A series of ternary lanthanide complexes Ln （C6H5CHOHCOO）3（phen） （H2O） （Ln= La, Ce, Pr, Nd, Sm, Eu） were synthesized with α-hydroxyl-phenyl-acetic acid and 1, 10-phenanthroline （phen） as ligands. The sturct...A series of ternary lanthanide complexes Ln （C6H5CHOHCOO）3（phen） （H2O） （Ln= La, Ce, Pr, Nd, Sm, Eu） were synthesized with α-hydroxyl-phenyl-acetic acid and 1, 10-phenanthroline （phen） as ligands. The sturcture and property of complexes were characterized by elemental analysis, IR, 1^H-NMR, UV and TGA, and the coordinate mede of both ligands was discussed. It was shown that the co-ordinate mode of 1, 10-phenanthroline was chelated, while α-hydraxyl-phenyl-acetate ion was monedentate or bridging. The mechanism of thermal determinde by thermogravimetry was indicated that the degree of co-ordinate ability of ligand was： α-hydroxyl-phenyl-acetate ion 〉 1, 10- phenanthroline（phen）.展开更多
The acid-base equilibrium of 1,10-phenanthroline (1,10-phen) in the presence of polyethylene glycol 400 (PEG-400, non-ionic) and tetrabutylammonium bromide (TBAB, ionic) micellar media has been studied by Calvin-Wilso...The acid-base equilibrium of 1,10-phenanthroline (1,10-phen) in the presence of polyethylene glycol 400 (PEG-400, non-ionic) and tetrabutylammonium bromide (TBAB, ionic) micellar media has been studied by Calvin-Wilson titration technique at different mole fractions (0.5% - 2.5%) of PEG-400 and TBAB micellar solutions at an ionic strength of 0.16 mol dm-3 NaCl and at a temperature of 298 K. The pH metric data were subjected to SCPHD program to obtain correction factor and Kw which were given as initial inputs for MINIQUAD75 program to refine protonation constants. HySS program was then used to generate the species distribution diagrams versus pH using the results obtained from the MINIQUAD75 program and SIM run data. The difference in values of protonation constants in aqueous medium (logβ1 = 4.93 & logβ2 = 6.22) and in the micellar media (PEG-400, logβ1 = 4.89 & logβ2 = 5.91 and TBAB, logβ1 = 4.84 & logβ2 = 5.73) is attributed to different intrinsic solvent characteristics of micelles. In case of ionic surfactants, the electrostatic micellar surface is an additional contributing factor.展开更多
Eight new Schiff bases of 5-nitro and 5-bromo-substituted 1,10-phenanthroline-2,9-dicarboxaldehydes with sulfur-containing amines, thiosemicarbazide, S-alkyl/aryl dithiocarbazates and 2-mercaptoaniline have been synth...Eight new Schiff bases of 5-nitro and 5-bromo-substituted 1,10-phenanthroline-2,9-dicarboxaldehydes with sulfur-containing amines, thiosemicarbazide, S-alkyl/aryl dithiocarbazates and 2-mercaptoaniline have been synthesized and characterized by a variety of spectroscopic methods. The condensation reactions of the dialdehydes with the amines were carried out both in the presence and absence of conc. sulfuric acid. A significant increase in yield of the Schiff bases was observed when the reactions were carried out in the presence of sulfuric acid.展开更多
Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antimicrobial and antimalarial properties. In this paper antibacterial studies against variety of plants and ...Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antimicrobial and antimalarial properties. In this paper antibacterial studies against variety of plants and human pathogenic bacteria with eight newly synthesized Schiff bases and several intermediate silyl compounds have been reported. The antibacterial activities of the synthesized compounds were primarily determined by paper disc diffusion method. The minimum inhibitory concentration (MIC) of each compound was also determined by tube dilution process. Seven different human pathogenic bacteria and eighteen different plant pathogenic bacteria were used for the antibacterial activity studies. While all synthesized compounds have shown significant antibacterial activity, one intermediate silyl compound has shown remarkably high antibacterial property. 5-substituted derivatives have shown relatively higher activity than non-substituted compounds. Polar substituent which increases hydrophilicity may have a positive impact on the antibacterial property.展开更多
Three new coordination polymers,namely [Zn（FDA）（phen）（H2O）·H2O]n（1）,[Cd（HFDA）（phen）2（NO3）]（2） and [Cd（FDA）（phen）]n（3）（H2FDA = 2,5-furandicarboxylic acid,phen = 1,10-phenanthroline） have be...Three new coordination polymers,namely [Zn（FDA）（phen）（H2O）·H2O]n（1）,[Cd（HFDA）（phen）2（NO3）]（2） and [Cd（FDA）（phen）]n（3）（H2FDA = 2,5-furandicarboxylic acid,phen = 1,10-phenanthroline） have been synthesized by the solvothermal method and characterized by elemental analysis,IR,powder X-ray diffraction,thermogravimetric analysis and X-ray single-crystal diffraction analysis.For 1,the neighboring Zn^2＋ ions are bridged by FDA2-as linkers to form one-dimensional（1D） chains,and phen ligands are as the terminal ligands.Furthermore,the 1D chains are packed into a three-dimensional（3D） supramolecular structure through hydrogen bonds and π-π interactions.For 2,the H2FDA ligand is partial deprotonation,which is a rare phenomenon among other coordination polymers based on H2FDA.Under the synergetic effect of phen ligands and the partial deprotonation of H2FDA,the structure of 2 is discrete.For 3,the Cd^2＋ ions are linked by two carboxylates of FDA^2-ligand to give rise to 1 D zig-zag chains,and phen ligands chelate the Cd^2＋ ions like 1.In addition,solid-state luminescent spectra of three coordination polymers were also studied at room temperature.展开更多
Two new coordination complexes[Mn(L)_(2)(DNSA)](1) and[Co(L)(1,4-bdc)]_n (2) have been achieved under hydrothermal conditions (H_(2)DNSA=3,5-dinitro-salicylic acid,1,4-bdc=1,4-benzenedicarboxylic acid and L=2-(2-fluor...Two new coordination complexes[Mn(L)_(2)(DNSA)](1) and[Co(L)(1,4-bdc)]_n (2) have been achieved under hydrothermal conditions (H_(2)DNSA=3,5-dinitro-salicylic acid,1,4-bdc=1,4-benzenedicarboxylic acid and L=2-(2-fluoro-6-fluorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline).1 crystallizes in monoclinic,space group P2_1/c with a=15.871(3),b=17.274(4),c=16.078(3)A,β=113.03(3)^(o),V=4056.6(16)A^(3),Z=4,C_(45)H_(22)Cl_(2)F_(2)Mn N_(10)O_(7),M_(r)=978.57,D_(c)=1.602 g/cm^(3),F(000)=1980,μ(Mo Ka)=0.536 mm^(–1),R=0.0437 and w R=0.1065.2 belongs to the monoclinic system,space group C2/c with a=14.665(2),b=30.856(4),c=11.237(2)A,β=111.166(2)^(o),V=4742.0(12)A^(3),Z=8,C_(27)H_(14)Cl Co FN_(4)O_(4),M_r=517.80,D_(c)=1.602 g/cm^(3),F(000)=2312,μ(Mo Ka)=0.889 mm^(–1),R=0.0364 and w R=0.0862.The central Mn(II) ion in 1 is six-coordinated by four nitrogen atoms from two L ligands and two oxygen atoms from one DNSA anion.In 2,the two kinds of 1,4-bdc ligands link neighboring Co(II) atoms to yield a two-dimensional layer structure.The luminescence of 1 has been studied in detail.Moreover,thermal behaviors of 1 and 2 are also investigated.展开更多
