Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one ...Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.展开更多
Background: There is limited research on the association between opportunity cost of time and sports and exercise due to lack of data on opportunity cost of time. Using a sample of 14142 adults from Health Survey for ...Background: There is limited research on the association between opportunity cost of time and sports and exercise due to lack of data on opportunity cost of time. Using a sample of 14142 adults from Health Survey for England (2006), we develop and test a composite index of opportunity cost of time (to address the current issues with data constraint on opportunity cost of time) in order to explore the relationship between opportunity cost of time and sports participation. Methods: Probit regression models are fitted adjusting for a range of covariates. Opportunity cost of time is measured with two proxy measures: a) composite index (consisting of various indicators of wage earnings) constructed using principal component analysis;and b) education and employment, approach in the literature. We estimate the relative impact of the composite index compared with current proxy measures, on prediction of sports participation. Findings: Findings suggest that higher opportunity cost of time is associated with increased likelihood of sports participation, regardless of the time intensity of activity or the measure of opportunity cost of time used. The relative impacts of the two proxy measures are comparable. Sports and exercise was found to be positively correlated with income. Another important positive correlate of sports and exercise is participation in voluntary activity. The research and policy implications of our findings are discussed.展开更多
AIM: To investigate the effects of exercise on healthy individuals of both genders. METHODS: This study lasted 6 years and involved about 800 healthy people. Individuals were divided into females and males and further...AIM: To investigate the effects of exercise on healthy individuals of both genders. METHODS: This study lasted 6 years and involved about 800 healthy people. Individuals were divided into females and males and further sub-divided into two groups; in the first group individuals run(or skied in the winter time) and then rested for 3 h, whereas individuals in the second group intensely cycled for 5 min. The status of health was determined by measuring the sedimentation rate and the intensity of exercises by measuring the heart rate. Blood samples were collected before and after exercise. RESULTS: We observed that in the first group a significant increase of the total white blood cells, segmented neutrophils, band neutrophils, eosinophils and to a lesser extent lymphocytes but not monocytes in the blood circulation. However, all cell types were increased in the circulation after 5 min intense exercise. No differences in the pattern of cell increase were observed among the genders. Activated partial thromboplastin time(APTT) and D-dimer were also measured in the blood of individuals who cycled intensely for 5 min to determine the coagulation and fibrinolytic activities in the blood. APTT is reduced and D-dimer values significantly increased after intense exercise. However, APTT was statistically lower in males than females, whereas no differences in the D-dimer values were observed among the genders. CONCLUSION: Our results indicate that exercise whether leisure or strenuous affects leukocytosis and hemostasis in both genders. A major advantage of this study is the high numbers of individuals involved and the inclusion of both females and males values.展开更多
The association between Leisure Time Physical Activity (LTPA) during pregnancy and foetal outcomes has been extensively investigated. However, epidemiological studies specifically referred to LPTA in the last months o...The association between Leisure Time Physical Activity (LTPA) during pregnancy and foetal outcomes has been extensively investigated. However, epidemiological studies specifically referred to LPTA in the last months of pregnancy are scarce. We evaluated the association between LPTA and the risk of both preterm delivery and small for gestational age (SGA) during the last three months of pregnancy in Italy. A nationwide case-control study was performed in nine Italian cities. A total of 299 preterm delivery, 364 SGA and 855 controls were enrolled in the study. A self-administered questionnaire was used to assess socio-demographic variables, medical and reproductive history, life-style habits and LTPA referred to the last three months of pregnancy. Univariate and multivariate regression analyses were performed in order to estimate Odds ratios and 95% CI. LTPA during the last three months of pregnancy decreases the risk of preterm delivery (adjusted OR = 0.56;95% CI 0.39 - 0.79). Among the different types of physical activity, walking, the most frequently referred activity, appears significantly protective against preterm delivery (adjusted OR = 0.53;95% CI 0.36 - 0.81). Moreover, a small protective effect of walking was evidenced against SGA (adjusted OR = 0.72;95% CI 0.51 - 1.00). In conclusion, a mild physical activity such as walking in the last three months of pregnancy seems to reduce the risk of preterm delivery and, at a lesser extent, of SGA, confirming the beneficial effects of physical activity along the whole pregnancy.展开更多
