Over the years immunotherapy has demonstrably improved the field of cancer treatment.However,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet need.Combination immunotherapies...Over the years immunotherapy has demonstrably improved the field of cancer treatment.However,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet need.Combination immunotherapies incor-porating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit.Nevertheless,substantial gaps remain in the current therapeutic armamentarium for CRC.In recent years,there has been a surge of interest in exploring novel treatment strategies,including the application of light-activated drugs in conjunction with optical devices.This approach holds promise for achie-ving localized and targeted delivery of cytotoxic agents,such as microtubule-targeting drugs,directly to cancerous cells within the colon.展开更多
BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,...BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious.展开更多
We have made a clerical error in Table 1 on the page of 239, Volume 23, No.4 of Journal of Medical Colleges of PLA (the article is entitled as Expression and role of AQP1 in cervical squamous carcinoma
To editorial board of Acta Mathematica Scientia(Acta MS) I was shocked when I was informed that the paper entitled"Eigenvalue Problem for the Laplacian Equations"by Shao Zhiqiang and Hong Jiaxing appeared in...To editorial board of Acta Mathematica Scientia(Acta MS) I was shocked when I was informed that the paper entitled"Eigenvalue Problem for the Laplacian Equations"by Shao Zhiqiang and Hong Jiaxing appeared in Acta MS(2007)Series B,no 2.For the past 15 years,I have not had any contact with Mr.Shao Zhiqiang and I have展开更多
Aims andscope of the Journal.Medical Journal of Chinese People's Liberation Army(Med J Chin PLA)is a multiple-subjects medical periodical published by the People's Military Medical Press,under the auspice of D...Aims andscope of the Journal.Medical Journal of Chinese People's Liberation Army(Med J Chin PLA)is a multiple-subjects medical periodical published by the People's Military Medical Press,under the auspice of Department of Health,General Logistics Department of PLA,and it展开更多
Aims andscope of the Journal .Medical Journal of Chinese People’s Liberation Army (Med J Chin PLA) is a multiple-subjects medical periodical published by the People’s Military Medical Press,under the auspice of Depa...Aims andscope of the Journal .Medical Journal of Chinese People’s Liberation Army (Med J Chin PLA) is a multiple-subjects medical periodical published by the People’s Military Medical Press,under the auspice of Department ofHealth, General Logistics Department of PLA,andit is issued展开更多
Aims and scope of the Journal. Medical Journal of Chinese People’s Liberation Army (Med J Chin PLA) is a multiple-subjects medical periodical published by the People’s Military Medical Press, under the auspice of De...Aims and scope of the Journal. Medical Journal of Chinese People’s Liberation Army (Med J Chin PLA) is a multiple-subjects medical periodical published by the People’s Military Medical Press, under the auspice of Department of Health, General Logistics Department of PLA, and it is issued domestically and abroad. Med J Chin PLA has become one of the source journals of statistics in Chinese Scientific Thesis and Chinese Scientific Quotation Database, the key periodical of multiple-subject medical journals, and is a prize journal of National Periodical Award and one of the Top Hundred Periodicals in China. Med J Chin PLA is issued monthly. Its permanent sections include Expert Forum, Research on Special Topics, Medical Treatises, Experimental Research, Clinical Research, Technology and Methodology, Discussion of Knotty Cases (Pathology), Reviews, Military Medical Sciences, News in Medicine etc. Manuscripts sent by both domestic and overseas writers are welcome. Contribution of reviews is usually invited by the Editors, but recommendations for topics and authors are welcomed.展开更多
BACKGROUND Hypertrophic scars(HSs)formation is a complication that occurs after wounds heal with secondary intention and sometimes after clean surgical incisions.Many treatments are in vogue now with varying successes...BACKGROUND Hypertrophic scars(HSs)formation is a complication that occurs after wounds heal with secondary intention and sometimes after clean surgical incisions.Many treatments are in vogue now with varying successes.Although the mechanism or mechanisms that cause a HS to form are not clearly understood,one thing that is clear is that once scar tissue matures,any intervention will not be successful.In this paper,we report on a case where a patient who was known to develop HS was treated with a new combination of ingredients(Phyto-chemicals+Silicone JUMI)to suppress HS formation.CASE SUMMARY A 68-year-old female of African descent presented a severe HS post total knee replacement(TKR),which the patient describes as itchy and painful.Due to complications caused by the scar,she was apprehensive about undergoing TKR on her other knee.However,after the TKR of the contralateral side post-removal of skin clips,JUMI anti-scar cream(JASC)was used to suppress excessive scar formation.CONCLUSION JASC appears potent and efficacious at suppressing excessive scar formation.We believe that this warrants further studies on larger patient groups and on different surgical sites.展开更多
Aims andscope of the Journal .Medical Journal of Chinese People’s Liberation Army ( Med J Chin PLA) is a multiple-subjects medical periodical publishedby the People’s Military Medical Press,under the auspice of Depa...Aims andscope of the Journal .Medical Journal of Chinese People’s Liberation Army ( Med J Chin PLA) is a multiple-subjects medical periodical publishedby the People’s Military Medical Press,under the auspice of Department of Health, General Logistics Department of PLA,andit展开更多
