期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
RING-OPENING COPOLYMERIZATION OF DL-LACTIDE AND POLY(ETHYLENE GLYCOL) INITIATED BY LANTHANUM ACETATE AND APPLICATION OF THE COPOLYMER AS MATRIX OF MICROSPHERES CONTAINING VIBRIO CHOLERA ANTIGENS 被引量:1
1
作者 Xian-mo Deng Xiao-hong Li +4 位作者 Ming-long Yuan Xiong-wei Li Cheng-dong Xiong Zhi-tang Huang Wen-xiang Jia Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, China West China University of Medical Sciences, Chengdu, 610041, China 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 1999年第3期265-270,共6页
Poly-dl-lactide-poly(ethylene glycol) (PELA) triblock copolymers were synthesized with lanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outer membrane protein (OMP) were ... Poly-dl-lactide-poly(ethylene glycol) (PELA) triblock copolymers were synthesized with lanthanum acetate as the initiator. PELA microspheres with entrapped Vibrio Cholera antigen and outer membrane protein (OMP) were prepared by a double emulsion W/O/W based on solvent extraction methods. The obtained microspheres showed smooth and spherical surface and their size varied between 0.5 and 5.0 mu m, which are suitable for oral targeting delivery system. The distribution tests in rabbits and mice through scanning electronic micrography and fluorescence microscope indicated that microspheres have successfully reached the immunization-related tissues, such as the liver, spleen and intestinal peyer's patches, following oral administration. The PELA microspheres were also evaluated as an efficient antigen delivery system by enhancing a higher protective ratio against live Vibrios Cholera. 展开更多
关键词 poly-dl-lactide-poly(ethylene glycol) Vibrio Cholera antigen lanthanum acetate microsphere protective ratio
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部