0.05),且再出血率0.00%(0/44)小于B组9.09%(4/44)、A组15.91%(7/44)(P<0.05),但A组、B组比较,差异无统计学意义;C组出血停止、黑便消失及住院时间<B组<A组(P<0.05);治疗后C组APTT、PT、D-D、Cor、ADH、胃泌素<B组<A组,FIB、R、α、MA>B组>A组(P<0.05);3组不良反应发生率对比,差异无统计学意义.结论口服血凝酶与康复新液应用于ANVUGIB患者中,可有效控制出血症状,改善凝血指标,调节血栓弹力图指标,降低再出血风险,有助于患者病情恢复.

清凉汤含漱联合康复新液喷剂防治鼻咽癌放射性口腔炎的临床研究

目的:观察予以鼻咽癌(NPC)并发放射性口腔炎病人清凉汤含漱联合康复新液喷剂治疗的临床效果。方法:选取2022年6月—2023年8月医院收治的60例NPC并发放射性口腔炎病人(均初次接受根治性放射治疗、治疗前口腔黏膜完整)为研究对象,按照随机数字表法分为对照组、观察组,每组30例。对照组采取生理盐水含漱治疗;观察组给予清凉汤含漱联合康复新液喷剂治疗。比较两组病人放射性口腔炎发生时间、C反应蛋白(CRP)水平、中医证候积分、治疗效果及口腔炎分级。结果:观察组病人放射性口腔炎发生时间长于对照组(P<0.05);治疗后观察组病人CRP水平、中医证候积分均低于对照组;观察组病人总有效率为90.00%,高于对照组的63.33%(P<0.05);观察组病人口腔炎分级程度轻于对照组(P<0.05)。结论:予以NPC并发放射性口腔炎病人清凉汤含漱+康复新液喷剂治疗可延缓放射性口腔炎发生时间,改善病人临床症状,减轻机体炎症水平,获得良好防治效果。