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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice
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作者 Yan Zheng Ei Ei Khine +9 位作者 Khin Mar Thi Ei Ei Nyein Likun Huang Lihui Lin Xiaofang Xie Min Htay Wai Lin Khin Than Oo Myat Myat Moe San San Aye Weiren Wu 《The Crop Journal》 SCIE CSCD 2024年第2期549-557,共9页
Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq ... Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability. 展开更多
关键词 BSA-seq QTL mapping large F3 population Multi-environment experiment Cross-validation
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Dihydroartemisinin enhances cell apoptosis in diffuse large B cell lymphoma by inhibiting the STAT3 activity
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作者 ZHENG CAO CHUNXIAO ZHOU +5 位作者 ZHIMIN WU CHUNYAN WU WEN ZHANG SHILV CHEN XINDONG ZHAO SHAOLING WU 《BIOCELL》 SCIE 2023年第5期1075-1083,共9页
Background:Dihydroartemisinin(DHA)is reported to be a potential anticancer agent,and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure.This study aimed to assess t... Background:Dihydroartemisinin(DHA)is reported to be a potential anticancer agent,and the mechanisms underlying the effects of DHA on diffuse large B cell lymphoma however are still obscure.This study aimed to assess the antitumor effect of DHA on diffuse large B cell lymphoma cells and to determine the potential underlying mechanisms of DHA-induced cell apoptosis.Methods:Here,the Cell Counting Kit 8 assay was conducted to study cell proliferation.We performed Annexin V-FITC/propidium iodide staining,real-time polymerase chain reaction,and western blot analysis to analyze cell apoptosis and potential molecular mechanisms.Results:The results showed that DHA substantially suppressed cell proliferation and induced cell apoptosis in vitro in a time-and concentration-dependent fashion.Moreover,STAT3 activity could be inhibited after stimulation with DHA.Conclusion:These results imply that the underlying anti-tumoral effect of DHA may increase apoptosis in diffuse large B cell lymphoma cells via the STAT3 signaling pathway.In addition,DHA might be an effective drug for diffuse large B cell lymphoma therapy. 展开更多
关键词 Diffuse large B cell lymphoma DIHYDROARTEMISININ STAT3 Cell apoptosis
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Development and preliminary results of a large-pixel two-layer LaBr_(3) Compton camera prototype
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作者 Ming-Hao Dong Zhi-Yang Yao Yong-Shun Xiao 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2023年第8期100-114,共15页
Lanthanum bromide(LaBr_(3))crystal has a high energy resolution and time resolution and has been used in Compton cameras(CCs)over the past few decades.However,LaBr_(3) crystal arrays are difficult to process because L... Lanthanum bromide(LaBr_(3))crystal has a high energy resolution and time resolution and has been used in Compton cameras(CCs)over the past few decades.However,LaBr_(3) crystal arrays are difficult to process because LaBr_(3) is easy to crack and break;thus,few LaBr_(3)-based CC prototypes have been built.In this study,we designed and fabricated a large-pixel LaBr_(3) CC prototype and evaluated its performance with regard to position,energy,and angular resolution.We used two 10×10 LaBr_(3) crystal arrays with a pixel size of 5 mm×5 mm,silicon photomultipliers(SiPMs),and corresponding decoding circuits to construct our prototype.Additionally,a framework based on a Voronoi diagram and a lookup table was developed for list-mode projection data acquisition.Monte Carlo(MC)simulations based on Geant4 and experiments were conducted to evaluate the performance of our CC prototype.The lateral position resolution was 5 mm,and the maximum deviation in the depth direction was 2.5 and 5 mm for the scatterer and absorber,respectively.The corresponding measured energy resolu-tions were 7.65%and 8.44%,respectively,at 511 keV.The experimental results of ^(137)Cs point-like sources were consistent with the MC simulation results with regard to the spatial positions and full widths at half maximum(FWHMs).The angular resolution of the fabricated prototype was approximately 6°when a point-like ^(137)Cs source was centrally placed at a distance of 5 cm from the scatterer.We proposed and investigated a large-pixel LaBr_(3) CC for the first time and verified its feasibility for use in accurate spatial positioning of radiative sources with a high angular resolution.The proposed CC can satisfy the requirements of radiative source imaging and positioning in the nuclear industry and medical applications. 展开更多