Let Ls be the last exit time from a compact set B of an elliptic diffusion process X. A moderate estimate for the distribution of Ls is obtained, and the sufficient and necessary condition for E^x（L^κB） 〈∞ is pr...Let Ls be the last exit time from a compact set B of an elliptic diffusion process X. A moderate estimate for the distribution of Ls is obtained, and the sufficient and necessary condition for E^x（L^κB） 〈∞ is proved.展开更多
To explore the dynamic effects of exercise on IRS-2 protein content and tyrosine phosphorylation in DM rats,Sixty SD rats were divided into six groups: normal control group(NC)、diabetes mellitus group(DMC) and exerci...To explore the dynamic effects of exercise on IRS-2 protein content and tyrosine phosphorylation in DM rats,Sixty SD rats were divided into six groups: normal control group(NC)、diabetes mellitus group(DMC) and exercise group.The exercise groups exercised for different periods of time.The content and tyrosine phosphorylation of IRS-2 protein were measured by Western bolt analysis.Result showed that contents of IRS-2 protein in 60,120,180 min groups were enhanced up to 19.0%,22.4% and 17.2%(P<0.01) respectively,and the tyrosine phosphorylation of IRS-2 protein in 60,120,180 min group enhanced up to 43.1%,80.4% and 53%(P<0.01) respectively,compared with the DMC group.We concluded that that the contents and the tyrosine phosphorylation of IRS-2 protein had obvious time trait after exercise.展开更多
[ Objective ] The study aimed to explore the release conditions for the conidia of Botryosphaena berengeriana and understand the release dynamic of conidia. [Method] The systematical survey on the release conditions f...[ Objective ] The study aimed to explore the release conditions for the conidia of Botryosphaena berengeriana and understand the release dynamic of conidia. [Method] The systematical survey on the release conditions for the conidia of B. berengeriana were conducted in two growing seasons in 2008 and 2009, combined with the collection of meteorological data around conidia release period, the weather conditions causing large amount release of B. berengedana were analyzed. [ Result] During a growing season, the conidia of pathogen appeared several large release peaks. Under the suitable temperature, when the precipitation lasted for 4 h, the conidia of B. berengeriana began to release with large amount, the amount of conidia reached the peak after release and trended to be stable during 4 - 12 h, which significantly reduced after 24 h, tended to dis- appear after 36 h, and completely disappeared after 72 h. [Conclusion] The dominant factor affecting B. berengeriana conidia release in large a- mount was precipitation, while the lasting time of precipitation played a decisive role.展开更多
[Objective] The aim was to analyze changing characters of four seasons in Jiyang, providing references for farming and disaster prevention in the area. [Methed] Changing characters of initial time and lasting periods ...[Objective] The aim was to analyze changing characters of four seasons in Jiyang, providing references for farming and disaster prevention in the area. [Methed] Changing characters of initial time and lasting periods of four seasons in Jiyang for 30 years were analyzed from meteorological standpoint with weather information from 1981 to 2010 observed in surface meteorological observation in Jiyang. [Result] Recent 30 years, initial time of spring and winter in Jiyang were earlier than before, especially for spring. In contrast, initial time of summer and autumn were later, especially for autumn. In addition, periods of spring and winter declined and the latter changed more significantly. Meanwhile, periods of summer and autumn extended and rate of linear trend for summer period was 0.042 hou/year. [Conclusion] The research indicated that lasting days of summer extended significantly and of spring and winter shortened under the background of global warming.展开更多
基金This work was supported by the National Natural Science Foundation of China(82172511)the Natural Science Foundation of Jiangsu Province(BK20210068)+4 种基金the Sanming Project of Medicine in Shenzhen(SZSM201612078)the Health Shanghai Initiative Special Fund[Medical-Sports Integration(JKSHZX-2022-02)]the Top Talent Support Program for Young-and Middle-aged People of Wuxi Municipal Health Commission(HB2020003)the Mega-project of Wuxi Commission of Health(Z202216)the High-end Medical Expert Team of the 2019 Taihu Talent Plan(2019-THRCTD-1)
文摘Dear Editor,Physical exercise has been shown to be associated with reduced cancer incidence and cancer-associated mortality[1,2],but the underlying mechanisms are obscure.Immunometabolic regulation has emerged as one of the most prominent mechanisms explaining the effects of exercise on cancer[1,2].Physical exercise primarily lowers blood cholesterol and triglycerides,and protects against cardiovascular diseases[3].However,whether physical exercise can modulate cholesterol metabolism in tumor cells is currently unknown.