The nonlinear refractive indexes n 2 for the ethanol solutions of 1,10-phenanthroline (2.0×10 -3 mol·L -1), [bis(1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1), and [nitrato-fluo...The nonlinear refractive indexes n 2 for the ethanol solutions of 1,10-phenanthroline (2.0×10 -3 mol·L -1), [bis(1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1), and [nitrato-fluoracil-bis (1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1) are first measured, the third-order nonlinear optical susceptibilities χ (3) and <γ> are calculated, and the mechanisms of the third-order optical nonlinearities enhanced by lanthanum (Ⅲ) are discussed preliminarily.展开更多
Toll-like receptors (TLRs) play a key role in B cell-mediated innate and adaptive immunity. It has been shown that interleukin 10 (IL-10)-producing regulatory B cells (B10 cells) can negatively regulate cellular immun...Toll-like receptors (TLRs) play a key role in B cell-mediated innate and adaptive immunity. It has been shown that interleukin 10 (IL-10)-producing regulatory B cells (B10 cells) can negatively regulate cellular immune responses and inflammation in autoimmune diseases. In this study, we determined the effect of TLR4 signaling on the CD40-activated B10 cell competency. The results demonstrated that LPS and CD40L synergistically stimulated proliferation of mouse splenocytes. The percentage of B10 cells in cultured splenocytes was significantly increased after CD40L stimulation but such increase was diminished by the addition of LPS. Such effects by LPS were only observed in cells from WT but not TLR4−/−mice. IL-10 mRNA expression and protein production in B10 cells from cultured splenocytes were significantly up-regulated by CD40L stimulation but were inhibited after the addition of LPS in a TLR4-dependent manner. This study suggests that LPS-induced TLR4 signaling attenuate CD40L-activated regulatory B10 cell competency.展开更多
The faradaic ion transfer of protonated 1,10-phenanthrolino [H(Phen)^+] across the interface between unbuffered aqueous and 1,2-dichloroethane(DCE)solutions was inves- tigated by means of current scan polarography at ...The faradaic ion transfer of protonated 1,10-phenanthrolino [H(Phen)^+] across the interface between unbuffered aqueous and 1,2-dichloroethane(DCE)solutions was inves- tigated by means of current scan polarography at ascending aqueous electrolyte electrode, as well as chronopotentiometry.It follows from the splitting of the waves observed at the pH of aqueous phase(sodium sulfate solution)between 2.5—3.8 that neutral reagent(Phen) distributes into the aqueous phase,where it is protonated.The positive wave is associated with the mass transfer controlled by the H^+ influx,whereas the negative one is by the Phen influx.The reverse chronopotentiometry indicated that all the protonated transfer processes were reversible.A good agreement between experimental results and theoretical treatment was achieved.The aqueous acid dissociation constant of protonated Phen,K_a,can be evalu- ated from the dependence of the wave heights on the pH in the base of the equilibrium.展开更多
文摘A series of ternary lanthanide complexes Ln （C6H5CHOHCOO）3（phen） （H2O） （Ln= La, Ce, Pr, Nd, Sm, Eu） were synthesized with α-hydroxyl-phenyl-acetic acid and 1, 10-phenanthroline （phen） as ligands. The sturcture and property of complexes were characterized by elemental analysis, IR, 1^H-NMR, UV and TGA, and the coordinate mede of both ligands was discussed. It was shown that the co-ordinate mode of 1, 10-phenanthroline was chelated, while α-hydraxyl-phenyl-acetate ion was monedentate or bridging. The mechanism of thermal determinde by thermogravimetry was indicated that the degree of co-ordinate ability of ligand was： α-hydroxyl-phenyl-acetate ion 〉 1, 10- phenanthroline（phen）.