关键词 Compton camera large pixel Gamma camera LaBr_(3)detector Prototype evaluation
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血清KLF2、NOS3水平对大动脉粥样硬化型急性脑梗死患者的诊断及病情评估价值
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作者 王天舒 景黎君 +1 位作者 杨亚琼 滕军放 《中国动脉硬化杂志》 CAS 2024年第6期527-531,共5页
[目的]探讨锌指样转录因子2(KLF2)、内皮型一氧化氮合酶3(NOS3)水平在大动脉粥样硬化(LAA)型急性脑梗死(ACI)患者诊断及病情评估中的价值。[方法]将150例LAA型ACI患者根据病情分为轻度组(n=36)、中度组(n=48)和重度组(n=66),另选取同期... [目的]探讨锌指样转录因子2(KLF2)、内皮型一氧化氮合酶3(NOS3)水平在大动脉粥样硬化(LAA)型急性脑梗死(ACI)患者诊断及病情评估中的价值。[方法]将150例LAA型ACI患者根据病情分为轻度组(n=36)、中度组(n=48)和重度组(n=66),另选取同期门诊健康体检者设为对照组(n=150)。比较各组血清KLF2、NOS3水平;ROC曲线分别分析血清KLF2、NOS3水平对LAA型ACI的诊断价值和对发生重度LAA型ACI的预测价值。[结果]LAA型ACI组患者血清KLF2、NOS3水平显著低于对照组(P<0.05)。轻、中、重度组LAA型ACI患者血清KLF2、NOS3水平依次显著降低(P<0.05)。血清KLF2、NOS3二者联合诊断LAA型ACI的AUC为0.858,灵敏度为73.33%,特异度为86.00%,优于KLF2、NOS3各自单独诊断(Z联合检测-KLF2=3.796,Z联合检测-NOS3=4.689,均P<0.001)。血清KLF2、NOS3二者联合预测发生重度LAA型ACI的AUC为0.878,灵敏度为77.27%,特异度为90.48%,优于KLF2、NOS3各自单独预测(Z联合检测-KLF2=2.401,P=0.016;Z联合检测-NOS3=3.070,P=0.002)。[结论]LAA型ACI患者血清KLF2、NOS3水平显著降低,且与病情严重程度显著负相关,二者联合应用对LAA型ACI诊断和病情预测具有较高的评估效能。 展开更多
关键词 锌指样转录因子2 内皮型一氧化氮合酶3 大动脉粥样硬化 急性脑梗死 疾病诊断 病情评估
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Fe-3%Si大尺寸合金单晶的制备及磁感系数的计算
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作者 游清雷 蒋奇武 +2 位作者 庞树芳 贾志伟 张海利 《鞍钢技术》 CAS 2024年第3期26-31,共6页
以取向Fe-3%Si合金热轧板为原材料,采用二次再结晶法制备了尺寸大于200 mm的合金单晶。随机选取3个单晶样品剪切成7个与轧向成不同角度、尺寸为50 mm×50 mm的样品,分别对所选样品进行单晶定向,并对每个样品的横、纵向磁性能进行了... 以取向Fe-3%Si合金热轧板为原材料,采用二次再结晶法制备了尺寸大于200 mm的合金单晶。随机选取3个单晶样品剪切成7个与轧向成不同角度、尺寸为50 mm×50 mm的样品,分别对所选样品进行单晶定向,并对每个样品的横、纵向磁性能进行了测量。以单晶定向结果为依据,计算每个单晶在晶体学坐标架下的极角和辐角,提出了一种单晶磁感系数的计算方法,并基于该方法以单晶磁性能实测值及其在晶体学坐标架下的极角和辐角为输入条件,测算了Fe-3%Si合金单晶磁感应强度系数并验证了其可靠性。采用该方法对{110}晶面平行于板面的任意方向单晶的磁感应强度进行了计算,为开展多晶材料磁性能计算提供了理论依据。 展开更多
关键词 Fe-3%Si合金 大尺寸单晶 磁感系数 定量计算
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Modeling and simulation of solvent behavior and temperature distribution within long stick propellants with large web thickness undergoing drying 被引量:2
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作者 Enfa Fu Qianling Liu +3 位作者 Yu Luan Yao Zhu Weidong He Zhenggang Xiao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2023年第10期42-55,共14页
Drying is a complicated physical process which involves simultaneous heat and mass transfer in the removal of solvents inside propellants.Inappropriate drying techniques may result in the formation of a hard skin laye... Drying is a complicated physical process which involves simultaneous heat and mass transfer in the removal of solvents inside propellants.Inappropriate drying techniques may result in the formation of a hard skin layer near the surface to block the free access of most solvent through for long stick propellants with large web thickness,which lead to lower drying efficiency and worse drying quality.This study aims to gain a comprehensive understanding of drying process and clarify the mechanism of the blocked layer near the propellant surface.A new three-dimensional coupled heat and mass transfer(3D-CHMT)model was successfully developed under transient conditions.The drying experiment results show that the 3DCHMT model could be applied to describe the drying process well since the relative error of the content of solvent between simulation and experiment values is only 5.5%.The solvent behavior simulation demonstrates that the mass transfer process can be divided into super-fast(SF)and subsequent minorfast(MF)stages,and the SF stage is vital to the prevention of the blocked layer against the free access for solvent molecules inside propellant grains.The effective solvent diffusion coefficient(Deff)of the