AIM:To study the causal relationship between obesityrelated anthropometric traits and myopia and the mediating role of educational attainment(EA).METHODS:Univariable Mendelian randomization(UVMR)was performed to evalu...AIM:To study the causal relationship between obesityrelated anthropometric traits and myopia and the mediating role of educational attainment(EA).METHODS:Univariable Mendelian randomization(UVMR)was performed to evaluate the causal association between body mass index(BMI),height,waist-hip ratio(WHR,adjusted for BMI),and mean spherical equivalent(MSE).BMI was divided into fat and fat-free mass and included in multivariable Mendelian randomization(MVMR)to explore the roles of different BMI components in the causal relationship between BMI and MSE.A mediation analysis based on two-step Mendelian randomization(MR)was carried out.Specifically,UVMR was conducted to estimate the causal effect of BMI on EA.The direct effect of EA on MSE was estimated from MVMR.The mediation effect of EA in the BMI-EA-MSE model was calculated by the product of coefficients method.Expression quantitative trait loci(eQTL)-MR,reverse MR,and Linkage Disequilibrium Score Regression(LDSC)were performed to assess the robustness.RESULTS:Genetically predicted higher BMI had a positive total effect on MSE(βIVW=0.26 D,95%CI=0.14 to 0.37 D,P<0.001),whereas there was no significant association between height,WHR,and MSE.Fat mass was found to play a significant role in the effect of body mass on MSE(βIVW=0.50 D,95%CI=0.21 to 0.78 D,P=0.001),but there was no significant association between fat-free mass and MSE.The causal effect of BMI on EA was-0.14(95%CI=-0.16 to-0.11,P<0.001),and the direct effect of EA on MSE was-0.63 D(95%CI=-0.81 to-0.44 D,P<0.001).The mediating effect of EA in the BMI-EA-MSE model was 0.09 D(95%CI=0.06 to 0.12 D),with a mediation proportion of 33%(95%CI=22.1%to 44.6%).No reverse causal associations were detected except for BMI on EA.The results of eQTL-MR and LDSC were consistent with each MR analysis.CONCLUSION:Genetically predicted higher BMI decreases the degree of myopia with a 33%mediation proportion by EA,and fat mass provides a dominant protective role in body mass-myopia.As a supplement to previous observational studies,it provides strong evidence for the relationship between anthropometric traits and refractive errors and offers a theoretical basis for future measures to prevent and control myopia.展开更多
Introduction: The Indian state of Uttar Pradesh (UP) for the past many years has been reported to have many cities with highly polluted air quality. The state has been taking meticulous steps in combating air pollutio...Introduction: The Indian state of Uttar Pradesh (UP) for the past many years has been reported to have many cities with highly polluted air quality. The state has been taking meticulous steps in combating air pollution in the form of action plans, introduced especially in its 17 non-attainment cities (NAC). To assess the progress and development of these action plans in UP, the present study has done an in-depth analysis and review of the state’s action plans and city micro action plans. Materials and Methods: In this research study, the analysis of the latest action plan reports, micro action plan reports as well as the recommendations for combating air pollution-related issues in the 17 NAC of the UP state has been well documented. Uttar Pradesh Pollution Control Board (UPPCB) has prepared these reports to highlight the progress of the plans in response to the growing air pollution in these cities. The information present in the reports has been used to further study sector-specific, category-specific action plans, institutional responsibility, and the present status of the action plans. Results: On average, the highest weightage in action plans was given to sector-specific categories such as Road dust and construction activities (24%). It was also observed that Urban local bodies (~50%) were majorly responsible to implement the action points and 56% of the action points were jointly implemented by multiple agencies.展开更多
基金Supported by Hubei Province Key Research and Development Program Project,Hubei Provincial Department of Science and Technology(No.2022BCA044)Key Scientific Research Projects of Health Commission of Hubei Province in 2023-2024,Health Commission of Hubei Province(No.WJ2023Z006).
文摘AIM:To study the causal relationship between obesityrelated anthropometric traits and myopia and the mediating role of educational attainment(EA).METHODS:Univariable Mendelian randomization(UVMR)was performed to evaluate the causal association between body mass index(BMI),height,waist-hip ratio(WHR,adjusted for BMI),and mean spherical equivalent(MSE).BMI was divided into fat and fat-free mass and included in multivariable Mendelian randomization(MVMR)to explore the roles of different BMI components in the causal relationship between BMI and MSE.A mediation analysis based on two-step Mendelian randomization(MR)was carried out.Specifically,UVMR was conducted to estimate the causal effect of BMI on EA.The direct effect of EA on MSE was estimated from MVMR.The mediation effect of EA in the BMI-EA-MSE model was calculated by the product of coefficients method.Expression quantitative trait loci(eQTL)-MR,reverse MR,and Linkage Disequilibrium Score Regression(LDSC)were performed to assess the robustness.RESULTS:Genetically predicted higher BMI had a positive total effect on MSE(βIVW=0.26 D,95%CI=0.14 to 0.37 D,P<0.001),whereas there was no significant association between height,WHR,and MSE.Fat mass was found to play a significant role in the effect of body mass on MSE(βIVW=0.50 D,95%CI=0.21 to 0.78 D,P=0.001),but there was no significant association between fat-free mass and MSE.The causal effect of BMI on EA was-0.14(95%CI=-0.16 to-0.11,P<0.001),and the direct effect of EA on MSE was-0.63 D(95%CI=-0.81 to-0.44 D,P<0.001).The mediating effect of EA in the BMI-EA-MSE model was 0.09 D(95%CI=0.06 to 0.12 D),with a mediation proportion of 33%(95%CI=22.1%to 44.6%).No reverse causal associations were detected except for BMI on EA.The results of eQTL-MR and LDSC were consistent with each MR analysis.CONCLUSION:Genetically predicted higher BMI decreases the degree of myopia with a 33%mediation proportion by EA,and fat mass provides a dominant protective role in body mass-myopia.As a supplement to previous observational studies,it provides strong evidence for the relationship between anthropometric traits and refractive errors and offers a theoretical basis for future measures to prevent and control myopia.
文摘Introduction: The Indian state of Uttar Pradesh (UP) for the past many years has been reported to have many cities with highly polluted air quality. The state has been taking meticulous steps in combating air pollution in the form of action plans, introduced especially in its 17 non-attainment cities (NAC). To assess the progress and development of these action plans in UP, the present study has done an in-depth analysis and review of the state’s action plans and city micro action plans. Materials and Methods: In this research study, the analysis of the latest action plan reports, micro action plan reports as well as the recommendations for combating air pollution-related issues in the 17 NAC of the UP state has been well documented. Uttar Pradesh Pollution Control Board (UPPCB) has prepared these reports to highlight the progress of the plans in response to the growing air pollution in these cities. The information present in the reports has been used to further study sector-specific, category-specific action plans, institutional responsibility, and the present status of the action plans. Results: On average, the highest weightage in action plans was given to sector-specific categories such as Road dust and construction activities (24%). It was also observed that Urban local bodies (~50%) were majorly responsible to implement the action points and 56% of the action points were jointly implemented by multiple agencies.