Periprosthetic joint infection(PJI)following total knee arthroplasty is one of the most catastrophic and costly complications that carries significant patient wellness as well as economic burdens.The road to efficient...Periprosthetic joint infection(PJI)following total knee arthroplasty is one of the most catastrophic and costly complications that carries significant patient wellness as well as economic burdens.The road to efficiently diagnosing and treating PJI is challenging,as there is still no gold standard method to reach the diagnosis as early as desired.There are also international controversies with respect to the best approach to manage PJI cases.In this review,we highlight recent advances in managing PJI following knee arthroplasty surgery and discuss in depth the two-stage revision method.展开更多
Evaluation,especially negative evaluation,is an important element in academic book reviews.Unfortunately,previous studies on evaluation strategies in Chinese and English book reviews are still limited in number.Recent...Evaluation,especially negative evaluation,is an important element in academic book reviews.Unfortunately,previous studies on evaluation strategies in Chinese and English book reviews are still limited in number.Recently,identity construction has been a hot research issue in various fields of social science.However,few studies have ever been conducted on how book reviewers construct various identities with the use of evaluation strategies.As such,this thesis tries to investigate how the negative evaluation,the most direct face-threatening evaluation,are linked closely to author’ s identity construction in Chinese and English book reviews,how the Chinese and English book reviewers make salient their appropriate identities with the skillful use of discourse strategies so as to avoid possible face-threatening.The present study collects fifteen Chinese and fifteen English academic book reviews as research data.An analysis of the data indicates that while there are similarities,there are also distinctive differences in the use of negative evaluation strategies and author’ s identity construction in Chinese and English book reviews.Specifically,with the use of negative evaluation,four important identities are constructed,namely,the author’ s identities as an authoritative writer,a polite and friendly evaluator,a responsible opinion holder and a kind academic ally.展开更多
文摘Over the years immunotherapy has demonstrably improved the field of cancer treatment.However,achieving long-term survival for colorectal cancer(CRC)patients remains a significant unmet need.Combination immunotherapies incor-porating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit.Nevertheless,substantial gaps remain in the current therapeutic armamentarium for CRC.In recent years,there has been a surge of interest in exploring novel treatment strategies,including the application of light-activated drugs in conjunction with optical devices.This approach holds promise for achie-ving localized and targeted delivery of cytotoxic agents,such as microtubule-targeting drugs,directly to cancerous cells within the colon.
文摘BACKGROUND Heart failure(HF),a common cardiovascular condition,is characterized by significant morbidity and mortality.While traditional Chinese medicine(TCM)is often used as a complementary approach in HF management,systematic evalua-tions of its impact on clinical outcomes,TCM syndrome scores,and B-type natriuretic peptide(BNP)levels are lacking.This study fills this gap through a comprehensive analysis of randomized controlled trials(RCTs)focusing on TCM for HF treatment.It encompasses an assessment of methodological quality,a meta-analysis,and an evaluation of evidence quality based on established standards.The results offer crucial insights into the potential advantages and constraints of TCM in HF management.RCTs on TCM for HF treatment published since the establishment of the database were searched in four Chinese and English databases,including China National Knowledge Infrastructure,Wanfang,VIP Information Chinese Science and Technology Journal,and PubMed.Methodological quality was assessed for the included studies with the Cochrane risk-of-bias assessment tool,and the meta-analysis and publication bias assessment was performed with the RevMan5.3 software.Finally,the quality of evidence was rated according to the GRADE criteria.RESULTS A total of 1098 RCTs were initially retrieved.After screening,16 RCTs were finally included in our study,which were published between 2020 and 2023.These RCTs involved 1660 HF patients,including 832 in the TCM group[TCM combined with conventional Western medicine(CMW)treatment]and 828 in the CWM group(CWM treatment).The course of treatments varied from 1 wk to 3 months.TCM syndrome differentiation was analyzed in 11 of the included RCTs.In all included RCTs,outcome indicators included comprehensive clinical outcomes,TCM syndrome scores,and BNP levels.The meta-analysis results showed significant differences between the TCM and CWM groups in terms of comprehensive clinical outcomes[risk ratio=-0.54;95%confidence interval(CI)=-0.61,-0.47;P<0.00001],TCM syndrome scores[weighted mean difference(WMD)=-142.07;95%CI=-147.56,-136.57;P<0.00001],and BNP levels(WMD=-142.07;95%CI=-147.56,-136.57;P<0.00001).According to the GRADE criteria,RCTs where"TCM improves clinical comprehensive outcomes"were rated as low-quality evidence,and RCTs where"TCM reduces TCM syndrome scores"or"TCM decreases BNP levels"were rated as medium-quality evidence.CONCLUSION TCM combined with CWM treatment effectively improves comprehensive clinical outcomes and diminishes TCM syndrome scores and BNP levels in HF patients.Given the low and medium quality of the included RCTs,the application of these results should be cautious.
