Two compounds with strongly insecticidal and fungicidal activity, Kurarinone and Sophoraflavanone G , were isolated from Sophora flavescens Ait under the direction of bioassay, and comfirmed by UV, IR, MS and NMR. The...Two compounds with strongly insecticidal and fungicidal activity, Kurarinone and Sophoraflavanone G , were isolated from Sophora flavescens Ait under the direction of bioassay, and comfirmed by UV, IR, MS and NMR. The insecticidal activity of flavonoids from Sophora flavescens Ait was first reported here. The study of structure-activity relationship indicated that the methylation of 5-hydroxy on the phenyl ring would decrease the insecticidal and fungicidal activity of flavonoids.展开更多
目的探讨苦参素(0MT)对三维适形放射治疗中晚期肺癌临床疗效及患者血清VEGF、MMP-9水平的影响。方法将136例中晚期肺癌患者临床资料,按照治疗方案分为对照组(62例)和观察组(74例)。对照组患者给予三维适形放射治疗,观察组在对照组基础...目的探讨苦参素(0MT)对三维适形放射治疗中晚期肺癌临床疗效及患者血清VEGF、MMP-9水平的影响。方法将136例中晚期肺癌患者临床资料,按照治疗方案分为对照组(62例)和观察组(74例)。对照组患者给予三维适形放射治疗,观察组在对照组基础上给予0MT治疗。比较两组中晚期肺癌患者近期疗效、毒副反应及血清VEGF、MMP-9水平。结果两组中晚期肺癌患者近期疗效评价结果显示,观察组总有效率高于对照组(75.7%vs 56.4%,P<0.05)。治疗期间,观察组患者骨髓抑制、胃肠道反应、肝功能损害毒副反应发生率均低于对照组(P<0.05)。治疗后,与对照组相比,观察组患者血清VEGF、MMP-9水平降低(347.3±38.2 vs 404.5±42.0ng/L,476.8±47.3 vs 512.2±53.5ng/L),组间比较均有统计学差异(P<0.05)。结论在三维适形放疗基础上给予0MT治疗可以提高中晚期肺癌近期疗效,降低毒副反应发生率,而且能够降低血清VEGF、MMP-9水平,临床上值得进一步研究。展开更多
文摘Two compounds with strongly insecticidal and fungicidal activity, Kurarinone and Sophoraflavanone G , were isolated from Sophora flavescens Ait under the direction of bioassay, and comfirmed by UV, IR, MS and NMR. The insecticidal activity of flavonoids from Sophora flavescens Ait was first reported here. The study of structure-activity relationship indicated that the methylation of 5-hydroxy on the phenyl ring would decrease the insecticidal and fungicidal activity of flavonoids.
文摘目的探讨苦参素(0MT)对三维适形放射治疗中晚期肺癌临床疗效及患者血清VEGF、MMP-9水平的影响。方法将136例中晚期肺癌患者临床资料,按照治疗方案分为对照组(62例)和观察组(74例)。对照组患者给予三维适形放射治疗,观察组在对照组基础上给予0MT治疗。比较两组中晚期肺癌患者近期疗效、毒副反应及血清VEGF、MMP-9水平。结果两组中晚期肺癌患者近期疗效评价结果显示,观察组总有效率高于对照组(75.7%vs 56.4%,P<0.05)。治疗期间,观察组患者骨髓抑制、胃肠道反应、肝功能损害毒副反应发生率均低于对照组(P<0.05)。治疗后,与对照组相比,观察组患者血清VEGF、MMP-9水平降低(347.3±38.2 vs 404.5±42.0ng/L,476.8±47.3 vs 512.2±53.5ng/L),组间比较均有统计学差异(P<0.05)。结论在三维适形放疗基础上给予0MT治疗可以提高中晚期肺癌近期疗效,降低毒副反应发生率,而且能够降低血清VEGF、MMP-9水平,临床上值得进一步研究。