propellant surface initially increases from 3.4×10^(-6)to 5.3×10^(-6)m^(2)/s as the temperature increases,and then decreases to 4.1×10^(-8)m^(2)/s at 60-100 min.The value of Deffof surface between 0-1.4 mm has a unique trend of change compared with other regions,and it is much lower than that of the internal at100 min under simulation conditions.Meanwhile,the temperature of the propellant surface increases rapidly at the SF stage(0-100 min)and then very slowly thereafter.Both the evolution of Deffand temperature distribution demonstrate that the blocked layer near the propellant surface has been formed in the time period of approximately 0-100 min and its thickness is about 1.4 mm.To mitigate the formation of blocked layer and improve its drying quality of finial propellant products effectively,it should be initially dried at lower drying temperature(30-40℃)in 0-100 min and then dried at higher drying temperature(50-60℃)to reduce drying time for later drying process in double base gun propellants.The present results can provide theoretical guidance for drying process and optimization of drying parameters for long stick propellants with large web thickness. 展开更多
关键词 Stick propellants DRYING large web thickness 3D numerical modeling Heat transfer Solvent behavior
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Stiffness of Postural Alignment System Based on 3-Axis Actuators for Large Aircraft Components 被引量:4
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作者 GUO Zhimin JIANG Junxia KE Yinglin 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2010年第4期524-531,共8页
Aircraft digital flexible assembly fixture and technologies are widely used in developed countries, while the traditional jig-based assembly mode is still used in China. The application study of aircraft digital flexi... Aircraft digital flexible assembly fixture and technologies are widely used in developed countries, while the traditional jig-based assembly mode is still used in China. The application study of aircraft digital flexible assembly system is just beginning in our country recently. To meet the requirements of automated posture alignment and join in digital assembly system for large aircraft components, a novel fitting fixture called 3-axis actuator is developed. On the basis of the actuators, three kinds of posture alignment system for large aircraft components are proposed, including the non-redundant system, the redundant actuating system, and the redundant leg system, and their constitutions and properties are introduced. Through deriving the feeding transmission stiffness model of single actuator and analyzing the inverse kinematics of these systems, the relationship between the external force and the changes of position and orientation of large aircraft component is obtained, and then the postural alignment stiffness models are established. With the method mentioned above, the postural alignment stiffness of three systems is computed by using the algebraic formulate, and the results show that redundant properties can increase system's postural alignment stiffness. As an example, a optimized layout of the assembly system for a given model of aircraft is developed, the results of application show that the layout has many advantages, such as high accuracy, stiffness, stability, reliability, efficiency and flexible, which can satisfy the requirement of aircraft digital assembly system well. The proposed study of postural alignment stiffness for different systems can supply the theoretic support for the optimization layout design of aircraft digital assembly system, and contribute to evaluate the system working performance of systems. 展开更多
关键词 3-axis actuator large aircraft component redundant postural alignment stiffness posture-holding
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Large-Scale Synthesis of Porous Bi2O3 with Oxygen Vacancies for Efficient Photodegradation of Methylene Blue 被引量:2
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作者 Li-rong Wang Ting-ting Hou +5 位作者 Yue Xin Wen-kun Zhu Shu-yi Yu Zi-cheng Xie Shu-quan Liang Liang-bing Wang 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2020年第4期500-506,I0002,共8页