文摘We have made a clerical error in Table 1 on the page of 239, Volume 23, No.4 of Journal of Medical Colleges of PLA (the article is entitled as Expression and role of AQP1 in cervical squamous carcinoma
文摘To editorial board of Acta Mathematica Scientia(Acta MS) I was shocked when I was informed that the paper entitled"Eigenvalue Problem for the Laplacian Equations"by Shao Zhiqiang and Hong Jiaxing appeared in Acta MS(2007)Series B,no 2.For the past 15 years,I have not had any contact with Mr.Shao Zhiqiang and I have
文摘Aims andscope of the Journal.Medical Journal of Chinese People's Liberation Army(Med J Chin PLA)is a multiple-subjects medical periodical published by the People's Military Medical Press,under the auspice of Department of Health,General Logistics Department of PLA,and it
文摘Aims andscope of the Journal .Medical Journal of Chinese People’s Liberation Army (Med J Chin PLA) is a multiple-subjects medical periodical published by the People’s Military Medical Press,under the auspice of Department ofHealth, General Logistics Department of PLA,andit is issued
文摘Aims and scope of the Journal. Medical Journal of Chinese People’s Liberation Army (Med J Chin PLA) is a multiple-subjects medical periodical published by the People’s Military Medical Press, under the auspice of Department of Health, General Logistics Department of PLA, and it is issued domestically and abroad. Med J Chin PLA has become one of the source journals of statistics in Chinese Scientific Thesis and Chinese Scientific Quotation Database, the key periodical of multiple-subject medical journals, and is a prize journal of National Periodical Award and one of the Top Hundred Periodicals in China. Med J Chin PLA is issued monthly. Its permanent sections include Expert Forum, Research on Special Topics, Medical Treatises, Experimental Research, Clinical Research, Technology and Methodology, Discussion of Knotty Cases (Pathology), Reviews, Military Medical Sciences, News in Medicine etc. Manuscripts sent by both domestic and overseas writers are welcome. Contribution of reviews is usually invited by the Editors, but recommendations for topics and authors are welcomed.
文摘BACKGROUND Hypertrophic scars(HSs)formation is a complication that occurs after wounds heal with secondary intention and sometimes after clean surgical incisions.Many treatments are in vogue now with varying successes.Although the mechanism or mechanisms that cause a HS to form are not clearly understood,one thing that is clear is that once scar tissue matures,any intervention will not be successful.In this paper,we report on a case where a patient who was known to develop HS was treated with a new combination of ingredients(Phyto-chemicals+Silicone JUMI)to suppress HS formation.CASE SUMMARY A 68-year-old female of African descent presented a severe HS post total knee replacement(TKR),which the patient describes as itchy and painful.Due to complications caused by the scar,she was apprehensive about undergoing TKR on her other knee.However,after the TKR of the contralateral side post-removal of skin clips,JUMI anti-scar cream(JASC)was used to suppress excessive scar formation.CONCLUSION JASC appears potent and efficacious at suppressing excessive scar formation.We believe that this warrants further studies on larger patient groups and on different surgical sites.
文摘Aims andscope of the Journal .Medical Journal of Chinese People’s Liberation Army ( Med J Chin PLA) is a multiple-subjects medical periodical publishedby the People’s Military Medical Press,under the auspice of Department of Health, General Logistics Department of PLA,andit
文摘Periprosthetic joint infection(PJI)following total knee arthroplasty is one of the most catastrophic and costly complications that carries significant patient wellness as well as economic burdens.The road to efficiently diagnosing and treating PJI is challenging,as there is still no gold standard method to reach the diagnosis as early as desired.There are also international controversies with respect to the best approach to manage PJI cases.In this review,we highlight recent advances in managing PJI following knee arthroplasty surgery and discuss in depth the two-stage revision method.
文摘Evaluation,especially negative evaluation,is an important element in academic book reviews.Unfortunately,previous studies on evaluation strategies in Chinese and English book reviews are still limited in number.Recently,identity construction has been a hot research issue in various fields of social science.However,few studies have ever been conducted on how book reviewers construct various identities with the use of evaluation strategies.As such,this thesis tries to investigate how the negative evaluation,the most direct face-threatening evaluation,are linked closely to author’ s identity construction in Chinese and English book reviews,how the Chinese and English book reviewers make salient their appropriate identities with the skillful use of discourse strategies so as to avoid possible face-threatening.The present study collects fifteen Chinese and fifteen English academic book reviews as research data.An analysis of the data indicates that while there are similarities,there are also distinctive differences in the use of negative evaluation strategies and author’ s identity construction in Chinese and English book reviews.Specifically,with the use of negative evaluation,four important identities are constructed,namely,the author’ s identities as an authoritative writer,a polite and friendly evaluator,a responsible opinion holder and a kind academic ally.