文摘Background: There is limited research on the association between opportunity cost of time and sports and exercise due to lack of data on opportunity cost of time. Using a sample of 14142 adults from Health Survey for England (2006), we develop and test a composite index of opportunity cost of time (to address the current issues with data constraint on opportunity cost of time) in order to explore the relationship between opportunity cost of time and sports participation. Methods: Probit regression models are fitted adjusting for a range of covariates. Opportunity cost of time is measured with two proxy measures: a) composite index (consisting of various indicators of wage earnings) constructed using principal component analysis;and b) education and employment, approach in the literature. We estimate the relative impact of the composite index compared with current proxy measures, on prediction of sports participation. Findings: Findings suggest that higher opportunity cost of time is associated with increased likelihood of sports participation, regardless of the time intensity of activity or the measure of opportunity cost of time used. The relative impacts of the two proxy measures are comparable. Sports and exercise was found to be positively correlated with income. Another important positive correlate of sports and exercise is participation in voluntary activity. The research and policy implications of our findings are discussed.
基金Supported by The Faculty of Medicine at the University of Oslo
文摘AIM: To investigate the effects of exercise on healthy individuals of both genders. METHODS: This study lasted 6 years and involved about 800 healthy people. Individuals were divided into females and males and further sub-divided into two groups; in the first group individuals run(or skied in the winter time) and then rested for 3 h, whereas individuals in the second group intensely cycled for 5 min. The status of health was determined by measuring the sedimentation rate and the intensity of exercises by measuring the heart rate. Blood samples were collected before and after exercise. RESULTS: We observed that in the first group a significant increase of the total white blood cells, segmented neutrophils, band neutrophils, eosinophils and to a lesser extent lymphocytes but not monocytes in the blood circulation. However, all cell types were increased in the circulation after 5 min intense exercise. No differences in the pattern of cell increase were observed among the genders. Activated partial thromboplastin time(APTT) and D-dimer were also measured in the blood of individuals who cycled intensely for 5 min to determine the coagulation and fibrinolytic activities in the blood. APTT is reduced and D-dimer values significantly increased after intense exercise. However, APTT was statistically lower in males than females, whereas no differences in the D-dimer values were observed among the genders. CONCLUSION: Our results indicate that exercise whether leisure or strenuous affects leukocytosis and hemostasis in both genders. A major advantage of this study is the high numbers of individuals involved and the inclusion of both females and males values.