Photocatalytic degradation of organic pollutants has become a hot research topic because of its low energy consumption and environmental-friendly characteristics.Bismuth oxide(Bi2O3)nanocrystals with a bandgap ranging... Photocatalytic degradation of organic pollutants has become a hot research topic because of its low energy consumption and environmental-friendly characteristics.Bismuth oxide(Bi2O3)nanocrystals with a bandgap ranging from 2.0 eV to 2.8 eV have attracted increasing attention due to high activity of photodegradation of organic pollutants by utilizing visible light.Though several methods have been developed to prepare Bi2O3-based semiconductor materials over recent years,it is still difficult to prepare highly active Bi2O3 catalysts in large scale with a simple method.Therefore,developing simple and feasible methods for the preparation of Bi2O3 nanocrystals in large scale is important for the potential applications in industrial wastewater treatment.In this work,we successfully prepared porous Bi2O3 in large scale via etching commercial Bi Sn powders,followed by thermal treatment with air.The acquired porous Bi2O3 exhibited excellent activity and stability in photocatalytic degradation of methylene blue.Further investigation of the mechanism witnessed that the suitable band structure of porous Bi2O3 allowed the generation of reactive oxygen species,such as O2^-·and·OH,which effectively degraded MB. 展开更多
关键词 Bi2O3 photocatalyst Photocatalytic degradation large scale Visible light PHOTOCATALYSIS
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Synthesis of Macro-Mesostructured γ-Al_2O_3 with Large Pore Volume and High Surface Area by a Facile Secondary Reforming Method 被引量:2
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作者 Meng Xiuhong Duan Linhai +2 位作者 Xie Xiaohua Wang Qiang Wang Haiyan 《China Petroleum Processing & Petrochemical Technology》 SCIE CAS 2014年第2期20-28,共9页
Through improving the aging process during synthesis of the support, γ-Al2O3 with large pore volume and high surface area was synthesized by a facile secondary reforming method. The synthesis parameters, such as the ... Through improving the aging process during synthesis of the support, γ-Al2O3 with large pore volume and high surface area was synthesized by a facile secondary reforming method. The synthesis parameters, such as the reaction temperature, the first aging temperature and the second aging temperature, were investigated. The textural properties of γ-Al2O3 were characterized by means of N2 adsorption-desorption isotherms, X-ray powder diffractometry (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and thermogravimetry (TG). The experimental results indicated that AACH and amorphous A1OOH were the precursors of alumina, which were formed via precipitation from solutions after reaction of aluminum sulphate with ammonium hydrogen carbonate. The precursor nanocrystallites grew and re-assembled during the secondary reforming process, which resulted in an increased pore size and pore volume and a decreased bulk density. The as-synthesized γ-Al2O3 materials featured meso/macroporosity, large pore volume (2.175 cm^3/g), high surface area (237.8 m^2/g), and low bulk density (0.284 g/mL). 展开更多
关键词 Γ-AL2O3 macro-mesostructured reforming method large pore volume high surface area.
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Controllable synthesis of a self-assembled ultralow Ru,Ni-doped Fe_(2)O_(3) lily as a bifunctional electrocatalyst for large-current-density alkaline seawater electrolysis 被引量:1
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作者 Tong Cui Xuejun Zhai +5 位作者 Lili Guo Jing-Qi Chi Yu Zhang Jiawei Zhu Xuemei Sun Lei Wang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2022年第8期2202-2211,共10页
Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllabl... Highly efficient and stable bifunctional electrocatalysts that can be used for large-current-density electrolysis of alkaline seawater are highly desirable for carbon-neutral economies,but their facile and controllable synthesis remains a challenge.Here,self-assembled ultralow Ru,Ni-doped Fe_(2)O_(3) with a lily shaped morphology was synthesized on iron foam(RuNi-Fe_(2)O_(3)/IF)via a facile one-step hydrothermal process,in which the intact lily shaped RuNi-Fe_(2)O_(3)/IF was obtained by adjusting the ratio of Ru/Ni.Benefitting from the Ru/Ni chemical substitution,the as-synthesized RuNi-Fe_(2)O_(3)/IF can act as free-standing dual-function electrodes that are applied to electrocatalysis for the hydrogen evolution(HER)and oxygen evolution reactions(OER)in 1.0 mol L^(-1) KOH,requiring an overpotential of 75.0 mV to drive 100 mA cm^(-2) for HER and 329.0 mV for OER.Moreover,the overall water splitting catalyzed by RuNi-Fe_(2)O_(3)/IF only demands ultralow cell voltages of 1.66 and 1.73 V to drive 100 mA cm^(-2) in 1.0 mol L^(-1) KOH and 1.0 mol L^(-1) KOH seawater electrolytes,respectively.The electrodes show remarkable long-term durability,maintaining current densities exceeding 100 mA cm^(-2) for more than 100 h and thus outperforming the two-electrode system composed of noble catalysts.This work provides an efficient,economical method to synthesize self-standing bifunctional electrodes for large-current-density alkaline seawater electrolysis,which is of significant importance for ecological protection and energy exploitation. 展开更多
关键词 RuNi-Fe_(2)O_(3)/IF Lily shape Bifunctional electrocatalyst Alkaline seawater splitting large current density
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Ywhab通过靶向Hsp90aa1抑制小鼠B细胞淋巴瘤38B9细胞生长 被引量:2
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作者 魏子辰 张毅 +5 位作者 许晗 王鑫 谷婷 庞磊 赵明超 郁多男 《中国病理生理杂志》 CAS CSCD 北大核心 2024年第3期395-403,共9页
目的:研究Ywhab在小鼠B细胞淋巴瘤发生发展中的作用,并探讨其可能的分子机制。方法:使用生物信息学分析Ywhab与弥漫性大B细胞淋巴瘤(DLBCL)的相关性。在小鼠B细胞淋巴瘤38B9细胞中感染逆转录病毒构建Ywhab基因过表达细胞系,并采用RT-qPC... 目的:研究Ywhab在小鼠B细胞淋巴瘤发生发展中的作用,并探讨其可能的分子机制。方法:使用生物信息学分析Ywhab与弥漫性大B细胞淋巴瘤(DLBCL)的相关性。在小鼠B细胞淋巴瘤38B9细胞中感染逆转录病毒构建Ywhab基因过表达细胞系,并采用RT-qPCR和Western blot验证Ywhab的mRNA及蛋白(14-3-3β)水平;通过细胞计数法、CCK-8法和小鼠皮下成瘤实验检测Ywhab过表达对38B9细胞在体内外生长的影响;RT-qPCR和Western blot检测细胞凋亡相关蛋白的表达;应用蛋白质免疫共沉淀联合蛋白质谱(CoIP-MS)筛选与14-3-3β特异性结合的蛋白并采用Western blot及分子对接分析进行验证。结果:Ywhab基因在DLBCL中低表达,其低表达预示DLBCL患者的临床预后较差。与正常小鼠骨髓B细胞相比,Ywhab在38B9细胞中低表达。Ywhab过表达能在体内外诱导38B9细胞凋亡,促进凋亡蛋白Puma、Noxa和Bax的mRNA及蛋白表达,抑制抗凋亡蛋白Bcl2的mRNA及蛋白表达(P<0.05)。14-3-3β蛋白能特异性结合Hsp90aa1蛋白并抑制其表达,从而促进38B9细胞凋亡。结论:Ywhab能够显著诱导小鼠B细胞淋巴瘤38B9细胞凋亡,其机制可能是通过靶向抑制Hsp90aa1蛋白表达来实现的。 展开更多
关键词 Ywhab基因 14-3-3β蛋白 弥漫性大B细胞淋巴瘤 38B9细胞 细胞凋亡 Hsp90aa1蛋白
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T-cell immunoglobulin mucin molecule-3, transformation growth factor β, and chemokine-12 and the prognostic status of diffuse large B-cell lymphoma 被引量:1
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作者 Hao Wu Hui-Cong Sun Gui-Fang Ouyang 《World Journal of Clinical Cases》 SCIE 2022年第32期11804-11811,共8页
BACKGROUND The effects of T-cell immunoglobulin mucin molecule-3(Tim-3),transforming growth factor β(TGF-β),and chemokine-12(CXCL12) expression on the prognosis of patients with diffuse large B-cell lymphoma(DLBCL) ... BACKGROUND The effects of T-cell immunoglobulin mucin molecule-3(Tim-3),transforming growth factor β(TGF-β),and chemokine-12(CXCL12) expression on the prognosis of patients with diffuse large B-cell lymphoma(DLBCL) have not been elucidated.AIM To examine the correlation between Tim-3,TGF-β and CXCL12 expression and DLBCL prognosis.METHODS Lymph node tissues of 97 patients with DLBCL and 93 normal-response hyperplastic lymph node tissues treated from January 2017 to May 2019 were selected as the DLBCL and control groups,respectively.The expression of Tim-3,TGF-β,and CXCL12 was detected immunohistochemically.Patients were followed up for 3 years,and progression-free survival was recorded.Cox mult-ifactorial analysis was performed to analyze the risk factors for poor prognosis.RESULTS The positive expression rates of Tim-3,TGF-β,and CXCL12 were higher in DLBCL tissues than in non-cancerous(control) tissues(P < 0.05).One-year postsurgery,the positive expression rates of Tim-3,TGF-β,and CXCL12 were higher in patients with effective treatment than in those with ineffective treatment(P < 0.05).The 3-year