The experimental study in this paper focuses on the effects of the layer orientation and sample shape on failure strength and fracture pattern of samples tested under Brazilian test conditions(i.e.diametrical loading ...The experimental study in this paper focuses on the effects of the layer orientation and sample shape on failure strength and fracture pattern of samples tested under Brazilian test conditions(i.e.diametrical loading of cylindrical discs)for one particular layered sandstone which is from Modave in the south of Belgium.The variations of the strength in combination with the failure patterns are examined as a function of the inclination angle between the layer plane and the loading direction.The experimental,results clearly show that the induced fracture patterns are a combination of tensile and/or shear fractures.In shape effect experiments the layer thickness and the number of layer boundaries are investigated.Different blocks of Modave sandstone are used to prepare samples.The layer thickness is different among the various blocks,but the layer thickness in each studied rock block can be considered to be constant;hence,the number of layer boundaries changes according to the sample diameter for samples of the same block.The experimental study shows that the layer thickness plays a more important role than the number of layer boundaries per sample.展开更多
Light hydrocarbon (methane, ethane, propane, butane and CO2) test and C isotopic analysis of CO are conducted for over 100 lower-layer atmospheric samples from the East China Sea slope and the Okinawa Trough. The resu...Light hydrocarbon (methane, ethane, propane, butane and CO2) test and C isotopic analysis of CO are conducted for over 100 lower-layer atmospheric samples from the East China Sea slope and the Okinawa Trough. The results show that the lower-layer atmosphere mainly consists of CO2 and then of CH4, and the CO2 concentrations are calculated to have a high average value of 0.87 omega/10(-2) about three times that of the regional background (0-3 omega/10(-2)). The result also shows that the average value of C isotope - 20.8 x 10(-3) is given to the CO2, inferring that it is inorganic gas. Thus, for the future 's work in the Okinawa Trough, special attention should be paid to CO2 hydrate, which is very possibly an important hydrate type.展开更多
A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition ...A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min using 100 mL phosphate buffer （pH 6.8） as release medium. The release amount was determined by HPLC with a C18 column （250 mm × 4.6 mm, 5 μm） using the mobile phase consisting of methanol -0.4% carboxylic acid （65：35） at a flow rate of 1 mL/min and UV detection at 242 nm. The current method demonstrates good linearity over the range 4.052- 405.2 μg/mL （r2=0.9999） with an average recovery of 105.5%（RSD= 1.25%）. The accumulative release of alliin/alliinase double-layer tablets had good homogeneity for withinand betweenbatches. The method established is simple, accurate and repeatable for the determination of allicin release from alliin/alliinase double-layer tablets.展开更多
Luquire et al. ' s impedance change model of a rectangular cross section probe coil above a structure with an arbitrary number of parallel layers was used to study the principle of measuring thicknesses of multi-l...Luquire et al. ' s impedance change model of a rectangular cross section probe coil above a structure with an arbitrary number of parallel layers was used to study the principle of measuring thicknesses of multi-layered structures in terms of eddy current testing voltage measurements. An experimental system for multi-layered thickness measurement was developed and several fitting models to formulate the relationships between detected impedance/voltage measurements and thickness are put forward using least square method. The determination of multi-layered thicknesses was investigated after inversing the voltage outputs of the detecting system. The best fitting and inversion models are presented.展开更多
Objective To investigate cumulative results of chemosensitivity test using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay in double-layer agarose. Methods A total of 2 491 patients with different kinds of cance...Objective To investigate cumulative results of chemosensitivity test using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay in double-layer agarose. Methods A total of 2 491 patients with different kinds of cancers were enrolled in the study, in which 18 kinds of different anticancer drugs were used. A computer soft was used to get patients’ information from chemosensitivity testing database and patients’ charts. ResultsThe total evaluability rate was 82.7% (2 060/2 491). Among all agents, the efficiency rates of 5-Fu, MMC, DDP, BLM and CBP were higher than the efficiency rates of others. The response rate range of different cancer in vitro sensitivity by using MTT assay in double layer agarose were from 9.2% (biliary duct) to 37.5% (malignant lymphoma). For colon and rectum cancer, 5-Fu, DDP, MMC and BLM were more sensitive than other anti-tumor agents. For breast carcinomas, ACTD and DDP were more sensitive. For gastric cancer, 5-Fu, DDP and BLM were more sensitive. For leukemia, VM-26 and HHRT were more sensitive. ACM was more sensitive to kidney and MXT and BLM were more sensitive to pancreas cancer. For Lung cancer, DDP and EPI were more sensitive. Mean true positive rate, mean true negative rate, mean sensitivity, mean specificity and mean accuracy were 44%, 92%, 72%, 77%, and 76%, respectively. Conclusion Chemosensitivity tesing using the MTT assay in a double layer agarose was a very useful reference to chem-therapy.展开更多
基金The fnancial support of the Research Council of the Katholieke Universiteit Leuven(OT-project OT/03/35)
文摘The experimental study in this paper focuses on the effects of the layer orientation and sample shape on failure strength and fracture pattern of samples tested under Brazilian test conditions(i.e.diametrical loading of cylindrical discs)for one particular layered sandstone which is from Modave in the south of Belgium.The variations of the strength in combination with the failure patterns are examined as a function of the inclination angle between the layer plane and the loading direction.The experimental,results clearly show that the induced fracture patterns are a combination of tensile and/or shear fractures.In shape effect experiments the layer thickness and the number of layer boundaries are investigated.Different blocks of Modave sandstone are used to prepare samples.The layer thickness is different among the various blocks,but the layer thickness in each studied rock block can be considered to be constant;hence,the number of layer boundaries changes according to the sample diameter for samples of the same block.The experimental study shows that the layer thickness plays a more important role than the number of layer boundaries per sample.