文摘The acid-base equilibrium of 1,10-phenanthroline (1,10-phen) in the presence of polyethylene glycol 400 (PEG-400, non-ionic) and tetrabutylammonium bromide (TBAB, ionic) micellar media has been studied by Calvin-Wilson titration technique at different mole fractions (0.5% - 2.5%) of PEG-400 and TBAB micellar solutions at an ionic strength of 0.16 mol dm-3 NaCl and at a temperature of 298 K. The pH metric data were subjected to SCPHD program to obtain correction factor and Kw which were given as initial inputs for MINIQUAD75 program to refine protonation constants. HySS program was then used to generate the species distribution diagrams versus pH using the results obtained from the MINIQUAD75 program and SIM run data. The difference in values of protonation constants in aqueous medium (logβ1 = 4.93 & logβ2 = 6.22) and in the micellar media (PEG-400, logβ1 = 4.89 & logβ2 = 5.91 and TBAB, logβ1 = 4.84 & logβ2 = 5.73) is attributed to different intrinsic solvent characteristics of micelles. In case of ionic surfactants, the electrostatic micellar surface is an additional contributing factor.
文摘Eight new Schiff bases of 5-nitro and 5-bromo-substituted 1,10-phenanthroline-2,9-dicarboxaldehydes with sulfur-containing amines, thiosemicarbazide, S-alkyl/aryl dithiocarbazates and 2-mercaptoaniline have been synthesized and characterized by a variety of spectroscopic methods. The condensation reactions of the dialdehydes with the amines were carried out both in the presence and absence of conc. sulfuric acid. A significant increase in yield of the Schiff bases was observed when the reactions were carried out in the presence of sulfuric acid.
文摘Schiff bases are known to possess anticancer, antibacterial, antifungal, antitubercular, anti-inflammatory, antimicrobial and antimalarial properties. In this paper antibacterial studies against variety of plants and human pathogenic bacteria with eight newly synthesized Schiff bases and several intermediate silyl compounds have been reported. The antibacterial activities of the synthesized compounds were primarily determined by paper disc diffusion method. The minimum inhibitory concentration (MIC) of each compound was also determined by tube dilution process. Seven different human pathogenic bacteria and eighteen different plant pathogenic bacteria were used for the antibacterial activity studies. While all synthesized compounds have shown significant antibacterial activity, one intermediate silyl compound has shown remarkably high antibacterial property. 5-substituted derivatives have shown relatively higher activity than non-substituted compounds. Polar substituent which increases hydrophilicity may have a positive impact on the antibacterial property.
基金supported by the National Natural Science Foundation of China(21501012)
文摘Three new coordination polymers,namely [Zn（FDA）（phen）（H2O）·H2O]n（1）,[Cd（HFDA）（phen）2（NO3）]（2） and [Cd（FDA）（phen）]n（3）（H2FDA = 2,5-furandicarboxylic acid,phen = 1,10-phenanthroline） have been synthesized by the solvothermal method and characterized by elemental analysis,IR,powder X-ray diffraction,thermogravimetric analysis and X-ray single-crystal diffraction analysis.For 1,the neighboring Zn^2＋ ions are bridged by FDA2-as linkers to form one-dimensional（1D） chains,and phen ligands are as the terminal ligands.Furthermore,the 1D chains are packed into a three-dimensional（3D） supramolecular structure through hydrogen bonds and π-π interactions.For 2,the H2FDA ligand is partial deprotonation,which is a rare phenomenon among other coordination polymers based on H2FDA.Under the synergetic effect of phen ligands and the partial deprotonation of H2FDA,the structure of 2 is discrete.For 3,the Cd^2＋ ions are linked by two carboxylates of FDA^2-ligand to give rise to 1 D zig-zag chains,and phen ligands chelate the Cd^2＋ ions like 1.In addition,solid-state luminescent spectra of three coordination polymers were also studied at room temperature.