progression-free survival of 97 patients with DLBCL was 67.01%(65/97).Univariate analysis revealed that clinical stage,bone marrow infiltration,International Prognostic Index(IPI) score,Tim-3 positivity,TGF-β positivity,and CXCL12 positivity were associated with poor prognosis(P < 0.05).Multivariate Cox regression analysis demonstrated that clinical stage Ⅲ–Ⅳ,bone marrow infiltration,mediate-to-high-risk IPI scores,Tim-3 positivity,TGF-β positivity,and CXCL12 positivity were independent risk factors affecting prognosis(P < 0.05).CONCLUSION DLBCL tissues exhibit high positive expression of Tim-3,TGF-β,and CXCL12,and a high expression of all three indicates a poor prognosis. 展开更多
关键词 T-cell immunoglobulin mucin molecule-3 Transforming growth factorβ Chemokine-12 Diffuse large B-cell lymphoma
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基于磁控溅射系统的大尺寸Ga_(2)O_(3)薄膜沉积模型与性能研究
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作者 肖厚恩 王顺利 《浙江理工大学学报(自然科学版)》 2024年第3期310-318,共9页
薄膜型Ga_(2)O_(3)光电探测器具有成本低廉、性能优异、可重复性高等优点,实现Ga_(2)O_(3)薄膜大尺寸均匀生长对批量制备薄膜型Ga_(2)O_(3)光电探测器具有重要意义。为了实现大尺寸Ga_(2)O_(3)薄膜的高效生长,采用Matlab软件对磁控溅射... 薄膜型Ga_(2)O_(3)光电探测器具有成本低廉、性能优异、可重复性高等优点,实现Ga_(2)O_(3)薄膜大尺寸均匀生长对批量制备薄膜型Ga_(2)O_(3)光电探测器具有重要意义。为了实现大尺寸Ga_(2)O_(3)薄膜的高效生长,采用Matlab软件对磁控溅射系统中倾斜圆形平面靶与旋转水平工作台上Ga_(2)O_(3)薄膜沉积模型进行了仿真,分析了靶基距和溅射靶转动角度对薄膜性能的影响,并进行了实验验证。结果表明:靶基距的增加会提高沉积薄膜的均匀性,在一定的靶基距下溅射靶转动角度的增加会使薄膜均匀性先提高后降低,Ga_(2)O_(3)薄膜均匀性实验分析结果与仿真结果基本一致;在靶基距为100 mm、溅射靶转动角度为35°的条件下,在蓝宝石衬底上沉积得到了平均厚度偏差为1.27%的Ga_(2)O_(3)薄膜;以沉积的薄膜批量制备Ga_(2)O_(3)光电探测器,得到的光电探测器对254 nm的光源具有基本一致的光响应。该研究为大批量制备高质量Ga_(2)O_(3)薄膜探测器提供了一定的理论依据。 展开更多
关键词 Ga_(2)O_(3) 磁控溅射 大尺寸 倾斜圆型平面靶 MATLAB
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Numerical Simulation of a New 3D Isolation System Designed for a Facility with Large Aspect Ratio
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作者 Ying Zhou Peng Chen 《Computer Modeling in Engineering & Sciences》 SCIE EI 2019年第9期759-777,共19页
This paper proposes a novel three-dimensional(3D)isolation system for facilities and presents the numerical simulation approach for the isolated system under earthquake excitations and impact effect using the OpenSees... This paper proposes a novel three-dimensional(3D)isolation system for facilities and presents the numerical simulation approach for the isolated system under earthquake excitations and impact effect using the OpenSees(Open System for Earthquake Engineering Simulation)software frame work.The 3D isolators combine the quasi-zero stiffness(QZS)system in the vertical direction and lead rubber bearing in the horizontal direction.Considering the large aspect ratio of the isolated facility,linear viscous dampers are designed in the vertical direction to diminish the overturning effect.The vertical QZS isolation system is characterized by a cubic force-displacement relation,thus,no elements or materials can model this mechanic behavior in the existing finite element software.This study takes advantage of the open source feature of the OpenSees to create a new material to represent the mechanic properties of the QZS system.Then the user-defined material is combined with the rubber isolator element to model the 3D isolator.Considering different soil types and input magnitudes,six sets of natural seismic records and artificial waves and half sine pulses are selected as the input excitations.A finite element model for the 3D isolated facility is established based on the combined element and the simulation is performed to calculate the time history response.The numerical simulation reveals the flexibility of the OpenSees to deal with new engineering problems,and the results prove that the new 3D isolation system can have an optimal isolation effect in both horizontal and vertical directions.The maximum acceleration response at the top of the facility is below the target limit,and the maximum deformation and the overturning motion of the isolation system can be controlled in a safe range. 展开更多
关键词 3D ISOLATION quasi-zero STIFFNESS OPENSEES FACILITY large ASPECT ratio
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SUPERPLASTICITY IN LARGE-GRAINED Fe_3Al ALLOYS