文摘The association between Leisure Time Physical Activity (LTPA) during pregnancy and foetal outcomes has been extensively investigated. However, epidemiological studies specifically referred to LPTA in the last months of pregnancy are scarce. We evaluated the association between LPTA and the risk of both preterm delivery and small for gestational age (SGA) during the last three months of pregnancy in Italy. A nationwide case-control study was performed in nine Italian cities. A total of 299 preterm delivery, 364 SGA and 855 controls were enrolled in the study. A self-administered questionnaire was used to assess socio-demographic variables, medical and reproductive history, life-style habits and LTPA referred to the last three months of pregnancy. Univariate and multivariate regression analyses were performed in order to estimate Odds ratios and 95% CI. LTPA during the last three months of pregnancy decreases the risk of preterm delivery (adjusted OR = 0.56;95% CI 0.39 - 0.79). Among the different types of physical activity, walking, the most frequently referred activity, appears significantly protective against preterm delivery (adjusted OR = 0.53;95% CI 0.36 - 0.81). Moreover, a small protective effect of walking was evidenced against SGA (adjusted OR = 0.72;95% CI 0.51 - 1.00). In conclusion, a mild physical activity such as walking in the last three months of pregnancy seems to reduce the risk of preterm delivery and, at a lesser extent, of SGA, confirming the beneficial effects of physical activity along the whole pregnancy.
基金Research supported in part by Tianyuan Fund ofr Mathematics of NSFC (10526021)A Grant from Ministry of Education
文摘Let Ls be the last exit time from a compact set B of an elliptic diffusion process X. A moderate estimate for the distribution of Ls is obtained, and the sufficient and necessary condition for E^x（L^κB） 〈∞ is proved.
文摘To explore the dynamic effects of exercise on IRS-2 protein content and tyrosine phosphorylation in DM rats,Sixty SD rats were divided into six groups: normal control group(NC)、diabetes mellitus group(DMC) and exercise group.The exercise groups exercised for different periods of time.The content and tyrosine phosphorylation of IRS-2 protein were measured by Western bolt analysis.Result showed that contents of IRS-2 protein in 60,120,180 min groups were enhanced up to 19.0%,22.4% and 17.2%(P<0.01) respectively,and the tyrosine phosphorylation of IRS-2 protein in 60,120,180 min group enhanced up to 43.1%,80.4% and 53%(P<0.01) respectively,compared with the DMC group.We concluded that that the contents and the tyrosine phosphorylation of IRS-2 protein had obvious time trait after exercise.
基金Supported by State Apple Industry Technology System Project(nybcytx-08-04-01)~~
文摘[ Objective ] The study aimed to explore the release conditions for the conidia of Botryosphaena berengeriana and understand the release dynamic of conidia. [Method] The systematical survey on the release conditions for the conidia of B. berengeriana were conducted in two growing seasons in 2008 and 2009, combined with the collection of meteorological data around conidia release period, the weather conditions causing large amount release of B. berengedana were analyzed. [ Result] During a growing season, the conidia of pathogen appeared several large release peaks. Under the suitable temperature, when the precipitation lasted for 4 h, the conidia of B. berengeriana began to release with large amount, the amount of conidia reached the peak after release and trended to be stable during 4 - 12 h, which significantly reduced after 24 h, tended to dis- appear after 36 h, and completely disappeared after 72 h. [Conclusion] The dominant factor affecting B. berengeriana conidia release in large a- mount was precipitation, while the lasting time of precipitation played a decisive role.
基金Supported by Research Project for Season Change in Jinan Region~~
文摘[Objective] The aim was to analyze changing characters of four seasons in Jiyang, providing references for farming and disaster prevention in the area. [Methed] Changing characters of initial time and lasting periods of four seasons in Jiyang for 30 years were analyzed from meteorological standpoint with weather information from 1981 to 2010 observed in surface meteorological observation in Jiyang. [Result] Recent 30 years, initial time of spring and winter in Jiyang were earlier than before, especially for spring. In contrast, initial time of summer and autumn were later, especially for autumn. In addition, periods of spring and winter declined and the latter changed more significantly. Meanwhile, periods of summer and autumn extended and rate of linear trend for summer period was 0.042 hou/year. [Conclusion] The research indicated that lasting days of summer extended significantly and of spring and winter shortened under the background of global warming.
