To investigate the effects of the free radical, 1, l-Diphenyl-2-picylhydrazyl, on cochlear blood flow, 20 guinea pigs were divided into 3 groups at random, 6 for control group, 6 for 1 mmol/ L group and 8 for 0. 1 mmo...To investigate the effects of the free radical, 1, l-Diphenyl-2-picylhydrazyl, on cochlear blood flow, 20 guinea pigs were divided into 3 groups at random, 6 for control group, 6 for 1 mmol/ L group and 8 for 0. 1 mmol/L group. 2 μl vehicle or drugs were dropped into round window membrane (RWM). Cochlear microcirculation was monitored by laser Doppler flowmeter (LDF), and mean arterial blood flow (MABP), which was transferred by pressure conductor sensor and preamplifier, was simultaneously recorded on the computer. Our results showed that MABP was stable throughout the experiment. Cochlear blood flow (CBF) increased by 10. 32 % (P<0. 05) in 1 mmol/L group, and decreased by 4. 89 % in 0. 1 mmol/L group (P<0. 05). In control group cochlear microcirculation showed no significant changes. It is concluded that DPPH exerted effects on cochlear microcirculation.展开更多
基金This project was supported by grants of the Research Foundation for Outstanding Scientists(Serial No.1995-144),the State Outstanding Young Scences Foundation(39925035)and Foundation for University Key Teachers by the Ministry of Education(2001).
文摘To investigate the effects of the free radical, 1, l-Diphenyl-2-picylhydrazyl, on cochlear blood flow, 20 guinea pigs were divided into 3 groups at random, 6 for control group, 6 for 1 mmol/ L group and 8 for 0. 1 mmol/L group. 2 μl vehicle or drugs were dropped into round window membrane (RWM). Cochlear microcirculation was monitored by laser Doppler flowmeter (LDF), and mean arterial blood flow (MABP), which was transferred by pressure conductor sensor and preamplifier, was simultaneously recorded on the computer. Our results showed that MABP was stable throughout the experiment. Cochlear blood flow (CBF) increased by 10. 32 % (P<0. 05) in 1 mmol/L group, and decreased by 4. 89 % in 0. 1 mmol/L group (P<0. 05). In control group cochlear microcirculation showed no significant changes. It is concluded that DPPH exerted effects on cochlear microcirculation.
