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Constructing Electron Microscope Labs: Challenges and Solutions
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作者 Limei Cha Markus Walkling-Ribeiro +2 位作者 Zhenxi Guo Yaron Kauffman Constance Van Horne 《Journal of Building Construction and Planning Research》 2024年第3期53-68,共16页
The construction of advanced laboratories for precision instruments, such as electron microscopes, involves unique challenges that are influenced by the specific environmental conditions required for optimal functiona... The construction of advanced laboratories for precision instruments, such as electron microscopes, involves unique challenges that are influenced by the specific environmental conditions required for optimal functionality. These include mitigating interference from magnetic fields and vibrations, which are critical for maintaining the precision and accuracy of the instruments used. This study aims to offer enhanced project management strategies and detailed construction solutions that address the environmental and technical needs specific to electron microscopy labs, thereby facilitating effective lab operations and extending the lifecycle of high-end precision instruments. Case studies of existing laboratory constructions, onsite investigations, and comprehensive reviews of the technical and environmental requirements provide the basis for a best practice for constructing sophisticated electron microscopy labs. The approach integrates both pre-construction planning and post-construction adjustments to create optimal operational environments. The findings suggest that successful lab constructions are those that incorporate thorough onsite assessments, strategic location choices, and the use of advanced construction materials and techniques specifically designed to counteract environmental challenges like magnetic and vibration interferences. Actionable guidelines for both planning and executing the construction of electron microscope labs highlighted in this tutorial are intended as an important resource to troubleshoot or upgrade existing lab facilities and to consult in preparation of future lab construction projects. 展开更多
关键词 laboratory construction Development Strategies MANAGEMENT Case Study Electron Microscope Magnetic Shielding VIBRATION
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江苏省新型冠状病毒核酸检测实验室能力建设调查 被引量:6
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作者 杜晶琳 史烨梁 +3 位作者 徐佳南 张思萌 温长康 黄自发 《中国卫生资源》 北大核心 2021年第3期238-242,共5页
目的了解江苏省各级疾病预防控制机构应对新型冠状病毒的实验室能力情况,为优化省、市和区(县)生物安全实验室网络布局、满足新型冠状病毒肺炎等重大疫情防控多层次检测需求提供政策依据。方法根据新型冠状病毒检测所需的实验室仪器、... 目的了解江苏省各级疾病预防控制机构应对新型冠状病毒的实验室能力情况,为优化省、市和区(县)生物安全实验室网络布局、满足新型冠状病毒肺炎等重大疫情防控多层次检测需求提供政策依据。方法根据新型冠状病毒检测所需的实验室仪器、专业技术人员、实验室备案与质量控制等关键指标制定调查表进行调查,并对调查结果进行统计学分析。结果江苏省共有疾病预防控制机构112家,配备生物安全实验室124个,核酸提取、定量聚合酶链式反应(polymerase chain reaction,PCR)仪器分别为85和112台,核酸检测专业人员有249人,仅有29个实验室完成PCR备案,全省每日最大检测样本数为5236个,占理论值的74.0%。结论江苏省新冠病毒核酸检测相关的实验室能力尚不均衡。省、市两级生物安全实验室能力建设较好,区(县)级较为薄弱,区(县)级疾病预防控制机构普遍存在仪器设备配备不足和检测人员缺乏等问题,具备核酸检测能力的机构较少;区域资源配置不均衡,苏北地区硬件设施和人员配置相对不足,具备核酸检测能力的机构较少;全省疾病预防控制机构的实验室均存在PCR备案和质量控制管理不完善的问题。 展开更多
关键词 新型冠状病毒核酸检测nucleic acid detection for novel coronavirus 实验室建设laboratory construction 检测能力detection ability 疾病预防控制机构disease control and prevention institution 江苏省Jiangsu Province
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