基金Supported by the National Natural Science Foundation of China(No.21805110)。
文摘Two new coordination complexes[Mn(L)_(2)(DNSA)](1) and[Co(L)(1,4-bdc)]_n (2) have been achieved under hydrothermal conditions (H_(2)DNSA=3,5-dinitro-salicylic acid,1,4-bdc=1,4-benzenedicarboxylic acid and L=2-(2-fluoro-6-fluorophenyl)-1H-imidazo[4,5-f][1,10]phenanthroline).1 crystallizes in monoclinic,space group P2_1/c with a=15.871(3),b=17.274(4),c=16.078(3)A,β=113.03(3)^(o),V=4056.6(16)A^(3),Z=4,C_(45)H_(22)Cl_(2)F_(2)Mn N_(10)O_(7),M_(r)=978.57,D_(c)=1.602 g/cm^(3),F(000)=1980,μ(Mo Ka)=0.536 mm^(–1),R=0.0437 and w R=0.1065.2 belongs to the monoclinic system,space group C2/c with a=14.665(2),b=30.856(4),c=11.237(2)A,β=111.166(2)^(o),V=4742.0(12)A^(3),Z=8,C_(27)H_(14)Cl Co FN_(4)O_(4),M_r=517.80,D_(c)=1.602 g/cm^(3),F(000)=2312,μ(Mo Ka)=0.889 mm^(–1),R=0.0364 and w R=0.0862.The central Mn(II) ion in 1 is six-coordinated by four nitrogen atoms from two L ligands and two oxygen atoms from one DNSA anion.In 2,the two kinds of 1,4-bdc ligands link neighboring Co(II) atoms to yield a two-dimensional layer structure.The luminescence of 1 has been studied in detail.Moreover,thermal behaviors of 1 and 2 are also investigated.
文摘The nonlinear refractive indexes n 2 for the ethanol solutions of 1,10-phenanthroline (2.0×10 -3 mol·L -1), [bis(1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1), and [nitrato-fluoracil-bis (1,10-phenanthroline) lanthanum (Ⅲ)] nitrate (1.0×10 -3 mol·L -1) are first measured, the third-order nonlinear optical susceptibilities χ (3) and <γ> are calculated, and the mechanisms of the third-order optical nonlinearities enhanced by lanthanum (Ⅲ) are discussed preliminarily.
文摘Toll-like receptors (TLRs) play a key role in B cell-mediated innate and adaptive immunity. It has been shown that interleukin 10 (IL-10)-producing regulatory B cells (B10 cells) can negatively regulate cellular immune responses and inflammation in autoimmune diseases. In this study, we determined the effect of TLR4 signaling on the CD40-activated B10 cell competency. The results demonstrated that LPS and CD40L synergistically stimulated proliferation of mouse splenocytes. The percentage of B10 cells in cultured splenocytes was significantly increased after CD40L stimulation but such increase was diminished by the addition of LPS. Such effects by LPS were only observed in cells from WT but not TLR4−/−mice. IL-10 mRNA expression and protein production in B10 cells from cultured splenocytes were significantly up-regulated by CD40L stimulation but were inhibited after the addition of LPS in a TLR4-dependent manner. This study suggests that LPS-induced TLR4 signaling attenuate CD40L-activated regulatory B10 cell competency.
基金Project supported by the National Natural Science Foundation of China.
文摘The faradaic ion transfer of protonated 1,10-phenanthrolino [H(Phen)^+] across the interface between unbuffered aqueous and 1,2-dichloroethane(DCE)solutions was inves- tigated by means of current scan polarography at ascending aqueous electrolyte electrode, as well as chronopotentiometry.It follows from the splitting of the waves observed at the pH of aqueous phase(sodium sulfate solution)between 2.5—3.8 that neutral reagent(Phen) distributes into the aqueous phase,where it is protonated.The positive wave is associated with the mass transfer controlled by the H^+ influx,whereas the negative one is by the Phen influx.The reverse chronopotentiometry indicated that all the protonated transfer processes were reversible.A good agreement between experimental results and theoretical treatment was achieved.The aqueous acid dissociation constant of protonated Phen,K_a,can be evalu- ated from the dependence of the wave heights on the pH in the base of the equilibrium.