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作者 LIN Dongliang(T. L. Lin),(SHAN Aidang, CHEN Mingwei Shanghai Jiaotong University, Shanghai 200030, China) 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 1995年第Z1期419-429,共11页
The superplasticity behavior of Fe-28Al, Fe-28Al-2Ti, Fe-28Al-4Ti (all composition reported in this paper are in atomic percent) alloys has been investigated by tensile testing.optical microscopy and transmission elec... The superplasticity behavior of Fe-28Al, Fe-28Al-2Ti, Fe-28Al-4Ti (all composition reported in this paper are in atomic percent) alloys has been investigated by tensile testing.optical microscopy and transmission electron mocroscopy.Tensile test were performed at 700 to 900℃ under a strain rate range of about 10-5/s to 10-2/s. Maximum strain rate sensitivity index m was found to be 0.5 and the largest elongation reached 620%. The flow activation energy was measured to be 263kJ/mol for Fe-28Al and 191kJ/ mol for Fe-28Al-2Ti, which are much lower than the creep activation energy generally observed in Fe3Al alloys. After deformation grain size became much finer from about 100 μm to 20-30μm.As combined with TEM observations, we suggested that a continuous recrystallization process took place and superplasticity may arise from this process. 展开更多
关键词 SUPERPLASTICITY Fe_3Al alloy large grains
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Efficient solution of large-scale matrix of acoustic wave equations in 3D frequency domain
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作者 Changcheng Li Xiaofei Chen 《Applied Geophysics》 SCIE CSCD 2021年第3期299-316,431,432,共20页
In 3D frequency domain seismic forward and inversion calculation,the huge amount of calculation and storage is one of the main factors that restrict the processing speed and calculation efficiency.The frequency domain... In 3D frequency domain seismic forward and inversion calculation,the huge amount of calculation and storage is one of the main factors that restrict the processing speed and calculation efficiency.The frequency domain finite-difference forward simulation algorithm based on the acoustic wave equation establishes a large bandwidth complex matrix according to the discretized acoustic wave equation,and then the frequency domain wave field value is obtained by solving the matrix equation.In this study,the predecessor's optimized five-point method is extended to a 3D seven-point finite-difference scheme,and then a perfectly matched layer absorbing boundary condition(PML)is added to establish the corresponding matrix equation.In order to solve the complex matrix,we transform it to the equivalent real number domain to expand the solvable range of the matrix,and establish two objective functions to transform the matrix solving problem into an optimization problem that can be solved using gradient methods,and then use conjugate gradient algorithm to solve the problem.Previous studies have shown that in the conjugate gradient algorithm,the product of the matrix and the vector is the main factor that affects the calculation efficiency.Therefore,this study proposes a method that transform bandwidth matrix and vector product problem into some equivalent vector and vector product algorithm,thereby reducing the amount of calculation and storage. 展开更多
关键词 Frequency domain acoustic wave simulation large bandwidth matrix conjugate gradient method 3D seven-point finite difference
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Correlation of the abnormal expression of HK-II and TNFAIP3 in diffuse large B-cell lymphoma with the malignant features of tumor cells
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作者 Ying Qin 《Journal of Hainan Medical University》 2018年第22期75-79,共5页