文摘Light hydrocarbon (methane, ethane, propane, butane and CO2) test and C isotopic analysis of CO are conducted for over 100 lower-layer atmospheric samples from the East China Sea slope and the Okinawa Trough. The results show that the lower-layer atmosphere mainly consists of CO2 and then of CH4, and the CO2 concentrations are calculated to have a high average value of 0.87 omega/10(-2) about three times that of the regional background (0-3 omega/10(-2)). The result also shows that the average value of C isotope - 20.8 x 10(-3) is given to the CO2, inferring that it is inorganic gas. Thus, for the future 's work in the Okinawa Trough, special attention should be paid to CO2 hydrate, which is very possibly an important hydrate type.
文摘A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min using 100 mL phosphate buffer （pH 6.8） as release medium. The release amount was determined by HPLC with a C18 column （250 mm × 4.6 mm, 5 μm） using the mobile phase consisting of methanol -0.4% carboxylic acid （65：35） at a flow rate of 1 mL/min and UV detection at 242 nm. The current method demonstrates good linearity over the range 4.052- 405.2 μg/mL （r2=0.9999） with an average recovery of 105.5%（RSD= 1.25%）. The accumulative release of alliin/alliinase double-layer tablets had good homogeneity for withinand betweenbatches. The method established is simple, accurate and repeatable for the determination of allicin release from alliin/alliinase double-layer tablets.
文摘Luquire et al. ' s impedance change model of a rectangular cross section probe coil above a structure with an arbitrary number of parallel layers was used to study the principle of measuring thicknesses of multi-layered structures in terms of eddy current testing voltage measurements. An experimental system for multi-layered thickness measurement was developed and several fitting models to formulate the relationships between detected impedance/voltage measurements and thickness are put forward using least square method. The determination of multi-layered thicknesses was investigated after inversing the voltage outputs of the detecting system. The best fitting and inversion models are presented.
文摘Objective To investigate cumulative results of chemosensitivity test using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl (MTT) assay in double-layer agarose. Methods A total of 2 491 patients with different kinds of cancers were enrolled in the study, in which 18 kinds of different anticancer drugs were used. A computer soft was used to get patients’ information from chemosensitivity testing database and patients’ charts. ResultsThe total evaluability rate was 82.7% (2 060/2 491). Among all agents, the efficiency rates of 5-Fu, MMC, DDP, BLM and CBP were higher than the efficiency rates of others. The response rate range of different cancer in vitro sensitivity by using MTT assay in double layer agarose were from 9.2% (biliary duct) to 37.5% (malignant lymphoma). For colon and rectum cancer, 5-Fu, DDP, MMC and BLM were more sensitive than other anti-tumor agents. For breast carcinomas, ACTD and DDP were more sensitive. For gastric cancer, 5-Fu, DDP and BLM were more sensitive. For leukemia, VM-26 and HHRT were more sensitive. ACM was more sensitive to kidney and MXT and BLM were more sensitive to pancreas cancer. For Lung cancer, DDP and EPI were more sensitive. Mean true positive rate, mean true negative rate, mean sensitivity, mean specificity and mean accuracy were 44%, 92%, 72%, 77%, and 76%, respectively. Conclusion Chemosensitivity tesing using the MTT assay in a double layer agarose was a very useful reference to chem-therapy.