Objective: To study the correlation of the abnormal expression of hexokinase-Ⅱ (HK-Ⅱ) and tumor necrosis factor alpha-induced protein 3 (TNFAIP3) in diffuse large B-cell lymphoma (DLBCL) with the malignant features ... Objective: To study the correlation of the abnormal expression of hexokinase-Ⅱ (HK-Ⅱ) and tumor necrosis factor alpha-induced protein 3 (TNFAIP3) in diffuse large B-cell lymphoma (DLBCL) with the malignant features of tumor cells. Methods: DLBCL patients who underwent surgical resection in our hospital between March 2016 and March 2018 were selected as the DLBCL group, and the patients who underwent surgical resection during the same period and were pathologically confirmed as reactive hyperplasia of lymph nodes were selected as the control group. The lesions were collected to measure the expression levels of HK-Ⅱ, TNFAIP3, proliferation genes and invasion genes. Results: HK-Ⅱ mRNA expression level in the lesions of the DLBCL group was significantly higher than that of the control group while TNFAIP3 mRNA expression level was significantly lower than that of the control group;HK-Ⅱ mRNA expression levels in the lesions of DLBCL group of patients with lymphoma stage ⅡI-IV and lymphoma group B were significantly higher than those of the patients with lymphoma stage I-Ⅱ and group A while TNFAIP3 mRNA expression levels were significantly lower than those of the patients with lymphoma stage I-Ⅱ and lymphoma group A;CyclinD2, PDE4B, BCL2, XIAP, CCL5, CXCR4 and MMP26 mRNA expression levels in the lesions of the DLBCL group were significantly higher than those of the control group, positively correlated with HK-Ⅱ and negatively correlated with TNFAIP3 while Caspase-3 and TIMP4 mRNA expression levels were significantly lower than those of the control group, negatively correlated with HK-Ⅱ and positively correlated with TNFAIP3. Conclusion: The high expression of HK-Ⅱ and the low expression of TNFAIP3 in DLBCL are closely related to the pathological process of tumor as well as the proliferation and invasion of tumor cells. 展开更多
关键词 Diffuse large B-CELL lymphoma Hexokinase-Ⅱ Tumor NECROSIS factor alpha-induced protein 3 Proliferation Invasion
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基于OCO-2/3卫星的中国超大型燃煤电厂CO_(2)排放量的遥感反演
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作者 郭文月 石玉胜 《中国科学院大学学报(中英文)》 CAS CSCD 北大核心 2024年第4期490-502,共13页
基于轨道碳观测者2/3(OCO-2/3)卫星数据和高斯羽流模型对发电厂CO_(2)排放量进行遥感反演。首先基于OCO-2(2014-09-06—2021-10-01)和OCO-3(2019-08-06—2021-10-01)数据检索中国超大型燃煤电厂(≥5000 MW)附近图像,共在托克托、嘉兴、... 基于轨道碳观测者2/3(OCO-2/3)卫星数据和高斯羽流模型对发电厂CO_(2)排放量进行遥感反演。首先基于OCO-2(2014-09-06—2021-10-01)和OCO-3(2019-08-06—2021-10-01)数据检索中国超大型燃煤电厂(≥5000 MW)附近图像,共在托克托、嘉兴、外高桥电厂附近识别到7个CO_(2)羽流。综合利用3种大气背景值确定方法,经过高斯羽流模型估算的CO_(2)排放量范围为43~77 kt/d,模型拟合的相关系数0.50~0.87。单个羽流的不确定性变化为8%~32%(1σ),风速是最大的不确定性(6%~31%),其次是背景值(5%~18%)、增强值(1%~21%)和羽流上升(1%~8%)。经验证,估算结果与碳监测行动、碳简报、全球电厂排放数据库等排放清单一致性较高(托克托:(76.48±15.75)kt/d、外高桥:(55.98±6.90)kt/d、嘉兴:(64.55±15.89)kt/d)。这项研究有助于监测点源碳排放,这不仅是电力行业开展碳减排的前提,也有助于针对性制定区域碳减排政策,从而减少人为碳排放。 展开更多
关键词 二氧化碳 高斯羽流模型 轨道碳观测者2号 轨道碳观测者3 超大型燃煤电厂
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纳米CaCO_(3)改性大掺量沸石粉混凝土性能研究
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作者 李志强 付晓琳 +2 位作者 贺向阳 朱赫 张帅 《非金属矿》 2024年第3期44-48,共5页
为研究纳米CaCO_(3)对大掺量沸石粉混凝土的性能优化作用,分别以单掺沸石粉和复掺沸石粉、纳米CaCO_(3)(NC)改性的方式制备高性能混凝土(HPC),并测试其工作性能、力学性能、抗氯离子渗透性及微观结构,研究NC对大掺量沸石粉混凝土的性能... 为研究纳米CaCO_(3)对大掺量沸石粉混凝土的性能优化作用,分别以单掺沸石粉和复掺沸石粉、纳米CaCO_(3)(NC)改性的方式制备高性能混凝土(HPC),并测试其工作性能、力学性能、抗氯离子渗透性及微观结构,研究NC对大掺量沸石粉混凝土的性能影响及作用机理。结果表明,大掺量沸石粉会降低混凝土工作性能和早期力学性能,但能够提高抗氯离子渗透性能和后期力学性能,当沸石粉掺量为20%时,HPC的7 d、28 d、90 d抗压强度分别为基准组的89.52%、97.60%、101.07%,劈裂抗拉强度为基准组的92.65%、99.85%、102.62%,抗氯离子渗透性能较基准组提高5.64%;在此基础上复掺NC后,沸石粉混凝土的负面影响得到改善,抗氯离子渗透性进一步增强。当NC掺量为1.0%时,HPC 7 d、28 d、90 d抗压强度分别较未掺NC时提高12.34%、8.90%、5.91%,劈裂抗拉强度提高14.76%、11.30%、7.95%,抗氯离子渗透性能提高20.92%。NC能够促进沸石粉水泥体系水化反应,优化水化产物形态,细化浆体孔隙结构,提高混凝土的致密性。当沸石粉掺量为20%,NC掺量为1.0%时,大掺量沸石粉混凝土的各项性能达到较优水平。 展开更多
关键词 大掺量沸石粉混凝土 纳米CaCO_(3) 力学性能 抗氯离子渗性能 微观结构
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大型铬铁矿热炉渣中Cr_(2)O_(3)含量影响因素研究与实践
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作者 李树民 陶旭 +2 位作者 王建新 王国强 曹靖雷 《铁合金》 CAS 2024年第5期13-16,共4页
介绍了通过研究铬矿特性、冶炼渣型、炉渣碱度、镁铝比以及合金中硅含量等参数与渣中Cr_(2)O_(3)含量的关系,借助Mintab数据分析软件明确了各参数和相关影响因素的优先级,从而有针对性的对原有工艺参数进行优化调整,有效的降低了渣中Cr_... 介绍了通过研究铬矿特性、冶炼渣型、炉渣碱度、镁铝比以及合金中硅含量等参数与渣中Cr_(2)O_(3)含量的关系,借助Mintab数据分析软件明确了各参数和相关影响因素的优先级,从而有针对性的对原有工艺参数进行优化调整,有效的降低了渣中Cr_(2)O_(3)含量并提高了铬综合收得率。 展开更多
关键词 大型 矿热炉 Cr_(2)O_(3)含量 影响因素 回收率
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